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Proteomic screening of plasma identifies potential noninvasive biomarkers associated with significant/advanced fibrosis in patients with nonalcoholic fatty liver disease.

Hou W, Janech MG, Sobolesky PM, Bland AM, Samsuddin S, Alazawi W, Syn WK.

Biosci Rep. 2020 Jan 31;40(1). pii: BSR20190395. doi: 10.1042/BSR20190395.


Amitriptyline Inhibits Nonalcoholic Steatohepatitis and Atherosclerosis Induced by High-Fat Diet and LPS through Modulation of Sphingolipid Metabolism.

Lu Z, Li Y, Syn WK, Wang Z, Lopes-Virella MF, Lyons TJ, Huang Y.

Am J Physiol Endocrinol Metab. 2019 Dec 10. doi: 10.1152/ajpendo.00181.2019. [Epub ahead of print]


Association of IFNL3 rs12979860 polymorphism with HCV-related hepatocellular carcinoma susceptibility in a Chinese population.

Hou W, Qiao K, Huo Z, Du Y, Wang C, Syn WK.

Clin Exp Gastroenterol. 2019 Nov 6;12:433-439. doi: 10.2147/CEG.S206194. eCollection 2019.


Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?

Morrison M, Hughes HY, Naggie S, Syn WK.

Dig Dis Sci. 2019 Dec;64(12):3394-3401. doi: 10.1007/s10620-019-05861-7. Epub 2019 Oct 23. Review.


Characteristics of amino acid substitutions within the "a" determinant region of hepatitis B virus in chronically infected patients with coexisting HBsAg and anti-HBs.

Hou W, Huo Z, Du Y, Wang C, Syn WK.

Clin Res Hepatol Gastroenterol. 2019 Oct 14. pii: S2210-7401(19)30189-5. doi: 10.1016/j.clinre.2019.08.005. [Epub ahead of print]


Evolving Management Strategies for Nonalcoholic Fatty Liver Disease-Targeting Primary Care Physicians.

Yadav Y, Syn WK, Basu R.

Diabetes Technol Ther. 2019 Nov;21(11):611-618. doi: 10.1089/dia.2019.0158. Epub 2019 Jul 29. No abstract available.


Low Free Triiodothyronine Is Associated with Advanced Fibrosis in Patients at High Risk for Nonalcoholic Steatohepatitis.

Manka P, Bechmann L, Best J, Sydor S, Claridge LC, Coombes JD, Canbay A, Moeller L, Gerken G, Wedemeyer H, Syn WK.

Dig Dis Sci. 2019 Aug;64(8):2351-2358. doi: 10.1007/s10620-019-05687-3. Epub 2019 Jun 3.


Fibrosis in Chronic Liver Disease: An Update on Diagnostic and Treatment Modalities.

Manka P, Zeller A, Syn WK.

Drugs. 2019 Jun;79(9):903-927. doi: 10.1007/s40265-019-01126-9. Review.


Non-nutritive sweeteners and their association with the metabolic syndrome and non-alcoholic fatty liver disease: a review of the literature.

Green CH, Syn WK.

Eur J Nutr. 2019 Aug;58(5):1785-1800. doi: 10.1007/s00394-019-01996-5. Epub 2019 May 22. Review.


The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes.

Arif E, Solanki AK, Srivastava P, Rahman B, Tash BR, Holzman LB, Janech MG, Martin R, Knölker HJ, Fitzgibbon WR, Deng P, Budisavljevic MN, Syn WK, Wang C, Lipschutz JH, Kwon SH, Nihalani D.

Kidney Int. 2019 Jul;96(1):139-158. doi: 10.1016/j.kint.2019.02.014. Epub 2019 Mar 4.


Current treatment options for nonalcoholic fatty liver disease.

Shetty A, Syn WK.

Curr Opin Gastroenterol. 2019 May;35(3):168-176. doi: 10.1097/MOG.0000000000000528.


Coming Complications of Nonalcoholic Fatty Liver Disease: Time to GNASH Your Teeth.

Dismuke-Greer CE, Syn WK.

Dig Dis Sci. 2019 Mar;64(3):606-608. doi: 10.1007/s10620-018-5426-4. No abstract available.


Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis.

Hou W, Syn WK.

Front Cell Dev Biol. 2018 Nov 12;6:150. doi: 10.3389/fcell.2018.00150. eCollection 2018.


Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

Glass O, Henao R, Patel K, Guy CD, Gruss HJ, Syn WK, Moylan CA, Streilein R, Hall R, Mae Diehl A, Abdelmalek MF.

Hepatol Commun. 2018 Sep 21;2(11):1344-1355. doi: 10.1002/hep4.1237. eCollection 2018 Nov.


Atorvastatin provides a new lipidome improving early regeneration after partial hepatectomy in osteopontin deficient mice.

Nuñez-Garcia M, Gomez-Santos B, Saenz de Urturi D, Mestre D, Gonzalez-Romero F, Buque X, Gutiérrez-de Juan V, Martinez-Chantar ML, Syn WK, Fresnedo O, Aspichueta P.

Sci Rep. 2018 Oct 2;8(1):14626. doi: 10.1038/s41598-018-32919-9.


Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease.

Shetty A, Hsu JW, Manka PP, Syn WK.

Dig Dis Sci. 2018 Dec;63(12):3187-3206. doi: 10.1007/s10620-018-5242-x. Epub 2018 Aug 18. Review.


Profile of drug resistance mutations in nucleos(t)ide analogue-experienced chronic hepatitis B patients in Tianjin, China.

Hou W, Trieu C, Du Y, Wang C, Syn WK.

Int J Antimicrob Agents. 2018 Nov;52(5):735-736. doi: 10.1016/j.ijantimicag.2018.07.024. Epub 2018 Aug 3. No abstract available.


Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.

Naggie S, Swiderska-Syn M, Choi S, Lusk S, Lan A, Ferrari G, Syn WK, Guy CD, Diehl AM.

Open Forum Infect Dis. 2018 Jun 11;5(7):ofy138. doi: 10.1093/ofid/ofy138. eCollection 2018 Jul.


Beyond the liver in patients with non-alcoholic fatty liver disease (NAFLD)-cause for concern?

Armstrong MJ, Haydon G, Syn WK.

Hepatobiliary Surg Nutr. 2018 Apr;7(2):138-142. doi: 10.21037/hbsn.2018.01.09. No abstract available.


Non-invasive markers of liver fibrosis in fatty liver disease are unreliable in people of South Asian descent.

De Silva S, Li W, Kemos P, Brindley JH, Mecci J, Samsuddin S, Chin-Aleong J, Feakins RM, Foster GR, Syn WK, Alazawi W.

Frontline Gastroenterol. 2018 Apr;9(2):115-121. doi: 10.1136/flgastro-2017-100865. Epub 2017 Nov 16.


Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment.

Manka P, Coombes JD, Boosman R, Gauthier K, Papa S, Syn WK.

Cancer Lett. 2018 Apr 10;419:175-186. doi: 10.1016/j.canlet.2018.01.055. Review.


Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells.

Mehta KJ, Coombes JD, Briones-Orta M, Manka PP, Williams R, Patel VB, Syn WK.

Am J Med Sci. 2018 Feb;355(2):183-190. doi: 10.1016/j.amjms.2017.08.012. Epub 2017 Aug 23.


Periodontitis is associated with significant hepatic fibrosis in patients with non-alcoholic fatty liver disease.

Alazawi W, Bernabe E, Tai D, Janicki T, Kemos P, Samsuddin S, Syn WK, Gillam D, Turner W.

PLoS One. 2017 Dec 8;12(12):e0185902. doi: 10.1371/journal.pone.0185902. eCollection 2017.


Methotrexate Hepatotoxicity and the Impact of Nonalcoholic Fatty Liver Disease.

Shetty A, Cho W, Alazawi W, Syn WK.

Am J Med Sci. 2017 Aug;354(2):172-181. doi: 10.1016/j.amjms.2017.03.014. Epub 2017 Mar 14. Review.


Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter.

Briones-Orta MA, Avendaño-Vázquez SE, Ivette Aparicio-Bautista D, Coombes JD, Weber GF, Syn WK.

Data Brief. 2017 Aug 2;14:538-542. doi: 10.1016/j.dib.2017.07.057. eCollection 2017 Oct.


Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver.

Nuñez-Garcia M, Gomez-Santos B, Buqué X, García-Rodriguez JL, Romero MR, Marin JJG, Arteta B, García-Monzón C, Castaño L, Syn WK, Fresnedo O, Aspichueta P.

