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Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.

Park D, Shakya R, Koivisto C, Pitarresi JR, Szabolcs M, Kladney R, Hadjis A, Mace TA, Ludwig T.

PLoS One. 2019 Dec 26;14(12):e0226714. doi: 10.1371/journal.pone.0226714. eCollection 2019.


Upregulation of ZIP14 and Altered Zinc Homeostasis in Muscles in Pancreatic Cancer Cachexia.

Shakri AR, Zhong TJ, Ma W, Coker C, Kim S, Calluori S, Scholze H, Szabolcs M, Caffrey T, Grandgenett PM, Hollingsworth MA, Tanji K, Kluger MD, Miller G, Biswas AK, Acharyya S.

Cancers (Basel). 2019 Dec 18;12(1). pii: E3. doi: 10.3390/cancers12010003.


Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.

Mameishvili E, Serafimidis I, Iwaszkiewicz S, Lesche M, Reinhardt S, Bölicke N, Büttner M, Stellas D, Papadimitropoulou A, Szabolcs M, Anastassiadis K, Dahl A, Theis F, Efstratiadis A, Gavalas A.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20679-20688. doi: 10.1073/pnas.1901075116. Epub 2019 Sep 23.


Phylogeography of a cryptic speciation continuum in Eurasian spadefoot toads (Pelobates).

Dufresnes C, Strachinis I, Suriadna N, Mykytynets G, Cogălniceanu D, Székely P, Vukov T, Arntzen JW, Wielstra B, Lymberakis P, Geffen E, Gafny S, Kumlutaş Y, Ilgaz Ç, Candan K, Mizsei E, Szabolcs M, Kolenda K, Smirnov N, Géniez P, Lukanov S, Crochet PA, Dubey S, Perrin N, Litvinchuk SN, Denoël M.

Mol Ecol. 2019 Jul;28(13):3257-3270. doi: 10.1111/mec.15133. Epub 2019 Jun 28.


Cytogenetic analysis of 130 renal oncocytomas identify three distinct and mutually exclusive diagnostic classes of chromosome aberrations.

Anderson CB, Lipsky M, Nandula SV, Freeman CE, Matthews T, Walsh CE, Li G, Szabolcs M, Mansukhani MM, McKiernan JM, Murty VV.

Genes Chromosomes Cancer. 2019 May 21. doi: 10.1002/gcc.22766. [Epub ahead of print]


The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection.

Billing D, Horiguchi M, Wu-Baer F, Taglialatela A, Leuzzi G, Nanez SA, Jiang W, Zha S, Szabolcs M, Lin CS, Ciccia A, Baer R.

Mol Cell. 2018 Oct 4;72(1):127-139.e8. doi: 10.1016/j.molcel.2018.08.016. Epub 2018 Sep 20.


Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents.

Stratikopoulos EE, Kiess N, Szabolcs M, Pegno S, Kakit C, Wu X, Poulikakos PI, Cheung P, Schmidt H, Parsons R.

Oncogene. 2019 Jan;38(1):47-59. doi: 10.1038/s41388-018-0436-4. Epub 2018 Aug 3.


The DNA resection protein CtIP promotes mammary tumorigenesis.

Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R.

Oncotarget. 2016 May 31;7(22):32172-83. doi: 10.18632/oncotarget.8605.


Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.

Stratikopoulos EE, Dendy M, Szabolcs M, Khaykin AJ, Lefebvre C, Zhou MM, Parsons R.

Cancer Cell. 2015 Jun 8;27(6):837-51. doi: 10.1016/j.ccell.2015.05.006.


Metformin and erlotinib synergize to inhibit basal breast cancer.

Lau YK, Du X, Rayannavar V, Hopkins B, Shaw J, Bessler E, Thomas T, Pires MM, Keniry M, Parsons RE, Cremers S, Szabolcs M, Maurer MA.

