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Items: 1 to 50 of 116

1.

Lipid metabolism in cancer cells under metabolic stress.

Munir R, Lisec J, Swinnen JV, Zaidi N.

Br J Cancer. 2019 Jun;120(12):1090-1098. doi: 10.1038/s41416-019-0451-4. Epub 2019 May 16. Review.

PMID:
31092908
2.

Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption.

Gianfrancesco MA, Dehairs J, L'homme L, Herinckx G, Esser N, Jansen O, Habraken Y, Lassence C, Swinnen JV, Rider MH, Piette J, Paquot N, Legrand-Poels S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1017-1030. doi: 10.1016/j.bbalip.2019.04.001. Epub 2019 Apr 4.

PMID:
30953761
3.

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM.

Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6.

PMID:
30728499
4.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P.

Cell Metab. 2018 Dec 4;28(6):866-880.e15. doi: 10.1016/j.cmet.2018.07.019. Epub 2018 Aug 23.

PMID:
30146486
5.

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.

Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F, Duarte JAG, Bosisio F, Van den Eynde K, Nys K, Pérez MV, Agostinis P, Waelkens E, Van den Oord J, Fendt SM, Marine JC, Swinnen JV.

Nat Commun. 2018 Jun 27;9(1):2500. doi: 10.1038/s41467-018-04664-0.

6.

Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway.

Khan NA, Garg AD, Agostinis P, Swinnen JV.

Oncotarget. 2017 Dec 16;9(3):3507-3518. doi: 10.18632/oncotarget.23335. eCollection 2018 Jan 9.

7.

Lipid degradation promotes prostate cancer cell survival.

Itkonen HM, Brown M, Urbanucci A, Tredwell G, Ho Lau C, Barfeld S, Hart C, Guldvik IJ, Takhar M, Heemers HV, Erho N, Bloch K, Davicioni E, Derua R, Waelkens E, Mohler JL, Clarke N, Swinnen JV, Keun HC, Rekvig OP, Mills IG.

Oncotarget. 2017 Jun 13;8(24):38264-38275. doi: 10.18632/oncotarget.16123.

8.

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

EV-TRACK Consortium, Van Deun J, Mestdagh P, Agostinis P, Akay Ö, Anand S, Anckaert J, Martinez ZA, Baetens T, Beghein E, Bertier L, Berx G, Boere J, Boukouris S, Bremer M, Buschmann D, Byrd JB, Casert C, Cheng L, Cmoch A, Daveloose D, De Smedt E, Demirsoy S, Depoorter V, Dhondt B, Driedonks TA, Dudek A, Elsharawy A, Floris I, Foers AD, Gärtner K, Garg AD, Geeurickx E, Gettemans J, Ghazavi F, Giebel B, Kormelink TG, Hancock G, Helsmoortel H, Hill AF, Hyenne V, Kalra H, Kim D, Kowal J, Kraemer S, Leidinger P, Leonelli C, Liang Y, Lippens L, Liu S, Lo Cicero A, Martin S, Mathivanan S, Mathiyalagan P, Matusek T, Milani G, Monguió-Tortajada M, Mus LM, Muth DC, Németh A, Nolte-'t Hoen EN, O'Driscoll L, Palmulli R, Pfaffl MW, Primdal-Bengtson B, Romano E, Rousseau Q, Sahoo S, Sampaio N, Samuel M, Scicluna B, Soen B, Steels A, Swinnen JV, Takatalo M, Thaminy S, Théry C, Tulkens J, Van Audenhove I, van der Grein S, Van Goethem A, van Herwijnen MJ, Van Niel G, Van Roy N, Van Vliet AR, Vandamme N, Vanhauwaert S, Vergauwen G, Verweij F, Wallaert A, Wauben M, Witwer KW, Zonneveld MI, De Wever O, Vandesompele J, Hendrix A.

Nat Methods. 2017 Feb 28;14(3):228-232. doi: 10.1038/nmeth.4185.

PMID:
28245209
9.

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency.

Tharkeshwar AK, Trekker J, Vermeire W, Pauwels J, Sannerud R, Priestman DA, Te Vruchte D, Vints K, Baatsen P, Decuypere JP, Lu H, Martin S, Vangheluwe P, Swinnen JV, Lagae L, Impens F, Platt FM, Gevaert K, Annaert W.

Sci Rep. 2017 Jan 30;7:41408. doi: 10.1038/srep41408.

10.

