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[Iron supplementation in iron deficiency anaemia].

van Heek J, Swinkels DW, Kramers K, de Wit HAJM, Rennings AJM.

Ned Tijdschr Geneeskd. 2019 Oct 1;163. pii: D3674. Dutch.


The multifaceted role of iron in renal health and disease.

van Swelm RPL, Wetzels JFM, Swinkels DW.

Nat Rev Nephrol. 2019 Sep 25. doi: 10.1038/s41581-019-0197-5. [Epub ahead of print] Review.


Twenty Years of Ferroportin Disease: A Review or An Update of Published Clinical, Biochemical, Molecular, and Functional Features.

Vlasveld LT, Janssen R, Bardou-Jacquet E, Venselaar H, Hamdi-Roze H, Drakesmith H, Swinkels DW.

Pharmaceuticals (Basel). 2019 Sep 9;12(3). pii: E132. doi: 10.3390/ph12030132. Review.


Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing.

Diepeveen LE, Laarakkers CM, Peters HPE, van Herwaarden AE, Groenewoud H, IntHout J, Wetzels JF, van Swelm RPL, Swinkels DW.

Pharmaceuticals (Basel). 2019 Aug 23;12(3). pii: E123. doi: 10.3390/ph12030123.


Mucosal lactoferrin response to genital tract infections is associated with iron and nutritional biomarkers in young Burkinabé women.

Roberts SA, Brabin L, Diallo S, Gies S, Nelson A, Stewart C, Swinkels DW, Geurts-Moespot AJ, Kazienga A, Ouedraogo S, D'Alessandro U, Tinto H, Brabin BJ.

Eur J Clin Nutr. 2019 Nov;73(11):1464-1472. doi: 10.1038/s41430-019-0444-7. Epub 2019 Jun 5.


Iron uptake by ZIP8 and ZIP14 in human proximal tubular epithelial cells.

van Raaij SEG, Srai SKS, Swinkels DW, van Swelm RPL.

Biometals. 2019 Apr;32(2):211-226. doi: 10.1007/s10534-019-00183-7. Epub 2019 Feb 26.


Malaria early in the first pregnancy: Potential impact of iron status.

Diallo S, Roberts SA, Gies S, Rouamba T, Swinkels DW, Geurts-Moespot AJ, Ouedraogo S, Ouedraogo GA, Tinto H, Brabin BJ.

Clin Nutr. 2019 Jan 26. pii: S0261-5614(19)30034-2. doi: 10.1016/j.clnu.2019.01.016. [Epub ahead of print]


Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia.

Kiers D, van Eijk LT, van der Hoeven JG, Swinkels DW, Pickkers P, Kox M.

Haematologica. 2019 Jun;104(6):e230-e232. doi: 10.3324/haematol.2018.202796. Epub 2019 Jan 17. No abstract available.


Iron handling by the human kidney: glomerular filtration and tubular reabsorption both contribute to urinary iron excretion.

van Raaij SEG, Rennings AJ, Biemond BJ, Schols SEM, Wiegerinck ETG, Roelofs HMJ, Hoorn EJ, Walsh SB, Nijenhuis T, Swinkels DW, van Swelm RPL.

Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F606-F614. doi: 10.1152/ajprenal.00425.2018. Epub 2019 Jan 9.


Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference material.

Diepeveen LE, Laarakkers CMM, Martos G, Pawlak ME, Uğuz FF, Verberne KESA, van Swelm RPL, Klaver S, de Haan AFJ, Pitts KR, Bansal SS, Abbas IM, Fillet M, Lefebvre T, Geurts-Moespot AJ, Girelli D, Castagna A, Herkert M, Itkonen O, Olbina G, Tomosugi N, Westerman ME, Delatour V, Weykamp CW, Swinkels DW.

Clin Chem Lab Med. 2019 May 27;57(6):864-872. doi: 10.1515/cclm-2018-0783.


Loss-of-function ferroportin disease: novel mechanistic insights and unanswered questions.

Vlasveld LT, Swinkels DW.

Haematologica. 2018 Nov;103(11):1753-1755. doi: 10.3324/haematol.2018.203315. No abstract available.


Chronic Adherence to a Ketogenic Diet Modifies Iron Metabolism in Elite Athletes.

McKay AKA, Peeling P, Pyne DB, Welvaert M, Tee N, Leckey JJ, Sharma AP, Ross MLR, Garvican-Lewis LA, Swinkels DW, Laarakkers CM, Burke LM.

