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Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models.

Sechi M, Lall RK, Afolabi SO, Singh A, Joshi DC, Chiu SY, Mukhtar H, Syed DN.

Sci Rep. 2018 Oct 24;8(1):15726. doi: 10.1038/s41598-018-33879-w.


Targeting epithelial to mesenchymal transition in prostate cancer by a novel compound, plectranthoic acid, isolated from Ficus microcarpa.

Akhtar N, Syed DN, Lall RK, Mirza B, Mukhtar H.

Mol Carcinog. 2018 May;57(5):653-663. doi: 10.1002/mc.22790. Epub 2018 Feb 27.


Synthetic transcription elongation factors license transcription across repressive chromatin.

Erwin GS, Grieshop MP, Ali A, Qi J, Lawlor M, Kumar D, Ahmad I, McNally A, Teider N, Worringer K, Sivasankaran R, Syed DN, Eguchi A, Ashraf M, Jeffery J, Xu M, Park PMC, Mukhtar H, Srivastava AK, Faruq M, Bradner JE, Ansari AZ.

Science. 2017 Dec 22;358(6370):1617-1622. doi: 10.1126/science.aan6414. Epub 2017 Nov 30.


Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism.

ALJohani AM, Syed DN, Ntambi JM.

Trends Endocrinol Metab. 2017 Dec;28(12):831-842. doi: 10.1016/j.tem.2017.10.003. Epub 2017 Oct 28. Review.


Ousting RAGE in melanoma: A viable therapeutic target?

Syed DN, Aljohani A, Waseem D, Mukhtar H.

Semin Cancer Biol. 2018 Apr;49:20-28. doi: 10.1016/j.semcancer.2017.10.008. Epub 2017 Oct 24. Review.


Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities.

Sechi M, Syed DN, Pala N, Mariani A, Marceddu S, Brunetti A, Mukhtar H, Sanna V.

Mater Sci Eng C Mater Biol Appl. 2016 Nov 1;68:594-602. doi: 10.1016/j.msec.2016.06.042. Epub 2016 Jun 14.


Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.

Chamcheu JC, Adhami VM, Esnault S, Sechi M, Siddiqui IA, Satyshur KA, Syed DN, Dodwad SM, Chaves-Rodriquez MI, Longley BJ, Wood GS, Mukhtar H.

Antioxid Redox Signal. 2017 Jan 10;26(2):49-69. doi: 10.1089/ars.2016.6769. Epub 2016 Oct 4.


Dietary flavonoid fisetin increases abundance of high-molecular-mass hyaluronan conferring resistance to prostate oncogenesis.

Lall RK, Syed DN, Khan MI, Adhami VM, Gong Y, Lucey JA, Mukhtar H.

Carcinogenesis. 2016 Sep;37(9):918-928. doi: 10.1093/carcin/bgw071. Epub 2016 Jun 22.


Exploring the molecular targets of dietary flavonoid fisetin in cancer.

Syed DN, Adhami VM, Khan N, Khan MI, Mukhtar H.

Semin Cancer Biol. 2016 Oct;40-41:130-140. doi: 10.1016/j.semcancer.2016.04.003. Epub 2016 May 6. Review.


The pentacyclic triterpenoid, plectranthoic acid, a novel activator of AMPK induces apoptotic death in prostate cancer cells.

Akhtar N, Syed DN, Khan MI, Adhami VM, Mirza B, Mukhtar H.

Oncotarget. 2016 Jan 26;7(4):3819-31. doi: 10.18632/oncotarget.6625.


FICZ: A Messenger of Light in Human Skin.

Syed DN, Mukhtar H.

J Invest Dermatol. 2015 Jun;135(6):1478-1481. doi: 10.1038/jid.2015.52.


Potent anti-proliferative, pro-apoptotic activity of the Maytenus royleanus extract against prostate cancer cells: evidence in in-vitro and in-vivo models.

Shabbir M, Syed DN, Lall RK, Khan MR, Mukhtar H.

PLoS One. 2015 Mar 23;10(3):e0119859. doi: 10.1371/journal.pone.0119859. eCollection 2015.


Dietary polyphenols in prevention and treatment of prostate cancer.

Lall RK, Syed DN, Adhami VM, Khan MI, Mukhtar H.

Int J Mol Sci. 2015 Feb 3;16(2):3350-76. doi: 10.3390/ijms16023350. Review.


Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis.

Chamcheu JC, Pal HC, Siddiqui IA, Adhami VM, Ayehunie S, Boylan BT, Noubissi FK, Khan N, Syed DN, Elmets CA, Wood GS, Afaq F, Mukhtar H.

Skin Pharmacol Physiol. 2015;28(4):177-88. doi: 10.1159/000368445. Epub 2015 Jan 22.


MicroRNAs and photocarcinogenesis.

Syed DN, Lall RK, Mukhtar H.

