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Metabolomics of exercise pulmonary hypertension are intermediate between controls and patients with pulmonary arterial hypertension.

Sanders JL, Han Y, Urbina MF, Systrom DM, Waxman AB.

Pulm Circ. 2019 Oct 30;9(4):2045894019882623. doi: 10.1177/2045894019882623. eCollection 2019 Oct-Dec.


Unexplained exertional intolerance associated with impaired systemic oxygen extraction.

Melamed KH, Santos M, Oliveira RKF, Urbina MF, Felsenstein D, Opotowsky AR, Waxman AB, Systrom DM.

Eur J Appl Physiol. 2019 Oct;119(10):2375-2389. doi: 10.1007/s00421-019-04222-6. Epub 2019 Sep 6.


Fatigue, Sleep, and Autoimmune and Related Disorders.

Zielinski MR, Systrom DM, Rose NR.

Front Immunol. 2019 Aug 6;10:1827. doi: 10.3389/fimmu.2019.01827. eCollection 2019. Review.


Dynamic right ventricular-pulmonary arterial uncoupling during maximum incremental exercise in exercise pulmonary hypertension and pulmonary arterial hypertension.

Singh I, Rahaghi FN, Naeije R, Oliveira RKF, Vanderpool RR, Waxman AB, Systrom DM.

Pulm Circ. 2019 Jul-Sep;9(3):2045894019862435. doi: 10.1177/2045894019862435.


Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension.

Singh I, Oliveira RKF, Naeije R, Rahaghi FN, Oldham WM, Systrom DM, Waxman AB.

Chest. 2019 Oct;156(4):724-732. doi: 10.1016/j.chest.2019.04.111. Epub 2019 May 20.


Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction: Role of Pulmonary Vascular Dysfunction.

Singh I, Rahaghi FN, Naeije R, Oliveira RKF, Systrom DM, Waxman AB.

Chest. 2019 Nov;156(5):933-943. doi: 10.1016/j.chest.2019.04.109. Epub 2019 May 16.


Perfusion Imaging Distinguishes Exercise Pulmonary Arterial Hypertension at Rest.

Kohli P, Kelly VJ, Kehl EG, Rodriguez-Lopez J, Hibbert KA, Kone M, Systrom DM, Waxman AB, Venegas JG, Channick R, Winkler T, Harris RS.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1438-1441. doi: 10.1164/rccm.201810-1899LE. No abstract available.


Right ventriculo-arterial uncoupling and impaired contractile reserve in obese patients with unexplained exercise intolerance.

McCabe C, Oliveira RKF, Rahaghi F, Faria-Urbina M, Howard L, Axell RG, Priest AN, Waxman AB, Systrom DM.

Eur J Appl Physiol. 2018 Jul;118(7):1415-1426. doi: 10.1007/s00421-018-3873-4. Epub 2018 Apr 30.


Pulmonary haemodynamics and mortality in chronic hypersensitivity pneumonitis.

Oliveira RKF, Ota-Arakaki JS, Gomes PS, Gimenez A, Messina CMS, Ramos RP, Ferreira EVM, Systrom DM, Pereira CAC.

Eur Respir J. 2018 Jun 21;51(6). pii: 1800430. doi: 10.1183/13993003.00430-2018. Print 2018 Jun. No abstract available.


Network Analysis to Risk Stratify Patients With Exercise Intolerance.

Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA.

Circ Res. 2018 Mar 16;122(6):864-876. doi: 10.1161/CIRCRESAHA.117.312482. Epub 2018 Feb 5.


Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?

Faria-Urbina M, Oliveira RKF, Segrera SA, Lawler L, Waxman AB, Systrom DM.

Pulm Circ. 2018 Jan-Mar;8(1):2045893218755325. doi: 10.1177/2045893218755325. Epub 2018 Jan 8.


Pulmonary Vascular Resistance During Exercise Predicts Long-Term Outcomes in Heart Failure With Preserved Ejection Fraction.

Huang W, Oliveira RKF, Lei H, Systrom DM, Waxman AB.

J Card Fail. 2018 Mar;24(3):169-176. doi: 10.1016/j.cardfail.2017.11.003. Epub 2017 Nov 24.


PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics.

Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA; PVDOMICS Study Group.

