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Items: 1 to 50 of 96

1.

C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance.

Jimenez RV, Wright TT, Jones NR, Wu J, Gibson AW, Szalai AJ.

Front Immunol. 2018 Mar 5;9:372. doi: 10.3389/fimmu.2018.00372. eCollection 2018.

2.

Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.

Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C.

J Clin Invest. 2018 Jan 2;128(1):309-322. doi: 10.1172/JCI89333. Epub 2017 Nov 27.

3.

C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.

Lai W, Tang Y, Huang XR, Ming-Kuen Tang P, Xu A, Szalai AJ, Lou TQ, Lan HY.

Kidney Int. 2016 Sep;90(3):610-26. doi: 10.1016/j.kint.2016.06.010. Epub 2016 Jul 26.

4.

C-reactive protein exacerbates renal ischemia-reperfusion injury: are myeloid-derived suppressor cells to blame?

Pegues MA, McWilliams IL, Szalai AJ.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F176-81. doi: 10.1152/ajprenal.00107.2016. Epub 2016 Apr 6.

5.

Human C-reactive protein impedes entry of leptin into the CNS and attenuates its physiological actions in the CNS.

Li J, Wei D, McCrory MA, Szalai AJ, Yang G, Li L, Li F, Zhao AZ.

Biochem J. 2016 May 1;473(9):1215-24. doi: 10.1042/BJ20151282. Epub 2016 Mar 1.

PMID:
26933237
6.

Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice.

Wright TT, Jimenez RV, Morgan TE, Bali N, Hou X, McCrory MA, Finch CE, Szalai AJ.

Autoimmune Dis. 2015;2015:640171. doi: 10.1155/2015/640171. Epub 2015 Sep 3.

7.

Effects of the Dietary ω3:ω6 Fatty Acid Ratio on Body Fat and Inflammation in Zebrafish (Danio rerio).

Powell ML, Pegues MA, Szalai AJ, Ghanta VK, D'Abramo LR, Watts SA.

Comp Med. 2015 Aug;65(4):289-94.

8.

The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis.

Danila MI, Westfall AO, Raman K, Chen L, Reynolds RJ, Hughes LB, Arnett DK, McGwin G, Szalai AJ, van der Heijde DM, Conn D, Callahan LF, Moreland LW, Bridges SL Jr.

Genes Immun. 2015 Oct;16(7):446-51. doi: 10.1038/gene.2015.24. Epub 2015 Jul 30.

9.

C-reactive protein directly suppresses Th1 cell differentiation and alleviates experimental autoimmune encephalomyelitis.

Zhang L, Liu SH, Wright TT, Shen ZY, Li HY, Zhu W, Potempa LA, Ji SR, Szalai AJ, Wu Y.

J Immunol. 2015 Jun 1;194(11):5243-52. doi: 10.4049/jimmunol.1402909. Epub 2015 Apr 27.

10.

Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patients.

Mrug M, Zhou J, Mrug S, Guay-Woodford LM, Yoder BK, Szalai AJ.

J Intern Med. 2014 Nov;276(5):539-40. doi: 10.1111/joim.12307. Epub 2014 Sep 30. No abstract available.

11.

C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein grafts.

Ji Y, Fish PM, Strawn TL, Lohman AW, Wu J, Szalai AJ, Fay WP.

J Thromb Haemost. 2014 Oct;12(10):1667-77. doi: 10.1111/jth.12680. Epub 2014 Aug 23.

12.

Human neutrophil flow chamber adhesion assay.

Zhou Y, Kucik DF, Szalai AJ, Edberg JC.

J Vis Exp. 2014 Jul 2;(89). doi: 10.3791/51410.

13.

Deletion of C-reactive protein ameliorates experimental cerebral malaria?

Szalai AJ, Barnum SR, Ramos TN.

Trans R Soc Trop Med Hyg. 2014 Sep;108(9):591-3. doi: 10.1093/trstmh/tru098. Epub 2014 Jul 7.

14.

Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors.

Bowling MR, Xing D, Kapadia A, Chen YF, Szalai AJ, Oparil S, Hage FG.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1477-1485. doi: 10.1161/ATVBAHA.114.303629. Epub 2014 May 29.

15.

Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular health.

Owsley C, Huisingh C, Jackson GR, Curcio CA, Szalai AJ, Dashti N, Clark M, Rookard K, McCrory MA, Wright TT, Callahan MA, Kline LB, Witherspoon CD, McGwin G Jr.

Invest Ophthalmol Vis Sci. 2014 May 22;55(8):4776-89. doi: 10.1167/iovs.14-14502.

16.

Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models.

Szalai AJ, McCrory MA, Xing D, Hage FG, Miller A, Oparil S, Chen YF, Mazzone M, Early R, Henry SP, Zanardi TA, Graham MJ, Crooke RM.

