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Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.
Carson JR, Carmosin RJ, Pitis PM, Vaught JL, Almond HR, Stables JP, Wolf HH, Swinyard EA, White HS.
J Med Chem. 1997 May 23;40(11):1578-84.
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Analysis of anticonvulsant and neurotoxic responses to combination therapy with carbamazepine, felbamate and phenytoin by response-surface modeling.
Gennings C, Sofia RD, Carchman RA, Carter WH Jr, Swinyard EA.
Arzneimittelforschung. 1995 Jul;45(7):739-48.
Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol .
White HS, Hunt J, Wolf HH, Swinyard EA, Falch E, Krogsgaard-Larsen P, Schousboe A.
Eur J Pharmacol. 1993 May 12;236(1):147-9.
Characterization of the anticonvulsant properties of F-721.
Swinyard EA, Wolf HH, White HS, Skeen GA, Stark LG, Albertson T, Pong SF, Drust EG.
Epilepsy Res. 1993 May;15(1):35-45.
A neuropharmacological evaluation of felbamate as a novel anticonvulsant.
White HS, Wolf HH, Swinyard EA, Skeen GA, Sofia RD.
Epilepsia. 1992 May-Jun;33(3):564-72.
Anticonvulsant profiles of the potent and orally active GABA uptake inhibitors SK&F 89976-A and SK&F 100330-A and four prototype antiepileptic drugs in mice and rats.
Swinyard EA, White HS, Wolf HH, Bondinell WE.
Epilepsia. 1991 Jul-Aug;32(4):569-77.
Preclinical profile of stereoisomers of the anticonvulsant remacemide in mice.
Palmer GC, Stagnitto ML, Ordy JM, Griffith RC, Napier JJ, Gentile RJ, Woodhead JH, White HS, Swinyard EA.
Epilepsy Res. 1991 Jan-Feb;8(1):36-48.
AHR-12245: a potential anti-absence drug.
Johnson DN, White HS, Swinyard EA, Albertson TE, Kilpatrick BF.
Epilepsy Res. 1991 Jan-Feb;8(1):64-70.
Comparison of midazolam and diazepam by the intramuscular route for the control of seizures in a mouse model of status epilepticus.
Raines A, Henderson TR, Swinyard EA, Dretchen KL.
Epilepsia. 1990 May-Jun;31(3):313-7.
Pharmacodynamics and pharmacokinetics of AHR-11748, a new antiepileptic agent, in rodents.
Johnson DN, Osman MA, Cheng LK, Swinyard EA.
Epilepsy Res. 1990 Apr;5(3):185-91.
Status of PR 934-423, a novel anticonvulsant targeted for generalized tonic/clonic seizures (new designation is FPL 12924AA).
Palmer GC, Harris EW, Napier JJ, Stagnitto ML, Garske GE, Griffith RC, Swinyard EA.
Prog Clin Biol Res. 1990;361:435-41. Review. No abstract available.
Effect of the selective N-methyl-D-aspartate receptor agonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid on [3H]flunitrazepam binding.
White HS, Bender AS, Swinyard EA.
Eur J Pharmacol. 1988 Feb 16;147(1):149-51. No abstract available.
Hypnotic action of pentobarbital in mice: a possible mechanism.
Chweh AY, Swinyard EA, Wolf HH.
Exp Neurol. 1987 Jul;97(1):70-6.
The effect of chronic felbamate administration on anticonvulsant activity and hepatic drug-metabolizing enzymes in mice and rats.
Swinyard EA, Woodhead JH, Franklin MR, Sofia RD, Kupferberg HJ.
Epilepsia. 1987 May-Jun;28(3):295-300.
Correlation of the hypnotic potency of benzodiazepines with inhibition of voltage-dependent calcium uptake into mouse brain synaptosomes.
Leslie SW, Chandler LJ, Chweh AY, Swinyard EA.
Eur J Pharmacol. 1986 Jul 15;126(1-2):129-34.
Involvement of a GABAergic mechanism in the pharmacologic action of phenytoin.
Pharmacol Biochem Behav. 1986 May;24(5):1301-4.
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
Lin-Michell E, Chweh AY, Swinyard EA.
J Pharmacol Exp Ther. 1986 May;237(2):486-9.
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
Ulloque RA, Chweh AY, Swinyard EA.
J Pharmacol Exp Ther. 1986 May;237(2):468-72.
Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice.
Chweh AY, Ulloque RA, Swinyard EA.
Eur J Pharmacol. 1986 Mar 18;122(2):161-5.
Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats.
Swinyard EA, Sofia RD, Kupferberg HJ.
Epilepsia. 1986 Jan-Feb;27(1):27-34.
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Coleman JC, Shenoy AK, Chweh AY, Swinyard EA.
Life Sci. 1985 Aug 26;37(8):749-55.
Antiepileptic drugs: detection, quantification, and evaluation.
Swinyard EA, Kupferberg HJ.
Fed Proc. 1985 Jul;44(10):2629-33.
Effect of picrotoxinin on benzodiazepine receptor binding.
Chweh AY, Ulloque RA, Swinyard EA, Wolf HH.
Neurochem Res. 1985 Jul;10(7):871-7.
gamma-Aminobutyric acid: temperature dependence in benzodiazepine receptor binding.
