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Keap1/Nrf2 Signaling: A New Player in Thyroid Pathophysiology and Thyroid Cancer.

Renaud CO, Ziros PG, Chartoumpekis DV, Bongiovanni M, Sykiotis GP.

Front Endocrinol (Lausanne). 2019 Aug 2;10:510. doi: 10.3389/fendo.2019.00510. eCollection 2019. Review.


Interaction of genetic variations in <i>NFE2L2</i> and <i>SELENOS</i> modulates the risk of Hashimoto's thyroiditis.

Santos LR, Durães C, Ziros PG, Pestana A, Esteves C, Neves C, Carvalho D, Bongiovanni M, Renaud CO, Chartoumpekis DV, Habeos I, Sobrinho-Simões M, Soares P, Sykiotis GP.

Thyroid. 2019 Aug 20. doi: 10.1089/thy.2018.0480. [Epub ahead of print]


Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively.

Matana A, Ziros PG, Chartoumpekis DV, Renaud C, Polašek O, Hayward C, Zemunik T, Sykiotis GP.

Biochem Pharmacol. 2019 Aug 14. pii: S0006-2952(19)30295-3. doi: 10.1016/j.bcp.2019.08.007. [Epub ahead of print]


Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.

Paunkov A, Chartoumpekis DV, Ziros PG, Chondrogianni N, Kensler TW, Sykiotis GP.

Curr Pharm Des. 2019 Jul 1. doi: 10.2174/1381612825666190701165821. [Epub ahead of print]


Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance.

Martins F, Sofiya L, Sykiotis GP, Lamine F, Maillard M, Fraga M, Shabafrouz K, Ribi C, Cairoli A, Guex-Crosier Y, Kuntzer T, Michielin O, Peters S, Coukos G, Spertini F, Thompson JA, Obeid M.

Nat Rev Clin Oncol. 2019 Sep;16(9):563-580. doi: 10.1038/s41571-019-0218-0. Review.


Expression of Prox1 in Medullary Thyroid Carcinoma Is Associated with Chromogranin A and Calcitonin Expression and with Ki67 Proliferative Index, but Not with Prognosis.

Saglietti C, La Rosa S, Sykiotis GP, Letovanec I, Bulliard JL, Piana S, Mermod M, Petrova T, Uccella S, Sessa F, Bongiovanni M.

Endocr Pathol. 2019 Jun;30(2):138-145. doi: 10.1007/s12022-019-9576-5.


Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.

Chartoumpekis DV, Ziros PG, Chen JG, Groopman JD, Kensler TW, Sykiotis GP.

Food Chem Toxicol. 2019 Apr;126:1-6. doi: 10.1016/j.fct.2019.02.004. Epub 2019 Feb 5.


New therapeutic perspectives to manage refractory immune checkpoint-related toxicities.

Martins F, Sykiotis GP, Maillard M, Fraga M, Ribi C, Kuntzer T, Michielin O, Peters S, Coukos G, Spertini F, Thompson JA, Obeid M.

Lancet Oncol. 2019 Jan;20(1):e54-e64. doi: 10.1016/S1470-2045(18)30828-3.


Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP.

Aging Cell. 2019 Feb;18(1):e12845. doi: 10.1111/acel.12845. Epub 2018 Dec 10.


Raman spectroscopy for the preoperative diagnosis of thyroid cancer and its subtypes: An in vitro proof-of-concept study.

O'Dea D, Bongiovanni M, Sykiotis GP, Ziros PG, Meade AD, Lyng FM, Malkin A.

Cytopathology. 2019 Jan;30(1):51-60. doi: 10.1111/cyt.12636. Epub 2018 Oct 25.


Subclinical hypothyroidism: new trials, old caveats.

Lamine F, De Giorgi S, Marino L, Michalaki M, Sykiotis GP.

Hormones (Athens). 2018 Jun;17(2):231-236. doi: 10.1007/s42000-018-0004-x. Epub 2018 Apr 27. Review.


Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial.

Blum MR, Gencer B, Adam L, Feller M, Collet TH, da Costa BR, Moutzouri E, Dopheide J, Depairon M, Sykiotis GP, Kearney P, Gussekloo J, Westendorp R, Stott DJ, Bauer DC, Rodondi N.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):2988-2997. doi: 10.1210/jc.2018-00279.


NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland.

Ziros PG, Habeos IG, Chartoumpekis DV, Ntalampyra E, Somm E, Renaud CO, Bongiovanni M, Trougakos IP, Yamamoto M, Kensler TW, Santisteban P, Carrasco N, Ris-Stalpers C, Amendola E, Liao XH, Rossich L, Thomasz L, Juvenal GJ, Refetoff S, Sykiotis GP.

Thyroid. 2018 Jun;28(6):780-798. doi: 10.1089/thy.2018.0018.


Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma.

Papadakis GE, Tabotta F, Levotanec I, Gonzalez M, Prior JO, La Rosa S, Sykiotis GP.

J Endocr Soc. 2018 Mar 23;2(4):386-390. doi: 10.1210/js.2018-00014. eCollection 2018 Apr 1.


The Bethesda System for Reporting Thyroid Cytopathology Explained for Practitioners: Frequently Asked Questions.

Bongiovanni M, Papadakis GE, Rouiller N, Marino L, Lamine F, Bisig B, Ziadi S, Sykiotis GP.

Thyroid. 2018 May;28(5):556-565. doi: 10.1089/thy.2017.0685.


[Subclinical hypothyroidism : should we still treat elderly patients? Clinical implications of a new trial in primary care].

Collet TH, Sykiotis GP, Aubert CE, Baumgartner C, Blum MR, Feller M, Stettler C, Rodondi N.

Rev Med Suisse. 2018 Feb 28;14(596):470-474. French.


Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures.

Cassatella D, Howard SR, Acierno JS, Xu C, Papadakis GE, Santoni FA, Dwyer AA, Santini S, Sykiotis GP, Chambion C, Meylan J, Marino L, Favre L, Li J, Liu X, Zhang J, Bouloux PM, Geyter C, Paepe A, Dhillo WS, Ferrara JM, Hauschild M, Lang-Muritano M, Lemke JR, Flück C, Nemeth A, Phan-Hug F, Pignatelli D, Popovic V, Pekic S, Quinton R, Szinnai G, l'Allemand D, Konrad D, Sharif S, Iyidir ÖT, Stevenson BJ, Yang H, Dunkel L, Pitteloud N.

Eur J Endocrinol. 2018 Apr;178(4):377-388. doi: 10.1530/EJE-17-0568. Epub 2018 Feb 1.


Rapid Remission of Graves' Hyperthyroidism Without Thionamides Under Immunosuppressive Treatment for Concomitant Autoimmune Hepatitis.

Papadakis GE, Lamine F, Chtioui H, Moschouri E, Christinet MF, Marino L, Favre L, Sciarra A, Sempoux C, Schneider A, Duss FR, Sartori C, Moradpour D, Sykiotis GP.

Thyroid. 2018 Feb;28(2):276-278. doi: 10.1089/thy.2017.0613. No abstract available.


FNA diagnosis of poorly differentiated thyroid carcinoma. A review of the recent literature.

Saglietti C, Onenerk AM, Faquin WC, Sykiotis GP, Ziadi S, Bongiovanni M.

Cytopathology. 2017 Dec;28(6):467-474. doi: 10.1111/cyt.12497. Epub 2017 Nov 2. Review.


Endocrine and neuroendocrine cytopathology.

Bongiovanni M, La Rosa S, Sykiotis GP.

Minerva Endocrinol. 2018 Sep;43(3):294-304. doi: 10.23736/S0391-1977.17.02744-4. Epub 2017 Sep 25. Review.


KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism.

Xu C, Messina A, Somm E, Miraoui H, Kinnunen T, Acierno J Jr, Niederländer NJ, Bouilly J, Dwyer AA, Sidis Y, Cassatella D, Sykiotis GP, Quinton R, De Geyter C, Dirlewanger M, Schwitzgebel V, Cole TR, Toogood AA, Kirk JM, Plummer L, Albrecht U, Crowley WF Jr, Mohammadi M, Tena-Sempere M, Prevot V, Pitteloud N.

EMBO Mol Med. 2017 Oct;9(10):1379-1397. doi: 10.15252/emmm.201607376.


β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.

Somm E, Henry H, Bruce SJ, Aeby S, Rosikiewicz M, Sykiotis GP, Asrih M, Jornayvaz FR, Denechaud PD, Albrecht U, Mohammadi M, Dwyer A, Acierno JS Jr, Schoonjans K, Fajas L, Greub G, Pitteloud N.

JCI Insight. 2017 Apr 20;2(8). pii: 91809. doi: 10.1172/jci.insight.91809. eCollection 2017 Apr 20.


Very low expression of PD-L1 in medullary thyroid carcinoma.

Bongiovanni M, Rebecchini C, Saglietti C, Bulliard JL, Marino L, de Leval L, Sykiotis GP.

Endocr Relat Cancer. 2017 Jun;24(6):L35-L38. doi: 10.1530/ERC-17-0104. Epub 2017 Apr 18. No abstract available.


Columnar cell variant of papillary thyroid carcinoma: Cytomorphological characteristics of 11 cases with histological correlation and literature review.

Bongiovanni M, Mermod M, Canberk S, Saglietti C, Sykiotis GP, Pusztaszeri M, Ragazzi M, Mazzucchelli L, Giovanella L, Piana S.