Oncotarget. 2014 Nov 15;5(21):10503-17.


Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer.

Stellas D, Szabolcs M, Koul S, Li Z, Polyzos A, Anagnostopoulos C, Cournia Z, Tamvakopoulos C, Klinakis A, Efstratiadis A.

J Natl Cancer Inst. 2014 Oct 11;106(12). pii: dju320. doi: 10.1093/jnci/dju320. Print 2014 Dec.


Portal Hypertension, Nodular Regenerative Hyperplasia of the Liver, and Obstructive Portal Venopathy due to Metastatic Breast Cancer.

Turk AT, Szabolcs MJ, Lefkowitch JH.

Case Rep Pathol. 2013;2013:826284. doi: 10.1155/2013/826284. Epub 2013 Jul 31.


HMGA2 is a driver of tumor metastasis.

Morishita A, Zaidi MR, Mitoro A, Sankarasharma D, Szabolcs M, Okada Y, D'Armiento J, Chada K.

Cancer Res. 2013 Jul 15;73(14):4289-99. doi: 10.1158/0008-5472.CAN-12-3848. Epub 2013 May 30.


The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.

Reczek CR, Szabolcs M, Stark JM, Ludwig T, Baer R.

J Cell Biol. 2013 May 27;201(5):693-707. doi: 10.1083/jcb.201302145.


High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions.

Lucas AL, Shakya R, Lipsyc MD, Mitchel EB, Kumar S, Hwang C, Deng L, Devoe C, Chabot JA, Szabolcs M, Ludwig T, Chung WK, Frucht H.

Clin Cancer Res. 2013 Jul 1;19(13):3396-403. doi: 10.1158/1078-0432.CCR-12-3020. Epub 2013 May 8.


Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

Shakya R, Gonda T, Quante M, Salas M, Kim S, Brooks J, Hirsch S, Davies J, Cullo A, Olive K, Wang TC, Szabolcs M, Tycko B, Ludwig T.

Cancer Res. 2013 Jan 15;73(2):885-96. doi: 10.1158/0008-5472.CAN-12-1880. Epub 2012 Nov 29.


BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.

Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin CS, deRooij DG, Hirsch S, Ravi K, Hicks JB, Szabolcs M, Jasin M, Baer R, Ludwig T.

Science. 2011 Oct 28;334(6055):525-8. doi: 10.1126/science.1209909.


Roles of HAUSP-mediated p53 regulation in central nervous system development.

Kon N, Zhong J, Kobayashi Y, Li M, Szabolcs M, Ludwig T, Canoll PD, Gu W.

Cell Death Differ. 2011 Aug;18(8):1366-75. doi: 10.1038/cdd.2011.12. Epub 2011 Feb 25.


Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.

Xuan S, Szabolcs M, Cinti F, Perincheri S, Accili D, Efstratiadis A.

J Biol Chem. 2010 Dec 24;285(52):41044-50. doi: 10.1074/jbc.M110.144790. Epub 2010 Oct 14.


Igf1r as a therapeutic target in a mouse model of basal-like breast cancer.

Klinakis A, Szabolcs M, Chen G, Xuan S, Hibshoosh H, Efstratiadis A.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2359-64. doi: 10.1073/pnas.0810221106. Epub 2009 Jan 27.


Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study.

Lau DH, Clausen C, Sosunov EA, Shlapakova IN, Anyukhovsky EP, Danilo P Jr, Rosen TS, Kelly C, Duffy HS, Szabolcs MJ, Chen M, Robinson RB, Lu J, Kumari S, Cohen IS, Rosen MR.

Circulation. 2009 Jan 6;119(1):19-27. doi: 10.1161/CIRCULATIONAHA.108.809301. Epub 2008 Dec 22.


Irs2 inactivation suppresses tumor progression in Pten+/- mice.

Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R.

Am J Pathol. 2009 Jan;174(1):276-86. doi: 10.2353/ajpath.2009.080086. Epub 2008 Dec 18.


