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Staphylococcal phosphatidylinositol-specific phospholipase C potentiates lung injury via complement sensitisation.

Lin YC, Liao YJ, Lee YH, Tseng SF, Liu JY, Chen YS, Shui HA, Lin FZ, Lin KH, Chen YC, Tsai MC, Sytwu HK, Wang CC, Chuang YP.

Cell Microbiol. 2019 Oct;21(10):e13085. doi: 10.1111/cmi.13085. Epub 2019 Jul 17.


Adoptive transfer of DMSO-induced regulatory T cells exhibits a similar preventive effect compared to an in vivo DMSO treatment for chemical-induced experimental encapsulating peritoneal sclerosis in mice.

Lin GJ, Wu CH, Yu CC, Lin JR, Liu XD, Chen YW, Chang HM, Hong ZJ, Cheng CP, Sytwu HK, Huang SH.

Toxicol Appl Pharmacol. 2019 Sep 1;378:114641. doi: 10.1016/j.taap.2019.114641. Epub 2019 Jun 26.


Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis.

Chen SJ, Lin GJ, Chen JW, Wang KC, Tien CH, Hu CF, Chang CN, Hsu WF, Fan HC, Sytwu HK.

Int J Mol Sci. 2019 Mar 16;20(6). pii: E1332. doi: 10.3390/ijms20061332. Review.


Molecular Epidemiology of Emerging Carbapenem Resistance in Acinetobacter nosocomialis and Acinetobacter pittii in Taiwan, 2010 to 2014.

Chen FJ, Huang WC, Liao YC, Wang HY, Lai JF, Kuo SC, Lauderdale TL, Sytwu HK.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02007-18. doi: 10.1128/AAC.02007-18. Print 2019 Apr.


Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.

Yang CY, Lin CK, Hsieh CC, Tsao CH, Lin CS, Peng B, Chen YT, Ting CC, Chang WC, Lin GJ, Sytwu HK, Chen YW.

Head Neck. 2019 May;41(5):1260-1269. doi: 10.1002/hed.25554. Epub 2018 Dec 10.


PrtA immunization fails to protect against pulmonary and invasive infection by Streptococcus pneumoniae.

Hsu CF, Hsiao CH, Tseng SF, Chen JR, Liao YJ, Chen SJ, Lin CS, Sytwu HK, Chuang YP.

Respir Res. 2018 Sep 25;19(1):187. doi: 10.1186/s12931-018-0895-8.


Insonation of Systemically Delivered Cisplatin-Loaded Microbubbles Significantly Attenuates Nephrotoxicity of Chemotherapy in Experimental Models of Head and Neck Cancer.

Chen HK, Zhang SM, Chang JL, Chen HC, Lin YC, Shih CP, Sytwu HK, Fang MC, Lin YY, Kuo CY, Liao AH, Chu YH, Wang CH.

Cancers (Basel). 2018 Sep 5;10(9). pii: E311. doi: 10.3390/cancers10090311.


SUMO-defective c-Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes.

Hsu CY, Yeh LT, Fu SH, Chien MW, Liu YW, Miaw SC, Chang DM, Sytwu HK.

J Clin Invest. 2018 Aug 31;128(9):3779-3793. doi: 10.1172/JCI98786. Epub 2018 Jul 30.


Characterization data for T cell-specific Blimp-1 transgenic C57BL/6 mice.

Wang AYL, Loh CYY, Chen SJ, Kao HK, Lin CH, Chuang SH, Lee CM, Sytwu HK, Wei FC.

Data Brief. 2018 May 8;19:117-127. doi: 10.1016/j.dib.2018.04.132. eCollection 2018 Aug.


Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1.

Wang AYL, Loh CYY, Chen SJ, Kao HK, Lin CH, Chuang SH, Lee CM, Sytwu HK, Wei FC.

Mol Immunol. 2018 Jul;99:53-65. doi: 10.1016/j.molimm.2018.04.004. Epub 2018 Apr 23.


The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases.

Chien MW, Fu SH, Hsu CY, Liu YW, Sytwu HK.

Int J Mol Sci. 2018 Mar 8;19(3). pii: E780. doi: 10.3390/ijms19030780. Review.


