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Items: 1 to 50 of 144

1.

The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification.

Rakvács Z, Kucsma N, Gera M, Igriczi B, Kiss K, Barna J, Kovács D, Vellai T, Bencs L, Reisecker JM, Szoboszlai N, Szakács G.

Cell Mol Life Sci. 2019 Oct;76(20):4131-4144. doi: 10.1007/s00018-019-03105-5. Epub 2019 May 3.

2.

Identification of anticancer OATP2B1 substrates by an in vitro triple-fluorescence-based cytotoxicity screen.

Windt T, Tóth S, Patik I, Sessler J, Kucsma N, Szepesi Á, Zdrazil B, Özvegy-Laczka C, Szakács G.

Arch Toxicol. 2019 Apr;93(4):953-964. doi: 10.1007/s00204-019-02417-6. Epub 2019 Mar 12.

3.

Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases.

Pape VFS, May NV, Gál GT, Szatmári I, Szeri F, Fülöp F, Szakács G, Enyedy ÉA.

Dalton Trans. 2018 Dec 4;47(47):17032-17045. doi: 10.1039/c8dt03088j.

PMID:
30460942
4.

Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells.

Varga K, Hollósi A, Pászty K, Hegedűs L, Szakács G, Tímár J, Papp B, Enyedi Á, Padányi R.

BMC Cancer. 2018 Oct 23;18(1):1029. doi: 10.1186/s12885-018-4945-x.

5.

The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition.

Hager S, Korbula K, Bielec B, Grusch M, Pirker C, Schosserer M, Liendl L, Lang M, Grillari J, Nowikovsky K, Pape VFS, Mohr T, Szakács G, Keppler BK, Berger W, Kowol CR, Heffeter P.

Cell Death Dis. 2018 Oct 15;9(11):1052. doi: 10.1038/s41419-018-1102-z.

6.

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters.

Temesszentandrási-Ambrus C, Tóth S, Verma R, Bánhegyi P, Szabadkai I, Baska F, Szántai-Kis C, Hartkoorn RC, Lingerfelt MA, Sarkadi B, Szakács G, Őrfi L, Nagaraja V, Ekins S, Telbisz Á.

PLoS One. 2018 Sep 5;13(9):e0202749. doi: 10.1371/journal.pone.0202749. eCollection 2018.

7.

Design of a migration assay for human gingival fibroblasts on biodegradable magnesium surfaces.

Amberg R, Elad A, Rothamel D, Fienitz T, Szakacs G, Heilmann S, Witte F.

Acta Biomater. 2018 Oct 1;79:158-167. doi: 10.1016/j.actbio.2018.08.034. Epub 2018 Aug 30.

PMID:
30172066
8.

ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation.

Bergam P, Reisecker JM, Rakvács Z, Kucsma N, Raposo G, Szakacs G, van Niel G.

J Mol Biol. 2018 Oct 12;430(20):3802-3818. doi: 10.1016/j.jmb.2018.06.033. Epub 2018 Jun 22.

PMID:
29940187
9.

Sensitivity enhancement for mycotoxin determination by optical waveguide lightmode spectroscopy using gold nanoparticles of different size and origin.

Adányi N, Nagy ÁG, Takács B, Szendrő I, Szakacs G, Szűcs R, Tóth-Szeles E, Lagzi I, Weiser D, Bódai V, Sátorhelyi P, Erdélyi B.

Food Chem. 2018 Nov 30;267:10-14. doi: 10.1016/j.foodchem.2018.04.089. Epub 2018 Apr 23.

PMID:
29934142
10.
11.

Development of novel cyclic NGR peptide-daunomycin conjugates with dual targeting property.

Tripodi AAP, Tóth S, Enyedi KN, Schlosser G, Szakács G, Mező G.

Beilstein J Org Chem. 2018 Apr 25;14:911-918. doi: 10.3762/bjoc.14.78. eCollection 2018.

12.

Green synthesis of gold nanoparticles by thermophilic filamentous fungi.

Molnár Z, Bódai V, Szakacs G, Erdélyi B, Fogarassy Z, Sáfrán G, Varga T, Kónya Z, Tóth-Szeles E, Szűcs R, Lagzi I.

Sci Rep. 2018 Mar 2;8(1):3943. doi: 10.1038/s41598-018-22112-3.

13.

Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1.

Patik I, Székely V, Német O, Szepesi Á, Kucsma N, Várady G, Szakács G, Bakos É, Özvegy-Laczka C.

Sci Rep. 2018 Feb 8;8(1):2630. doi: 10.1038/s41598-018-20815-1.

14.

