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Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses.

Anikeeva N, Fischer NO, Blanchette CD, Sykulev Y.

J Immunol. 2019 Jan 15;202(2):591-597. doi: 10.4049/jimmunol.1801196. Epub 2018 Dec 12.


Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue.

Steblyanko M, Anikeeva N, Buggert M, Betts MR, Sykulev Y.

J Vis Exp. 2018 Jul 30;(137). doi: 10.3791/58143.


Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.

Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg JK, Eller MA, Streeck H, Jansson M, Nowak P, Sönnerborg A, Canaday DH, Naji A, Wherry EJ, Robb ML, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC, Betts MR.

PLoS Pathog. 2018 Apr 13;14(4):e1006973. doi: 10.1371/journal.ppat.1006973. eCollection 2018 Apr.


Evaluating frequency and quality of pathogen-specific T cells.

Anikeeva N, Grosso D, Flomenberg N, Sykulev Y.

Nat Commun. 2016 Oct 27;7:13264. doi: 10.1038/ncomms13264.


Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner.

Steblyanko M, Anikeeva N, Campbell KS, Keen JH, Sykulev Y.

J Biol Chem. 2015 May 8;290(19):11833-42. doi: 10.1074/jbc.M114.614719. Epub 2015 Mar 16.


Herman N. Eisen: Mentor to many.

Kranz DM, Sykulev Y.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1650-1. doi: 10.1073/pnas.1500050112. Epub 2015 Jan 23. No abstract available.


Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents.

Anikeeva N, Sykulev Y, Delikatny EJ, Popov AV.

Am J Nucl Med Mol Imaging. 2014 Sep 6;4(6):507-24. eCollection 2014.


Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity.

Anikeeva N, Steblyanko M, Fayngerts S, Kopylova N, Marshall DJ, Powers GD, Sato T, Campbell KS, Sykulev Y.

Eur J Immunol. 2014 Aug;44(8):2331-9. doi: 10.1002/eji.201344179. Epub 2014 Jun 5.


Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.

Anikeeva N, Gakamsky D, Schøller J, Sykulev Y.

PLoS One. 2012;7(8):e41466. doi: 10.1371/journal.pone.0041466. Epub 2012 Aug 3.


The mechanisms of inactivation of the Tag7-Hsp70 cytotoxic complex.

Yashin DV, Dukhanina EA, Kabanova OD, Romanova EA, Lukyanova TI, Sheludchenkov AA, Sykulev YK, Gnuchev NV, Sashchenko LP.

Dokl Biol Sci. 2012 Jan-Feb;442:62-3. doi: 10.1134/S0012496612010140. Epub 2012 Mar 17. No abstract available.


Enteric alpha defensins in norm and pathology.

Lisitsyn NA, Bukurova YA, Nikitina IG, Krasnov GS, Sykulev Y, Beresten SF.

Ann Clin Microbiol Antimicrob. 2012 Jan 11;11:1. doi: 10.1186/1476-0711-11-1. Review.


Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes.

Anikeeva N, Sykulev Y.

Immunol Res. 2011 Dec;51(2-3):183-94. doi: 10.1007/s12026-011-8252-8. Review.


T cell receptor signaling kinetics takes the stage.

Sykulev Y.

Sci Signal. 2010 Dec 21;3(153):pe50. doi: 10.1126/scisignal.3153pe50. Review.


A novel composite immunotoxin that suppresses rabies virus production by the infected cells.

Mareeva T, Wanjalla C, Schnell MJ, Sykulev Y.

J Immunol Methods. 2010 Feb 28;353(1-2):78-86. doi: 10.1016/j.jim.2009.11.010. Epub 2009 Nov 22.


Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain.

Beal AM, Anikeeva N, Varma R, Cameron TO, Vasiliver-Shamis G, Norris PJ, Dustin ML, Sykulev Y.

Immunity. 2009 Oct 16;31(4):632-42. doi: 10.1016/j.immuni.2009.09.004.


Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?

Anikeeva N, Mareeva T, Liu W, Sykulev Y.

Clin Immunol. 2009 Jan;130(1):98-109. doi: 10.1016/j.clim.2008.08.025. Epub 2008 Oct 8.


Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.

Beal AM, Anikeeva N, Varma R, Cameron TO, Norris PJ, Dustin ML, Sykulev Y.

J Immunol. 2008 Oct 1;181(7):4815-24.


How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide.

Mareeva T, Martinez-Hackert E, Sykulev Y.

J Biol Chem. 2008 Oct 24;283(43):29053-9. doi: 10.1074/jbc.M804996200. Epub 2008 Aug 14.


Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.

Tsatsanis C, Vaporidi K, Zacharioudaki V, Androulidaki A, Sykulev Y, Margioris AN, Tsichlis PN.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2987-92. doi: 10.1073/pnas.0708381104. Epub 2008 Feb 19.


Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.

Anikeeva N, Lebedeva T, Clapp AR, Goldman ER, Dustin ML, Mattoussi H, Sykulev Y.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16846-51. Epub 2006 Oct 31.


Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.

Martinez-Hackert E, Anikeeva N, Kalams SA, Walker BD, Hendrickson WA, Sykulev Y.

J Biol Chem. 2006 Jul 21;281(29):20205-12. Epub 2006 May 15.


Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.

Norris PJ, Stone JD, Anikeeva N, Heitman JW, Wilson IC, Hirschkorn DF, Clark MJ, Moffett HF, Cameron TO, Sykulev Y, Stern LJ, Walker BD.