Circ Res. 2017 Oct 27;121(10):1136-1139. doi: 10.1161/CIRCRESAHA.117.311737. No abstract available.


Functional impact of exercise pulmonary hypertension in patients with borderline resting pulmonary arterial pressure.

Oliveira RKF, Faria-Urbina M, Maron BA, Santos M, Waxman AB, Systrom DM.

Pulm Circ. 2017 Jul-Sep;7(3):654-665. doi: 10.1177/2045893217709025. Epub 2017 Jun 8.


Hemodynamic and metabolic characteristics associated with development of a right ventricular outflow tract pressure gradient during upright exercise.

van Riel ACMJ, Systrom DM, Oliveira RKF, Landzberg MJ, Mulder BJM, Bouma BJ, Maron BA, Shah AM, Waxman AB, Opotowsky AR.

PLoS One. 2017 Jun 21;12(6):e0179053. doi: 10.1371/journal.pone.0179053. eCollection 2017.


Invasive cardiopulmonary exercise testing in the evaluation of unexplained dyspnea: Insights from a multidisciplinary dyspnea center.

Huang W, Resch S, Oliveira RK, Cockrill BA, Systrom DM, Waxman AB.

Eur J Prev Cardiol. 2017 Jul;24(11):1190-1199. doi: 10.1177/2047487317709605. Epub 2017 May 16.


Accuracy of Echocardiography to Estimate Pulmonary Artery Pressures With Exercise: A Simultaneous Invasive-Noninvasive Comparison.

van Riel AC, Opotowsky AR, Santos M, Rivero JM, Dhimitri A, Mulder BJ, Bouma BJ, Landzberg MJ, Waxman AB, Systrom DM, Shah AM.

Circ Cardiovasc Imaging. 2017 Apr;10(4). pii: e005711. doi: 10.1161/CIRCIMAGING.116.005711.


Development of a Right Ventricular Outflow Tract Gradient During Upright Exercise: A Hemodynamic Observation.

van Riel AC, Systrom DM, Oliveira RK, Landzberg MJ, Mulder BJ, Bouma BJ, Maron BA, Shah AM, Waxman AB, Opotowsky AR.

J Am Coll Cardiol. 2017 Feb 7;69(5):595-597. doi: 10.1016/j.jacc.2016.11.039. No abstract available.


Left ventricular deformation at rest predicts exercise-induced elevation in pulmonary artery wedge pressure in patients with unexplained dyspnoea.

Biering-Sørensen T, Santos M, Rivero J, McCullough SD, West E, Opotowsky AR, Waxman AB, Systrom DM, Shah AM.

Eur J Heart Fail. 2017 Jan;19(1):101-110. doi: 10.1002/ejhf.659. Epub 2016 Nov 22.


Poster 26 A Randomized Trial of Cardiac Rehabilitation for Adolescents and Adults with Congenital Heart Disease.

Tikkanen AU, Rhodes J, Landzberg M, Bhatt A, Systrom DM, Waxman A, Moko L, Bradley R, Crouter S, Opotowsky A.

PM R. 2016 Sep;8(9S):S169. doi: 10.1016/j.pmrj.2016.07.069. Epub 2016 Sep 24. No abstract available.


Dyspnea and an Arteriovenous Fistula.

Moniodis AE, Ginns JN, Systrom DM.

Ann Am Thorac Soc. 2016 Aug;13(8):1419-23. doi: 10.1513/AnnalsATS.201603-171CC. No abstract available.


Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing.

Oldham WM, Lewis GD, Opotowsky AR, Waxman AB, Systrom DM.

Pulm Circ. 2016 Mar;6(1):55-62. doi: 10.1086/685054.


Pulmonary haemodynamics during recovery from maximum incremental cycling exercise.

Oliveira RK, Waxman AB, Agarwal M, Badr Eslam R, Systrom DM.

Eur Respir J. 2016 Jul;48(1):158-67. doi: 10.1183/13993003.00023-2016. Epub 2016 Apr 28.


Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice.

Berry NC, Manyoo A, Oldham WM, Stephens TE, Goldstein RH, Waxman AB, Tracy JA, Leary PJ, Leopold JA, Kinlay S, Opotowsky AR, Systrom DM, Maron BA.

Pulm Circ. 2015 Dec;5(4):610-8. doi: 10.1086/683815. Review.


