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Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1. Landsverk HB et al. Nucleic Acids Res. (2019)

p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775. Hauge S et al. Cell Cycle. (2019)

A novel role for ATR/Rad3 in G1 phase. Bøe CA et al. Sci Rep. (2018)

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Items: 43


p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775.

Hauge S, Macurek L, Syljuåsen RG.

Cell Cycle. 2019 Apr;18(8):834-847. doi: 10.1080/15384101.2019.1593649. Epub 2019 Apr 3.


Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1.

Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG.

Nucleic Acids Res. 2019 Feb 28;47(4):1797-1813. doi: 10.1093/nar/gky1233.


A novel role for ATR/Rad3 in G1 phase.

Bøe CA, Håland TW, Boye E, Syljuåsen RG, Grallert B.

Sci Rep. 2018 May 2;8(1):6880. doi: 10.1038/s41598-018-25238-6.


TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency.

Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevær RL, Aukrust P, Fevang B, Blomhoff HK.

PLoS One. 2017 Oct 3;12(10):e0185708. doi: 10.1371/journal.pone.0185708. eCollection 2017.


Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features.

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z.

Oncotarget. 2017 Jan 24;8(4):7208-7213. doi: 10.18632/oncotarget.14800. No abstract available.


Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading.

Hauge S, Naucke C, Hasvold G, Joel M, Rødland GE, Juzenas P, Stokke T, Syljuåsen RG.

Oncotarget. 2017 Feb 14;8(7):10966-10979. doi: 10.18632/oncotarget.14089.


MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features.

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z.

Oncotarget. 2016 Jun 28;7(26):40297-40313. doi: 10.18632/oncotarget.9610. Erratum in: Oncotarget. 2017 Jan 24;8(4):7208-7213.


Hypoxia-induced alterations of G2 checkpoint regulators.

Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG.

Mol Oncol. 2016 May;10(5):764-73. doi: 10.1016/j.molonc.2015.12.015. Epub 2016 Jan 8.


Simultaneous measurement of passage through the restriction point and MCM loading in single cells.

Håland TW, Boye E, Stokke T, Grallert B, Syljuåsen RG.

Nucleic Acids Res. 2015 Dec 15;43(22):e150. doi: 10.1093/nar/gkv744. Epub 2015 Aug 6.


Targeting lung cancer through inhibition of checkpoint kinases.

Syljuåsen RG, Hasvold G, Hauge S, Helland Å.

Front Genet. 2015 Feb 27;6:70. doi: 10.3389/fgene.2015.00070. eCollection 2015.


Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy.

Halvorsen AR, Helland A, Fleischer T, Haug KM, Grenaker Alnaes GI, Nebdal D, Syljuåsen RG, Touleimat N, Busato F, Tost J, Saetersdal AB, Børresen-Dale AL, Kristensen V, Edvardsen H.

Int J Cancer. 2014 Nov 1;135(9):2085-95. doi: 10.1002/ijc.28862. Epub 2014 Apr 5.


PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule.

Lund-Andersen C, Patzke S, Nähse-Kumpf V, Syljuåsen RG.

Radiother Oncol. 2014 Feb;110(2):355-61. doi: 10.1016/j.radonc.2013.12.014. Epub 2014 Feb 4.


The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation.

Hasvold G, Nähse-Kumpf V, Tkacz-Stachowska K, Rofstad EK, Syljuåsen RG.

Mol Cancer Ther. 2013 May;12(5):705-16. doi: 10.1158/1535-7163.MCT-12-0879. Epub 2013 May 1.


Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.

Beck H, Nähse-Kumpf V, Larsen MS, O'Hanlon KA, Patzke S, Holmberg C, Mejlvang J, Groth A, Nielsen O, Syljuåsen RG, Sørensen CS.

Mol Cell Biol. 2012 Oct;32(20):4226-36. Epub 2012 Aug 20.


Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI.

Halle C, Andersen E, Lando M, Aarnes EK, Hasvold G, Holden M, Syljuåsen RG, Sundfør K, Kristensen GB, Holm R, Malinen E, Lyng H.

Cancer Res. 2012 Oct 15;72(20):5285-95. doi: 10.1158/0008-5472.CAN-12-1085. Epub 2012 Aug 13.


Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.

Sørensen CS, Syljuåsen RG.

Nucleic Acids Res. 2012 Jan;40(2):477-86. doi: 10.1093/nar/gkr697. Epub 2011 Sep 21. Review.


The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells.

Tkacz-Stachowska K, Lund-Andersen C, Velissarou A, Myklebust JH, Stokke T, Syljuåsen RG.

Radiother Oncol. 2011 Oct;101(1):24-7. doi: 10.1016/j.radonc.2011.05.060. Epub 2011 Jun 30.