Dissecting the Forces that Dominate Dimerization of the Nucleotide Binding Domains of ABCB1.

Szöllősi D, Szakács G, Chiba P, Stockner T.

Biophys J. 2018 Jan 23;114(2):331-342. doi: 10.1016/j.bpj.2017.11.022.

15.

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions.

Szabó E, Türk D, Telbisz Á, Kucsma N, Horváth T, Szakács G, Homolya L, Sarkadi B, Várady G.

PLoS One. 2018 Jan 17;13(1):e0190629. doi: 10.1371/journal.pone.0190629. eCollection 2018.

16.

Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development.

Heffeter P, Pape VFS, Enyedy ÉA, Keppler BK, Szakacs G, Kowol CR.

Antioxid Redox Signal. 2019 Mar 10;30(8):1062-1082. doi: 10.1089/ars.2017.7487. Epub 2018 Feb 26.

PMID:
29334758
17.

Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography.

Bauer M, Matsuda A, Wulkersdorfer B, Philippe C, Traxl A, Özvegy-Laczka C, Stanek J, Nics L, Klebermass EM, Poschner S, Jäger W, Patik I, Bakos É, Szakács G, Wadsak W, Hacker M, Zeitlinger M, Langer O.

Clin Pharmacol Ther. 2018 Jul;104(1):139-147. doi: 10.1002/cpt.888. Epub 2017 Nov 3.

18.

Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis.

Sohail MI, Schmid D, Wlcek K, Spork M, Szakács G, Trauner M, Stockner T, Chiba P.

Mol Pharmacol. 2017 Oct;92(4):401-413. doi: 10.1124/mol.117.108688. Epub 2017 Aug 7.

PMID:
28784620
19.

Microhardness and In Vitro Corrosion of Heat-Treated Mg-Y-Ag Biodegradable Alloy.

Vlček M, Lukáč F, Kudrnová H, Smola B, Stulíková I, Luczak M, Szakács G, Hort N, Willumeit-Römer R.

Materials (Basel). 2017 Jan 11;10(1). pii: E55. doi: 10.3390/ma10010055.

20.

Pegylated liposomal formulation of doxorubicin overcomes drug resistance in a genetically engineered mouse model of breast cancer.

Füredi A, Szebényi K, Tóth S, Cserepes M, Hámori L, Nagy V, Karai E, Vajdovich P, Imre T, Szabó P, Szüts D, Tóvári J, Szakács G.

J Control Release. 2017 Sep 10;261:287-296. doi: 10.1016/j.jconrel.2017.07.010. Epub 2017 Jul 9.

PMID:
28700899
21.

[Renal transplantations in the Centre for Nephrology in Szombathely, 1976-2016].

Dobos A, Ruzsa E, Molnár E, Szakács G, Kulcsár I.

Orv Hetil. 2017 Jun;158(25):984-991. doi: 10.1556/650.2017.30782. Hungarian.

PMID:
28627948
22.

NGR-peptide-drug conjugates with dual targeting properties.

Enyedi KN, Tóth S, Szakács G, Mező G.

PLoS One. 2017 Jun 2;12(6):e0178632. doi: 10.1371/journal.pone.0178632. eCollection 2017.

23.

Cell type-dependent HIF1 α-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells.

Tátrai E, Bartal A, Gacs A, Paku S, Kenessey I, Garay T, Hegedűs B, Molnár E, Cserepes MT, Hegedűs Z, Kucsma N, Szakács G, Tóvári J.

Oncotarget. 2017 Jul 4;8(27):44498-44510. doi: 10.18632/oncotarget.17806.

24.

Synthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters.

Dankó B, Tóth S, Martins A, Vágvölgyi M, Kúsz N, Molnár J, Chang FR, Wu YC, Szakács G, Hunyadi A.

ChemMedChem. 2017 Jun 7;12(11):850-859. doi: 10.1002/cmdc.201700225. Epub 2017 May 23.

PMID:
28436164
25.

Comparative solution equilibrium studies of antitumor ruthenium(η6-p-cymene) and rhodium(η5-C5Me5) complexes of 8-hydroxyquinolines.

Dömötör O, Pape VFS, May NV, Szakács G, Enyedy ÉA.

Dalton Trans. 2017 Mar 27;46(13):4382-4396. doi: 10.1039/c7dt00439g.

PMID:
28287667
26.

Identification of Extracellular Segments by Mass Spectrometry Improves Topology Prediction of Transmembrane Proteins.

Langó T, Róna G, Hunyadi-Gulyás É, Turiák L, Varga J, Dobson L, Várady G, Drahos L, Vértessy BG, Medzihradszky KF, Szakács G, Tusnády GE.