J Neurochem. 1985 Jul;45(1):240-3.
Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice.
Neurosci Lett. 1985 Jun 24;57(3):279-82.
gamma-Aminobutyric acid modulation of benzodiazepine receptor binding in vitro does not predict the pharmacologic activity of all benzodiazepine receptor ligands.
Neurosci Lett. 1985 Mar 15;54(2-3):173-7.
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Piredda SG, Woodhead JH, Swinyard EA.
J Pharmacol Exp Ther. 1985 Mar;232(3):741-5.
Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines.
Chweh AY, Swinyard EA, Wolf HH, Kupferberg HJ.
Life Sci. 1985 Feb 25;36(8):737-44.
Anticonvulsant activity and neurotoxicity of piperonyl butoxide in mice.
Ater SB, Swinyard EA, Tolman KG, Franklin MR.
Epilepsia. 1984 Oct;25(5):551-5.
Effects of SKF525A, phenobarbital, fasting, and carnitine on the anticonvulsant activity and neurotoxicity of valproate in mice.
Ater SB, Swinyard EA, Tolman KG, Madsen JA, Matsuo F.
Epilepsia. 1984 Oct;25(5):599-604.
Hypnotic action of benzodiazepines: a possible mechanism.
Chweh AY, Lin YB, Swinyard EA.
Life Sci. 1984 Apr 30;34(18):1763-8.
Benzodiazepine inhibition of flunitrazepam receptor binding, adenosine uptake, and pentylenetetrazol-induced seizures in mice.
Can J Physiol Pharmacol. 1984 Jan;62(1):132-5.
Correlations among minimal neurotoxicity, anticonvulsant activity, and displacing potencies in [3H]flunitrazepam binding of benzodiazepines.
Epilepsia. 1983 Dec;24(6):668-77.
Pentylenetetrazol may discriminate between different types of benzodiazepine receptors.
J Neurochem. 1983 Sep;41(3):830-3.
Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats.
Shenoy AK, Miyahara JT, Swinyard EA, Kupferberg HJ.
Epilepsia. 1982 Aug;23(4):399-408.
Altered neurochemical parameters in the brains of mice (Frings) susceptible to audiogenic seizures.
Bakhit C, Shenoy AK, Swinyard EA, Gibb JW.
Brain Res. 1982 Jul 22;244(1):45-52.
Influence of maximal audiogenic or electroshock seizures on the release of 3H-GABA from mouse brain in vitro.
Shenoy AK, Miyahara JT, Swinyard EA.
Proc West Pharmacol Soc. 1981;24:89-91. No abstract available.
History of the antiepileptic drugs.
Swinyard EA.
Adv Neurol. 1980;27:1-9. No abstract available.
Drug contamination of mortars and pestles.
Swinyard EA, Woodhead JH.
J Pharm Sci. 1978 Dec;67(12):1758-9.
Antiepileptic drug development: II. Anticonvulsant drug screening.
Krall RL, Penry JK, White BG, Kupferberg HJ, Swinyard EA.
Epilepsia. 1978 Aug;19(4):409-28. No abstract available.
Antiepileptic drug development: I. History and a program for progress.
Krall RL, Penry JK, Kupferberg HJ, Swinyard EA.
Epilepsia. 1978 Aug;19(4):393-408. No abstract available.
Research and graduate education in pharmacy: looking back--looking forward.
Am J Pharm Educ. 1977 Nov;41(4):409-14. No abstract available.
Nonspecific effect of bis(2-ethylhexyl) phthalate on hexobarbital sleep time.
Swinyard EA, Woodhead JH, Petersen RV.
J Pharm Sci. 1976 May;65(5):733-4.
Effect of diphenylhydantoin on hexobarbital sleep time in mice and rats.
Kemp JW, Tannhauser M, Swinyard EA.
Arch Int Pharmacodyn Ther. 1971 Sep;193(1):37-47. No abstract available.
6-sulfanilamidoindazole induced arthritis and periarthritis in rats. A new model of experimental inflammation.
Miller ML, Ward JR, Cole BC, Swinyard EA.
Arthritis Rheum. 1970 May-Jun;13(3):222-35. No abstract available.
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Epilepsia. 1969 Jun;10(2):107-19. Review. No abstract available.
Anticonvulsant properties of some benzodiazepines.
Swinyard EA, Castellion AW.
J Pharmacol Exp Ther. 1966 Mar;151(3):369-75. No abstract available.
Effect of maturation on the development and reproducibility of audiogenic and electroshock seizures in mice.
Castellion AW, Swinyard EA, Goodman LS.
Exp Neurol. 1965 Oct;13(2):206-17. No abstract available.
EFFECT OF EPINEPHRINE AND NOREPINEPHRINE ON EXCITABILITY OF CENTRAL NERVOUS SYSTEM OF MICE.
SWINYARD EA, BOSON FC, GOODMAN LS.
J Pharmacol Exp Ther. 1964 Apr;144:52-9. No abstract available.
THE EFFECT OF EXPERIMENTALLY-INDUCED STRESS ON PENTYLENETETRAZOL SEIZURE THRESHOLD IN MICE.
SWINYARD EA, MIYAHARA JT, CLARK LD, GOODMAN LS.
Psychopharmacologia. 1963 Jul 2;4:343-53. No abstract available.
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