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Items: 1 to 50 of 103


CDK and Mec1/Tel1-catalyzed phosphorylation of Sae2 regulate different responses to DNA damage.

Yu TY, Garcia VE, Symington LS.

Nucleic Acids Res. 2019 Dec 2;47(21):11238-11249. doi: 10.1093/nar/gkz814.


DNA Polymerase Delta Synthesizes Both Strands during Break-Induced Replication.

Donnianni RA, Zhou ZX, Lujan SA, Al-Zain A, Garcia V, Glancy E, Burkholder AB, Kunkel TA, Symington LS.

Mol Cell. 2019 Nov 7;76(3):371-381.e4. doi: 10.1016/j.molcel.2019.07.033. Epub 2019 Sep 5.


Recognition for Discoveries in DNA Repair.

Klein HL, Symington LS.

N Engl J Med. 2019 Aug 15;381(7):677-679. doi: 10.1056/NEJMcibr1907358. No abstract available.


Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination.

Steinfeld JB, Beláň O, Kwon Y, Terakawa T, Al-Zain A, Smith MJ, Crickard JB, Qi Z, Zhao W, Rothstein R, Symington LS, Sung P, Boulton SJ, Greene EC.

Genes Dev. 2019 Sep 1;33(17-18):1191-1207. doi: 10.1101/gad.328062.119. Epub 2019 Aug 1.


Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.

Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, Polleys EJ, Putnam CD, Radchenko EA, Saada AA, Sakofsky CJ, Shim EY, Stracy M, Xia J, Yan Z, Yin Y, Aguilera A, Argueso JL, Freudenreich CH, Gasser SM, Gordenin DA, Haber JE, Ira G, Jinks-Robertson S, King MC, Kolodner RD, Kuzminov A, Lambert SA, Lee SE, Miller KM, Mirkin SM, Petes TD, Rosenberg SM, Rothstein R, Symington LS, Zawadzki P, Kim N, Lisby M, Malkova A.

Microb Cell. 2019 Jan 7;6(1):1-64. doi: 10.15698/mic2019.01.664. Review.


Role of the Mre11 Complex in Preserving Genome Integrity.

Oh J, Symington LS.

Genes (Basel). 2018 Nov 29;9(12). pii: E589. doi: 10.3390/genes9120589. Review.


Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection.

Yu TY, Kimble MT, Symington LS.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11961-E11969. doi: 10.1073/pnas.1816539115. Epub 2018 Dec 3.


Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability.

Oh J, Lee SJ, Rothstein R, Symington LS.

Cell Rep. 2018 Nov 13;25(7):1681-1692.e4. doi: 10.1016/j.celrep.2018.10.030.


Processing of DNA Double-Strand Breaks in Yeast.

Gnügge R, Oh J, Symington LS.

Methods Enzymol. 2018;600:1-24. doi: 10.1016/bs.mie.2017.11.007. Epub 2018 Feb 1.


Keeping it real: MRX-Sae2 clipping of natural substrates.

Gnügge R, Symington LS.

Genes Dev. 2017 Dec 1;31(23-24):2311-2312. doi: 10.1101/gad.310771.117. Review.


Erratum: A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation.

Wei J, Zhang Y, Yu TY, Sadre-Bazzaz K, Rudolph MJ, Amodeo GA, Symington LS, Walz T, Tong L.

Cell Discov. 2017 Jan 17;3:16055. doi: 10.1038/celldisc.2016.55. eCollection 2017.


RPA Stabilization of Single-Stranded DNA Is Critical for Break-Induced Replication.

Ruff P, Donnianni RA, Glancy E, Oh J, Symington LS.

Cell Rep. 2016 Dec 20;17(12):3359-3368. doi: 10.1016/j.celrep.2016.12.003.


A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation.

Wei J, Zhang Y, Yu TY, Sadre-Bazzaz K, Rudolph MJ, Amodeo GA, Symington LS, Walz T, Tong L.

Cell Discov. 2016 Nov 29;2:16044. eCollection 2016. Erratum in: Cell Discov. 2017 Jan 17;3:16055.


Stressing Out About RAD52.

Ciccia A, Symington LS.