Longitudinal microcomputed tomography-derived biomarkers for lung metastasis detection in a syngeneic mouse model: added value to bioluminescence imaging.

Marien E, Hillen A, Vanderhoydonc F, Swinnen JV, Vande Velde G.

Lab Invest. 2017 Jan;97(1):24-33. doi: 10.1038/labinvest.2016.114. Epub 2016 Nov 21.

11.

Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma.

Janky R, Binda MM, Allemeersch J, Van den Broeck A, Govaere O, Swinnen JV, Roskams T, Aerts S, Topal B.

BMC Cancer. 2016 Aug 12;16:632. doi: 10.1186/s12885-016-2540-6.

12.

CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing.

Dehairs J, Talebi A, Cherifi Y, Swinnen JV.

Sci Rep. 2016 Jul 1;6:28973. doi: 10.1038/srep28973.

13.

Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism.

Cai Y, Crowther J, Pastor T, Abbasi Asbagh L, Baietti MF, De Troyer M, Vazquez I, Talebi A, Renzi F, Dehairs J, Swinnen JV, Sablina AA.

Cancer Cell. 2016 May 9;29(5):751-766. doi: 10.1016/j.ccell.2016.04.003.

14.

Androgen control of lipid metabolism in prostate cancer: novel insights and future applications.

Butler LM, Centenera MM, Swinnen JV.

Endocr Relat Cancer. 2016 May;23(5):R219-27. doi: 10.1530/ERC-15-0556. Epub 2016 Apr 29. Review.

PMID:
27130044
15.

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma.

Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette-Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV.

Oncotarget. 2016 Mar 15;7(11):12582-97. doi: 10.18632/oncotarget.7179.

16.

Identification of drugs that restore primary cilium expression in cancer cells.

Khan NA, Willemarck N, Talebi A, Marchand A, Binda MM, Dehairs J, Rueda-Rincon N, Daniels VW, Bagadi M, Thimiri Govinda Raj DB, Vanderhoydonc F, Munck S, Chaltin P, Swinnen JV.

Oncotarget. 2016 Mar 1;7(9):9975-92. doi: 10.18632/oncotarget.7198.

17.

Mammalian models of chemically induced primary malignancies exploitable for imaging-based preclinical theragnostic research.

Liu Y, Yin T, Feng Y, Cona MM, Huang G, Liu J, Song S, Jiang Y, Xia Q, Swinnen JV, Bormans G, Himmelreich U, Oyen R, Ni Y.

Quant Imaging Med Surg. 2015 Oct;5(5):708-29. doi: 10.3978/j.issn.2223-4292.2015.06.01. Review.

18.

Lipidomics in drug development.

Dehairs J, Derua R, Rueda-Rincon N, Swinnen JV.

Drug Discov Today Technol. 2015 Jun;13:33-8. doi: 10.1016/j.ddtec.2015.03.002. Epub 2015 May 7. Review.

PMID:
26190681
19.

p53 attenuates AKT signaling by modulating membrane phospholipid composition.

Rueda-Rincon N, Bloch K, Derua R, Vyas R, Harms A, Hankemeier T, Khan NA, Dehairs J, Bagadi M, Binda MM, Waelkens E, Marine JC, Swinnen JV.

Oncotarget. 2015 Aug 28;6(25):21240-54.

20.

Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.

Gijs HL, Willemarck N, Vanderhoydonc F, Khan NA, Dehairs J, Derua R, Waelkens E, Taketomi Y, Murakami M, Agostinis P, Annaert W, Swinnen JV.

Mol Biol Cell. 2015 Jun 15;26(12):2321-32. doi: 10.1091/mbc.E14-10-1472. Epub 2015 Apr 22.

21.

Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles.

Marien E, Meister M, Muley T, Fieuws S, Bordel S, Derua R, Spraggins J, Van de Plas R, Dehairs J, Wouters J, Bagadi M, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Waelkens E, Swinnen JV.

Int J Cancer. 2015 Oct 1;137(7):1539-48. doi: 10.1002/ijc.29517. Epub 2015 Apr 7.

22.

Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs.

Leyssens C, Marien E, Verlinden L, Derua R, Waelkens E, Swinnen JV, Verstuyf A.

J Steroid Biochem Mol Biol. 2015 Apr;148:172-8. doi: 10.1016/j.jsbmb.2015.01.018. Epub 2015 Jan 24. Review.

PMID:
25625664
23.

Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells.