The hormonal action of IGF1 in postnatal mouse growth.

Stratikopoulos E, Szabolcs M, Dragatsis I, Klinakis A, Efstratiadis A.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83. doi: 10.1073/pnas.0809223105. Epub 2008 Nov 25.


The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. doi: 10.1073/pnas.0711032105. Epub 2008 Apr 28.


Regenerative therapies in electrophysiology and pacing.

Rosen MR, Brink PR, Cohen IS, Danilo P Jr, Robinson RB, Rosen AB, Szabolcs MJ.

J Interv Card Electrophysiol. 2008 Aug;22(2):87-98. doi: 10.1007/s10840-008-9208-3. Epub 2008 Mar 25. Review.


RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model.

Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W, Song F, Bakr S, Szabolcs M, D'Agati V, Liu R, Homma S, Schmidt AM, Yan SF, Ramasamy R.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1823-32. doi: 10.1152/ajpheart.01210.2007. Epub 2008 Feb 1.


PKCbeta modulates ischemia-reperfusion injury in the heart.

Kong L, Andrassy M, Chang JS, Huang C, Asai T, Szabolcs MJ, Homma S, Liu R, Zou YS, Leitges M, Yan SD, Ramasamy R, Schmidt AM, Yan SF.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1862-70. doi: 10.1152/ajpheart.01346.2007. Epub 2008 Feb 1.


Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

Saal LH, Gruvberger-Saal SK, Persson C, Lövgren K, Jumppanen M, Staaf J, Jönsson G, Pires MM, Maurer M, Holm K, Koujak S, Subramaniyam S, Vallon-Christersson J, Olsson H, Su T, Memeo L, Ludwig T, Ethier SP, Krogh M, Szabolcs M, Murty VV, Isola J, Hibshoosh H, Parsons R, Borg A.

Nat Genet. 2008 Jan;40(1):102-7. Epub 2007 Dec 9.


Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice.

Son NH, Park TS, Yamashita H, Yokoyama M, Huggins LA, Okajima K, Homma S, Szabolcs MJ, Huang LS, Goldberg IJ.

J Clin Invest. 2007 Oct;117(10):2791-801.


Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart.

Plotnikov AN, Shlapakova I, Szabolcs MJ, Danilo P Jr, Lorell BH, Potapova IA, Lu Z, Rosen AB, Mathias RT, Brink PR, Robinson RB, Cohen IS, Rosen MR.

Circulation. 2007 Aug 14;116(7):706-13. Epub 2007 Jul 23.


Identification of the benign mesenchymal tumor gene HMGA2 in lymphangiomyomatosis.

D'Armiento J, Imai K, Schiltz J, Kolesnekova N, Sternberg D, Benson K, Pardo A, Selman M, Smolarek T, Vundavalli M, Sonnet J, Szabolcs M, Chada K.

Cancer Res. 2007 Mar 1;67(5):1902-9.


Notch, Myc and breast cancer.

Efstratiadis A, Szabolcs M, Klinakis A.

Cell Cycle. 2007 Feb 15;6(4):418-29. Epub 2007 Feb 9. Review.


Blockade of RAGE suppresses alloimmune reactions in vitro and delays allograft rejection in murine heart transplantation.

Moser B, Szabolcs MJ, Ankersmit HJ, Lu Y, Qu W, Weinberg A, Herold KC, Schmidt AM.

Am J Transplant. 2007 Feb;7(2):293-302. Erratum in: Am J Transplant. 2007 May;7(5):1318.


Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice.

Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9262-7. Epub 2006 Jun 2.


Transcriptional repressor Blimp-1 regulates T cell homeostasis and function.

Martins GA, Cimmino L, Shapiro-Shelef M, Szabolcs M, Herron A, Magnusdottir E, Calame K.

Nat Immunol. 2006 May;7(5):457-65. Epub 2006 Mar 26.


