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Prion dimer is heterogenous and is modulated by multiple negative and positive motifs.

Gao Z, Shi J, Cai L, Luo M, Wong BS, Dong X, Sy MS, Li C.

Biochem Biophys Res Commun. 2019 Feb 5;509(2):570-576. doi: 10.1016/j.bbrc.2018.12.113. Epub 2018 Dec 29.


CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.

Zhang H, Zhang C, Tang H, Gao S, Sun F, Yang Y, Zhou W, Hu Y, Ke C, Wu Y, Ding Z, Guo L, Pei R, Chen X, Sy MS, Zhang B, Li C.

Hepatology. 2018 Nov;68(5):1710-1725. doi: 10.1002/hep.30073.


Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production.

Wu GR, Mu TC, Gao ZX, Wang J, Sy MS, Li CY.

J Biol Chem. 2017 Nov 17;292(46):18747-18759. doi: 10.1074/jbc.M117.787283. Epub 2017 Sep 12.


Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type.

Cracco L, Notari S, Cali I, Sy MS, Chen SG, Cohen ML, Ghetti B, Appleby BS, Zou WQ, Caughey B, Safar JG, Gambetti P.

Sci Rep. 2017 Jan 16;7:38280. doi: 10.1038/srep38280.


Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1.

Wang Y, Yu S, Huang D, Cui M, Hu H, Zhang L, Wang W, Parameswaran N, Jackson M, Osborne B, Bedogni B, Li C, Sy MS, Xin W, Zhou L.

Am J Pathol. 2016 Nov;186(11):2945-2956. doi: 10.1016/j.ajpath.2016.07.010. Epub 2016 Sep 14. Erratum in: Am J Pathol. 2017 Mar;187(3):689.


Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.

Ni CL, Seth D, Fonseca FV, Wang L, Xiao TS, Gruber P, Sy MS, Stamler JS, Tartakoff AM.

PLoS One. 2016 Sep 22;11(9):e0163359. doi: 10.1371/journal.pone.0163359. eCollection 2016.


Glycosylphosphatidylinositol anchor modification machinery deficiency is responsible for the formation of pro-prion protein (PrP) in BxPC-3 cells and increases cancer cell motility.

Yang L, Gao Z, Hu L, Wu G, Yang X, Zhang L, Zhu Y, Wong BS, Xin W, Sy MS, Li C.

J Biol Chem. 2016 Mar 25;291(13):6785. doi: 10.1074/jbc.A115.705830. No abstract available.


Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan.

Gao Z, Zhang H, Hu F, Yang L, Yang X, Zhu Y, Sy MS, Li C.

Cell Signal. 2016 Jun;28(6):652-62. doi: 10.1016/j.cellsig.2016.03.010. Epub 2016 Mar 19.


Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Protein and Increases Cancer Cell Motility.

Yang L, Gao Z, Hu L, Wu G, Yang X, Zhang L, Zhu Y, Wong BS, Xin W, Sy MS, Li C.

J Biol Chem. 2016 Feb 19;291(8):3905-17. doi: 10.1074/jbc.M115.705830. Epub 2015 Dec 18. Erratum in: J Biol Chem. 2016 Mar 25;291(13):6785.


Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints.

Ai M, Cui Y, Sy MS, Lee DM, Zhang LX, Larson KM, Kurek KC, Jay GD, Warman ML.

PLoS One. 2015 Feb 2;10(2):e0116237. doi: 10.1371/journal.pone.0116237. eCollection 2015.


A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells.

Yang L, Zhang Y, Hu L, Zhu Y, Sy MS, Li C.

Virol Sin. 2014 Aug;29(4):228-36. doi: 10.1007/s12250-014-3480-4. Epub 2014 Aug 14.


Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

Kim C, Haldiman T, Surewicz K, Cohen Y, Chen W, Blevins J, Sy MS, Cohen M, Kong Q, Telling GC, Surewicz WK, Safar JG.

PLoS Pathog. 2012;8(8):e1002835. doi: 10.1371/journal.ppat.1002835. Epub 2012 Aug 2.


Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate.

Kim C, Haldiman T, Cohen Y, Chen W, Blevins J, Sy MS, Cohen M, Safar JG.

PLoS Pathog. 2011 Sep;7(9):e1002242. doi: 10.1371/journal.ppat.1002242. Epub 2011 Sep 8.


A multistage pathway for human prion protein aggregation in vitro: from multimeric seeds to β-oligomers and nonfibrillar structures.

Cho KR, Huang Y, Yu S, Yin S, Plomp M, Qiu SR, Lakshminarayanan R, Moradian-Oldak J, Sy MS, De Yoreo JJ.

J Am Chem Soc. 2011 Jun 8;133(22):8586-93. doi: 10.1021/ja1117446. Epub 2011 May 17.


Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository.

Sy MS, Altekruse SF, Li C, Lynch CF, Goodman MT, Hernandez BY, Zhou L, Saber MS, Hewitt SM, Xin W.

Cancer Biomark. 2011-2012;10(6):251-8. doi: 10.3233/CBM-2012-0256.


Role of the highly conserved middle region of prion protein (PrP) in PrP-lipid interaction.

Wang F, Yin S, Wang X, Zha L, Sy MS, Ma J.

Biochemistry. 2010 Sep 21;49(37):8169-76. doi: 10.1021/bi101146v.


Binding of pro-prion to filamin A: by design or an unfortunate blunder.

Li C, Xin W, Sy MS.

Oncogene. 2010 Sep 30;29(39):5329-45. doi: 10.1038/onc.2010.307. Epub 2010 Aug 9. Review.


Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.

Li C, Yu S, Nakamura F, Pentikäinen OT, Singh N, Yin S, Xin W, Sy MS.

J Biol Chem. 2010 Sep 24;285(39):30328-39. doi: 10.1074/jbc.M110.147413. Epub 2010 Jul 21.


Paradoxical role of prion protein aggregates in redox-iron induced toxicity.

Das D, Luo X, Singh A, Gu Y, Ghosh S, Mukhopadhyay CK, Chen SG, Sy MS, Kong Q, Singh N.

PLoS One. 2010 Jul 6;5(7):e11420. doi: 10.1371/journal.pone.0011420.


The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers.

Sy MS, Li C, Yu S, Xin W.

Biomark Med. 2010 Jun;4(3):453-64. doi: 10.2217/bmm.10.14.


PrP conformational transitions alter species preference of a PrP-specific antibody.

Zou WQ, Langeveld J, Xiao X, Chen S, McGeer PL, Yuan J, Payne MC, Kang HE, McGeehan J, Sy MS, Greenspan NS, Kaplan D, Wang GX, Parchi P, Hoover E, Kneale G, Telling G, Surewicz WK, Kong Q, Guo JP.

J Biol Chem. 2010 Apr 30;285(18):13874-84. doi: 10.1074/jbc.M109.088831. Epub 2010 Mar 1.


The saga of prion: to cut or not to cut.

Sy MS.

Cell Res. 2009 Sep;19(9):1039-40. doi: 10.1038/cr.2009.102. Epub 2009 Sep 3. No abstract available.


Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide.

Tan J, Mao G, Cui MZ, Lamb B, Sy MS, Xu X.

Neurobiol Dis. 2009 Dec;36(3):453-60. doi: 10.1016/j.nbd.2009.08.010. Epub 2009 Aug 27.


Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer.

Li C, Yu S, Nakamura F, Yin S, Xu J, Petrolla AA, Singh N, Tartakoff A, Abbott DW, Xin W, Sy MS.

J Clin Invest. 2009 Sep;119(9):2725-36. doi: 10.1172/JCI39542. Epub 2009 Aug 17.


Ligand binding promotes prion protein aggregation--role of the octapeptide repeats.

Yu S, Yin S, Pham N, Wong P, Kang SC, Petersen RB, Li C, Sy MS.

FEBS J. 2008 Nov;275(22):5564-75. doi: 10.1111/j.1742-4658.2008.06680.x.


Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model.

Tan J, Mao G, Cui MZ, Kang SC, Lamb B, Wong BS, Sy MS, Xu X.

J Neurochem. 2008 Nov;107(3):722-33. doi: 10.1111/j.1471-4159.2008.05643.x. Epub 2008 Sep 20.


Binding of recombinant but not endogenous prion protein to DNA causes DNA internalization and expression in mammalian cells.

Yin S, Fan X, Yu S, Li C, Sy MS.

J Biol Chem. 2008 Sep 12;283(37):25446-54. doi: 10.1074/jbc.M800814200. Epub 2008 Jul 11.


Normal cellular prion protein with a methionine at position 129 has a more exposed helix 1 and is more prone to aggregate.

Pham N, Yin S, Yu S, Wong P, Kang SC, Li C, Sy MS.

Biochem Biophys Res Commun. 2008 Apr 18;368(4):875-81. doi: 10.1016/j.bbrc.2008.01.172. Epub 2008 Feb 12.


The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2.

Fitzmaurice TJ, Burke DF, Hopkins L, Yang S, Yu S, Sy MS, Thackray AM, Bujdoso R.

Biochem J. 2008 Jan 15;409(2):367-75.


The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.

Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D.

EMBO J. 2007 Sep 5;26(17):4038-50. Epub 2007 Aug 16.


Cyclodextrins inhibit replication of scrapie prion protein in cell culture.

Prior M, Lehmann S, Sy MS, Molloy B, McMahon HE.