Med Sci Sports Exerc. 2019 Mar;51(3):548-555. doi: 10.1249/MSS.0000000000001816.


Variable workup calls for guideline development for type 2A hereditary haemochromatosis.

Smit SL, Peters TMA, Gisbertz IAM, Moolenaar W, Hendriks Y, Vincent HH, Houtsma D, Loosveld OJL, van Herwaarden AE, Rennings AJM, Swinkels DW.

Neth J Med. 2018 Oct;76(8):365-373.


An intensified training schedule in recreational male runners is associated with increases in erythropoiesis and inflammation and a net reduction in plasma hepcidin.

Moretti D, Mettler S, Zeder C, Lundby C, Geurts-Moetspot A, Monnard A, Swinkels DW, Brittenham GM, Zimmermann MB.

Am J Clin Nutr. 2018 Dec 1;108(6):1324-1333. doi: 10.1093/ajcn/nqy247.


Association of anemia with health-related quality of life and survival: a large population-based cohort study.

Wouters HJCM, van der Klauw MM, de Witte T, Stauder R, Swinkels DW, Wolffenbuttel BHR, Huls G.

Haematologica. 2019 Mar;104(3):468-476. doi: 10.3324/haematol.2018.195552. Epub 2018 Oct 11.


Role of the Complement System in Chronic Central Serous Chorioretinopathy: A Genome-Wide Association Study.

Schellevis RL, van Dijk EHC, Breukink MB, Altay L, Bakker B, Koeleman BPC, Kiemeney LA, Swinkels DW, Keunen JEE, Fauser S, Hoyng CB, den Hollander AI, Boon CJF, de Jong EK.

JAMA Ophthalmol. 2018 Oct 1;136(10):1128-1136. doi: 10.1001/jamaophthalmol.2018.3190.


The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2.

Riley LG, Heeney MM, Rudinger-Thirion J, Frugier M, Campagna DR, Zhou R, Hale GA, Hilliard LM, Kaplan JA, Kwiatkowski JL, Sieff CA, Steensma DP, Rennings AJ, Simons A, Schaap N, Roodenburg RJ, Kleefstra T, Arenillas L, Fita-Torró J, Ahmed R, Abboud M, Bechara E, Farah R, Tamminga RYJ, Bottomley SS, Sanchez M, Huls G, Swinkels DW, Christodoulou J, Fleming MD.

Haematologica. 2018 Dec;103(12):2008-2015. doi: 10.3324/haematol.2017.182659. Epub 2018 Jul 19.


Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells.

van Raaij SEG, Masereeuw R, Swinkels DW, van Swelm RPL.

Toxicol Lett. 2018 Oct 1;295:179-186. doi: 10.1016/j.toxlet.2018.06.1218. Epub 2018 Jun 28.


Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis.

van Swelm RPL, Vos M, Verhoeven F, Thévenod F, Swinkels DW.

Cell Death Dis. 2018 May 1;9(5):550. doi: 10.1038/s41419-018-0568-z.


Effects of Weekly Iron and Folic Acid Supplements on Malaria Risk in Nulliparous Women in Burkina Faso: A Periconceptional, Double-Blind, Randomized Controlled Noninferiority Trial.

Gies S, Diallo S, Roberts SA, Kazienga A, Powney M, Brabin L, Ouedraogo S, Swinkels DW, Geurts-Moespot AJ, Claeys Y, D'Alessandro U, Tinto H, Faragher B, Brabin B.

J Infect Dis. 2018 Aug 24;218(7):1099-1109. doi: 10.1093/infdis/jiy257.


Biochemical Effects on the Liver of 1 Month of Alcohol Abstinence in Moderate Alcohol Consumers.

Munsterman ID, Groefsema MM, Weijers G, Klein WM, Swinkels DW, Drenth JPH, Schellekens AFA, Tjwa ETTL.

Alcohol Alcohol. 2018 Jul 1;53(4):435-438. doi: 10.1093/alcalc/agy031.


Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function.

Hoes MF, Grote Beverborg N, Kijlstra JD, Kuipers J, Swinkels DW, Giepmans BNG, Rodenburg RJ, van Veldhuisen DJ, de Boer RA, van der Meer P.

Eur J Heart Fail. 2018 May;20(5):910-919. doi: 10.1002/ejhf.1154. Epub 2018 Feb 27.


A Stepwise Procedure to Define a Data Collection Framework for a Clinical Biobank.

