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Items: 27

1.

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort.

Havulinna AS, Sysi-Aho M, Hilvo M, Kauhanen D, Hurme R, Ekroos K, Salomaa V, Laaksonen R.

Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2424-2430. Epub 2016 Oct 20.

PMID:
27765765
2.

Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome.

Sales S, Graessler J, Ciucci S, Al-Atrib R, Vihervaara T, Schuhmann K, Kauhanen D, Sysi-Aho M, Bornstein SR, Bickle M, Cannistraci CV, Ekroos K, Shevchenko A.

Sci Rep. 2016 Jun 14;6:27710. doi: 10.1038/srep27710.

3.

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol.

Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D, Suoniemi M, Hurme R, März W, Scharnagl H, Stojakovic T, Vlachopoulou E, Lokki ML, Nieminen MS, Klingenberg R, Matter CM, Hornemann T, Jüni P, Rodondi N, Räber L, Windecker S, Gencer B, Pedersen ER, Tell GS, Nygård O, Mach F, Sinisalo J, Lüscher TF.

Eur Heart J. 2016 Jul 1;37(25):1967-76. doi: 10.1093/eurheartj/ehw148. Epub 2016 Apr 28.

4.

Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides.

Kauhanen D, Sysi-Aho M, Koistinen KM, Laaksonen R, Sinisalo J, Ekroos K.

Anal Bioanal Chem. 2016 May;408(13):3475-83. doi: 10.1007/s00216-016-9425-z. Epub 2016 Feb 27.

PMID:
26922344
5.

RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold.

Marcher AB, Loft A, Nielsen R, Vihervaara T, Madsen JG, Sysi-Aho M, Ekroos K, Mandrup S.

Cell Rep. 2015 Dec 1;13(9):2000-13. doi: 10.1016/j.celrep.2015.10.069. Epub 2015 Nov 25.

6.

Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study.

Cheng JM, Suoniemi M, Kardys I, Vihervaara T, de Boer SP, Akkerhuis KM, Sysi-Aho M, Ekroos K, Garcia-Garcia HM, Oemrawsingh RM, Regar E, Koenig W, Serruys PW, van Geuns RJ, Boersma E, Laaksonen R.

Atherosclerosis. 2015 Dec;243(2):560-6. doi: 10.1016/j.atherosclerosis.2015.10.022. Epub 2015 Oct 23.

PMID:
26523994
7.

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access.

Salek RM, Neumann S, Schober D, Hummel J, Billiau K, Kopka J, Correa E, Reijmers T, Rosato A, Tenori L, Turano P, Marin S, Deborde C, Jacob D, Rolin D, Dartigues B, Conesa P, Haug K, Rocca-Serra P, O'Hagan S, Hao J, van Vliet M, Sysi-Aho M, Ludwig C, Bouwman J, Cascante M, Ebbels T, Griffin JL, Moing A, Nikolski M, Oresic M, Sansone SA, Viant MR, Goodacre R, Günther UL, Hankemeier T, Luchinat C, Walther D, Steinbeck C.

Metabolomics. 2015;11(6):1587-1597. Epub 2015 May 26.

8.

Statistical methods for handling unwanted variation in metabolomics data.

De Livera AM, Sysi-Aho M, Jacob L, Gagnon-Bartsch JA, Castillo S, Simpson JA, Speed TP.

Anal Chem. 2015 Apr 7;87(7):3606-15. doi: 10.1021/ac502439y. Epub 2015 Mar 6.

9.

Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients.

Hilvo M, Gade S, Hyötyläinen T, Nekljudova V, Seppänen-Laakso T, Sysi-Aho M, Untch M, Huober J, von Minckwitz G, Denkert C, Orešič M, Loibl S.

Int J Cancer. 2014 Apr 1;134(7):1725-33. doi: 10.1002/ijc.28491. Epub 2013 Oct 8.

10.

Interfacial properties of high-density lipoprotein-like lipid droplets with different lipid and apolipoprotein A-I compositions.

Koivuniemi A, Sysi-Aho M, Orešič M, Ollila S.

Biophys J. 2013 May 21;104(10):2193-201. doi: 10.1016/j.bpj.2013.02.058.

11.

Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes.

Oresic M, Gopalacharyulu P, Mykkänen J, Lietzen N, Mäkinen M, Nygren H, Simell S, Simell V, Hyöty H, Veijola R, Ilonen J, Sysi-Aho M, Knip M, Hyötyläinen T, Simell O.

Diabetes. 2013 Sep;62(9):3268-74. doi: 10.2337/db13-0159. Epub 2013 Apr 29.

12.

Integrated model of metabolism and autoimmune response in β-cell death and progression to type 1 diabetes.

Marinković T, Sysi-Aho M, Orešič M.

PLoS One. 2012;7(12):e51909. doi: 10.1371/journal.pone.0051909. Epub 2012 Dec 14.

13.

Metabolic regulation in progression to autoimmune diabetes.