Cancer Cytopathol. 2017 Jun;125(6):389-397. doi: 10.1002/cncy.21860. Epub 2017 Apr 3. Review.


Genetic testing facilitates prepubertal diagnosis of congenital hypogonadotropic hypogonadism.

Xu C, Lang-Muritano M, Phan-Hug F, Dwyer AA, Sykiotis GP, Cassatella D, Acierno J Jr, Mohammadi M, Pitteloud N.

Clin Genet. 2017 Aug;92(2):213-216. doi: 10.1111/cge.12996. Epub 2017 Mar 30.


Educational Level Is Related to Physical Fitness in Patients with Type 2 Diabetes - A Cross-Sectional Study.

Allet L, Giet O, Barral J, Junod N, Durrer D, Amati F, Sykiotis GP, Marques-Vidal P, Puder JJ.

PLoS One. 2016 Oct 12;11(10):e0164176. doi: 10.1371/journal.pone.0164176. eCollection 2016.


A Simple Protocol for High Efficiency Protein Isolation After RNA Isolation from Mouse Thyroid and Other Very Small Tissue Samples.

Ziros PG, Chartoumpekis DV, Sykiotis GP.

Methods Mol Biol. 2016;1449:383-93. doi: 10.1007/978-1-4939-3756-1_25.


Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice.

Ziros P, Zagoriti Z, Lagoumintzis G, Kyriazopoulou V, Iskrenova RP, Habeos EI, Sykiotis GP, Chartoumpekis DV, Habeos IG.

PLoS One. 2016 Sep 1;11(9):e0162024. doi: 10.1371/journal.pone.0162024. eCollection 2016.


Redox Status and Proteostasis in Ageing and Disease.

Rizzi F, Trougakos IP, Pintus G, Sykiotis GP.

Oxid Med Cell Longev. 2016;2016:7476241. doi: 10.1155/2016/7476241. Epub 2016 Feb 22. No abstract available.


Congenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations.

Villanueva C, Jacobson-Dickman E, Xu C, Manouvrier S, Dwyer AA, Sykiotis GP, Beenken A, Liu Y, Tommiska J, Hu Y, Tiosano D, Gerard M, Leger J, Drouin-Garraud V, Lefebvre H, Polak M, Carel JC, Phan-Hug F, Hauschild M, Plummer L, Rey JP, Raivio T, Bouloux P, Sidis Y, Mohammadi M, de Roux N, Pitteloud N.

Genet Med. 2015 Aug;17(8):651-9. doi: 10.1038/gim.2014.166. Epub 2014 Nov 13.


Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.

Chartoumpekis DV, Sykiotis GP.

N Engl J Med. 2014 May 1;370(18):1767. doi: 10.1056/NEJMc1400872. No abstract available.


Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism.

Dwyer AA, Sykiotis GP, Hayes FJ, Boepple PA, Lee H, Loughlin KR, Dym M, Sluss PM, Crowley WF Jr, Pitteloud N.

J Clin Endocrinol Metab. 2013 Nov;98(11):E1790-5. doi: 10.1210/jc.2013-2518. Epub 2013 Sep 13.


Nrf2 is commonly activated in papillary thyroid carcinoma, and it controls antioxidant transcriptional responses and viability of cancer cells.

Ziros PG, Manolakou SD, Habeos IG, Lilis I, Chartoumpekis DV, Koika V, Soares P, Kyriazopoulou VE, Scopa CD, Papachristou DJ, Sykiotis GP.

J Clin Endocrinol Metab. 2013 Aug;98(8):E1422-7. doi: 10.1210/jc.2013-1510. Epub 2013 Jun 13.


Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.

Tsakiri EN, Sykiotis GP, Papassideri IS, Terpos E, Dimopoulos MA, Gorgoulis VG, Bohmann D, Trougakos IP.

Aging Cell. 2013 Oct;12(5):802-13. doi: 10.1111/acel.12111. Epub 2013 Jun 28.


Hepatic gene expression profiling in Nrf2 knockout mice after long-term high-fat diet-induced obesity.

Chartoumpekis DV, Ziros PG, Zaravinos A, Iskrenova RP, Psyrogiannis AI, Kyriazopoulou VE, Sykiotis GP, Habeos IG.

Oxid Med Cell Longev. 2013;2013:340731. doi: 10.1155/2013/340731. Epub 2013 Apr 18.


Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N.

Am J Hum Genet. 2013 May 2;92(5):725-43. doi: 10.1016/j.ajhg.2013.04.008.


Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.

Rahman MM, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D.

Aging Cell. 2013 Aug;12(4):554-62. doi: 10.1111/acel.12078. Epub 2013 May 16.


Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.

