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Items: 21


Development of the Texas A&M Superfund Research Program Computational Platform for Data Integration, Visualization, and Analysis.

Mukherjee R, Onel M, Beykal B, Szafran AT, Stossi F, Mancini MA, Zhou L, Wright FA, Pistikopoulos EN.

ESCAPE. 2019;46:967-972. doi: 10.1016/B978-0-12-818634-3.50162-4. Epub 2019 Jul 25.


Leveraging Image-Derived Phenotypic Measurements for Drug-Target Interaction Predictions.

Kuthuru S, Szafran AT, Stossi F, Mancini MA, Rao A.

Cancer Inform. 2019 Jun 12;18:1176935119856595. doi: 10.1177/1176935119856595. eCollection 2019.


Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.

Xia J, Chiu LY, Nehring RB, Bravo Núñez MA, Mei Q, Perez M, Zhai Y, Fitzgerald DM, Pribis JP, Wang Y, Hu CW, Powell RT, LaBonte SA, Jalali A, Matadamas Guzmán ML, Lentzsch AM, Szafran AT, Joshi MC, Richters M, Gibson JL, Frisch RL, Hastings PJ, Bates D, Queitsch C, Hilsenbeck SG, Coarfa C, Hu JC, Siegele DA, Scott KL, Liang H, Mancini MA, Herman C, Miller KM, Rosenberg SM.

Cell. 2019 Jan 10;176(1-2):127-143.e24. doi: 10.1016/j.cell.2018.12.008.


Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis.

Szafran AT, Stossi F, Mancini MG, Walker CL, Mancini MA.

PLoS One. 2017 Jul 13;12(7):e0180141. doi: 10.1371/journal.pone.0180141. eCollection 2017.


High-Content Screening Identifies Src Family Kinases as Potential Regulators of AR-V7 Expression and Androgen-Independent Cell Growth.

Szafran AT, Stephan C, Bolt M, Mancini MG, Marcelli M, Mancini MA.

Prostate. 2017 Jan;77(1):82-93. doi: 10.1002/pros.23251. Epub 2016 Oct 4.


Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer.

Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A.

Nat Commun. 2016 May 19;7:11612. doi: 10.1038/ncomms11612.


CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy.

Sun H, Mediwala SN, Szafran AT, Mancini MA, Marcelli M.

Horm Cancer. 2016 Jun;7(3):196-210. doi: 10.1007/s12672-016-0257-2. Epub 2016 Mar 8.


Use of HCA in subproteome-immunization and screening of hybridoma supernatants to define distinct antibody binding patterns.

Szafran AT, Mancini MG, Nickerson JA, Edwards DP, Mancini MA.

Methods. 2016 Mar 1;96:75-84. doi: 10.1016/j.ymeth.2015.10.021. Epub 2015 Oct 30.


The myImageAnalysis project: a web-based application for high-content screening.

Szafran AT, Mancini MA.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):87-99. doi: 10.1089/adt.2013.532.


The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way.

Mediwala SN, Sun H, Szafran AT, Hartig SM, Sonpavde G, Hayes TG, Thiagarajan P, Mancini MA, Marcelli M.

Prostate. 2013 Feb 15;73(3):267-77. doi: 10.1002/pros.22566. Epub 2012 Jul 20.


Numerical framework to model temporally resolved multi-stage dynamic systems.

Zakharov MN, Bhasin S, Szafran AT, Mancini MA, Jasuja R.

Comput Methods Programs Biomed. 2012 Nov;108(2):750-9. doi: 10.1016/j.cmpb.2012.04.010. Epub 2012 Jun 22.


A framework for image-based classification of mitotic cells in asynchronous populations.

Slattery SD, Newberg JY, Szafran AT, Hall RM, Brinkley BR, Mancini MA.

Assay Drug Dev Technol. 2012 Apr;10(2):161-78. doi: 10.1089/adt.2011.0397. Epub 2011 Nov 15.


Automated microscopy and image analysis for androgen receptor function.

Hartig SM, Newberg JY, Bolt MJ, Szafran AT, Marcelli M, Mancini MA.

Methods Mol Biol. 2011;776:313-31. doi: 10.1007/978-1-61779-243-4_18.


Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine.

Szafran AT, Sun H, Hartig S, Shen Y, Mediwala SN, Bell J, McPhaul MJ, Mancini MA, Marcelli M.

Adv Exp Med Biol. 2011;707:63-5. doi: 10.1007/978-1-4419-8002-1_15. No abstract available.


Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancer.

Narayanan R, Yepuru M, Szafran AT, Szwarc M, Bohl CE, Young NL, Miller DD, Mancini MA, Dalton JT.

Cancer Res. 2010 Jan 15;70(2):842-51. doi: 10.1158/0008-5472.CAN-09-3206. Epub 2010 Jan 12.


Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine.

Szafran AT, Hartig S, Sun H, Uray IP, Szwarc M, Shen Y, Mediwala SN, Bell J, McPhaul MJ, Mancini MA, Marcelli M.

PLoS One. 2009 Dec 9;4(12):e8179. doi: 10.1371/journal.pone.0008179.


Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects.

Szafran AT, Szwarc M, Marcelli M, Mancini MA.

PLoS One. 2008;3(11):e3605. doi: 10.1371/journal.pone.0003605. Epub 2008 Nov 3.


Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation.

Amazit L, Pasini L, Szafran AT, Berno V, Wu RC, Mielke M, Jones ED, Mancini MG, Hinojos CA, O'Malley BW, Mancini MA.

Mol Cell Biol. 2007 Oct;27(19):6913-32. Epub 2007 Jul 23.


High-resolution, high-throughput microscopy analyses of nuclear receptor and coregulator function.

Berno V, Hinojos CA, Amazit L, Szafran AT, Mancini MA.

Methods Enzymol. 2006;414:188-210.


Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent.

Sharp ZD, Mancini MG, Hinojos CA, Dai F, Berno V, Szafran AT, Smith KP, Lele TP, Ingber DE, Mancini MA.

J Cell Sci. 2006 Oct 1;119(Pt 19):4101-16. Epub 2006 Sep 12. Erratum in: J Cell Sci. 2006 Oct 15;119(Pt 20):4365. Lele, Tanmay T [corrected to Lele, Tanmay P].


Quantifying effects of ligands on androgen receptor nuclear translocation, intranuclear dynamics, and solubility.

Marcelli M, Stenoien DL, Szafran AT, Simeoni S, Agoulnik IU, Weigel NL, Moran T, Mikic I, Price JH, Mancini MA.

J Cell Biochem. 2006 Jul 1;98(4):770-88.


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