Photochem Photobiol. 2015 Jan-Feb;91(1):173-87. doi: 10.1111/php.12346. Epub 2014 Dec 16. Review.


Biotransformed soybean extract (BSE) inhibits melanoma cell growth and viability in vitro: involvement of nuclear factor-kappa B signaling.

Vilela FM, Syed DN, Chamcheu JC, Calvo-Castro LA, Fortes VS, Fonseca MJ, Mukhtar H.

PLoS One. 2014 Jul 29;9(7):e103248. doi: 10.1371/journal.pone.0103248. eCollection 2014.


Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma.

Syed DN, Lall RK, Chamcheu JC, Haidar O, Mukhtar H.

Arch Biochem Biophys. 2014 Dec 1;563:108-117. doi: 10.1016/ Epub 2014 Jul 9.


YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin.

Khan MI, Adhami VM, Lall RK, Sechi M, Joshi DC, Haidar OM, Syed DN, Siddiqui IA, Chiu SY, Mukhtar H.

Oncotarget. 2014 May 15;5(9):2462-74.


Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling.

Syed DN, Chamcheu JC, Khan MI, Sechi M, Lall RK, Adhami VM, Mukhtar H.

Biochem Pharmacol. 2014 Jun 1;89(3):349-60. doi: 10.1016/j.bcp.2014.03.007. Epub 2014 Mar 24.


MicroRNAs in skin response to UV radiation.

Syed DN, Khan MI, Shabbir M, Mukhtar H.

Curr Drug Targets. 2013 Sep;14(10):1128-34. Review.


Protective effect of tropical highland blackberry juice (Rubus adenotrichos Schltdl.) against UVB-mediated damage in human epidermal keratinocytes and in a reconstituted skin equivalent model.

Calvo-Castro L, Syed DN, Chamcheu JC, Vilela FM, Pérez AM, Vaillant F, Rojas M, Mukhtar H.

Photochem Photobiol. 2013 Sep-Oct;89(5):1199-207. doi: 10.1111/php.12104. Epub 2013 Jul 8.


Ozone and SIRT3: an unexplored paradigm.

Syed DN, Mukhtar H.

Exp Dermatol. 2013 Jun;22(6):396. doi: 10.1111/exd.12143.


Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: studies in submerged and three-dimensional epidermal equivalent models.

Chamcheu JC, Afaq F, Syed DN, Siddiqui IA, Adhami VM, Khan N, Singh S, Boylan BT, Wood GS, Mukhtar H.

Exp Dermatol. 2013 May;22(5):342-8. doi: 10.1111/exd.12140.


Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin.

Syed DN, Adhami VM, Khan MI, Mukhtar H.

Anticancer Agents Med Chem. 2013 Sep;13(7):995-1001. Review.


Fisetin: a dietary antioxidant for health promotion.

Khan N, Syed DN, Ahmad N, Mukhtar H.

Antioxid Redox Signal. 2013 Jul 10;19(2):151-62. doi: 10.1089/ars.2012.4901. Epub 2012 Dec 18. Review.


Pomegranate extracts and cancer prevention: molecular and cellular activities.

Syed DN, Chamcheu JC, Adhami VM, Mukhtar H.

Anticancer Agents Med Chem. 2013 Oct;13(8):1149-61. Review.


Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management.

Adhami VM, Syed DN, Khan N, Mukhtar H.

Biochem Pharmacol. 2012 Nov 15;84(10):1277-81. doi: 10.1016/j.bcp.2012.07.012. Epub 2012 Jul 25. Review.


Progress towards genetic and pharmacological therapies for keratin genodermatoses: current perspective and future promise.

Chamcheu JC, Wood GS, Siddiqui IA, Syed DN, Adhami VM, Teng JM, Mukhtar H.

Exp Dermatol. 2012 Jul;21(7):481-9. doi: 10.1111/j.1600-0625.2012.01534.x. Review.


Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes.

Syed DN, Afaq F, Mukhtar H.

Photochem Photobiol. 2012 Sep-Oct;88(5):1184-90. doi: 10.1111/j.1751-1097.2012.01115.x. Epub 2012 Mar 19.


Gender bias in skin cancer: role of catalase revealed.

Syed DN, Mukhtar H.

J Invest Dermatol. 2012 Mar;132(3 Pt 1):512-4. doi: 10.1038/jid.2011.423.


Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model.

Adhami VM, Siddiqui IA, Syed DN, Lall RK, Mukhtar H.

Carcinogenesis. 2012 Mar;33(3):644-51. doi: 10.1093/carcin/bgr308. Epub 2011 Dec 22.


Pomegranate fruit extract inhibits UVB-induced inflammation and proliferation by modulating NF-κB and MAPK signaling pathways in mouse skin.

Khan N, Syed DN, Pal HC, Mukhtar H, Afaq F.