Martin S, Dudek-Perić AM, Maes H, Garg AD, Gabrysiak M, Demirsoy S, Swinnen JV, Agostinis P.

Biochem Pharmacol. 2015 Feb 1;93(3):290-304. doi: 10.1016/j.bcp.2014.12.003. Epub 2014 Dec 18.

PMID:
25529535
24.

Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment.

Daniëls VW, Smans K, Royaux I, Chypre M, Swinnen JV, Zaidi N.

PLoS One. 2014 Sep 12;9(9):e106913. doi: 10.1371/journal.pone.0106913. eCollection 2014.

25.

Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids.

Zaidi N, Lupien L, Kuemmerle NB, Kinlaw WB, Swinnen JV, Smans K.

Prog Lipid Res. 2013 Oct;52(4):585-9. doi: 10.1016/j.plipres.2013.08.005. Epub 2013 Aug 31. Review.

26.

Evaluation of androgen-induced effects on the uptake of [18F]FDG, [11C]choline and [11C]acetate in an androgen-sensitive and androgen-independent prostate cancer xenograft model.

Emonds KM, Swinnen JV, Lerut E, Koole M, Mortelmans L, Mottaghy FM.

EJNMMI Res. 2013 Apr 24;3(1):31. doi: 10.1186/2191-219X-3-31.

27.

ATP-citrate lyase: a key player in cancer metabolism.

Zaidi N, Swinnen JV, Smans K.

Cancer Res. 2012 Aug 1;72(15):3709-14. doi: 10.1158/0008-5472.CAN-11-4112. Epub 2012 Jul 10. Review.

28.

ATP citrate lyase knockdown induces growth arrest and apoptosis through different cell- and environment-dependent mechanisms.

Zaidi N, Royaux I, Swinnen JV, Smans K.

Mol Cancer Ther. 2012 Sep;11(9):1925-35. doi: 10.1158/1535-7163.MCT-12-0095. Epub 2012 Jun 20.

29.

The development of an inducible androgen receptor knockout model in mouse to study the postmeiotic effects of androgens on germ cell development.

Willems A, De Gendt K, Deboel L, Swinnen JV, Verhoeven G.

Spermatogenesis. 2011 Oct;1(4):341-353. Epub 2011 Oct 1.

30.

5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells.

Isebaert SF, Swinnen JV, McBride WH, Begg AC, Haustermans KM.

Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1515-23. doi: 10.1016/j.ijrobp.2011.06.1964. Epub 2011 Sep 21.

PMID:
21944462
31.

Insulin-like growth factor-type 1 receptor inhibitor NVP-AEW541 enhances radiosensitivity of PTEN wild-type but not PTEN-deficient human prostate cancer cells.

Isebaert SF, Swinnen JV, McBride WH, Haustermans KM.

Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):239-47. doi: 10.1016/j.ijrobp.2011.03.030.

PMID:
21816290
32.

Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis.

Peeters A, Swinnen JV, Van Veldhoven PP, Baes M.

Biochimie. 2011 Oct;93(10):1828-38. doi: 10.1016/j.biochi.2011.06.034. Epub 2011 Jul 5.

PMID:
21756965
33.

Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells.

De Gendt K, Denolet E, Willems A, Daniels VW, Clinckemalie L, Denayer S, Wilkinson MF, Claessens F, Swinnen JV, Verhoeven G.

Biol Reprod. 2011 Nov;85(5):934-45. doi: 10.1095/biolreprod.110.090704. Epub 2011 Jul 6.

34.

Do androgens control the uptake of 18F-FDG, 11C-choline and 11C-acetate in human prostate cancer cell lines?

Emonds KM, Swinnen JV, van Weerden WM, Vanderhoydonc F, Nuyts J, Mortelmans L, Mottaghy FM.

Eur J Nucl Med Mol Imaging. 2011 Oct;38(10):1842-53. doi: 10.1007/s00259-011-1861-6. Epub 2011 Jul 6.

PMID:
21732108
35.

Lipoprotein lipase links dietary fat to solid tumor cell proliferation.

Kuemmerle NB, Rysman E, Lombardo PS, Flanagan AJ, Lipe BC, Wells WA, Pettus JR, Froehlich HM, Memoli VA, Morganelli PM, Swinnen JV, Timmerman LA, Chaychi L, Fricano CJ, Eisenberg BL, Coleman WB, Kinlaw WB.