Age-related upper limits of normal for maximum upright exercise pulmonary haemodynamics.

Oliveira RK, Agarwal M, Tracy JA, Karin AL, Opotowsky AR, Waxman AB, Systrom DM.

Eur Respir J. 2016 Apr;47(4):1179-88. doi: 10.1183/13993003.01307-2015. Epub 2015 Dec 17.


E/e' Ratio in Patients With Unexplained Dyspnea: Lack of Accuracy in Estimating Left Ventricular Filling Pressure.

Santos M, Rivero J, McCullough SD, West E, Opotowsky AR, Waxman AB, Systrom DM, Shah AM.

Circ Heart Fail. 2015 Jul;8(4):749-56. doi: 10.1161/CIRCHEARTFAILURE.115.002161. Epub 2015 Jun 11.


Exercise oscillatory ventilation in patients with Fontan physiology.

Nathan AS, Loukas B, Moko L, Wu F, Rhodes J, Rathod RH, Systrom DM, Ubeda Tikkanen A, Shafer K, Lewis GD, Landzberg MJ, Opotowsky AR.

Circ Heart Fail. 2015 Mar;8(2):304-11. doi: 10.1161/CIRCHEARTFAILURE.114.001749. Epub 2014 Dec 30.


Central cardiac limit to aerobic capacity in patients with exertional pulmonary venous hypertension: implications for heart failure with preserved ejection fraction.

Santos M, Opotowsky AR, Shah AM, Tracy J, Waxman AB, Systrom DM.

Circ Heart Fail. 2015 Mar;8(2):278-85. doi: 10.1161/CIRCHEARTFAILURE.114.001551. Epub 2014 Dec 30.


Inadequate venous return as a primary cause for Fontan circulatory limitation.

Opotowsky AR, Halpern D, Kulik TJ, Systrom DM, Wu F.

J Heart Lung Transplant. 2014 Nov;33(11):1194-6. doi: 10.1016/j.healun.2014.07.007. Epub 2014 Jul 15. No abstract available.


Measuring central pulmonary pressures during exercise in COPD: how to cope with respiratory effects.

Boerrigter BG, Waxman AB, Westerhof N, Vonk-Noordegraaf A, Systrom DM.

Eur Respir J. 2014 May;43(5):1316-25. doi: 10.1183/09031936.00016913. Epub 2013 Oct 31.


Effects of exercise and lifestyle modification on fitness, insulin resistance, skeletal muscle oxidative phosphorylation and intramyocellular lipid content in obese children and adolescents.

McCormack SE, McCarthy MA, Harrington SG, Farilla L, Hrovat MI, Systrom DM, Thomas BJ, Torriani M, McInnis K, Grinspoon SK, Fleischman A.

Pediatr Obes. 2014 Aug;9(4):281-91. doi: 10.1111/j.2047-6310.2013.00180.x. Epub 2013 Jun 25.


The invasive cardiopulmonary exercise test.

Maron BA, Cockrill BA, Waxman AB, Systrom DM.

Circulation. 2013 Mar 12;127(10):1157-64. doi: 10.1161/CIRCULATIONAHA.112.104463. No abstract available.


Pulmonary vascular responses to exercise: a haemodynamic observation.

Saggar R, Lewis GD, Systrom DM, Champion HC, Naeije R, Saggar R.

Eur Respir J. 2012 Feb;39(2):231-4. doi: 10.1183/09031936.00166211. No abstract available.


Exercise oscillatory ventilation in systolic heart failure: an indicator of impaired hemodynamic response to exercise.

Murphy RM, Shah RV, Malhotra R, Pappagianopoulos PP, Hough SS, Systrom DM, Semigran MJ, Lewis GD.

Circulation. 2011 Sep 27;124(13):1442-51. doi: 10.1161/CIRCULATIONAHA.111.024141. Epub 2011 Aug 29.


Skeletal muscle mitochondrial function is associated with longitudinal growth velocity in children and adolescents.

McCormack SE, McCarthy MA, Farilla L, Hrovat MI, Systrom DM, Grinspoon SK, Fleischman A.

J Clin Endocrinol Metab. 2011 Oct;96(10):E1612-8. doi: 10.1210/jc.2011-1218. Epub 2011 Aug 10.


Pulmonary vascular response patterns during exercise in left ventricular systolic dysfunction predict exercise capacity and outcomes.