Sysi-Aho M, Ermolov A, Gopalacharyulu PV, Tripathi A, Seppänen-Laakso T, Maukonen J, Mattila I, Ruohonen ST, Vähätalo L, Yetukuri L, Härkönen T, Lindfors E, Nikkilä J, Ilonen J, Simell O, Saarela M, Knip M, Kaski S, Savontaus E, Orešič M.

PLoS Comput Biol. 2011 Oct;7(10):e1002257. doi: 10.1371/journal.pcbi.1002257. Epub 2011 Oct 27.

14.

Metabolome in schizophrenia and other psychotic disorders: a general population-based study.

Orešič M, Tang J, Seppänen-Laakso T, Mattila I, Saarni SE, Saarni SI, Lönnqvist J, Sysi-Aho M, Hyötyläinen T, Perälä J, Suvisaari J.

Genome Med. 2011 Mar 23;3(3):19. doi: 10.1186/gm233.

15.

Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression.

Hilvo M, Denkert C, Lehtinen L, Müller B, Brockmöller S, Seppänen-Laakso T, Budczies J, Bucher E, Yetukuri L, Castillo S, Berg E, Nygren H, Sysi-Aho M, Griffin JL, Fiehn O, Loibl S, Richter-Ehrenstein C, Radke C, Hyötyläinen T, Kallioniemi O, Iljin K, Oresic M.

Cancer Res. 2011 May 1;71(9):3236-45. doi: 10.1158/0008-5472.CAN-10-3894. Epub 2011 Mar 17.

16.

Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy.

Sysi-Aho M, Koikkalainen J, Seppänen-Laakso T, Kaartinen M, Kuusisto J, Peuhkurinen K, Kärkkäinen S, Antila M, Lauerma K, Reissell E, Jurkko R, Lötjönen J, Heliö T, Orešič M.

PLoS One. 2011 Jan 20;6(1):e15744. doi: 10.1371/journal.pone.0015744.

17.

Metabolome in progression to Alzheimer's disease.

Orešič M, Hyötyläinen T, Herukka SK, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H.

Transl Psychiatry. 2011 Dec 13;1:e57. doi: 10.1038/tp.2011.55.

18.

Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome.

Lankinen M, Schwab U, Gopalacharyulu PV, Seppänen-Laakso T, Yetukuri L, Sysi-Aho M, Kallio P, Suortti T, Laaksonen DE, Gylling H, Poutanen K, Kolehmainen M, Oresic M.

Nutr Metab Cardiovasc Dis. 2010 May;20(4):249-57. doi: 10.1016/j.numecd.2009.04.009. Epub 2009 Jun 23.

PMID:
19553094
19.

Bioinformatics and computational methods for lipidomics.

Niemelä PS, Castillo S, Sysi-Aho M, Oresic M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2855-62. doi: 10.1016/j.jchromb.2009.01.025. Epub 2009 Jan 24. Review.

PMID:
19200789
20.

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.

Oresic M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, Katajamaa M, Hekkala A, Mattila I, Keskinen P, Yetukuri L, Reinikainen A, Lähde J, Suortti T, Hakalax J, Simell T, Hyöty H, Veijola R, Ilonen J, Lahesmaa R, Knip M, Simell O.

J Exp Med. 2008 Dec 22;205(13):2975-84. doi: 10.1084/jem.20081800. Epub 2008 Dec 15.

21.

Gender-dependent progression of systemic metabolic states in early childhood.

Nikkilä J, Sysi-Aho M, Ermolov A, Seppänen-Laakso T, Simell O, Kaski S, Oresic M.

Mol Syst Biol. 2008;4:197. doi: 10.1038/msb.2008.34. Epub 2008 Jun 3.

22.

Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults.

Kekkonen RA, Sysi-Aho M, Seppanen-Laakso T, Julkunen I, Vapaatalo H, Oresic M, Korpela R.

World J Gastroenterol. 2008 May 28;14(20):3188-94.

23.

Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles.

Sysi-Aho M, Vehtari A, Velagapudi VR, Westerbacka J, Yetukuri L, Bergholm R, Taskinen MR, Yki-Järvinen H, Oresic M.

Bioinformatics. 2007 Jul 1;23(13):i519-28.

PMID:
17646339
24.

Normalization method for metabolomics data using optimal selection of multiple internal standards.

Sysi-Aho M, Katajamaa M, Yetukuri L, Oresic M.

BMC Bioinformatics. 2007 Mar 15;8:93.

25.

Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study.

Pietiläinen KH, Sysi-Aho M, Rissanen A, Seppänen-Laakso T, Yki-Järvinen H, Kaprio J, Oresic M.

PLoS One. 2007 Feb 14;2(2):e218.

26.

A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle.

Laaksonen R, Katajamaa M, Päivä H, Sysi-Aho M, Saarinen L, Junni P, Lütjohann D, Smet J, Van Coster R, Seppänen-Laakso T, Lehtimäki T, Soini J, Oresic M.

PLoS One. 2006 Dec 20;1:e97.

27.

Searching for good strategies in adaptive minority games.

Sysi-Aho M, Chakraborti A, Kaski K.

Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Mar;69(3 Pt 2):036125. Epub 2004 Mar 31.

PMID:
15089379

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