Manders P, Peters TMA, Siezen AE, van Rooij IALM, Snijder R, Swinkels DW, Zielhuis GA.

Biopreserv Biobank. 2018 Apr;16(2):138-147. doi: 10.1089/bio.2017.0084. Epub 2018 Feb 13.


Definition of Iron Deficiency Based on the Gold Standard of Bone Marrow Iron Staining in Heart Failure Patients.

Grote Beverborg N, Klip IT, Meijers WC, Voors AA, Vegter EL, van der Wal HH, Swinkels DW, van Pelt J, Mulder AB, Bulstra SK, Vellenga E, Mariani MA, de Boer RA, van Veldhuisen DJ, van der Meer P.

Circ Heart Fail. 2018 Feb;11(2):e004519. doi: 10.1161/CIRCHEARTFAILURE.117.004519.


Utility of zinc protoporphyrin in management of whole blood donors.

Schotten N, Zalpuri S, Pasker-de Jong PCM, Swinkels DW, van den Hurk K, de Kort WLAM, van Kraaij MGJ, van Noord PAH.

Transfusion. 2018 Mar;58(3):692-700. doi: 10.1111/trf.14480. Epub 2018 Jan 26.


Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey.

Hohlbaum AM, Gille H, Trentmann S, Kolodziejczyk M, Rattenstetter B, Laarakkers CM, Katzmann G, Christian HJ, Andersen N, Allersdorfer A, Olwill SA, Meibohm B, Audoly LP, Swinkels DW, van Swelm RPL.

Br J Pharmacol. 2018 Apr;175(7):1054-1065. doi: 10.1111/bph.14143. Epub 2018 Feb 23.


Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromes.

de Swart L, Reiniers C, Bagguley T, van Marrewijk C, Bowen D, Hellström-Lindberg E, Tatic A, Symeonidis A, Huls G, Cermak J, van de Loosdrecht AA, Garelius H, Culligan D, Macheta M, Spanoudakis M, Panagiotidis P, Krejci M, Blijlevens N, Langemeijer S, Droste J, Swinkels DW, Smith A, de Witte T; EUMDS Steering Committee.

Haematologica. 2018 Jan;103(1):69-79. doi: 10.3324/haematol.2017.171884. Epub 2017 Nov 9.


Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials.

Stoffel NU, Cercamondi CI, Brittenham G, Zeder C, Geurts-Moespot AJ, Swinkels DW, Moretti D, Zimmermann MB.

Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9.


Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption.

Staroń R, Lipiński P, Lenartowicz M, Bednarz A, Gajowiak A, Smuda E, Krzeptowski W, Pieszka M, Korolonek T, Hamza I, Swinkels DW, Van Swelm RPL, Starzyński RR.

PLoS One. 2017 Jul 13;12(7):e0181117. doi: 10.1371/journal.pone.0181117. eCollection 2017.


Prediction of human iron bioavailability using rapid c-ELISAs for human plasma hepcidin.

Stoffel NU, Zeder C, Fort E, Swinkels DW, Zimmermann MB, Moretti D.

Clin Chem Lab Med. 2017 Jul 26;55(8):1186-1192. doi: 10.1515/cclm-2017-0097.


Factors influencing the post-exercise hepcidin-25 response in elite athletes.

Peeling P, McKay AKA, Pyne DB, Guelfi KJ, McCormick RH, Laarakkers CM, Swinkels DW, Garvican-Lewis LA, Ross MLR, Sharma AP, Leckey JJ, Burke LM.

Eur J Appl Physiol. 2017 Jun;117(6):1233-1239. doi: 10.1007/s00421-017-3611-3. Epub 2017 Apr 13.


A rare splice donor mutation in the haptoglobin gene associates with blood lipid levels and coronary artery disease.

Bjornsson E, Helgason H, Halldorsson G, Helgadottir A, Gylfason A, Kehr B, Jonasdottir A, Jonasdottir A, Sigurdsson A, Oddsson A, Thorleifsson G, Magnusson OT, Gretarsdottir S, Zink F, Kristjansson RP, Asgeirsdottir M, Swinkels DW, Kiemeney LA, Eyjolfsson GI, Sigurdardottir O, Masson G, Olafsson I, Thorgeirsson G, Holm H, Thorsteinsdottir U, Gudbjartsson DF, Sulem P, Stefansson K.

Hum Mol Genet. 2017 Jun 15;26(12):2364-2376. doi: 10.1093/hmg/ddx123.