Lewis GD, Murphy RM, Shah RV, Pappagianopoulos PP, Malhotra R, Bloch KD, Systrom DM, Semigran MJ.

Circ Heart Fail. 2011 May;4(3):276-85. doi: 10.1161/CIRCHEARTFAILURE.110.959437. Epub 2011 Feb 3.


Increased skeletal muscle phosphocreatine recovery after sub-maximal exercise is associated with increased carotid intima-media thickness.

Makimura H, Stanley TL, Sun N, Connelly JM, Hemphill LC, Hrovat MI, Systrom DM, Grinspoon SK.

Atherosclerosis. 2011 Mar;215(1):214-7. doi: 10.1016/j.atherosclerosis.2010.11.037. Epub 2010 Dec 5.


The association of growth hormone parameters with skeletal muscle phosphocreatine recovery in adult men.

Makimura H, Stanley TL, Sun N, Hrovat MI, Systrom DM, Grinspoon SK.

J Clin Endocrinol Metab. 2011 Mar;96(3):817-23. doi: 10.1210/jc.2010-2264. Epub 2010 Dec 22.


Skeletal muscle phosphocreatine recovery after submaximal exercise in children and young and middle-aged adults.

Fleischman A, Makimura H, Stanley TL, McCarthy MA, Kron M, Sun N, Chuzi S, Hrovat MI, Systrom DM, Grinspoon SK.

J Clin Endocrinol Metab. 2010 Sep;95(9):E69-74. doi: 10.1210/jc.2010-0527. Epub 2010 Jun 16.


Metabolic signatures of exercise in human plasma.

Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE.

Sci Transl Med. 2010 May 26;2(33):33ra37. doi: 10.1126/scitranslmed.3001006.


Mitochondrial function and insulin resistance in overweight and normal-weight children.

Fleischman A, Kron M, Systrom DM, Hrovat M, Grinspoon SK.

J Clin Endocrinol Metab. 2009 Dec;94(12):4923-30. doi: 10.1210/jc.2009-1590. Epub 2009 Oct 21.


Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone.

Lewis GD, Shah RV, Pappagianopolas PP, Systrom DM, Semigran MJ.

Circ Heart Fail. 2008 Nov;1(4):227-33. doi: 10.1161/CIRCHEARTFAILURE.108.785501.


Exercise-induced pulmonary arterial hypertension.

Tolle JJ, Waxman AB, Van Horn TL, Pappagianopoulos PP, Systrom DM.

Circulation. 2008 Nov 18;118(21):2183-9. doi: 10.1161/CIRCULATIONAHA.108.787101. Epub 2008 Nov 3.


Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension.

Lewis GD, Shah R, Shahzad K, Camuso JM, Pappagianopoulos PP, Hung J, Tawakol A, Gerszten RE, Systrom DM, Bloch KD, Semigran MJ.

Circulation. 2007 Oct 2;116(14):1555-62. Epub 2007 Sep 4.


Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults.

Fleischman A, Johnsen S, Systrom DM, Hrovat M, Farrar CT, Frontera W, Fitch K, Thomas BJ, Torriani M, Côté HC, Grinspoon SK.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1666-73. Epub 2007 Feb 6.


Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure.

Lewis GD, Lachmann J, Camuso J, Lepore JJ, Shin J, Martinovic ME, Systrom DM, Bloch KD, Semigran MJ.

Circulation. 2007 Jan 2;115(1):59-66. Epub 2006 Dec 18.


Case records of the Massachusetts General Hospital. Case 19-2005. A 17-year-old girl with respiratory distress and hemiparesis after surviving a tsunami.

Kao AY, Munandar R, Ferrara SL, Systrom DM, Sheridan RL, Cash SS, Ryan ET.

N Engl J Med. 2005 Jun 23;352(25):2628-36. No abstract available.


Case records of the Massachusetts General Hospital. Case 9-2005. A 67-year-old man with acute respiratory failure.

Systrom DM, Wittram C.

N Engl J Med. 2005 Mar 24;352(12):1238-46. No abstract available.


Diagnosis of pulmonary vascular limit to exercise by cardiopulmonary exercise testing.

Markowitz DH, Systrom DM.

J Heart Lung Transplant. 2004 Jan;23(1):88-95.


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