Mol Cancer Ther. 2011 Mar;10(3):427-36. doi: 10.1158/1535-7163.MCT-10-0802. Epub 2011 Jan 31.

36.

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.

Willems A, Batlouni SR, Esnal A, Swinnen JV, Saunders PT, Sharpe RM, França LR, De Gendt K, Verhoeven G.

PLoS One. 2010 Nov 30;5(11):e14168. doi: 10.1371/journal.pone.0014168.

37.

Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.

Willemarck N, Rysman E, Brusselmans K, Van Imschoot G, Vanderhoydonc F, Moerloose K, Lerut E, Verhoeven G, van Roy F, Vleminckx K, Swinnen JV.

Cancer Res. 2010 Nov 15;70(22):9453-62. doi: 10.1158/0008-5472.CAN-10-2324. Epub 2010 Oct 1.

38.

De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.

Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, Van Veldhoven PP, Waltregny D, Daniëls VW, Machiels J, Vanderhoydonc F, Smans K, Waelkens E, Verhoeven G, Swinnen JV.

Cancer Res. 2010 Oct 15;70(20):8117-26. doi: 10.1158/0008-5472.CAN-09-3871. Epub 2010 Sep 28.

39.

Androgens and spermatogenesis: lessons from transgenic mouse models.

Verhoeven G, Willems A, Denolet E, Swinnen JV, De Gendt K.

Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1537-56. doi: 10.1098/rstb.2009.0117. Review.

40.

Fatty acid synthesis is a therapeutic target in human liposarcoma.

Olsen AM, Eisenberg BL, Kuemmerle NB, Flanagan AJ, Morganelli PM, Lombardo PS, Swinnen JV, Kinlaw WB.

Int J Oncol. 2010 May;36(5):1309-14.

41.

Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment.

De Gendt K, McKinnell C, Willems A, Saunders PT, Sharpe RM, Atanassova N, Swinnen JV, Verhoeven G.

Biol Reprod. 2009 Dec;81(6):1083-92. doi: 10.1095/biolreprod.109.078360. Epub 2009 Jul 8.

PMID:
19587329
42.

Early effects of Sertoli cell-selective androgen receptor ablation on testicular gene expression.

Willems A, De Gendt K, Allemeersch J, Smith LB, Welsh M, Swinnen JV, Verhoeven G.

Int J Androl. 2010 Jun 1;33(3):507-17. doi: 10.1111/j.1365-2605.2009.00964.x. Epub 2009 Apr 12.

PMID:
19392831
43.

Molecular imaging of prostate cancer.

Emonds KM, Swinnen JV, Mortelmans L, Mottaghy FM.

Methods. 2009 Jun;48(2):193-9. doi: 10.1016/j.ymeth.2009.03.021. Epub 2009 Apr 9. Review.

PMID:
19362147
44.

Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells.

Beckers A, Organe S, Timmermans L, Scheys K, Peeters A, Brusselmans K, Verhoeven G, Swinnen JV.

Cancer Res. 2007 Sep 1;67(17):8180-7.

45.

Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.

Brusselmans K, Timmermans L, Van de Sande T, Van Veldhoven PP, Guan G, Shechter I, Claessens F, Verhoeven G, Swinnen JV.

J Biol Chem. 2007 Jun 29;282(26):18777-85. Epub 2007 May 5.

46.

Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model.

Schauwaers K, De Gendt K, Saunders PT, Atanassova N, Haelens A, Callewaert L, Moehren U, Swinnen JV, Verhoeven G, Verrijdt G, Claessens F.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4961-6. Epub 2007 Mar 12.

47.

Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

Beckers A, Organe S, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, Brusselmans K, Verhoeven G, Swinnen JV.

Mol Cancer Ther. 2006 Sep;5(9):2211-7.

48.

Increased lipogenesis in cancer cells: new players, novel targets.

Swinnen JV, Brusselmans K, Verhoeven G.

Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):358-65. Review.

PMID:
16778563
49.

Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model.

Venken K, De Gendt K, Boonen S, Ophoff J, Bouillon R, Swinnen JV, Verhoeven G, Vanderschueren D.

J Bone Miner Res. 2006 Apr;21(4):576-85. Epub 2006 Apr 5.

50.

Androgen activation of the sterol regulatory element-binding protein pathway: Current insights.

Heemers HV, Verhoeven G, Swinnen JV.

Mol Endocrinol. 2006 Oct;20(10):2265-77. Epub 2006 Feb 2. Review.

PMID:
16455816

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