Mediators Inflamm. 2014;2014:353614. doi: 10.1155/2014/353614. Epub 2014 Apr 2.

17.

C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration.

Tang Y, Huang XR, Lv J, Chung AC, Zhang Y, Chen JZ, Szalai AJ, Xu A, Lan HY.

Clin Sci (Lond). 2014 May;126(9):645-59. doi: 10.1042/CS20130471.

PMID:
24206243
18.

Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils.

Zhou Y, Wu J, Kucik DF, White NB, Redden DT, Szalai AJ, Bullard DC, Edberg JC.

Arthritis Rheum. 2013 Nov;65(11):2907-16. doi: 10.1002/art.38117.

19.

C-reactive protein exacerbates renal ischemia-reperfusion injury.

Pegues MA, McCrory MA, Zarjou A, Szalai AJ.

Am J Physiol Renal Physiol. 2013 Jun 1;304(11):F1358-65. doi: 10.1152/ajprenal.00476.2012. Epub 2013 Mar 27.

20.

Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine.

Mukerji R, Mirza S, Roche AM, Widener RW, Croney CM, Rhee DK, Weiser JN, Szalai AJ, Briles DE.

J Immunol. 2012 Dec 1;189(11):5327-35. doi: 10.4049/jimmunol.1201967. Epub 2012 Oct 26.

21.

Associations of C-Reactive Protein to Indices of Vascular Health and the Influence of Serum 25(OH)D Status in Healthy Adults.

Ashraf AP, Fisher G, Alvarez J, Dudenbostel T, Calhoun DA, Szalai AJ, Gower BA.

J Nutr Metab. 2012;2012:475975. doi: 10.1155/2012/475975. Epub 2012 Sep 16.

22.

Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement.

Zhou J, Ouyang X, Schoeb TR, Bolisetty S, Cui X, Mrug S, Yoder BK, Johnson MR, Szalai AJ, Mrug M.

J Am Soc Nephrol. 2012 Jul;23(7):1161-71. doi: 10.1681/ASN.2011050442. Epub 2012 Apr 19.

23.

A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans.

Jones NR, Pegues MA, McCrory MA, Singleton W, Bethune C, Baker BF, Norris DA, Crooke RM, Graham MJ, Szalai AJ.

Mol Ther Nucleic Acids. 2012 Nov 13;1:e52. doi: 10.1038/mtna.2012.44.

24.

Biomarkers of inflammation and hemostasis associated with left ventricular mass: The Multiethnic Study of Atherosclerosis (MESA).

Arnett DK, McClelland RL, Bank A, Bluemke DA, Cushman M, Szalai AJ, Jain N, Gomes AS, Heckbert SR, Hundley WG, Lima JA.

Int J Mol Epidemiol Genet. 2011;2(4):391-400. Epub 2011 Nov 28.

25.

An about-face for C-reactive protein?

Szalai AJ.

Clin Chem. 2011 Oct;57(10):1351-3. doi: 10.1373/clinchem.2011.172296. Epub 2011 Aug 5. No abstract available.

26.

C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.

Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY.

Diabetologia. 2011 Oct;54(10):2713-23. doi: 10.1007/s00125-011-2237-y. Epub 2011 Jul 9.

PMID:
21744073
27.

Collagen-induced arthritis is exacerbated in C-reactive protein-deficient mice.

Jones NR, Pegues MA, McCrory MA, Kerr SW, Jiang H, Sellati R, Berger V, Villalona J, Parikh R, McFarland M, Pantages L, Madwed JB, Szalai AJ.

Arthritis Rheum. 2011 Sep;63(9):2641-50. doi: 10.1002/art.30444.

28.

C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice.

Li ZI, Chung AC, Zhou L, Huang XR, Liu F, Fu P, Fan JM, Szalai AJ, Lan HY.

Lab Invest. 2011 Jun;91(6):837-51. doi: 10.1038/labinvest.2011.42. Epub 2011 Mar 7.

29.

Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent.

Hu XZ, Wright TT, Jones NR, Ramos TN, Skibinski GA, McCrory MA, Barnum SR, Szalai AJ.

Autoimmune Dis. 2010 Oct 12;2011:484936. doi: 10.4061/2011/484936.

30.

Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence.

Li J, Wang JP, Ghiran I, Cerny A, Szalai AJ, Briles DE, Finberg RW.

Infect Immun. 2010 Jul;78(7):3129-35. doi: 10.1128/IAI.01263-09. Epub 2010 May 3.

31.

C-reactive protein-mediated vascular injury requires complement.

Hage FG, Oparil S, Xing D, Chen YF, McCrory MA, Szalai AJ.

Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1189-95. doi: 10.1161/ATVBAHA.110.205377. Epub 2010 Mar 25.

32.

C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease.