Tsakiri EN, Sykiotis GP, Papassideri IS, Gorgoulis VG, Bohmann D, Trougakos IP.

FASEB J. 2013 Jun;27(6):2407-20. doi: 10.1096/fj.12-221408. Epub 2013 Mar 1.


An ancient founder mutation in PROKR2 impairs human reproduction.

Avbelj Stefanija M, Jeanpierre M, Sykiotis GP, Young J, Quinton R, Abreu AP, Plummer L, Au MG, Balasubramanian R, Dwyer AA, Florez JC, Cheetham T, Pearce SH, Purushothaman R, Schinzel A, Pugeat M, Jacobson-Dickman EE, Ten S, Latronico AC, Gusella JF, Dode C, Crowley WF Jr, Pitteloud N.

Hum Mol Genet. 2012 Oct 1;21(19):4314-24. doi: 10.1093/hmg/dds264. Epub 2012 Jul 5.


Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia.

Raivio T, Avbelj M, McCabe MJ, Romero CJ, Dwyer AA, Tommiska J, Sykiotis GP, Gregory LC, Diaczok D, Tziaferi V, Elting MW, Padidela R, Plummer L, Martin C, Feng B, Zhang C, Zhou QY, Chen H, Mohammadi M, Quinton R, Sidis Y, Radovick S, Dattani MT, Pitteloud N.

J Clin Endocrinol Metab. 2012 Apr;97(4):E694-9. doi: 10.1210/jc.2011-2938. Epub 2012 Feb 8.


Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice.

Chartoumpekis DV, Ziros PG, Psyrogiannis AI, Papavassiliou AG, Kyriazopoulou VE, Sykiotis GP, Habeos IG.

Diabetes. 2011 Oct;60(10):2465-73. doi: 10.2337/db11-0112. Epub 2011 Aug 18.


Nrf2 activation diminishes during adipocyte differentiation of ST2 cells.

Chartoumpekis DV, Ziros PG, Sykiotis GP, Zaravinos A, Psyrogiannis AI, Kyriazopoulou VE, Spandidos DA, Habeos IG.

Int J Mol Med. 2011 Nov;28(5):823-8. doi: 10.3892/ijmm.2011.761. Epub 2011 Jul 29.


Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.

Barone MC, Sykiotis GP, Bohmann D.

Dis Model Mech. 2011 Sep;4(5):701-7. doi: 10.1242/dmm.007575. Epub 2011 Jun 30.


Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.

Tornberg J, Sykiotis GP, Keefe K, Plummer L, Hoang X, Hall JE, Quinton R, Seminara SB, Hughes V, Van Vliet G, Van Uum S, Crowley WF, Habuchi H, Kimata K, Pitteloud N, Bülow HE.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11524-9. doi: 10.1073/pnas.1102284108. Epub 2011 Jun 23.


A genetic basis for functional hypothalamic amenorrhea.

Caronia LM, Martin C, Welt CK, Sykiotis GP, Quinton R, Thambundit A, Avbelj M, Dhruvakumar S, Plummer L, Hughes VA, Seminara SB, Boepple PA, Sidis Y, Crowley WF Jr, Martin KA, Hall JE, Pitteloud N.

N Engl J Med. 2011 Jan 20;364(3):215-25. doi: 10.1056/NEJMoa0911064.


The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation.

Sykiotis GP, Habeos IG, Samuelson AV, Bohmann D.

Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):41-8. doi: 10.1097/MCO.0b013e32834136f2. Review.


Oligogenic basis of isolated gonadotropin-releasing hormone deficiency.

Sykiotis GP, Plummer L, Hughes VA, Au M, Durrani S, Nayak-Young S, Dwyer AA, Quinton R, Hall JE, Gusella JF, Seminara SB, Crowley WF Jr, Pitteloud N.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15140-4. doi: 10.1073/pnas.1009622107. Epub 2010 Aug 9.


Deciphering genetic disease in the genomic era: the model of GnRH deficiency.

Sykiotis GP, Pitteloud N, Seminara SB, Kaiser UB, Crowley WF Jr.

Sci Transl Med. 2010 May 19;2(32):32rv2. doi: 10.1126/scitranslmed.3000288. Review.


Complex genetics in idiopathic hypogonadotropic hypogonadism.

Pitteloud N, Durrani S, Raivio T, Sykiotis GP.

Front Horm Res. 2010;39:142-153. doi: 10.1159/000312700. Epub 2010 Apr 8. Review.


Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes.

Sykiotis GP, Hoang XH, Avbelj M, Hayes FJ, Thambundit A, Dwyer A, Au M, Plummer L, Crowley WF Jr, Pitteloud N.

J Clin Endocrinol Metab. 2010 Jun;95(6):3019-27. doi: 10.1210/jc.2009-2582. Epub 2010 Apr 9.

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