J Lipid Res. 2017 Sep;58(9):1903-1915. doi: 10.1194/jlr.M078980. Epub 2017 Jul 28.


Gene expression profiling in bladder cancer identifies potential therapeutic targets.

Hussain SA, Palmer DH, Syn WK, Sacco JJ, Greensmith RM, Elmetwali T, Aachi V, Lloyd BH, Jithesh PV, Arrand J, Barton D, Ansari J, Sibson DR, James ND.

Int J Oncol. 2017 Apr;50(4):1147-1159. doi: 10.3892/ijo.2017.3893. Epub 2017 Mar 2.


Osteopontin splice variants and polymorphisms in cancer progression and prognosis.

Briones-Orta MA, Avendaño-Vázquez SE, Aparicio-Bautista DI, Coombes JD, Weber GF, Syn WK.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):93-108.A. doi: 10.1016/j.bbcan.2017.02.005. Epub 2017 Feb 28. Review.


Infliximab and Dexamethasone Attenuate the Ductular Reaction in Mice.

Verhulst S, Best J, Syn WK, Reynaert H, Hellemans KH, Canbay A, Dolle L, van Grunsven LA.

Sci Rep. 2016 Nov 8;6:36586. doi: 10.1038/srep36586.


Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Pereira TA, Syn WK, Pereira FE, Lambertucci JR, Secor WE, Diehl AM.

Int J Parasitol. 2016 Dec;46(13-14):829-832. doi: 10.1016/j.ijpara.2016.08.004. Epub 2016 Oct 10.


Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni.

Pereira TA, Syn WK, Amâncio FF, Cunha PH, Caporali JF, Trindade GV, Santos ET, Souza MM, Andrade ZA, Witek RP, Secor WE, Pereira FE, Lambertucci JR, Diehl AM.

PLoS Negl Trop Dis. 2016 Oct 18;10(10):e0005057. doi: 10.1371/journal.pntd.0005057. eCollection 2016 Oct.


NASH Cirrhosis - the New Burden in Liver Transplantation: How Should It Be Managed?

Canbay A, Sowa JP, Syn WK, Treckmann J.

Visc Med. 2016 Aug;32(4):234-238. Epub 2016 Jul 29. Review.


Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies.

Best J, Verhulst S, Syn WK, Lagaisse K, van Hul N, Heindryckx F, Sowa JP, Peeters L, Van Vlierberghe H, Leclercq IA, Canbay A, Dollé L, van Grunsven LA.

PLoS One. 2016 Sep 12;11(9):e0162286. doi: 10.1371/journal.pone.0162286. eCollection 2016.


Osteopontin-A Master Regulator of Epithelial-Mesenchymal Transition.

Kothari AN, Arffa ML, Chang V, Blackwell RH, Syn WK, Zhang J, Mi Z, Kuo PC.

J Clin Med. 2016 Mar 23;5(4). pii: E39. doi: 10.3390/jcm5040039. Review.


Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.

Swiderska-Syn M, Xie G, Michelotti GA, Jewell ML, Premont RT, Syn WK, Diehl AM.

Hepatology. 2016 Jul;64(1):232-44. doi: 10.1002/hep.28542. Epub 2016 Apr 21.


Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis.

Chen YY, Jeffery HC, Hunter S, Bhogal R, Birtwistle J, Braitch MK, Roberts S, Ming M, Hannah J, Thomas C, Adali G, Hübscher SG, Syn WK, Afford S, Lalor PF, Adams DH, Oo YH.

Hepatology. 2016 Jul;64(1):138-50. doi: 10.1002/hep.28517. Epub 2016 Apr 15.


Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.

Coombes JD, Choi SS, Swiderska-Syn M, Manka P, Reid DT, Palma E, Briones-Orta MA, Xie G, Younis R, Kitamura N, Della Peruta M, Bitencourt S, Dollé L, Oo YH, Mi Z, Kuo PC, Williams R, Chokshi S, Canbay A, Claridge LC, Eksteen B, Diehl AM, Syn WK.

Biochim Biophys Acta. 2016 Jan;1862(1):135-44. doi: 10.1016/j.bbadis.2015.10.028. Epub 2015 Oct 31.


Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Pereira TA, Syn WK, Machado MV, Vidigal PV, Resende V, Voieta I, Xie G, Otoni A, Souza MM, Santos ET, Chan IS, Trindade GV, Choi SS, Witek RP, Pereira FE, Secor WE, Andrade ZA, Lambertucci JR, Diehl AM.

