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CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis.

Simbulan-Rosenthal CM, Dougherty R, Vakili S, Ferraro AM, Kuo LW, Alobaidi R, Aljehane L, Gaur A, Sykora P, Glasgow E, Agarwal S, Rosenthal DS.

Cancers (Basel). 2019 Oct 3;11(10). pii: E1490. doi: 10.3390/cancers11101490.


Camptothecin Efficacy to Poison Top1 Is Altered by Bisphenol A in Mouse Embryonic Fibroblasts.

Sonavane M, Sykora P, Andrews JF, Sobol RW, Gassman NR.

Chem Res Toxicol. 2018 Jun 18;31(6):510-519. doi: 10.1021/acs.chemrestox.8b00050. Epub 2018 Jun 5.


Application of the CometChip platform to assess DNA damage in field-collected blood samples from turtles.

Sykora P, Chiari Y, Heaton A, Moreno N, Glaberman S, Sobol RW.

Environ Mol Mutagen. 2018 May;59(4):322-333. doi: 10.1002/em.22183. Epub 2018 Mar 14.


Next generation high throughput DNA damage detection platform for genotoxic compound screening.

Sykora P, Witt KL, Revanna P, Smith-Roe SL, Dismukes J, Lloyd DG, Engelward BP, Sobol RW.

Sci Rep. 2018 Feb 9;8(1):2771. doi: 10.1038/s41598-018-20995-w.


Germline gene therapy is compatible with human dignity.

Sykora P, Caplan A.

EMBO Rep. 2017 Dec;18(12):2086. doi: 10.15252/embr.201745378. Epub 2017 Nov 15. No abstract available.


The Council of Europe should not reaffirm the ban on germline genome editing in humans.

Sykora P, Caplan A.

EMBO Rep. 2017 Nov;18(11):1871-1872. doi: 10.15252/embr.201745246. Epub 2017 Oct 6. No abstract available.


DNA Polymerase Beta Participates in Mitochondrial DNA Repair.

Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM 3rd, Sobol RW, Yasui A, Bohr VA.

Mol Cell Biol. 2017 Jul 28;37(16). pii: e00237-17. doi: 10.1128/MCB.00237-17. Print 2017 Aug 15.


DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.

Misiak M, Vergara Greeno R, Baptiste BA, Sykora P, Liu D, Cordonnier S, Fang EF, Croteau DL, Mattson MP, Bohr VA.

Aging Cell. 2017 Feb;16(1):162-172. doi: 10.1111/acel.12541. Epub 2016 Sep 30.


Novel SCN1A variants in Dravet syndrome and evaluating a wide approach of patient selection.

Surovy M, Soltysova A, Kolnikova M, Sykora P, Ilencikova D, Ficek A, Radvanszky J, Kadasi L.

Gen Physiol Biophys. 2016 Jul;35(3):333-42. doi: 10.4149/gpb_2016002. Epub 2016 Apr 5.


Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.

Akbari M, Sykora P, Bohr VA.

Sci Rep. 2015 Aug 10;5:12876. doi: 10.1038/srep12876.


The impact of base excision DNA repair in age-related neurodegenerative diseases.

Leandro GS, Sykora P, Bohr VA.

Mutat Res. 2015 Jun;776:31-9. doi: 10.1016/j.mrfmmm.2014.12.011. Epub 2015 Jan 4. Review.


Commercial microwave links instead of rain gauges: fiction or reality?

Fencl M, Rieckermann J, Sýkora P, Stránský D, Bareš V.

Water Sci Technol. 2015;71(1):31-7. doi: 10.2166/wst.2014.466.


DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.

Sykora P, Misiak M, Wang Y, Ghosh S, Leandro GS, Liu D, Tian J, Baptiste BA, Cong WN, Brenerman BM, Fang E, Becker KG, Hamilton RJ, Chigurupati S, Zhang Y, Egan JM, Croteau DL, Wilson DM 3rd, Mattson MP, Bohr VA.

Nucleic Acids Res. 2015 Jan;43(2):943-59. doi: 10.1093/nar/gku1356. Epub 2014 Dec 30.


Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.

Lu H, Fang EF, Sykora P, Kulikowicz T, Zhang Y, Becker KG, Croteau DL, Bohr VA.

Cell Death Dis. 2014 May 15;5:e1226. doi: 10.1038/cddis.2014.168.


Base excision repair in the mammalian brain: implication for age related neurodegeneration.

Sykora P, Wilson DM 3rd, Bohr VA.

Mech Ageing Dev. 2013 Oct;134(10):440-8. doi: 10.1016/j.mad.2013.04.005. Epub 2013 May 2.


Current status of epilepsy health care for adult patients from central and eastern European Union countries--a survey of members of the Central Europe Epilepsy Experts Working Group.

Jędrzejczak J, Marusic P, Haldre S, Majkowska-Zwolińska B, Bojinova-Tchamova V, Mameniskiene R, Mindruta I, Ravnik IM, Szupera Z, Sykora P, Verzbickis A, Daniluk J.