A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance.

Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS.

EMBO Rep. 2011 Jul 1;12(7):705-12. doi: 10.1038/embor.2011.99.


Protein phosphatase 1 regulators in DNA damage signaling.

Küntziger T, Landsverk HB, Collas P, Syljuåsen RG.

Cell Cycle. 2011 May 1;10(9):1356-62. Epub 2011 May 1. Review.


SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.

Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS.

J Cell Biol. 2011 Jan 10;192(1):43-54. doi: 10.1083/jcb.201009076.


The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.

Landsverk HB, Mora-Bermúdez F, Landsverk OJ, Hasvold G, Naderi S, Bakke O, Ellenberg J, Collas P, Syljuåsen RG, Küntziger T.

EMBO Rep. 2010 Nov;11(11):868-75. doi: 10.1038/embor.2010.134. Epub 2010 Oct 1.


High-throughput siRNA screens using γH2AX as marker uncover key regulators of genome integrity in mammalian cells.

Beck H, Menzel T, Syljuåsen RG, Sørensen CS.

Cell Cycle. 2010 Jun 15;9(12):2257-8. Epub 2010 Jun 15. No abstract available.


p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors.

Petersen L, Hasvold G, Lukas J, Bartek J, Syljuåsen RG.

Cell Prolif. 2010 Aug;43(4):365-71. doi: 10.1111/j.1365-2184.2010.00685.x.


Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

Beck H, Nähse V, Larsen MS, Groth P, Clancy T, Lees M, Jørgensen M, Helleday T, Syljuåsen RG, Sørensen CS.

J Cell Biol. 2010 Mar 8;188(5):629-38. doi: 10.1083/jcb.200905059. Epub 2010 Mar 1.


Checkpoint adaptation in human cells.

Syljuåsen RG.

Oncogene. 2007 Aug 30;26(40):5833-9. Epub 2007 Mar 26. Review.


Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.

Syljuåsen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J.

Mol Cell Biol. 2005 May;25(9):3553-62.


The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

Sørensen CS, Hansen LT, Dziegielewski J, Syljuåsen RG, Lundin C, Bartek J, Helleday T.

Nat Cell Biol. 2005 Feb;7(2):195-201. Epub 2005 Jan 23.


Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

Syljuåsen RG, Sørensen CS, Nylandsted J, Lukas C, Lukas J, Bartek J.

Cancer Res. 2004 Dec 15;64(24):9035-40.


Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.

Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J.

Nat Cell Biol. 2004 Sep;6(9):884-91. Epub 2004 Aug 15.


ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.

Sørensen CS, Syljuåsen RG, Lukas J, Bartek J.

Cell Cycle. 2004 Jul;3(7):941-5. Epub 2004 Jul 13.


Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines.

Löffler H, Syljuåsen RG, Bartkova J, Worm J, Lukas J, Bartek J.

Oncogene. 2003 Nov 6;22(50):8063-71.


Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J.

Cancer Cell. 2003 Mar;3(3):247-58.


The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J.

Nature. 2001 Apr 12;410(6830):842-7.


Molecular events in radiation transformation.

Syljuåsen RG, Krolewski B, Little JB.

Radiat Res. 2001 Jan;155(1 Pt 2):215-221.


Rapid destruction of human Cdc25A in response to DNA damage.

Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, Bartek J, Lukas J.

Science. 2000 May 26;288(5470):1425-9.


c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency.

Whang YE, Tran C, Henderson C, Syljuasen RG, Rozengurt N, McBride WH, Sawyers CL.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5486-91.


Radiation-induced apoptosis and cell cycle progression in Jurkat T cells.

Syljuâsen RG, McBride WH.

Radiat Res. 1999 Sep;152(3):328-31.


Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53 status.

Syljuåsen RG, Krolewski B, Little JB.

Cancer Res. 1999 Mar 1;59(5):1008-14.


Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection.

Syljuåsen RG, Belldegrun A, Tso CL, Withers HR, McBride WH.

Radiat Res. 1997 Nov;148(5):443-8.


Effects of IL-3 gene expression on tumor response to irradiation in vitro and in vivo.

Chiang CS, Syljuäsen RG, Hong JH, Wallis A, Dougherty GJ, McBride WH.

Cancer Res. 1997 Sep 15;57(18):3899-903.


Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells.

Syljuåsen RG, Hong JH, McBride WH.

Radiat Res. 1996 Sep;146(3):276-82.


The effects of cytokine gene transfer into tumors on host cell infiltration and regression.

McBride WH, Economou JS, Syljuåsen RG, Parrish C, Hackman D, Latham V, Chiang CS, Dougherty GJ.

Anticancer Res. 1996 May-Jun;16(3A):1139-43. Review.


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