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Items: 35


Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle.

Han X, Møller LLV, De Groote E, Bojsen-Møller KN, Davey J, Henríquez-Olguin C, Li Z, Knudsen JR, Jensen TE, Madsbad S, Gregorevic P, Richter EA, Sylow L.

J Cachexia Sarcopenia Muscle. 2019 Aug 11. doi: 10.1002/jcsm.12474. [Epub ahead of print]


Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.

Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE.

EMBO J. 2019 Aug 5:e102578. doi: 10.15252/embj.2019102578. [Epub ahead of print]


Rho GTPases-Emerging Regulators of Glucose Homeostasis and Metabolic Health.

Møller LLV, Klip A, Sylow L.

Cells. 2019 May 9;8(5). pii: E434. doi: 10.3390/cells8050434. Review.


Differential effects of high-fat diet and exercise training on bone and energy metabolism.

Picke AK, Sylow L, Møller LLV, Kjøbsted R, Schmidt FN, Steejn MW, Salbach-Hirsch J, Hofbauer C, Blüher M, Saalbach A, Busse B, Rauner M, Hofbauer LC.

Bone. 2018 Nov;116:120-134. doi: 10.1016/j.bone.2018.07.015. Epub 2018 Jul 20.


Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training.

Kleinert M, Parker BL, Jensen TE, Raun SH, Pham P, Han X, James DE, Richter EA, Sylow L.

Sci Rep. 2018 Jul 16;8(1):10723. doi: 10.1038/s41598-018-28540-5.


Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.

Raun SH, Ali M, Kjøbsted R, Møller LLV, Federspiel MA, Richter EA, Jensen TE, Sylow L.

J Physiol. 2018 Jun;596(12):2283-2299. doi: 10.1113/JP275602. Epub 2018 May 10.


β-Actin shows limited mobility and is required only for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle.

Madsen AB, Knudsen JR, Henriquez-Olguin C, Angin Y, Zaal KJ, Sylow L, Schjerling P, Ralston E, Jensen TE.

Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E110-E125. doi: 10.1152/ajpendo.00392.2017. Epub 2018 Mar 13.


Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects.

Gliemann L, Rytter N, Lindskrog M, Slingsby MHL, Åkerström T, Sylow L, Richter EA, Hellsten Y.

J Physiol. 2017 Aug 15;595(16):5557-5571. doi: 10.1113/JP274623.


Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice.

Kleinert M, Parker BL, Fritzen AM, Knudsen JR, Jensen TE, Kjøbsted R, Sylow L, Ruegg M, James DE, Richter EA.

J Physiol. 2017 Jul 15;595(14):4845-4855. doi: 10.1113/JP274203. Epub 2017 Jun 11.


Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise.

Sylow L, Møller LLV, Kleinert M, D'Hulst G, De Groote E, Schjerling P, Steinberg GR, Jensen TE, Richter EA.

Diabetes. 2017 Jun;66(6):1548-1559. doi: 10.2337/db16-1138. Epub 2017 Apr 7.


Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling.

Sjøberg KA, Frøsig C, Kjøbsted R, Sylow L, Kleinert M, Betik AC, Shaw CS, Kiens B, Wojtaszewski JFP, Rattigan S, Richter EA, McConell GK.

Diabetes. 2017 Jun;66(6):1501-1510. doi: 10.2337/db16-1327. Epub 2017 Mar 14.


Exercise-stimulated glucose uptake - regulation and implications for glycaemic control.

Sylow L, Kleinert M, Richter EA, Jensen TE.

Nat Rev Endocrinol. 2017 Mar;13(3):133-148. doi: 10.1038/nrendo.2016.162. Epub 2016 Oct 14. Review.


The Cancer Drug Dasatinib Increases PGC-1α in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice.

Sylow L, Long JZ, Lokurkar IA, Zeng X, Richter EA, Spiegelman BM.

Endocrinology. 2016 Nov;157(11):4184-4191. Epub 2016 Sep 2.


mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3.

Kleinert M, Parker BL, Chaudhuri R, Fazakerley DJ, Serup A, Thomas KC, Krycer JR, Sylow L, Fritzen AM, Hoffman NJ, Jeppesen J, Schjerling P, Ruegg MA, Kiens B, James DE, Richter EA.

Mol Metab. 2016 Jun 22;5(8):646-655. doi: 10.1016/j.molmet.2016.06.007. eCollection 2016 Aug.


Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells.

Sylow L.

Lab Invest. 2016 Sep;96(9):1026. doi: 10.1038/labinvest.2016.58. No abstract available.


Decreased spontaneous activity in AMPK α2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism.

Møller LL, Sylow L, Gøtzsche CR, Serup AK, Christiansen SH, Weikop P, Kiens B, Woldbye DP, Richter EA.

Physiol Behav. 2016 Oct 1;164(Pt A):300-5. doi: 10.1016/j.physbeh.2016.06.010. Epub 2016 Jun 13.


Rac1 in Muscle Is Dispensable for Improved Insulin Action After Exercise in Mice.

Sylow L, Møller LL, D'Hulst G, Schjerling P, Jensen TE, Richter EA.

Endocrinology. 2016 Aug;157(8):3009-15. doi: 10.1210/en.2016-1220. Epub 2016 Jun 10.


Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice.

Sylow L, Nielsen IL, Kleinert M, Møller LL, Ploug T, Schjerling P, Bilan PJ, Klip A, Jensen TE, Richter EA.