Mol Immunol. 2006 Mar;43(9):1349-57. Epub 2005 Oct 7.


ICAM-1 co-stimulates target cells to facilitate antigen presentation.

Lebedeva T, Dustin ML, Sykulev Y.

Curr Opin Immunol. 2005 Jun;17(3):251-8. Review.


Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes.

Anikeeva N, Somersalo K, Sims TN, Thomas VK, Dustin ML, Sykulev Y.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6437-42. Epub 2005 Apr 25.


Antibody specific for the peptide.major histocompatibility complex. Is it T cell receptor-like?

Mareeva T, Lebedeva T, Anikeeva N, Manser T, Sykulev Y.

J Biol Chem. 2004 Oct 22;279(43):44243-9. Epub 2004 Aug 9.


Cytotoxic T lymphocytes form an antigen-independent ring junction.

Somersalo K, Anikeeva N, Sims TN, Thomas VK, Strong RK, Spies T, Lebedeva T, Sykulev Y, Dustin ML.

J Clin Invest. 2004 Jan;113(1):49-57.


Soluble HIV-specific T cell receptor: expression, purification and analysis of the specificity.

Anikeeva N, Lebedeva T, Sumaroka M, Kalams SA, Sykulev Y.

J Immunol Methods. 2003 Jun 1;277(1-2):75-86.


Distinct molecular mechanisms account for the specificity of two different T-cell receptors.

Anikeeva N, Lebedeva T, Krogsgaard M, Tetin SY, Martinez-Hackert E, Kalams SA, Davis MM, Sykulev Y.

Biochemistry. 2003 Apr 29;42(16):4709-16.


Differential splicing generates Tvl-1/RFXANK isoforms with different functions.

Das S, Lin JH, Papamatheakis J, Sykulev Y, Tsichlis PN.

J Biol Chem. 2002 Nov 22;277(47):45172-80. Epub 2002 Sep 4.


Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.

Norris PJ, Sumaroka M, Brander C, Moffett HF, Boswell SL, Nguyen T, Sykulev Y, Walker BD, Rosenberg ES.

J Virol. 2001 Oct;75(20):9771-9.


Potent cytolytic response by a CD8+ CTL clone to multiple peptides from the same protein in association with an allogeneic class I MHC molecule.

Kageyama S, Tsomides TJ, Fukusen N, Papayannopoulos IA, Eisen HN, Sykulev Y.

J Immunol. 2001 Mar 1;166(5):3028-34.


Peptide antagonism and T cell receptor interactions with peptide-MHC complexes.

Sykulev Y, Vugmeyster Y, Brunmark A, Ploegh HL, Eisen HN.

Immunity. 1998 Oct;9(4):475-83.


Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response.

Sykulev Y, Joo M, Vturina I, Tsomides TJ, Eisen HN.

Immunity. 1996 Jun;4(6):565-71.


Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins.

Eisen HN, Sykulev Y, Tsomides TJ.

Adv Protein Chem. 1996;49:1-56. Review. No abstract available.


The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.

Sykulev Y, Cohen RJ, Eisen HN.

Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):11990-2.


Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses.

Kageyama S, Tsomides TJ, Sykulev Y, Eisen HN.

J Immunol. 1995 Jan 15;154(2):567-76.


High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

Sykulev Y, Brunmark A, Tsomides TJ, Kageyama S, Jackson M, Peterson PA, Eisen HN.

Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11487-91.


Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes.

Sykulev Y, Brunmark A, Jackson M, Cohen RJ, Peterson PA, Eisen HN.

Immunity. 1994 Apr;1(1):15-22.


Particle counting by flow cytometry can determine intrinsic equilibrium constants for antibody-ligand interactions in solution.

Sykulev YK, Cohen RJ, Eisen HN.

Mol Immunol. 1993 Jan;30(1):101-4. No abstract available.


Quantitation of reversible binding by particle counting: hapten-antibody interaction as a model system.

Sykulev YK, Sherman DA, Cohen RJ, Eisen HN.

Proc Natl Acad Sci U S A. 1992 May 15;89(10):4703-7.


Spin labeling of immunoglobulin M and E carbohydrates.

Sykulev YK, Nezlin RS.

Immunol Lett. 1982 Sep;5(3):121-6.


Structural studies of immunoglobulins spin-labeled at the carbohydrate moiety.

Nezlin RS, Sykulev YK.

Mol Immunol. 1982 Mar;19(3):347-56. Review. No abstract available.


Hapten-induced changes in pig anti-dansyl antibodies revealed by EPR spectra of spin-labelled antibodies.

Käiväräinen AI, Rozhkov SP, Sykulev YuK, Lavrent'yev VV, Franĕk F.

Immunol Lett. 1981 Apr;3(1):5-11.


Slow conformational change in anti-dansyl antibody as a consequence of hapten binding: demonstration by ESR spectra.

Timofeev VP, Dudich IV, Sykulev YK, Nezlin RS, Franĕk F.

FEBS Lett. 1979 Jun 1;102(1):103-6. No abstract available.


Spin-label study of segmental flexibility of anti-hapten antibodies. Precipitating pig anti-Dnp antibody is more flexible than non-precipitating.

Sykulev YK, Timofeev VP, Nezlin RS, Misharin AY, Franĕk F.

FEBS Lett. 1979 May 1;101(1):27-30. No abstract available.

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