Role of melatonin receptor 1A and pituitary homeobox-1 coexpression in protecting tubular epithelial cells in membranous nephropathy.

Huang YS, Lu KC, Chao TK, Chen JS, Chen A, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC.

J Pineal Res. 2018 Aug;65(1):e12482. doi: 10.1111/jpi.12482. Epub 2018 Mar 25.


Differentiation of Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells Results in Downregulation of c-Myc and DNA Replication Pathways with Immunomodulation Toward CD4 and CD8 Cells.

Wang LT, Jiang SS, Ting CH, Hsu PJ, Chang CC, Sytwu HK, Liu KJ, Yen BL.

Stem Cells. 2018 Jun;36(6):903-914. doi: 10.1002/stem.2795. Epub 2018 Feb 12.


Role of Galectins in Tumors and in Clinical Immunotherapy.

Chou FC, Chen HY, Kuo CC, Sytwu HK.

Int J Mol Sci. 2018 Feb 1;19(2). pii: E430. doi: 10.3390/ijms19020430. Review.


Inhibition of tumor necrosis factor signaling attenuates renal immune cell infiltration in experimental membranous nephropathy.

Huang YS, Fu SH, Lu KC, Chen JS, Hsieh HY, Sytwu HK, Wu CC.

Oncotarget. 2017 Dec 4;8(67):111631-111641. doi: 10.18632/oncotarget.22881. eCollection 2017 Dec 19.


Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells.

Yang CY, Hsieh CC, Lin CK, Lin CS, Peng B, Lin GJ, Sytwu HK, Chang WL, Chen YW.

BMC Complement Altern Med. 2017 Dec 29;17(1):555. doi: 10.1186/s12906-017-2063-y.


Peripheral Autoimmune Regulator Induces Exhaustion of CD4+ and CD8+ Effector T Cells to Attenuate Autoimmune Diabetes in Non-Obese Diabetic Mice.

Kulshrestha D, Yeh LT, Chien MW, Chou FC, Sytwu HK.

Front Immunol. 2017 Sep 15;8:1128. doi: 10.3389/fimmu.2017.01128. eCollection 2017.


Differential modulation of IL-12 family cytokines in autoimmune islet graft failure in mice.

Chou FC, Chen HY, Chen HH, Lin GJ, Lin SH, Sytwu HK.

Diabetologia. 2017 Dec;60(12):2409-2417. doi: 10.1007/s00125-017-4418-9. Epub 2017 Sep 19.


New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function.

Fu SH, Yeh LT, Chu CC, Yen BL, Sytwu HK.

J Biomed Sci. 2017 Jul 21;24(1):49. doi: 10.1186/s12929-017-0354-8. Review.


Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.

Yang CY, Lin CK, Tsao CH, Hsieh CC, Lin GJ, Ma KH, Shieh YS, Sytwu HK, Chen YW.

Oncotarget. 2017 May 16;8(20):33756-33769. doi: 10.18632/oncotarget.16808.


A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke.

Lee HT, Liu SP, Lin CH, Lee SW, Hsu CY, Sytwu HK, Hsieh CH, Shyu WC.

Theranostics. 2017 Feb 8;7(4):855-875. doi: 10.7150/thno.17558. eCollection 2017.


OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis.

Liu YL, Yang SS, Chen SJ, Lin YC, Chu CC, Huang HH, Chang FW, Yu MH, Lin SH, Wu GJ, Sytwu HK.

Sci Rep. 2016 Nov 17;6:37205. doi: 10.1038/srep37205.


Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials.

Wang LT, Ting CH, Yen ML, Liu KJ, Sytwu HK, Wu KK, Yen BL.

J Biomed Sci. 2016 Nov 4;23(1):76. Review.


Interleukin 26 suppresses receptor activator of nuclear factor κB ligand induced osteoclastogenesis via down-regulation of nuclear factor of activated T-cells, cytoplasmic 1 and nuclear factor κB activity.

Peng YJ, Wang CY, Lin YH, Lin GJ, Huang SH, Shyu JF, Sytwu HK, Cheng CP.

Rheumatology (Oxford). 2016 Nov;55(11):2074-2083. Epub 2016 Aug 21.


Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth.