J Physiol. 2016 Sep 1;594(17):4997-5008. doi: 10.1113/JP272039. Epub 2016 Jun 16.


Reply from Lykke Sylow, Lisbeth L. V. Møller, Maximilian Kleinert, Erik A. Richter and Thomas E. Jensen.

Sylow L, Møller LL, Kleinert M, Richter EA, Jensen TE.

J Physiol. 2015 May 1;593(9):2239-40. doi: 10.1113/JP270414. No abstract available.


PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.

Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA.

Biochem J. 2015 May 1;467(3):461-72. doi: 10.1042/BJ20141142.


Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle.

D'Hulst G, Sylow L, Hespel P, Deldicque L.

Eur J Appl Physiol. 2015 Jun;115(6):1219-31. doi: 10.1007/s00421-015-3103-2. Epub 2015 Jan 11.


Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1.

Sylow L, Møller LL, Kleinert M, Richter EA, Jensen TE.

J Physiol. 2015 Feb 1;593(3):645-56. doi: 10.1113/jphysiol.2014.284281. Epub 2015 Jan 15.


Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca(2+) release.

Jensen TE, Sylow L, Rose AJ, Madsen AB, Angin Y, Maarbjerg SJ, Richter EA.

Mol Metab. 2014 Jul 28;3(7):742-53. doi: 10.1016/j.molmet.2014.07.005. eCollection 2014 Oct.


Rac1--a novel regulator of contraction-stimulated glucose uptake in skeletal muscle.

Sylow L, Møller LL, Kleinert M, Richter EA, Jensen TE.

Exp Physiol. 2014 Dec 1;99(12):1574-80. doi: 10.1113/expphysiol.2014.079194. Epub 2014 Sep 18. Review.


Is contraction-stimulated glucose transport feedforward regulated by Ca2+?

Jensen TE, Angin Y, Sylow L, Richter EA.

Exp Physiol. 2014 Dec 1;99(12):1562-8. doi: 10.1113/expphysiol.2014.081679. Epub 2014 Aug 28. Review.


Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo.

Kleinert M, Sylow L, Fazakerley DJ, Krycer JR, Thomas KC, Oxbøll AJ, Jordy AB, Jensen TE, Yang G, Schjerling P, Kiens B, James DE, Ruegg MA, Richter EA.

Mol Metab. 2014 Jun 27;3(6):630-41. doi: 10.1016/j.molmet.2014.06.004. eCollection 2014 Sep.


Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance.

Sylow L, Kleinert M, Pehmøller C, Prats C, Chiu TT, Klip A, Richter EA, Jensen TE.

Cell Signal. 2014 Feb;26(2):323-31. doi: 10.1016/j.cellsig.2013.11.007. Epub 2013 Nov 9.


AMPK and insulin action--responses to ageing and high fat diet.

Frøsig C, Jensen TE, Jeppesen J, Pehmøller C, Treebak JT, Maarbjerg SJ, Kristensen JM, Sylow L, Alsted TJ, Schjerling P, Kiens B, Wojtaszewski JF, Richter EA.

PLoS One. 2013 May 6;8(5):e62338. doi: 10.1371/journal.pone.0062338. Print 2013.


Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle.

Sylow L, Jensen TE, Kleinert M, Højlund K, Kiens B, Wojtaszewski J, Prats C, Schjerling P, Richter EA.

Diabetes. 2013 Jun;62(6):1865-75. doi: 10.2337/db12-1148. Epub 2013 Feb 19.


LKB1 regulates lipid oxidation during exercise independently of AMPK.

Jeppesen J, Maarbjerg SJ, Jordy AB, Fritzen AM, Pehmøller C, Sylow L, Serup AK, Jessen N, Thorsen K, Prats C, Qvortrup K, Dyck JR, Hunter RW, Sakamoto K, Thomson DM, Schjerling P, Wojtaszewski JF, Richter EA, Kiens B.

Diabetes. 2013 May;62(5):1490-9. doi: 10.2337/db12-1160. Epub 2013 Jan 24.


Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle.

Sylow L, Jensen TE, Kleinert M, Mouatt JR, Maarbjerg SJ, Jeppesen J, Prats C, Chiu TT, Boguslavsky S, Klip A, Schjerling P, Richter EA.

Diabetes. 2013 Apr;62(4):1139-51. doi: 10.2337/db12-0491. Epub 2012 Dec 28.


Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.

Jorgensen SB, O'Neill HM, Sylow L, Honeyman J, Hewitt KA, Palanivel R, Fullerton MD, Öberg L, Balendran A, Galic S, van der Poel C, Trounce IA, Lynch GS, Schertzer JD, Steinberg GR.

Diabetes. 2013 Jan;62(1):56-64. doi: 10.2337/db12-0443. Epub 2012 Sep 6.


Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.

Pullen TJ, Sylow L, Sun G, Halestrap AP, Richter EA, Rutter GA.

Diabetes. 2012 Jul;61(7):1719-25. doi: 10.2337/db11-1531. Epub 2012 Apr 20.


Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle.

Chiu TT, Jensen TE, Sylow L, Richter EA, Klip A.

Cell Signal. 2011 Oct;23(10):1546-54. doi: 10.1016/j.cellsig.2011.05.022. Epub 2011 Jun 13. Review.


Current understanding of increased insulin sensitivity after exercise - emerging candidates.

Maarbjerg SJ, Sylow L, Richter EA.

Acta Physiol (Oxf). 2011 Jul;202(3):323-35. doi: 10.1111/j.1748-1716.2011.02267.x. Epub 2011 Apr 19. Review.


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