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Post-exposure prophylaxis with rVSV-ZEBOV following exposure to a patient with Ebola virus disease relapse in the UK: an operational, safety and immunogenicity report.

Davis C, Tipton T, Sabir S, Aitken C, Bennett S, Becker S, Evans T, Fehling SK, Gunson R, Hall Y, Jackson C, Johanssen I, Kieny MP, McMenamin J, Spence E, Strecker T, Sykes C, Templeton K, Thorburn F, Peters E, Henao Restrepo AM, White B, Zambon M, Carroll MW, Thomson EC.

Clin Infect Dis. 2019 Nov 30. pii: ciz1165. doi: 10.1093/cid/ciz1165. [Epub ahead of print]


Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens as HIV Preexposure Prophylaxis.

Srinivas N, Cottrell M, Maffuid K, Prince HA, Nelson JAE, White N, Sykes C, Dellon ES, Madanick RD, Shaheen NJ, Gonzalez D, Kashuba ADM.

Antimicrob Agents Chemother. 2020 Jan 27;64(2). pii: e01729-19. doi: 10.1128/AAC.01729-19. Print 2020 Jan 27.


Actin shells control buckling and wrinkling of biomembranes.

Kusters R, Simon C, Lopes Dos Santos R, Caorsi V, Wu S, Joanny JF, Sens P, Sykes C.

Soft Matter. 2019 Dec 4;15(47):9647-9653. doi: 10.1039/c9sm01902b.


Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs.

Devanathan AS, Pirone JR, Akkina R, Remling-Mulder L, Luciw P, Adamson L, Garcia JV, Kovarova M, White NR, Schauer AP, Blake K, Sykes C, Burgunder EM, Srinivas N, Rosen EP, Kashuba ADM.

Antimicrob Agents Chemother. 2019 Dec 20;64(1). pii: e01639-19. doi: 10.1128/AAC.01639-19. Print 2019 Dec 20.


Food insecurity is associated with lower levels of antiretroviral drug concentrations in hair among a cohort of women living with HIV in the United States.

Leddy AM, Sheira LA, Tamraz B, Sykes C, Kashuba ADM, Wilson TE, Adedimeji A, Merenstein D, Cohen MH, Wentz EL, Adimora AA, Ofotokun I, Metsch LR, Turan JM, Bacchetti P, Weiser SD.

Clin Infect Dis. 2019 Oct 14. pii: ciz1007. doi: 10.1093/cid/ciz1007. [Epub ahead of print]


Gas filaments of the cosmic web located around active galaxies in a protocluster.

Umehata H, Fumagalli M, Smail I, Matsuda Y, Swinbank AM, Cantalupo S, Sykes C, Ivison RJ, Steidel CC, Shapley AE, Vernet J, Yamada T, Tamura Y, Kubo M, Nakanishi K, Kajisawa M, Hatsukade B, Kohno K.

Science. 2019 Oct 4;366(6461):97-100. doi: 10.1126/science.aaw5949.


Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery.

Benhabbour SR, Kovarova M, Jones C, Copeland DJ, Shrivastava R, Swanson MD, Sykes C, Ho PT, Cottrell ML, Sridharan A, Fix SM, Thayer O, Long JM, Hazuda DJ, Dayton PA, Mumper RJ, Kashuba ADM, Victor Garcia J.

Nat Commun. 2019 Sep 20;10(1):4324. doi: 10.1038/s41467-019-12141-5.


Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species.

Thompson CG, Rosen EP, Prince HMA, White N, Sykes C, de la Cruz G, Mathews M, Deleage C, Estes JD, Charlins P, Mulder LR, Kovarova M, Adamson L, Arora S, Dellon ES, Peery AF, Shaheen NJ, Gay C, Muddiman DC, Akkina R, Garcia JV, Luciw P, Kashuba ADM.

Sci Transl Med. 2019 Jul 3;11(499). pii: eaap8758. doi: 10.1126/scitranslmed.aap8758.


Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans.

Burgunder E, Fallon JK, White N, Schauer AP, Sykes C, Remling-Mulder L, Kovarova M, Adamson L, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM.

J Pharmacol Exp Ther. 2019 Sep;370(3):360-368. doi: 10.1124/jpet.119.259150. Epub 2019 Jun 24.


Depot medroxyprogesterone acetate and the vaginal microbiome as modifiers of tenofovir diphosphate and lamivudine triphosphate concentrations in the female genital tract of Ugandan women: Implications for TDF/3TC in pre-exposure prophylaxis.

Nicol MR, Eneh P, Nakalega R, Kaiser T, Kabwigu S, Isingel E, Beksinska M, Sykes C, Fowler MG, Brown TT, Staley C, Kiweewa Matovu F.

Clin Infect Dis. 2019 May 25. pii: ciz443. doi: 10.1093/cid/ciz443. [Epub ahead of print]


Population Modeling Highlights Drug Disposition Differences Between Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate in the Blood and Semen.

Greene SA, Chen J, Prince HMA, Sykes C, Schauer AP, Blake K, Nelson JAE, Gay CL, Cohen MS, Dumond JB.

Clin Pharmacol Ther. 2019 Oct;106(4):821-830. doi: 10.1002/cpt.1464. Epub 2019 May 31.


Decreased Tenofovir Diphosphate Concentrations in a Transgender Female Cohort: Implications for Human Immunodeficiency Virus Preexposure Prophylaxis.

Cottrell ML, Prince HMA, Schauer AP, Sykes C, Maffuid K, Poliseno A, Chun TW, Huiting E, Stanczyk FZ, Peery AF, Dellon ES, Adams JL, Gay C, Kashuba ADM.

Clin Infect Dis. 2019 Nov 27;69(12):2201-2204. doi: 10.1093/cid/ciz290.


A case of rifampicin-induced haemolysis.

Sykes CA, Shepherd J, McGoldrick C, Kennedy N, Raafat A.

Int J Tuberc Lung Dis. 2019 Feb 1;23(2):239-240. doi: 10.5588/ijtld.18.0255.


Predicting Efavirenz Concentrations in the Brain Tissue of HIV-Infected Individuals and Exploring their Relationship to Neurocognitive Impairment.

Srinivas N, Joseph SB, Robertson K, Kincer LP, Menezes P, Adamson L, Schauer AP, Blake KH, White N, Sykes C, Luciw P, Eron JJ, Forrest A, Price RW, Spudich S, Swanstrom R, Kashuba ADM.

Clin Transl Sci. 2019 May;12(3):302-311. doi: 10.1111/cts.12620. Epub 2019 Feb 27.


The 2018 biomembrane curvature and remodeling roadmap.

Bassereau P, Jin R, Baumgart T, Deserno M, Dimova R, Frolov VA, Bashkirov PV, Grubmüller H, Jahn R, Risselada HJ, Johannes L, Kozlov MM, Lipowsky R, Pucadyil TJ, Zeno WF, Stachowiak JC, Stamou D, Breuer A, Lauritsen L, Simon C, Sykes C, Voth GA, Weikl TR.

J Phys D Appl Phys. 2018 Aug;51(34). pii: 343001. doi: 10.1088/1361-6463/aacb98. Epub 2018 Jul 20.


Differential extracellular, but similar intracellular, disposition of two tenofovir formulations in the male genital tract.

Dumond JB, Greene SA, Prince HMA, Chen J, Maas BM, Sykes C, Schauer AP, Blake KH, Nelson JAE, Gay CL, Kashuba ADM, Cohen MS.

Antivir Ther. 2019;24(1):45-50. doi: 10.3851/IMP3277.


Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species.

Srinivas N, Rosen EP, Gilliland WM Jr, Kovarova M, Remling-Mulder L, De La Cruz G, White N, Adamson L, Schauer AP, Sykes C, Luciw P, Garcia JV, Akkina R, Kashuba ADM.