Zhang R, Zhang YY, Huang XR, Wu Y, Chung AC, Wu EX, Szalai AJ, Wong BC, Lau CP, Lan HY.

Hypertension. 2010 Apr;55(4):953-60. doi: 10.1161/HYPERTENSIONAHA.109.140608. Epub 2010 Feb 15.

PMID:
20157054
33.

The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk.

Hage FG, Szalai AJ.

Curr Atheroscler Rep. 2009 Mar;11(2):124-30. Review.

PMID:
19228486
34.

Antibody to the type 3 capsule facilitates immune adherence of pneumococci to erythrocytes and augments their transfer to macrophages.

Li J, Szalai AJ, Hollingshead SK, Nahm MH, Briles DE.

Infect Immun. 2009 Jan;77(1):464-71. doi: 10.1128/IAI.00892-08. Epub 2008 Nov 10.

35.

Deletion of both ICAM-1 and C3 enhances severity of experimental autoimmune encephalomyelitis compared to C3-deficient mice.

Smith SS, Ludwig M, Wohler JE, Bullard DC, Szalai AJ, Barnum SR.

Neurosci Lett. 2008 Sep 12;442(2):158-60. doi: 10.1016/j.neulet.2008.07.005. Epub 2008 Jul 6.

36.

Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion.

Li X, Su K, Ji C, Szalai AJ, Wu J, Zhang Y, Zhou T, Kimberly RP, Edberg JC.

J Immunol. 2008 Jul 15;181(2):1012-8.

37.

Impaired endothelial function in C-reactive protein overexpressing mice.

Teoh H, Quan A, Lovren F, Wang G, Tirgari S, Szmitko PE, Szalai AJ, Ward ME, Verma S.

Atherosclerosis. 2008 Dec;201(2):318-25. doi: 10.1016/j.atherosclerosis.2008.02.034. Epub 2008 Mar 20.

PMID:
18433756
38.

Neointimal formation is reduced after arterial injury in human crp transgenic mice.

Danenberg HD, Grad E, Swaminathan RV, Chen Z, Seifert P, Szalai AJ, Lotan C, Simon DI, Edelman ER.

Atherosclerosis. 2008 Nov;201(1):85-91. doi: 10.1016/j.atherosclerosis.2008.01.013. Epub 2008 Feb 13.

39.

Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent.

Xing D, Hage FG, Chen YF, McCrory MA, Feng W, Skibinski GA, Majid-Hassan E, Oparil S, Szalai AJ.

Am J Pathol. 2008 Jan;172(1):22-30. Epub 2007 Dec 6.

40.

Overexpression of innate immune response genes in a model of recessive polycystic kidney disease.

Mrug M, Zhou J, Woo Y, Cui X, Szalai AJ, Novak J, Churchill GA, Guay-Woodford LM.

Kidney Int. 2008 Jan;73(1):63-76. Epub 2007 Oct 24.

41.

PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation.

Li J, Glover DT, Szalai AJ, Hollingshead SK, Briles DE.

Infect Immun. 2007 Dec;75(12):5877-85. Epub 2007 Oct 8.

42.

C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk.

Hage FG, Szalai AJ.

J Am Coll Cardiol. 2007 Sep 18;50(12):1115-22. Epub 2007 Sep 4. Review.

43.

Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease.

Szalai AJ, Hu X, Adams JE, Barnum SR.

Mol Immunol. 2007 May;44(12):3132-6. Epub 2007 Mar 13.

44.

C-reactive protein polymorphism and Crohn's disease.

Szalai AJ, Alarcón GS.

Aliment Pharmacol Ther. 2007 Feb 15;25(4):519; author reply 520-1. No abstract available.

45.

Induction of leptin resistance through direct interaction of C-reactive protein with leptin.

Chen K, Li F, Li J, Cai H, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ.

Nat Med. 2006 Apr;12(4):425-32. Epub 2006 Apr 2.

PMID:
16582918
46.

Experimental autoimmune uveitis in the C57BL/6 mouse.

Read RW, Vogt SD, Barnum SR, Szalai AJ.

Exp Eye Res. 2006 Jul;83(1):229-30; author reply 231. Epub 2006 Mar 9. No abstract available.

PMID:
16524572
47.

Complement and demyelinating disease: no MAC needed?

Barnum SR, Szalai AJ.

Brain Res Rev. 2006 Aug 30;52(1):58-68. Epub 2006 Jan 26. Review.

PMID:
16443278
48.

Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated.

Osmers I, Szalai AJ, Tenner AJ, Barnum SR.

Mol Immunol. 2006 Apr;43(10):1722-5. Epub 2005 Nov 28.

PMID:
16310250
50.

Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis.

Read RW, Szalai AJ, Vogt SD, McGwin G, Barnum SR.

Exp Eye Res. 2006 Mar;82(3):389-94. Epub 2005 Sep 6.

PMID:
16143328

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