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Items: 32


Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein.

Oberst MD, Augé C, Morris C, Kentner S, Mulgrew K, McGlinchey K, Hair J, Hanabuchi S, Du Q, Damschroder M, Feng H, Eck S, Buss N, de Haan L, Pierce AJ, Park H, Sylwester A, Axthelm MK, Picker L, Morris NP, Weinberg A, Hammond SA.

Mol Cancer Ther. 2018 May;17(5):1024-1038. doi: 10.1158/1535-7163.MCT-17-0200. Epub 2018 Mar 15.


Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.

Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Randall KT, Selseth AN, Rundstrom P, Herlache L, Lewis MS, Park H, Planer SL, Turner JM, Fischer M, Armstrong C, Zweig RC, Valvo J, Braun JM, Shankar S, Lu L, Sylwester AW, Legasse AW, Messerle M, Jarvis MA, Amon LM, Aderem A, Alter G, Laddy DJ, Stone M, Bonavia A, Evans TG, Axthelm MK, Früh K, Edlefsen PT, Picker LJ.

Nat Med. 2018 Feb;24(2):130-143. doi: 10.1038/nm.4473. Epub 2018 Jan 15.


A new perspective of the structural complexity of HCMV-specific T-cell responses.

Sylwester A, Nambiar KZ, Caserta S, Klenerman P, Picker LJ, Kern F.

Mech Ageing Dev. 2016 Sep;158:14-22. doi: 10.1016/j.mad.2016.03.002. Epub 2016 Mar 5.


Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.

Okoye AA, Rohankhedkar M, Konfe AL, Abana CO, Reyes MD, Clock JA, Duell DM, Sylwester AW, Sammader P, Legasse AW, Park BS, Axthelm MK, Nikolich-Žugich J, Picker LJ.

J Immunol. 2015 Nov 1;195(9):4292-305. doi: 10.4049/jimmunol.1500609. Epub 2015 Sep 28.


Heterogeneity of CD4+ and CD8+ T-cell responses to cytomegalovirus in HIV-infected and HIV-uninfected men who have sex with men.

Li H, Margolick JB, Bream JH, Nilles TL, Langan S, Bui HT, Sylwester AW, Picker LJ, Leng SX.

J Infect Dis. 2014 Aug 1;210(3):400-4. doi: 10.1093/infdis/jiu093. Epub 2014 Feb 14.


Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV Gag protein-induced T cell responses in nonhuman primates.

Park H, Adamson L, Ha T, Mullen K, Hagen SI, Nogueron A, Sylwester AW, Axthelm MK, Legasse A, Piatak M Jr, Lifson JD, McElrath JM, Picker LJ, Seder RA.

J Immunol. 2013 Apr 15;190(8):4103-15. doi: 10.4049/jimmunol.1202958. Epub 2013 Mar 15.


Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.

Fukazawa Y, Park H, Cameron MJ, Lefebvre F, Lum R, Coombes N, Mahyari E, Hagen SI, Bae JY, Reyes MD 3rd, Swanson T, Legasse AW, Sylwester A, Hansen SG, Smith AT, Stafova P, Shoemaker R, Li Y, Oswald K, Axthelm MK, McDermott A, Ferrari G, Montefiori DC, Edlefsen PT, Piatak M Jr, Lifson JD, Sékaly RP, Picker LJ.

Nat Med. 2012 Nov;18(11):1673-81. doi: 10.1038/nm.2934. Epub 2012 Sep 9.


Optimization and qualification of an 8-color intracellular cytokine staining assay for quantifying T cell responses in rhesus macaques for pre-clinical vaccine studies.

Donaldson MM, Kao SF, Eslamizar L, Gee C, Koopman G, Lifton M, Schmitz JE, Sylwester AW, Wilson A, Hawkins N, Self SG, Roederer M, Foulds KE.

J Immunol Methods. 2012 Dec 14;386(1-2):10-21. doi: 10.1016/j.jim.2012.08.011. Epub 2012 Aug 28.


Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection.

Okoye AA, Rohankhedkar M, Abana C, Pattenn A, Reyes M, Pexton C, Lum R, Sylwester A, Planer SL, Legasse A, Park BS, Piatak M Jr, Lifson JD, Axthelm MK, Picker LJ.

J Exp Med. 2012 Apr 9;209(4):641-51. doi: 10.1084/jem.20112071. Epub 2012 Mar 26.


Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques.

Cicin-Sain L, Sylwester AW, Hagen SI, Siess DC, Currier N, Legasse AW, Fischer MB, Koudelka CW, Axthelm MK, Nikolich-Zugich J, Picker LJ.