Xenobiotica. 2019 Oct;49(10):1192-1201. doi: 10.1080/00498254.2018.1539278. Epub 2018 Dec 17.


The Effect of Blood Loss on Cefazolin Levels in Women Undergoing Cesarean Delivery.

Dotters-Katz SK, Smid MC, Grace MR, Gunatilake RP, Sykes C, Blake K, Boggess KA, Patil AS, Manuck T.

Am J Perinatol. 2019 Jun;36(7):688-694. doi: 10.1055/s-0038-1673654. Epub 2018 Oct 18.


Ultra-long-acting removable drug delivery system for HIV treatment and prevention.

Kovarova M, Benhabbour SR, Massud I, Spagnuolo RA, Skinner B, Baker CE, Sykes C, Mollan KR, Kashuba ADM, García-Lerma JG, Mumper RJ, Garcia JV.

Nat Commun. 2018 Oct 8;9(1):4156. doi: 10.1038/s41467-018-06490-w.


Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair.

Sykes C, Blake K, White N, Schauer AP, Guzman BB, Cottrell ML, Tamraz B, Kashuba ADM.

Anal Bioanal Chem. 2018 Nov;410(29):7773-7781. doi: 10.1007/s00216-018-1394-y. Epub 2018 Oct 2.


A Pharmacokinetic/Pharmacodynamic Model to Predict Effective HIV Prophylaxis Dosing Strategies for People Who Inject Drugs.

Garrett KL, Chen J, Maas BM, Cottrell ML, Prince HA, Sykes C, Schauer AP, White N, Dumond JB.

J Pharmacol Exp Ther. 2018 Nov;367(2):245-251. doi: 10.1124/jpet.118.251009. Epub 2018 Aug 27.


Interplay between membrane tension and the actin cytoskeleton determines shape changes.

Simon C, Caorsi V, Campillo C, Sykes C.

Phys Biol. 2018 Jul 30;15(6):065004. doi: 10.1088/1478-3975/aad1ab.


Virological and immunological responses to raltegravir and dolutegravir in the gut-associated lymphoid tissue of HIV-infected men and women.

Weber MD, Andrews E, Prince HA, Sykes C, Rosen EP, Bay C, Shaheen NJ, Madanick RD, Dellon ES, De Paris K, Nelson JA, Gay CL, Kashuba AD.

Antivir Ther. 2018;23(6):495-504. doi: 10.3851/IMP3236.


Rilpivirine Plasma and Cervicovaginal Concentrations in Women During Pregnancy and Postpartum.

Eke AC, Chakhtoura N, Kashuba A, Best BM, Sykes C, Wang J, Stek AM, Smith E, Calabrese S, Capparelli EV, Mirochnick M; IMPAACT P1026s Protocol Team.

J Acquir Immune Defic Syndr. 2018 Jul 1;78(3):308-313. doi: 10.1097/QAI.0000000000001677.


Differences in Local and Systemic TFV PK Among Premenopausal Versus Postmenopausal Women Exposed to TFV 1% Vaginal Gel.

Thurman AR, Chandra N, Yousefieh N, Kimble T, Anderson SM, Cottrell M, Sykes C, Kashuba A, Schwartz JL, Doncel GF.

J Acquir Immune Defic Syndr. 2018 May 1;78(1):82-92. doi: 10.1097/QAI.0000000000001648.


The role of menopause in tenofovir diphosphate and emtricitabine triphosphate concentrations in cervical tissue.

Nicol MR, Brewers LM, Kashuba ADM, Sykes C.

AIDS. 2018 Jan 2;32(1):11-15. doi: 10.1097/QAD.0000000000001678.


Validation of an LC-MS/MS assay to simultaneously monitor the intracellular active metabolites of tenofovir, emtricitabine, and lamivudine in dried blood spots.

Schauer AP, Sykes C, Cottrell ML, Prince H, Kashuba ADM.