J Virol. 2007 Oct;81(20):11195-207. Epub 2007 Aug 15.


Normal cellular prion protein is a ligand of selectins: binding requires Le(X) but is inhibited by sLe(X).

Li C, Wong P, Pan T, Xiao F, Yin S, Chang B, Kang SC, Ironside J, Sy MS.

Biochem J. 2007 Sep 1;406(2):333-41.


Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans.

Yin S, Pham N, Yu S, Li C, Wong P, Chang B, Kang SC, Biasini E, Tien P, Harris DA, Sy MS.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7546-51. Epub 2007 Apr 24.


Early onset fatal familial insomnia with rapid progression in a Chinese family line.

Yu S, Zhang Y, Li S, Sy MS, Sun S, Tien P, Xiao G.

J Neurol. 2007 Sep;254(9):1300-1. Epub 2007 Mar 25. No abstract available.


Aggregation of prion protein with insertion mutations is proportional to the number of inserts.

Yu S, Yin S, Li C, Wong P, Chang B, Xiao F, Kang SC, Yan H, Xiao G, Tien P, Sy MS.

Biochem J. 2007 Apr 15;403(2):343-51.


Prion protein in milk.

Franscini N, El Gedaily A, Matthey U, Franitza S, Sy MS, Bürkle A, Groschup M, Braun U, Zahn R.

PLoS One. 2006 Dec 20;1:e71.


Altered prion protein glycosylation in the aging mouse brain.

Goh AX, Li C, Sy MS, Wong BS.

J Neurochem. 2007 Feb;100(3):841-54. Epub 2006 Nov 27.


Test for detection of disease-associated prion aggregate in the blood of infected but asymptomatic animals.

Chang B, Cheng X, Yin S, Pan T, Zhang H, Wong P, Kang SC, Xiao F, Yan H, Li C, Wolfe LL, Miller MW, Wisniewski T, Greene MI, Sy MS.

Clin Vaccine Immunol. 2007 Jan;14(1):36-43. Epub 2006 Nov 1.


Novel single chain antibodies to the prion protein identified by phage display.

Adamson CS, Yao Y, Vasiljevic S, Sy MS, Ren J, Jones IM.

Virology. 2007 Feb 5;358(1):166-77. Epub 2006 Sep 25.


Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.

Pankiewicz J, Prelli F, Sy MS, Kascsak RJ, Kascsak RB, Spinner DS, Carp RI, Meeker HC, Sadowski M, Wisniewski T.

Eur J Neurosci. 2006 May;23(10):2635-47.


Prion proteins with insertion mutations have altered N-terminal conformation and increased ligand binding activity and are more susceptible to oxidative attack.

Yin S, Yu S, Li C, Wong P, Chang B, Xiao F, Kang SC, Yan H, Xiao G, Grassi J, Tien P, Sy MS.

J Biol Chem. 2006 Apr 21;281(16):10698-705. Epub 2006 Feb 14.


KDEL-tagged anti-prion intrabodies impair PrP lysosomal degradation and inhibit scrapie infectivity.

Vetrugno V, Cardinale A, Filesi I, Mattei S, Sy MS, Pocchiari M, Biocca S.

Biochem Biophys Res Commun. 2005 Dec 30;338(4):1791-7. Epub 2005 Nov 2.


An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates.

Pan T, Chang B, Wong P, Li C, Li R, Kang SC, Robinson JD, Thompsett AR, Tein P, Yin S, Barnard G, McConnell I, Brown DR, Wisniewski T, Sy MS.

J Virol. 2005 Oct;79(19):12355-64.


Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models.

Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, Yuan J, Zheng M, Bai H, Deng H, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG, Gambetti P.

J Neurosci. 2005 Aug 31;25(35):7944-9.


Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract.

Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL.

J Clin Pathol. 2005 Jul;58(7):687-94.


Mucosal vaccination delays or prevents prion infection via an oral route.

Goñi F, Knudsen E, Schreiber F, Scholtzova H, Pankiewicz J, Carp R, Meeker HC, Rubenstein R, Brown DR, Sy MS, Chabalgoity JA, Sigurdsson EM, Wisniewski T.

Neuroscience. 2005;133(2):413-21.


Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding.

Zaidi SI, Richardson SL, Capellari S, Song L, Smith MA, Ghetti B, Sy MS, Gambetti P, Petersen RB.

J Alzheimers Dis. 2005 Apr;7(2):159-71; discussion 173-80.


Biochemical fingerprints of prion diseases: scrapie prion protein in human prion diseases that share prion genotype and type.

Pan T, Li R, Kang SC, Pastore M, Wong BS, Ironside J, Gambetti P, Sy MS.

J Neurochem. 2005 Jan;92(1):132-42.

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