Liao AH, Lu YJ, Lin YC, Chen HK, Sytwu HK, Wang CH.

Theranostics. 2016 Apr 11;6(6):817-27. doi: 10.7150/thno.14932. eCollection 2016.


Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells.

Yang CY, Lin CK, Lin GJ, Hsieh CC, Huang SH, Ma KH, Shieh YS, Sytwu HK, Chen YW.

Clin Oral Investig. 2017 Jan;21(1):419-427. doi: 10.1007/s00784-016-1808-1. Epub 2016 Apr 13.


DNA demethylation of the TIM-3 promoter is critical for its stable expression on T cells.

Chou FC, Kuo CC, Chen HY, Chen HH, Sytwu HK.

Genes Immun. 2016 Apr;17(3):179-86. doi: 10.1038/gene.2016.6. Epub 2016 Feb 18.


CD146+ mesenchymal stem cells display greater therapeutic potential than CD146- cells for treating collagen-induced arthritis in mice.

Wu CC, Liu FL, Sytwu HK, Tsai CY, Chang DM.

Stem Cell Res Ther. 2016 Feb 3;7:23. doi: 10.1186/s13287-016-0285-4.


Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs).

Hsu PJ, Liu KJ, Chao YY, Sytwu HK, Yen BL.

J Vis Exp. 2015 Dec 24;(106):e53265. doi: 10.3791/53265.


Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis.

Chen SJ, Huang SH, Chen JW, Wang KC, Yang YR, Liu PF, Lin GJ, Sytwu HK.

Int Immunopharmacol. 2016 Feb;31:169-77. doi: 10.1016/j.intimp.2015.12.020. Epub 2015 Dec 29.


Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation.

Ka SM, Lin JC, Lin TJ, Liu FC, Chao LK, Ho CL, Yeh LT, Sytwu HK, Hua KF, Chen A.

Arthritis Res Ther. 2015 Nov 19;17:331. doi: 10.1186/s13075-015-0844-6.


Glucosamine Modulates T Cell Differentiation through Down-regulating N-Linked Glycosylation of CD25.

Chien MW, Lin MH, Huang SH, Fu SH, Hsu CY, Yen BL, Chen JT, Chang DM, Sytwu HK.

J Biol Chem. 2015 Dec 4;290(49):29329-44. doi: 10.1074/jbc.M115.674671. Epub 2015 Oct 14.


Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Wang WB, Yen ML, Liu KJ, Hsu PJ, Lin MH, Chen PM, Sudhir PR, Chen CH, Chen CH, Sytwu HK, Yen BL.

Stem Cell Reports. 2015 Sep 8;5(3):392-404. doi: 10.1016/j.stemcr.2015.07.013. Epub 2015 Aug 28.


Hypoxia Induces a Metabolic Shift and Enhances the Stemness and Expansion of Cochlear Spiral Ganglion Stem/Progenitor Cells.

Chen HC, Lee JT, Shih CP, Chao TT, Sytwu HK, Li SL, Fang MC, Chen HK, Lin YC, Kuo CY, Wang CH.

Biomed Res Int. 2015;2015:359537. doi: 10.1155/2015/359537. Epub 2015 Jul 5.


Daxx and TCF4 interaction links to oral squamous cell carcinoma growth by promoting cell cycle progression via induction of cyclin D1 expression.

Lin GJ, Huang YS, Lin CK, Huang SH, Shih HM, Sytwu HK, Chen YW.

Clin Oral Investig. 2016 Apr;20(3):533-40. doi: 10.1007/s00784-015-1536-y. Epub 2015 Jul 24.


Carbon Monoxide Inhibits Receptor Activator of NF-κB (RANKL)-Induced Osteoclastogenesis.

Tseng FJ, Chia WT, Wang CH, Shyu JF, Gou GH, Shui HA, Sytwu HK, Pan RY, Weng CF.

Cell Physiol Biochem. 2015;36(3):1250-8. doi: 10.1159/000430294. Epub 2015 Jul 1.


Resveratrol ameliorates renal damage, increases expression of heme oxygenase-1, and has anti-complement, anti-oxidative, and anti-apoptotic effects in a murine model of membranous nephropathy.