J Immunol. 2011 Aug 15;187(4):1722-32. doi: 10.4049/jimmunol.1100560. Epub 2011 Jul 15.


Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.

Okoye A, Park H, Rohankhedkar M, Coyne-Johnson L, Lum R, Walker JM, Planer SL, Legasse AW, Sylwester AW, Piatak M Jr, Lifson JD, Sodora DL, Villinger F, Axthelm MK, Schmitz JE, Picker LJ.

J Exp Med. 2009 Jul 6;206(7):1575-88. doi: 10.1084/jem.20090356. Epub 2009 Jun 22.


Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.

Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.

J Exp Med. 2007 Sep 3;204(9):2171-85. Epub 2007 Aug 27. Erratum in: J Exp Med. 2007 Oct;204(10):2493.


Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects.

Sylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, Sleath PR, Grabstein KH, Hosken NA, Kern F, Nelson JA, Picker LJ.

J Exp Med. 2005 Sep 5;202(5):673-85.


Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.

Picker LJ, Hagen SI, Lum R, Reed-Inderbitzin EF, Daly LM, Sylwester AW, Walker JM, Siess DC, Piatak M Jr, Wang C, Allison DB, Maino VC, Lifson JD, Kodama T, Axthelm MK.

J Exp Med. 2004 Nov 15;200(10):1299-314.


CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.

Sylwester AW, Grivel JC, Fitzgerald W, Rossio JL, Lifson JD, Margolis LB.

J Virol. 1998 Nov;72(11):9345-7.


Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency.

Glushakova S, Grivel JC, Fitzgerald W, Sylwester A, Zimmerberg J, Margolis LB.

Nat Med. 1998 Mar;4(3):346-9.


The invasive and destructive behavior of HIV-induced T cell syncytia on collagen and endothelium.

Sylwester A, Daniels K, Soll DR.

J Leukoc Biol. 1998 Feb;63(2):233-44.


HIV-induced T cell syncytia are self-perpetuating and the primary cause of T cell death in culture.

Sylwester A, Murphy S, Shutt D, Soll DR.

J Immunol. 1997 Apr 15;158(8):3996-4007.


T cells and HIV-induced T cell syncytia exhibit the same motility cycle.

Sylwester A, Shutt D, Wessels D, Stapleton JT, Stites J, Kennedy RC, Soll DR.

J Leukoc Biol. 1995 Apr;57(4):643-50.


Phagocytosis of individual CD4+ T cells by HIV-induced T cell syncytia.

Murphy S, Sylwester A, Kennedy RC, Soll DR.

AIDS Res Hum Retroviruses. 1995 Apr;11(4):433-42.


HIV-induced syncytia of a T cell line form single giant pseudopods and are motile.

Sylwester A, Wessels D, Anderson SA, Warren RQ, Shutt DC, Kennedy RC, Soll DR.

J Cell Sci. 1993 Nov;106 ( Pt 3):941-53.


Primary structure of a cardioactive neuropeptide from the tobacco hawkmoth, Manduca sexta.

Cheung CC, Loi PK, Sylwester AW, Lee TD, Tublitz NJ.

FEBS Lett. 1992 Nov 23;313(2):165-8.


Insect cardioactive peptides in Manduca sexta: a comparison of the biochemical and molecular characteristics of cardioactive peptides in larvae and adults.

Tublitz NJ, Cheung CC, Edwards KK, Sylwester AW, Reynolds SE.

J Exp Biol. 1992 Apr;165:265-72. No abstract available.


Insect cardioactive peptides: regulation of hindgut activity by cardioacceleratory peptide 2 (CAP2) during wandering behaviour in Manduca sexta larvae.

Tublitz NJ, Allen AT, Cheung CC, Edwards KK, Kimble DP, Loi PK, Sylwester AW.

J Exp Biol. 1992 Apr;165:241-64.


Pressure dependence of the orientational ordering in solid C60.

Samara GA, Schirber JE, Morosin B, Hansen LV, Loy D, Sylwester AP.

Phys Rev Lett. 1991 Nov 25;67(22):3136-3139. No abstract available.


From behavior to molecules: an integrated approach to the study of neuropeptides.

Tublitz N, Brink D, Broadie KS, Loi PK, Sylwester AW.

Trends Neurosci. 1991 Jun;14(6):254-9. Review.


Composite electrodes based on carbonized poly(acrylonitrile) foams.

Wang J, Brennsteiner A, Sylwester AP.

Anal Chem. 1990 May 15;62(10):1102-4. No abstract available.


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