Mol Cell. 2016 Dec 15;64(6):1017-1019. doi: 10.1016/j.molcel.2016.11.036.


Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex.

Oh J, Al-Zain A, Cannavo E, Cejka P, Symington LS.

Mol Cell. 2016 Oct 20;64(2):405-415. doi: 10.1016/j.molcel.2016.09.011. Epub 2016 Oct 13.


Mechanism and regulation of DNA end resection in eukaryotes.

Symington LS.

Crit Rev Biochem Mol Biol. 2016 May-Jun;51(3):195-212. doi: 10.3109/10409238.2016.1172552. Epub 2016 Apr 20. Review.


Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification.

Deng SK, Yin Y, Petes TD, Symington LS.

Mol Cell. 2015 Nov 5;60(3):500-8. doi: 10.1016/j.molcel.2015.09.027.


Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

Sfeir A, Symington LS.

Trends Biochem Sci. 2015 Nov;40(11):701-714. doi: 10.1016/j.tibs.2015.08.006. Epub 2015 Oct 1. Review.


Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.

Chen H, Donnianni RA, Handa N, Deng SK, Oh J, Timashev LA, Kowalczykowski SC, Symington LS.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1880-7. doi: 10.1073/pnas.1503331112. Epub 2015 Mar 23.


Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity.

Deng SK, Chen H, Symington LS.

Bioessays. 2015 Mar;37(3):305-13. doi: 10.1002/bies.201400161. Epub 2014 Nov 14. Review.


Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae.

Symington LS, Rothstein R, Lisby M.

Genetics. 2014 Nov;198(3):795-835. doi: 10.1534/genetics.114.166140. Review.


DNA repair: Making the cut.

Symington LS.

Nature. 2014 Oct 2;514(7520):39-40. doi: 10.1038/nature13751. Epub 2014 Sep 17. No abstract available.


DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum.

Lee AH, Symington LS, Fidock DA.

Microbiol Mol Biol Rev. 2014 Sep;78(3):469-86. doi: 10.1128/MMBR.00059-13. Review.


Sgs1 and Exo1 suppress targeted chromosome duplication during ends-in and ends-out gene targeting.

Štafa A, Miklenić M, Zunar B, Lisnić B, Symington LS, Svetec IK.

DNA Repair (Amst). 2014 Oct;22:12-23. doi: 10.1016/j.dnarep.2014.07.004. Epub 2014 Aug 2.


End resection at double-strand breaks: mechanism and regulation.

Symington LS.

Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8). pii: a016436. doi: 10.1101/cshperspect.a016436. Review.


The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability.

Eissler CL, Mazón G, Powers BL, Savinov SN, Symington LS, Hall MC.

Mol Cell. 2014 Apr 10;54(1):80-93. doi: 10.1016/j.molcel.2014.02.012. Epub 2014 Mar 13.


RPA antagonizes microhomology-mediated repair of DNA double-strand breaks.

Deng SK, Gibb B, de Almeida MJ, Greene EC, Symington LS.

Nat Struct Mol Biol. 2014 Apr;21(4):405-12. doi: 10.1038/nsmb.2786. Epub 2014 Mar 9.


Template switching during break-induced replication is promoted by the Mph1 helicase in Saccharomyces cerevisiae.

Stafa A, Donnianni RA, Timashev LA, Lam AF, Symington LS.

Genetics. 2014 Apr;196(4):1017-28. doi: 10.1534/genetics.114.162297. Epub 2014 Feb 4.


Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates.

Mazón G, Symington LS.

Mol Cell. 2013 Oct 10;52(1):63-74. doi: 10.1016/j.molcel.2013.09.007.


Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae.

Bernstein KA, Mimitou EP, Mihalevic MJ, Chen H, Sunjaveric I, Symington LS, Rothstein R.

Genetics. 2013 Dec;195(4):1241-51. doi: 10.1534/genetics.113.157370. Epub 2013 Oct 4.


Break-induced replication occurs by conservative DNA synthesis.

Donnianni RA, Symington LS.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13475-80. doi: 10.1073/pnas.1309800110. Epub 2013 Jul 29.


RPA coordinates DNA end resection and prevents formation of DNA hairpins.

Chen H, Lisby M, Symington LS.