RAGE: a journey from the complications of diabetes to disorders of the nervous system - striking a fine balance between injury and repair.

Rong LL, Gooch C, Szabolcs M, Herold KC, Lalla E, Hays AP, Yan SF, Yan SS, Schmidt AM.

Restor Neurol Neurosci. 2005;23(5-6):355-65. Review.


PEG10 is a c-MYC target gene in cancer cells.

Li CM, Margolin AA, Salas M, Memeo L, Mansukhani M, Hibshoosh H, Szabolcs M, Klinakis A, Tycko B.

Cancer Res. 2006 Jan 15;66(2):665-72.


Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene.

Li Z, Szabolcs M, Terwilliger JD, Efstratiadis A.

Carcinogenesis. 2006 May;27(5):1054-67. Epub 2006 Jan 9.


Role for Akt3/protein kinase Bgamma in attainment of normal brain size.

Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ.

Mol Cell Biol. 2005 Mar;25(5):1869-78.


RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways.

Rong LL, Yan SF, Wendt T, Hans D, Pachydaki S, Bucciarelli LG, Adebayo A, Qu W, Lu Y, Kostov K, Lalla E, Yan SD, Gooch C, Szabolcs M, Trojaborg W, Hays AP, Schmidt AM.

FASEB J. 2004 Dec;18(15):1818-25.


Antagonism of RAGE suppresses peripheral nerve regeneration.

Rong LL, Trojaborg W, Qu W, Kostov K, Yan SD, Gooch C, Szabolcs M, Hays AP, Schmidt AM.

FASEB J. 2004 Dec;18(15):1812-7.


Effects of inhibition of poly(adenosine diphosphate-ribose) synthase on acute cardiac allograft rejection.

Liu Y, Son NH, Szabolcs MJ, Ma N, Sciacca RR, Albala A, Edwards N, Cannon PJ.

Transplantation. 2004 Sep 15;78(5):668-74.


Central role for aldose reductase pathway in myocardial ischemic injury.

Hwang YC, Kaneko M, Bakr S, Liao H, Lu Y, Lewis ER, Yan S, Ii S, Itakura M, Rui L, Skopicki H, Homma S, Schmidt AM, Oates PJ, Szabolcs M, Ramasamy R.

FASEB J. 2004 Aug;18(11):1192-9.


Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.

Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A, Artavanis-Tsakonas S.

Am J Pathol. 2004 Aug;165(2):695-705.


Metabolic and functional protection by selective inhibition of nitric oxide synthase 2 during ischemia-reperfusion in isolated perfused hearts.

Ramasamy R, Hwang YC, Liu Y, Son NH, Ma N, Parkinson J, Sciacca R, Albala A, Edwards N, Szabolcs MJ, Cannon PJ.

Circulation. 2004 Apr 6;109(13):1668-73. Epub 2004 Mar 29.


A mouse model of uterine leiomyosarcoma.

Politi K, Szabolcs M, Fisher P, Kljuic A, Ludwig T, Efstratiadis A.

Am J Pathol. 2004 Jan;164(1):325-36.


'Designer' tumors in mice.

Politi K, Kljuic A, Szabolcs M, Fisher P, Ludwig T, Efstratiadis A.

Oncogene. 2004 Feb 26;23(8):1558-65.


Disturbed regulation of cholesterol synthesis in monocytes of obese patients with hypercholesterolemia.

Paragh G, Balogh Z, Kovács E, Szabolcs M, Szabó J, Csapó K, Fóris G.

Metabolism. 2003 Jan;52(1):1-6.


The effect of selective inhibition of cyclooxygenase (COX)-2 on acute cardiac allograft rejection.

Ma N, Szabolcs MJ, Sun J, Albala A, Sciacca RR, Zhong M, Edwards N, Cannon PJ.

Transplantation. 2002 Dec 15;74(11):1528-34.


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