Wu CC, Huang YS, Chen JS, Huang CF, Su SL, Lu KC, Lin YF, Chu P, Lin SH, Sytwu HK.

PLoS One. 2015 May 8;10(5):e0125726. doi: 10.1371/journal.pone.0125726. eCollection 2015.


Letter to the Editor: Fusion antibody Fc-endostatin.

Hueng DY, Sytwu HK.

J Neurosurg. 2015 May;122(5):1249. doi: 10.3171/2012.2.JNS111886. Epub 2015 Feb 27. No abstract available.


Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis.

Li CH, Lin MH, Chu SH, Tu PH, Fang CC, Yen CH, Liang PI, Huang JC, Su YC, Sytwu HK, Chen YM.

Mol Med. 2015 Mar 24;20:684-96. doi: 10.2119/molmed.2014.00133.


Dimethyl sulfoxide inhibits spontaneous diabetes and autoimmune recurrence in non-obese diabetic mice by inducing differentiation of regulatory T cells.

Lin GJ, Sytwu HK, Yu JC, Chen YW, Kuo YL, Yu CC, Chang HM, Chan DC, Huang SH.

Toxicol Appl Pharmacol. 2015 Jan 15;282(2):207-14. doi: 10.1016/j.taap.2014.11.012. Epub 2014 Dec 4.


Impact of the glpQ2 gene on virulence in a Streptococcus pneumoniae serotype 19A sequence type 320 strain.

Chuang YP, Peng ZR, Tseng SF, Lin YC, Sytwu HK, Hsieh YC.

Infect Immun. 2015 Feb;83(2):682-92. doi: 10.1128/IAI.02357-14. Epub 2014 Nov 24.


Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance.

Cheng CJ, Sung CC, Wu ST, Lin YC, Sytwu HK, Huang CL, Lin SH.

J Clin Endocrinol Metab. 2015 Jan;100(1):E155-63. doi: 10.1210/jc.2014-3009.


Modified salicylanilide and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione derivatives as novel inhibitors of osteoclast differentiation and bone resorption.

Chen CL, Liu FL, Lee CC, Chen TC, Ahmed Ali AA, Sytwu HK, Chang DM, Huang HS.

J Med Chem. 2014 Oct 9;57(19):8072-85. doi: 10.1021/jm5007897. Epub 2014 Sep 25.


Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice.

Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF.

Cell Transplant. 2015;24(8):1555-70. doi: 10.3727/096368914X683016. Epub 2014 Jul 15.


Urinary Xist is a potential biomarker for membranous nephropathy.

Huang YS, Hsieh HY, Shih HM, Sytwu HK, Wu CC.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):415-21. doi: 10.1016/j.bbrc.2014.08.077. Epub 2014 Aug 23.


A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo.

Chen YW, Huang HS, Shieh YS, Ma KH, Huang SH, Hueng DY, Sytwu HK, Lin GJ.

PLoS One. 2014 Aug 15;9(8):e104703. doi: 10.1371/journal.pone.0104703. eCollection 2014. Erratum in: PLoS One. 2014;9(11):e113703.


Targeting tumour necrosis factor receptor 1 assembly reverses Th17-mediated colitis through boosting a Th2 response.

Fu SH, Lin MH, Yeh LT, Wang YL, Chien MW, Lin SH, Chang DM, Sytwu HK.

Gut. 2015 May;64(5):765-75. doi: 10.1136/gutjnl-2013-306585. Epub 2014 Jul 10.


Interactomics profiling of the negative regulatory function of carbon monoxide on RANKL-treated RAW 264.7 cells during osteoclastogenesis.

Tseng FJ, Chia WT, Shyu JF, Gou GH, Sytwu HK, Hsia CW, Tseng MJ, Pan RY.

BMC Syst Biol. 2014 May 18;8:57. doi: 10.1186/1752-0509-8-57.


Induction of immunomodulatory monocytes by human mesenchymal stem cell-derived hepatocyte growth factor through ERK1/2.

Chen PM, Liu KJ, Hsu PJ, Wei CF, Bai CH, Ho LJ, Sytwu HK, Yen BL.

J Leukoc Biol. 2014 Aug;96(2):295-303. doi: 10.1189/jlb.3A0513-242R. Epub 2014 Apr 8.


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