Clin Sci (Lond). 2015 Nov;129(10):875-83. doi: 10.1042/CS20150117. Epub 2015 Jul 21.


Higher Thyroid-Stimulating Hormone, Triiodothyronine and Thyroxine Values Are Associated with Better Outcome in Acute Liver Failure.

Anastasiou O, Sydor S, Sowa JP, Manka P, Katsounas A, Syn WK, Führer D, Gieseler RK, Bechmann LP, Gerken G, Moeller LC, Canbay A.

PLoS One. 2015 Jul 6;10(7):e0132189. doi: 10.1371/journal.pone.0132189. eCollection 2015.


Hepatitis E Virus Infection as a Possible Cause of Acute Liver Failure in Europe.

Manka P, Bechmann LP, Coombes JD, Thodou V, Schlattjan M, Kahraman A, Syn WK, Saner F, Gerken G, Baba H, Verheyen J, Timm J, Canbay A.

Clin Gastroenterol Hepatol. 2015 Oct;13(10):1836-1842.e2; quiz e157-8. doi: 10.1016/j.cgh.2015.04.014. Epub 2015 Apr 23.


Role of liver progenitors in liver regeneration.

Best J, Manka P, Syn WK, Dollé L, van Grunsven LA, Canbay A.

Hepatobiliary Surg Nutr. 2015 Feb;4(1):48-58. doi: 10.3978/j.issn.2304-3881.2015.01.16. Review.


Practical approach to non-alcoholic fatty liver disease in patients with diabetes.

Tai FW, Syn WK, Alazawi W.

Diabet Med. 2015 Sep;32(9):1121-33. doi: 10.1111/dme.12725. Epub 2015 Mar 18. Review.


Osteopontin mediates an MZF1-TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer.

Weber CE, Kothari AN, Wai PY, Li NY, Driver J, Zapf MA, Franzen CA, Gupta GN, Osipo C, Zlobin A, Syn WK, Zhang J, Kuo PC, Mi Z.

Oncogene. 2015 Sep 10;34(37):4821-33. doi: 10.1038/onc.2014.410. Epub 2014 Dec 22.


Mini-laparoscopy guided liver biopsy increases diagnostic accuracy in acute liver failure.

Dechêne A, Sowa JP, Schlattjan M, Wree A, Blomeyer S, Best J, Maldonado EJ, Bechmann LP, Gerken G, Baba HA, Syn WK, Canbay A.

Digestion. 2014;90(4):240-7. doi: 10.1159/000366517. Epub 2014 Dec 19.


Differential osteopontin functions: The role of osteopontin isoforms.

Coombes JD, Syn WK.

Hepatology. 2015 Jul;62(1):323-4. doi: 10.1002/hep.27555. Epub 2015 May 6. No abstract available.


Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently.

Beilfuss A, Sowa JP, Sydor S, Beste M, Bechmann LP, Schlattjan M, Syn WK, Wedemeyer I, Mathé Z, Jochum C, Gerken G, Gieseler RK, Canbay A.

Gut. 2015 May;64(5):791-9. doi: 10.1136/gutjnl-2014-307024. Epub 2014 Aug 18.


Low levels of blood lipids are associated with etiology and lethal outcome in acute liver failure.

Manka P, Olliges V, Bechmann LP, Schlattjan M, Jochum C, Treckmann JW, Saner FH, Gerken G, Syn WK, Canbay A.

PLoS One. 2014 Jul 15;9(7):e102351. doi: 10.1371/journal.pone.0102351. eCollection 2014.


Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice.

Coombes JD, Swiderska-Syn M, Dollé L, Reid D, Eksteen B, Claridge L, Briones-Orta MA, Shetty S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, Canbay A, Adams DH, Diehl AM, van Grunsven LA, Choi SS, Syn WK.

Gut. 2015 Jul;64(7):1120-31. doi: 10.1136/gutjnl-2013-306484. Epub 2014 Jun 5.


Endoscopic management is the treatment of choice for bile leaks after liver resection.

Dechêne A, Jochum C, Fingas C, Paul A, Heider D, Syn WK, Gerken G, Canbay A, Zöpf T.

Gastrointest Endosc. 2014 Oct;80(4):626-633.e1. doi: 10.1016/j.gie.2014.02.1028. Epub 2014 May 3.


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