Seizure. 2013 Jul;22(6):452-6. doi: 10.1016/j.seizure.2013.03.001. Epub 2013 Mar 23.


Intra-abdominal hypertension and acute pancreatitis.

Mifkovic A, Skultety J, Sykora P, Prochotsky A, Okolicany R.

Bratisl Lek Listy. 2013;114(3):166-71. Review.


Modulation of DNA base excision repair during neuronal differentiation.

Sykora P, Yang JL, Ferrarelli LK, Tian J, Tadokoro T, Kulkarni A, Weissman L, Keijzers G, Wilson DM 3rd, Mattson MP, Bohr VA.

Neurobiol Aging. 2013 Jul;34(7):1717-27. doi: 10.1016/j.neurobiolaging.2012.12.016. Epub 2013 Feb 1.


Human RECQL5 participates in the removal of endogenous DNA damage.

Tadokoro T, Ramamoorthy M, Popuri V, May A, Tian J, Sykora P, Rybanska I, Wilson DM 3rd, Croteau DL, Bohr VA.

Mol Biol Cell. 2012 Nov;23(21):4273-85. doi: 10.1091/mbc.E12-02-0110. Epub 2012 Sep 12.


Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype.

Ramamoorthy M, Sykora P, Scheibye-Knudsen M, Dunn C, Kasmer C, Zhang Y, Becker KG, Croteau DL, Bohr VA.

Free Radic Biol Med. 2012 Sep 15;53(6):1371-80. doi: 10.1016/j.freeradbiomed.2012.07.018. Epub 2012 Aug 3.


Evaluation of sewer infiltration/inflow using COD mass flux method: case study in Prague.

Bareš V, Stránský D, Sýkora P.

Water Sci Technol. 2012;66(3):673-80. doi: 10.2166/wst.2012.229.


Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation.

Berquist BR, Canugovi C, Sykora P, Wilson DM 3rd, Bohr VA.

Nucleic Acids Res. 2012 Sep 1;40(17):8392-405. Epub 2012 Jun 28.


Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.

Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM 3rd, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA.

J Exp Med. 2012 Apr 9;209(4):855-69. doi: 10.1084/jem.20111721. Epub 2012 Apr 2.


RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity.

Croteau DL, Rossi ML, Canugovi C, Tian J, Sykora P, Ramamoorthy M, Wang ZM, Singh DK, Akbari M, Kasiviswanathan R, Copeland WC, Bohr VA.

Aging Cell. 2012 Jun;11(3):456-66. doi: 10.1111/j.1474-9726.2012.00803.x. Epub 2012 Mar 2.


Repair of persistent strand breaks in the mitochondrial genome.

Sykora P, Wilson DM 3rd, Bohr VA.

Mech Ageing Dev. 2012 Apr;133(4):169-75. doi: 10.1016/j.mad.2011.11.003. Epub 2011 Nov 28. Review.


RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression.

Ramamoorthy M, Tadokoro T, Rybanska I, Ghosh AK, Wersto R, May A, Kulikowicz T, Sykora P, Croteau DL, Bohr VA.

Nucleic Acids Res. 2012 Feb;40(4):1621-35. doi: 10.1093/nar/gkr844. Epub 2011 Oct 19.


The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency.

Yang JL, Sykora P, Wilson DM 3rd, Mattson MP, Bohr VA.

Mech Ageing Dev. 2011 Aug;132(8-9):405-11. doi: 10.1016/j.mad.2011.06.005. Epub 2011 Jun 25. Review.


Aprataxin localizes to mitochondria and preserves mitochondrial function.

Sykora P, Croteau DL, Bohr VA, Wilson DM 3rd.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7437-42. doi: 10.1073/pnas.1100084108. Epub 2011 Apr 18.


Chronic ethanol feeding causes depression of mitochondrial elongation factor Tu in the rat liver: implications for the mitochondrial ribosome.

Weiser B, Gonye G, Sykora P, Crumm S, Cahill A.

Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G815-22. doi: 10.1152/ajpgi.00108.2010. Epub 2011 Feb 24.


The mitochondrial transcription factor A functions in mitochondrial base excision repair.

Canugovi C, Maynard S, Bayne AC, Sykora P, Tian J, de Souza-Pinto NC, Croteau DL, Bohr VA.

DNA Repair (Amst). 2010 Oct 5;9(10):1080-9. doi: 10.1016/j.dnarep.2010.07.009. Epub 2010 Aug 23.


Methylenetetrahydrofolate reductase gene polymorphisms and neural tube defects epidemiology in the Slovak population.

Behunova J, Klimcakova L, Zavadilikova E, Potocekova D, Sykora P, Podracka L.

Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):695-700. doi: 10.1002/bdra.20692.


Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder.