Sci Rep. 2017 Feb 13;7:42610. doi: 10.1038/srep42610.

27.

Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line-Specific Effects from P-Glycoprotein-Induced Toxicity.

Füredi A, Tóth S, Szebényi K, Pape VF, Türk D, Kucsma N, Cervenak L, Tóvári J, Szakács G.

Mol Cancer Ther. 2017 Jan;16(1):45-56. doi: 10.1158/1535-7163.MCT-16-0333-T. Epub 2016 Oct 19.

28.

Effects of Corroded and Non-Corroded Biodegradable Mg and Mg Alloys on Viability, Morphology and Differentiation of MC3T3-E1 Cells Elicited by Direct Cell/Material Interaction.

Mostofi S, Bonyadi Rad E, Wiltsche H, Fasching U, Szakacs G, Ramskogler C, Srinivasaiah S, Ueçal M, Willumeit R, Weinberg AM, Schaefer U.

PLoS One. 2016 Jul 26;11(7):e0159879. doi: 10.1371/journal.pone.0159879. eCollection 2016.

29.

Shotgun Lipidomic Profiling of the NCI60 Cell Line Panel Using Rapid Evaporative Ionization Mass Spectrometry.

Strittmatter N, Lovrics A, Sessler J, McKenzie JS, Bodai Z, Doria ML, Kucsma N, Szakacs G, Takats Z.

Anal Chem. 2016 Aug 2;88(15):7507-14. doi: 10.1021/acs.analchem.6b00187. Epub 2016 Jul 15.

30.

Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression.

Englinger B, Lötsch D, Pirker C, Mohr T, van Schoonhoven S, Boidol B, Lardeau CH, Spitzwieser M, Szabó P, Heffeter P, Lang I, Cichna-Markl M, Grasl-Kraupp B, Marian B, Grusch M, Kubicek S, Szakács G, Berger W.

Oncotarget. 2016 Aug 2;7(31):50161-50179. doi: 10.18632/oncotarget.10324.

31.

Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance.

Pape VF, Tóth S, Füredi A, Szebényi K, Lovrics A, Szabó P, Wiese M, Szakács G.

Eur J Med Chem. 2016 Jul 19;117:335-54. doi: 10.1016/j.ejmech.2016.03.078. Epub 2016 Mar 30.

PMID:
27161177
32.

A single active catalytic site is sufficient to promote transport in P-glycoprotein.

Bársony O, Szalóki G, Türk D, Tarapcsák S, Gutay-Tóth Z, Bacsó Z, Holb IJ, Székvölgyi L, Szabó G, Csanády L, Szakács G, Goda K.

Sci Rep. 2016 Apr 27;6:24810. doi: 10.1038/srep24810.

33.

Characterization of Disease-Associated Mutations in Human Transmembrane Proteins.

Molnár J, Szakács G, Tusnády GE.

PLoS One. 2016 Mar 17;11(3):e0151760. doi: 10.1371/journal.pone.0151760. eCollection 2016.

34.

In vitro and in vivo comparison of binary Mg alloys and pure Mg.

Myrissa A, Agha NA, Lu Y, Martinelli E, Eichler J, Szakács G, Kleinhans C, Willumeit-Römer R, Schäfer U, Weinberg AM.

Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:865-74. doi: 10.1016/j.msec.2015.12.064. Epub 2015 Dec 30.

35.

[Relevance of animal models in the development of compounds targeting multidrug resistant cancer].

Füredi A, Tóth S, Hámori L, Nagy V, Tóvári J, Szakács G.

Magy Onkol. 2015 Dec;59(4):338-45. Epub 2015 Oct 28. Hungarian.

36.

Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate.

Patik I, Kovacsics D, Német O, Gera M, Várady G, Stieger B, Hagenbuch B, Szakács G, Özvegy-Laczka C.

Biochem Pharmacol. 2015 Dec 15;98(4):649-58. doi: 10.1016/j.bcp.2015.09.015. Epub 2015 Sep 28.

37.

Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling.

Szebényi K, Füredi A, Kolacsek O, Pergel E, Bősze Z, Bender B, Vajdovich P, Tóvári J, Homolya L, Szakács G, Héja L, Enyedi Á, Sarkadi B, Apáti Á, Orbán TI.

Sci Rep. 2015 Aug 3;5:12645. doi: 10.1038/srep12645.

38.

A novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune system.

Tóth A, Brózik A, Szakács G, Sarkadi B, Hegedüs T.

PLoS One. 2015 Feb 20;10(2):e0115533. doi: 10.1371/journal.pone.0115533. eCollection 2015.