Photochem Photobiol. 2012 Sep-Oct;88(5):1126-34. doi: 10.1111/j.1751-1097.2011.01063.x. Epub 2012 Jan 13.


α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth.

Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H.

Carcinogenesis. 2012 Feb;33(2):413-9. doi: 10.1093/carcin/bgr291. Epub 2011 Dec 9.


Botanicals for the prevention and treatment of cutaneous melanoma.

Syed DN, Mukhtar H.

Pigment Cell Melanoma Res. 2011 Aug;24(4):688-702. doi: 10.1111/j.1755-148X.2011.00851.x. Epub 2011 Apr 12. Review.


Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels.

Syed DN, Afaq F, Maddodi N, Johnson JJ, Sarfaraz S, Ahmad A, Setaluri V, Mukhtar H.

J Invest Dermatol. 2011 Jun;131(6):1291-9. doi: 10.1038/jid.2011.6. Epub 2011 Feb 24.


Keratin gene mutations in disorders of human skin and its appendages.

Chamcheu JC, Siddiqui IA, Syed DN, Adhami VM, Liovic M, Mukhtar H.

Arch Biochem Biophys. 2011 Apr 15;508(2):123-37. doi: 10.1016/ Epub 2010 Dec 19. Review.


Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.

Afaq F, Khan N, Syed DN, Mukhtar H.

Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. doi: 10.1111/j.1751-1097.2010.00815.x. Epub 2010 Oct 14.


Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention.

Johnson JJ, Syed DN, Suh Y, Heren CR, Saleem M, Siddiqui IA, Mukhtar H.

Cancer Prev Res (Phila). 2010 Sep;3(9):1112-23. doi: 10.1158/1940-6207.CAPR-10-0168. Epub 2010 Aug 24.


Aryl hydrocarbon receptor is an ozone sensor in human skin.

Afaq F, Zaid MA, Pelle E, Khan N, Syed DN, Matsui MS, Maes D, Mukhtar H.

J Invest Dermatol. 2009 Oct;129(10):2396-403. doi: 10.1038/jid.2009.85. Epub 2009 Jun 18.


Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice.

Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Mukhtar H.

Carcinogenesis. 2008 Oct;29(10):2011-8. doi: 10.1093/carcin/bgn180. Epub 2008 Aug 5.


Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables.

Afaq F, Zaman N, Khan N, Syed DN, Sarfaraz S, Zaid MA, Mukhtar H.

Int J Cancer. 2008 Oct 1;123(7):1508-15. doi: 10.1002/ijc.23675.


Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation.

Syed DN, Afaq F, Sarfaraz S, Khan N, Kedlaya R, Setaluri V, Mukhtar H.

Toxicol Appl Pharmacol. 2008 Aug 15;231(1):52-60. doi: 10.1016/j.taap.2008.03.023. Epub 2008 Apr 9.


Dietary agents for chemoprevention of prostate cancer.

Syed DN, Suh Y, Afaq F, Mukhtar H.

Cancer Lett. 2008 Jul 8;265(2):167-76. doi: 10.1016/j.canlet.2008.02.050. Epub 2008 Apr 18. Review.


Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells.

Khan N, Afaq F, Syed DN, Mukhtar H.

Carcinogenesis. 2008 May;29(5):1049-56. doi: 10.1093/carcin/bgn078. Epub 2008 Mar 20.


Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5'-AMP-activated protein kinase (AMPK) pathway.

Johnson JJ, Syed DN, Heren CR, Suh Y, Adhami VM, Mukhtar H.

Pharm Res. 2008 Sep;25(9):2125-34. doi: 10.1007/s11095-008-9552-0. Epub 2008 Feb 21.


Phytochemicals for prevention of solar ultraviolet radiation-induced damages.

Adhami VM, Syed DN, Khan N, Afaq F.

Photochem Photobiol. 2008 Mar-Apr;84(2):489-500. doi: 10.1111/j.1751-1097.2007.00293.x. Epub 2008 Feb 7. Review.


Cannabinoids for cancer treatment: progress and promise.

Sarfaraz S, Adhami VM, Syed DN, Afaq F, Mukhtar H.

Cancer Res. 2008 Jan 15;68(2):339-42. doi: 10.1158/0008-5472.CAN-07-2785. Review.


Chemoprevention of prostate cancer through dietary agents: progress and promise.

Syed DN, Khan N, Afaq F, Mukhtar H.

Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2193-203. Review.


Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx.

Zaid MA, Afaq F, Syed DN, Dreher M, Mukhtar H.

Photochem Photobiol. 2007 Jul-Aug;83(4):882-8.


Pomegranate derived products for cancer chemoprevention.

Syed DN, Afaq F, Mukhtar H.

Semin Cancer Biol. 2007 Oct;17(5):377-85. Epub 2007 May 29. Review.


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