Leen WG, Klepper J, Verbeek MM, Leferink M, Hofste T, van Engelen BG, Wevers RA, Arthur T, Bahi-Buisson N, Ballhausen D, Bekhof J, van Bogaert P, Carrilho I, Chabrol B, Champion MP, Coldwell J, Clayton P, Donner E, Evangeliou A, Ebinger F, Farrell K, Forsyth RJ, de Goede CG, Gross S, Grunewald S, Holthausen H, Jayawant S, Lachlan K, Laugel V, Leppig K, Lim MJ, Mancini G, Marina AD, Martorell L, McMenamin J, Meuwissen ME, Mundy H, Nilsson NO, Panzer A, Poll-The BT, Rauscher C, Rouselle CM, Sandvig I, Scheffner T, Sheridan E, Simpson N, Sykora P, Tomlinson R, Trounce J, Webb D, Weschke B, Scheffer H, Willemsen MA.

Brain. 2010 Mar;133(Pt 3):655-70. doi: 10.1093/brain/awp336. Epub 2010 Feb 2.


Sewer infiltration/inflow: long-term monitoring based on diurnal variation of pollutant mass flux.

Bares V, Stránský D, Sýkora P.

Water Sci Technol. 2009;60(1):1-7. doi: 10.2166/wst.2009.280.


Glucose transporter type 1 (GLUT-1) deficiency.

Bzduch V, Sykora P, Behulova D, Kolnikova M, Klcova V.

Bratisl Lek Listy. 2008;109(10):471-2. No abstract available.


S-adenosyl-L-methionine co-administration prevents the ethanol-elicited dissociation of hepatic mitochondrial ribosomes in male rats.

Sykora P, Kharbanda KK, Crumm SE, Cahill A.

Alcohol Clin Exp Res. 2009 Jan;33(1):1-9. doi: 10.1111/j.1530-0277.2008.00803.x. Epub 2008 Sep 30.


Glucose transporter type 1 (GLUT-1) deficiency.

Bzduch V, Sykora P, Behulova D, Kolnikova M, Klcova V.

Bratisl Lek Listy. 2008;109(5):245. No abstract available.


Alcoholic liver disease and the mitochondrial ribosome: methods of analysis.

Cahill A, Sykora P.

Methods Mol Biol. 2008;447:381-94. doi: 10.1007/978-1-59745-242-7_25.


Modulation of DNA polymerase beta-dependent base excision repair in cultured human cells after low dose exposure to arsenite.

Sykora P, Snow ET.

Toxicol Appl Pharmacol. 2008 May 1;228(3):385-94. doi: 10.1016/j.taap.2007.12.019. Epub 2007 Dec 27.


Ethanol feeding enhances age-related deterioration of the rat hepatic mitochondrion.

Cahill A, Hershman S, Davies A, Sykora P.

Am J Physiol Gastrointest Liver Physiol. 2005 Dec;289(6):G1115-23. Epub 2005 Jul 14.


Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk?

Snow ET, Sykora P, Durham TR, Klein CB.

Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):557-64. Review.


Antibiotic use and development of resistance in blood culture isolates: 8 years of experience from a cancer referral center.

Krcméry V Jr, Sykora P, Trupl J, Kunova A, Sabo A, Jurga L, Novotny J, Mateicka F, Babela R, Pichnova E, Gould IM.

J Chemother. 2001 Apr;13(2):133-42.


Results of modified Norwood's operation for hypoplastic left heart syndrome.

Hraska V, Nosál M, Sýkora P, Soják V, Sagát M, Kunovský P.

Eur J Cardiothorac Surg. 2000 Aug;18(2):214-9.


Resistance to antimicrobial chemotherapy: a prescription for research and action.

Levin BR, Antia R, Berliner E, Bloland P, Bonhoeffer S, Cohen M, DeRouin T, Fields PI, Jafari H, Jernigan D, Lipsitch M, McGowan JE Jr, Mead P, Nowak M, Porco T, Sykora P, Simonsen L, Spitznagel J, Tauxe R, Tenover F.

Am J Med Sci. 1998 Feb;315(2):87-94.


Macroevolution of plasmids: a model for plasmid speciation.

Sýkora P.

J Theor Biol. 1992 Nov 7;159(1):53-65.


Elimination of plasmids pKM 101 and F'lac from Salmonella typhimurium and Escherichia coli by bisammonium salt. The effect of outer membrane pattern.

Sýkora P, Ceplíková V, Foltýnová Z, Horniak L, Ebringer L.

Folia Microbiol (Praha). 1991;36(3):240-5.


Cognitive ethology and applied philosophy.

Sykora P.

Trends Ecol Evol. 1990 Dec;5(12):423. doi: 10.1016/0169-5347(90)90032-9. No abstract available.


A kinetic model for plasmid curing.

Sýkora P, Foltýnova Z, Smitálova K.

Plasmid. 1989 Mar;21(2):85-98.


[Changes in stretch reflexes in acute respiratory diseases in infants].

Sýkora P.

Cesk Pediatr. 1983 Aug;38(8):501-5. Slovak. No abstract available.


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