39.

Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein.

Kiss K, Kucsma N, Brozik A, Tusnady GE, Bergam P, van Niel G, Szakacs G.

Biochem J. 2015 Apr 1;467(1):127-39. doi: 10.1042/BJ20141085.

40.

Synthesis and characterization of the anticancer and metal binding properties of novel pyrimidinylhydrazone derivatives.

Pape VF, Türk D, Szabó P, Wiese M, Enyedy EA, Szakács G.

J Inorg Biochem. 2015 Mar;144:18-30. doi: 10.1016/j.jinorgbio.2014.12.015. Epub 2014 Dec 20.

41.

Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter.

Gál Z, Hegedüs C, Szakács G, Váradi A, Sarkadi B, Özvegy-Laczka C.

Biochim Biophys Acta. 2015 Feb;1848(2):477-87. doi: 10.1016/j.bbamem.2014.11.006. Epub 2014 Nov 14.

42.

Screening the expression of ABCB6 in erythrocytes reveals an unexpectedly high frequency of Lan mutations in healthy individuals.

Koszarska M, Kucsma N, Kiss K, Varady G, Gera M, Antalffy G, Andrikovics H, Tordai A, Studzian M, Strapagiel D, Pulaski L, Tani Y, Sarkadi B, Szakacs G.

PLoS One. 2014 Oct 31;9(10):e111590. doi: 10.1371/journal.pone.0111590. eCollection 2014.

43.

Ultrasound-assisted extraction and characterization of hydrolytic and oxidative enzymes produced by solid state fermentation.

Szabo OE, Csiszar E, Toth K, Szakacs G, Koczka B.

Ultrason Sonochem. 2015 Jan;22:249-56. doi: 10.1016/j.ultsonch.2014.07.001. Epub 2014 Jul 8.

PMID:
25043555
44.

Sucrose esters increase drug penetration, but do not inhibit p-glycoprotein in caco-2 intestinal epithelial cells.

Kiss L, Hellinger É, Pilbat AM, Kittel Á, Török Z, Füredi A, Szakács G, Veszelka S, Sipos P, Ózsvári B, Puskás LG, Vastag M, Szabó-Révész P, Deli MA.

J Pharm Sci. 2014 Oct;103(10):3107-19. doi: 10.1002/jps.24085. Epub 2014 Jul 16.

PMID:
25042090
45.

Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance.

Szakács G, Hall MD, Gottesman MM, Boumendjel A, Kachadourian R, Day BJ, Baubichon-Cortay H, Di Pietro A.

Chem Rev. 2014 Jun 11;114(11):5753-74. doi: 10.1021/cr4006236. Epub 2014 Apr 23. Review. No abstract available.

46.

Expression pattern of the human ABC transporters in pluripotent embryonic stem cells and in their derivatives.

Erdei Z, Lőrincz R, Szebényi K, Péntek A, Varga N, Likó I, Várady G, Szakács G, Orbán TI, Sarkadi B, Apáti A.

Cytometry B Clin Cytom. 2014 Sep;86(5):299-310. doi: 10.1002/cyto.b.21168. Epub 2014 Apr 11.

47.

Inhibition of Escherichia coli in cultivated cattle manure.

Weinberg ZG, Szakacs G, Chen Y, Pinto R, Bernstein S, Konya B, Sela Saldinger S.

J Anim Sci. 2014 May;92(5):2336-41. doi: 10.2527/jas.2013-7285. Epub 2014 Mar 18.

PMID:
24663194
48.

ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity.

Gauthier C, Ozvegy-Laczka C, Szakacs G, Sarkadi B, Di Pietro A.

Front Pharmacol. 2013 Nov 7;4:138. doi: 10.3389/fphar.2013.00138. eCollection 2013.

49.

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2.

Winter E, Lecerf-Schmidt F, Gozzi G, Peres B, Lightbody M, Gauthier C, Ozvegy-Laczka C, Szakacs G, Sarkadi B, Creczynski-Pasa TB, Boumendjel A, Di Pietro A.

J Med Chem. 2013 Dec 27;56(24):9849-60. doi: 10.1021/jm401649j. Epub 2013 Dec 13.

PMID:
24304387
50.

ABCC6 is a basolateral plasma membrane protein.

Pomozi V, Le Saux O, Brampton C, Apana A, Iliás A, Szeri F, Martin L, Monostory K, Paku S, Sarkadi B, Szakács G, Váradi A.

Circ Res. 2013 May 24;112(11):e148-51. doi: 10.1161/CIRCRESAHA.111.300194. Epub 2013 Apr 26.

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