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Items: 19


SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.

Ensign SP, Roos A, Mathews IT, Dhruv HD, Tuncali S, Sarkaria JN, Symons MH, Loftus JC, Berens ME, Tran NL.

Mol Cancer Res. 2016 Mar;14(3):302-12. doi: 10.1158/1541-7786.MCR-15-0183. Epub 2016 Jan 13.


Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.

Fortin Ensign SP, Mathews IT, Symons MH, Berens ME, Tran NL.

Front Oncol. 2013 Oct 4;3:241. doi: 10.3389/fonc.2013.00241. Review.


Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.

Fortin SP, Ennis MJ, Schumacher CA, Zylstra-Diegel CR, Williams BO, Ross JT, Winkles JA, Loftus JC, Symons MH, Tran NL.

Mol Cancer Res. 2012 Jul;10(7):958-68. doi: 10.1158/1541-7786.MCR-11-0616. Epub 2012 May 9.


Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling.

Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, Segall JE.

Mol Med. 2012 May 9;18:519-27. doi: 10.2119/molmed.2011.00217.


Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach.

Vader P, van der Meel R, Symons MH, Fens MH, Pieters E, Wilschut KJ, Storm G, Jarzabek M, Gallagher WM, Schiffelers RM, Byrne AT.

Angiogenesis. 2011 Dec;14(4):457-66. doi: 10.1007/s10456-011-9229-x. Epub 2011 Jul 26.


The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy.

van der Meel R, Symons MH, Kudernatsch R, Kok RJ, Schiffelers RM, Storm G, Gallagher WM, Byrne AT.

Drug Discov Today. 2011 Mar;16(5-6):219-28. doi: 10.1016/j.drudis.2011.01.005. Epub 2011 Jan 22. Review.


Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression.

Wu R, Abramson AL, Symons MH, Steinberg BM.

Int J Cancer. 2010 Nov 1;127(9):2230-7. doi: 10.1002/ijc.25226.


Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.

Coniglio SJ, Zavarella S, Symons MH.

Mol Cell Biol. 2008 Jun;28(12):4162-72. doi: 10.1128/MCB.01532-07. Epub 2008 Apr 14.


Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas.

Wu R, Coniglio SJ, Chan A, Symons MH, Steinberg BM.

Mol Med. 2007 Mar-Apr;13(3-4):143-50.


Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection.

Fan S, Gao M, Meng Q, Laterra JJ, Symons MH, Coniglio S, Pestell RG, Goldberg ID, Rosen EM.

Oncogene. 2005 Mar 3;24(10):1749-66.


Modulation of Rac localization and function by dynamin.

Schlunck G, Damke H, Kiosses WB, Rusk N, Symons MH, Waterman-Storer CM, Schmid SL, Schwartz MA.

Mol Biol Cell. 2004 Jan;15(1):256-67. Epub 2003 Nov 14.


Fast receptor-induced formation of glycerophosphoinositol-4-phosphate, a putative novel intracellular messenger in the Ras pathway.

Falasca M, Carvelli A, Iurisci C, Qiu RG, Symons MH, Corda D.

Mol Biol Cell. 1997 Mar;8(3):443-53.


Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx.

Peppelenbosch MP, Tertoolen LG, de Vries-Smits AM, Qiu RG, M'Rabet L, Symons MH, de Laat SW, Bos JL.

J Biol Chem. 1996 Apr 5;271(14):7883-6.


Rac mediates growth factor-induced arachidonic acid release.

Peppelenbosch MP, Qiu RG, de Vries-Smits AM, Tertoolen LG, de Laat SW, McCormick F, Hall A, Symons MH, Bos JL.

Cell. 1995 Jun 16;81(6):849-56.


A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts.

Symons MH, Mitchison TJ.

J Cell Biol. 1992 Sep;118(5):1235-44.


Control of actin polymerization in live and permeabilized fibroblasts.

Symons MH, Mitchison TJ.

J Cell Biol. 1991 Aug;114(3):503-13.


Immunodiagnosis of parasitic zoonoses: purification of Toxocara canis antigens by affinity chromatography.

Welch JS, Symons MH, Dobson C.

Int J Parasitol. 1983 Apr;13(2):171-8. No abstract available.


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