Mol Cell. 2013 May 23;50(4):589-600. doi: 10.1016/j.molcel.2013.04.032.


Overcoming the chromatin barrier to end resection.

Chen H, Symington LS.

Cell Res. 2013 Mar;23(3):317-9. doi: 10.1038/cr.2012.148. Epub 2012 Nov 13.


The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.

Mazón G, Lam AF, Ho CK, Kupiec M, Symington LS.

Nat Struct Mol Biol. 2012 Sep;19(9):964-71. doi: 10.1038/nsmb.2359. Epub 2012 Aug 12.


Sgs1--the maestro of recombination.

Klein HL, Symington LS.

Cell. 2012 Apr 13;149(2):257-9. doi: 10.1016/j.cell.2012.03.020.


Double-strand break end resection and repair pathway choice.

Symington LS, Gautier J.

Annu Rev Genet. 2011;45:247-71. doi: 10.1146/annurev-genet-110410-132435. Epub 2011 Sep 12. Review.


RAD51-independent inverted-repeat recombination by a strand-annealing mechanism.

Mott C, Symington LS.

DNA Repair (Amst). 2011 Apr 3;10(4):408-15. doi: 10.1016/j.dnarep.2011.01.007. Epub 2011 Feb 12.


DNA end resection--unraveling the tail.

Mimitou EP, Symington LS.

DNA Repair (Amst). 2011 Mar 7;10(3):344-8. doi: 10.1016/j.dnarep.2010.12.004. Epub 2011 Jan 11. Review.


Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.

Ho CK, Mazón G, Lam AF, Symington LS.

Mol Cell. 2010 Dec 22;40(6):988-1000. doi: 10.1016/j.molcel.2010.11.016.


Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2.

Mimitou EP, Symington LS.

EMBO J. 2010 Oct 6;29(19):3358-69. doi: 10.1038/emboj.2010.193. Epub 2010 Aug 20.


SnapShot: Homologous recombination in DNA double-strand break repair.

Mazón G, Mimitou EP, Symington LS.

Cell. 2010 Aug 20;142(4):646, 646.e1. doi: 10.1016/j.cell.2010.08.006. No abstract available.


Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replication.

Marrero VA, Symington LS.

PLoS Genet. 2010 Jul 8;6(7):e1001007. doi: 10.1371/journal.pgen.1001007.


Initiation and completion of spontaneous mitotic recombination occur in different cell cycle phases.

Symington LS.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8045-6. doi: 10.1073/pnas.1003050107. Epub 2010 Apr 23. No abstract available.


Identification of nucleases and phosphatases by direct biochemical screen of the Saccharomyces cerevisiae proteome.

Ho CK, Lam AF, Symington LS.

PLoS One. 2009 Sep 15;4(9):e6993. doi: 10.1371/journal.pone.0006993.


Breaking up just got easier to do.

Klein HL, Symington LS.

Cell. 2009 Jul 10;138(1):20-2. doi: 10.1016/j.cell.2009.06.039.


DNA end resection: many nucleases make light work.

Mimitou EP, Symington LS.

DNA Repair (Amst). 2009 Sep 2;8(9):983-95. doi: 10.1016/j.dnarep.2009.04.017. Epub 2009 May 26. Review.


Nucleases and helicases take center stage in homologous recombination.

Mimitou EP, Symington LS.

Trends Biochem Sci. 2009 May;34(5):264-72. doi: 10.1016/j.tibs.2009.01.010. Epub 2009 Apr 15. Review.


Suppression of the double-strand-break-repair defect of the Saccharomyces cerevisiae rad57 mutant.

Fung CW, Mozlin AM, Symington LS.

Genetics. 2009 Apr;181(4):1195-206. doi: 10.1534/genetics.109.100842. Epub 2009 Feb 2.


Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex.

Smith CE, Lam AF, Symington LS.

Mol Cell Biol. 2009 Mar;29(6):1432-41. doi: 10.1128/MCB.01469-08. Epub 2009 Jan 12.


Resolving resolvases: the final act?

Symington LS, Holloman WK.

Mol Cell. 2008 Dec 5;32(5):603-4. doi: 10.1016/j.molcel.2008.11.011.

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