J Pharm Biomed Anal. 2018 Feb 5;149:40-45. doi: 10.1016/j.jpba.2017.10.030. Epub 2017 Oct 31.


Adaptive Response of Actin Bundles under Mechanical Stress.

Rückerl F, Lenz M, Betz T, Manzi J, Martiel JL, Safouane M, Paterski-Boujemaa R, Blanchoin L, Sykes C.

Biophys J. 2017 Sep 5;113(5):1072-1079. doi: 10.1016/j.bpj.2017.07.017.


Systematic review and meta-analysis: is bowel preparation still necessary in small bowel capsule endoscopy?

Yung DE, Rondonotti E, Sykes C, Pennazio M, Plevris JN, Koulaouzidis A.

Expert Rev Gastroenterol Hepatol. 2017 Oct;11(10):979-993. doi: 10.1080/17474124.2017.1359540. Epub 2017 Aug 1. Review.


Multimodal analysis of drug transporter expression in gastrointestinal tissue.

Thompson CG, Fallon JK, Mathews M, Charlins P, Remling-Mulder L, Kovarova M, Adamson L, Srinivas N, Schauer A, Sykes C, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM.

AIDS. 2017 Jul 31;31(12):1669-1678. doi: 10.1097/QAD.0000000000001554.


Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues.

Cottrell ML, Garrett KL, Prince HMA, Sykes C, Schauer A, Emerson CW, Peery A, Rooney JF, McCallister S, Gay C, Kashuba ADM.

J Antimicrob Chemother. 2017 Jun 1;72(6):1731-1740. doi: 10.1093/jac/dkx064.


Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection.

Maas BM, Francis O, Mollan KR, Lee C, Cottrell ML, Prince HM, Sykes C, Trezza C, Torrice C, White N, Malone S, Hudgens MG, Sharpless NE, Dumond JB.

PLoS One. 2016 Dec 30;11(12):e0168709. doi: 10.1371/journal.pone.0168709. eCollection 2016.


Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV-Infected Subjects With Aging Biomarkers.

Dumond JB, Chen J, Cottrell M, Trezza CR, Prince H, Sykes C, Torrice C, White N, Malone S, Wang R, Patterson KB, Sharpless NE, Forrest A.

CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):128-135. doi: 10.1002/psp4.12151. Epub 2016 Dec 29.


p16INK4a , a Senescence Marker, Influences Tenofovir/Emtricitabine Metabolite Disposition in HIV-Infected Subjects.

Dumond JB, Collins JW, Cottrell ML, Trezza CR, Prince H, Sykes C, Torrice C, White N, Malone S, Wang R, Patterson KB, Sharpless NE, Forrest A.

CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):120-127. doi: 10.1002/psp4.12150. Epub 2016 Dec 26.


The validity of suspected blood indicator software in capsule endoscopy: a systematic review and meta-analysis.

Yung DE, Sykes C, Koulaouzidis A.

Expert Rev Gastroenterol Hepatol. 2017 Jan;11(1):43-51. Epub 2016 Nov 21. Review.


Fluctuations of a membrane nanotube revealed by high-resolution force measurements.

Valentino F, Sens P, Lemière J, Allard A, Betz T, Campillo C, Sykes C.

Soft Matter. 2016 Nov 28;12(47):9429-9435.


How cellular membrane properties are affected by the actin cytoskeleton.

Lemière J, Valentino F, Campillo C, Sykes C.

Biochimie. 2016 Nov;130:33-40. doi: 10.1016/j.biochi.2016.09.019. Epub 2016 Sep 28. Review.


HIV-1-RNA Decay and Dolutegravir Concentrations in Semen of Patients Starting a First Antiretroviral Regimen.

Imaz A, Martinez-Picado J, Niubó J, Kashuba AD, Ferrer E, Ouchi D, Sykes C, Rozas N, Acerete L, Curto J, Vila A, Podzamczer D.

J Infect Dis. 2016 Nov 15;214(10):1512-1519. Epub 2016 Aug 30.


Elvitegravir concentrations in seminal plasma in HIV-1-infected men.

Imaz A, Niubó J, Kashuba AD, Ferrer E, Sykes C, Rozas N, Acerete L, Vila A, Podzamczer D.

HIV Med. 2017 Mar;18(3):225-230. doi: 10.1111/hiv.12417. Epub 2016 Aug 1.


Making a diagnosis of hypertension and defining treatment threshold in very low birth weight infants' need revision?

Viswanathan S, Kumar D, Sykes C, Olbrych S, Patel N, Super DM, Darusz J, Raina R.

J Renal Inj Prev. 2016 Jun 1;5(2):55-60. doi: 10.15171/jrip.2016.13. eCollection 2016.


Cell-sized liposome doublets reveal active tension build-up driven by acto-myosin dynamics.

Caorsi V, Lemière J, Campillo C, Bussonnier M, Manzi J, Betz T, Plastino J, Carvalho K, Sykes C.

Soft Matter. 2016 Jul 20;12(29):6223-31. doi: 10.1039/c6sm00856a.


Saquinavir Loaded Acetalated Dextran Microconfetti - a Long Acting Protease Inhibitor Injectable.

Collier MA, Gallovic MD, Bachelder EM, Sykes CD, Kashuba A, Ainslie KM.

Pharm Res. 2016 Aug;33(8):1998-2009. doi: 10.1007/s11095-016-1936-y. Epub 2016 May 6.


Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design.

Cottrell ML, Prince HM, Allmon A, Mollan KR, Hudgens MG, Sykes C, White N, Malone S, Dellon ES, Madanick RD, Shaheen NJ, Patterson KB, Kashuba AD.

J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):498-506. doi: 10.1097/QAI.0000000000000996.


A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine.

Cottrell ML, Yang KH, Prince HM, Sykes C, White N, Malone S, Dellon ES, Madanick RD, Shaheen NJ, Hudgens MG, Wulff J, Patterson KB, Nelson JA, Kashuba AD.

J Infect Dis. 2016 Jul 1;214(1):55-64. doi: 10.1093/infdis/jiw077. Epub 2016 Feb 24.


Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis.

Veselinovic M, Yang KH, Sykes C, Remling-Mulder L, Kashuba AD, Akkina R.

Virology. 2016 Feb;489:173-8. doi: 10.1016/j.virol.2015.12.014. Epub 2016 Jan 6.


Tenofovir/emtricitabine metabolites and endogenous nucleotide exposures are associated with p16(INK4a) expression in subjects on combination therapy.

Dumond JB, Francis O, Cottrell M, Trezza C, Prince HM, Mollan K, Sykes C, Torrice C, White N, Malone S, Wang R, Van Dam C, Patterson KB, Hudgens MG, Sharpless NE, Forrest A.

Antivir Ther. 2016;21(5):441-5. doi: 10.3851/IMP3017. Epub 2016 Jan 5.


F-actin mechanics control spindle centring in the mouse zygote.

Chaigne A, Campillo C, Voituriez R, Gov NS, Sykes C, Verlhac MH, Terret ME.

Nat Commun. 2016 Jan 4;7:10253. doi: 10.1038/ncomms10253.


Analysis of Antiretrovirals in Single Hair Strands for Evaluation of Drug Adherence with Infrared-Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging.

Rosen EP, Thompson CG, Bokhart MT, Prince HM, Sykes C, Muddiman DC, Kashuba AD.

Anal Chem. 2016 Jan 19;88(2):1336-44. doi: 10.1021/acs.analchem.5b03794. Epub 2015 Dec 30.


Mechanics of Biomimetic Liposomes Encapsulating an Actin Shell.

Guevorkian K, Manzi J, Pontani LL, Brochard-Wyart F, Sykes C.

Biophys J. 2015 Dec 15;109(12):2471-2479. doi: 10.1016/j.bpj.2015.10.050.

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