Interleukin-6 and Hepcidin Levels during Hormone-Deplete and Hormone-Replete Phases of an Oral Contraceptive Cycle: A Pilot Study.

Sim M, Dawson B, Landers G, Swinkels DW, Wiegerinck E, Yeap BB, Trinder D, Peeling P.

Ann Nutr Metab. 2017;70(2):100-105. doi: 10.1159/000465530. Epub 2017 Mar 23.


Oral iron supplementation: Potential implications for the gut microbiome and metabolome in patients with CKD.

Kortman GAM, Reijnders D, Swinkels DW.

Hemodial Int. 2017 Jun;21 Suppl 1:S28-S36. doi: 10.1111/hdi.12553. Epub 2017 Mar 22. Review.


TFR2-related haemochromatosis in the Netherlands: a cause of arthralgia in young adulthood.

Peters TM, Meulders AF, Redert K, Cuijpers ML, Rennings AJ, Janssen MC, Blijlevens NM, Swinkels DW.

Neth J Med. 2017 Mar;75(2):56-64.


Cohort Profile: The Nijmegen Biomedical Study (NBS).

Galesloot TE, Vermeulen SH, Swinkels DW, de Vegt F, Franke B, den Heijer M, de Graaf J, Verbeek ALM, Kiemeney LALM.

Int J Epidemiol. 2017 Aug 1;46(4):1099-1100j. doi: 10.1093/ije/dyw268. No abstract available.


EPO and hepcidin plasma concentrations in blood donors and β-thalassemia intermedia are not related to commercially tested plasma ERFE concentrations.

Schotten N, Laarakkers CM, Roelofs RW, Origa R, van Kraaij MG, Swinkels DW.

Am J Hematol. 2017 Mar;92(3):E29-E31. doi: 10.1002/ajh.24636. No abstract available.


Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin.

Galesloot TE, Verweij N, Traglia M, Barbieri C, van Dijk F, Geurts-Moespot AJ, Girelli D, Kiemeney LA, Sweep FC, Swertz MA, van der Meer P, Camaschella C, Toniolo D, Vermeulen SH, van der Harst P, Swinkels DW.

PLoS One. 2016 Nov 15;11(11):e0166628. doi: 10.1371/journal.pone.0166628. eCollection 2016.


Catalytic iron and acute kidney injury.

Leaf DE, Swinkels DW.

Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F871-F876. doi: 10.1152/ajprenal.00388.2016. Epub 2016 Aug 17. Review.


The donation interval of 56 days requires extension to 180 days for whole blood donors to recover from changes in iron metabolism.

Schotten N, Pasker-de Jong PC, Moretti D, Zimmermann MB, Geurts-Moespot AJ, Swinkels DW, van Kraaij MG.

Blood. 2016 Oct 27;128(17):2185-2188. Epub 2016 Sep 1. No abstract available.


Cardiac Hepcidin Expression Associates with Injury Independent of Iron.

van Breda GF, Bongartz LG, Zhuang W, van Swelm RP, Pertijs J, Braam B, Cramer MJ, Swinkels DW, Doevendans PA, Verhaar MC, Masereeuw R, Joles JA, Gaillard CA.

Am J Nephrol. 2016;44(5):368-378. Epub 2016 Oct 22.


Serum ferritin and risk for new-onset heart failure and cardiovascular events in the community.

Klip IT, Voors AA, Swinkels DW, Bakker SJ, Kootstra-Ros JE, Lam CS, van der Harst P, van Veldhuisen DJ, van der Meer P.

Eur J Heart Fail. 2017 Mar;19(3):348-356. doi: 10.1002/ejhf.622. Epub 2016 Oct 19.


Iron refractory iron deficiency anemia: a heterogeneous disease that is not always iron refractory.

Donker AE, Schaap CC, Novotny VM, Smeets R, Peters TM, van den Heuvel BL, Raphael MF, Rijneveld AW, Appel IM, Vlot AJ, Versluijs AB, van Gelder M, Granzen B, Janssen MC, Rennings AJ, van de Veerdonk FL, Brons PP, Bakkeren DL, Nijziel MR, Vlasveld LT, Swinkels DW.

Am J Hematol. 2016 Dec;91(12):E482-E490. doi: 10.1002/ajh.24561.


Pharmacokinetics of Ferric Pyrophosphate Citrate, a Novel Iron Salt, Administered Intravenously to Healthy Volunteers.

Pratt RD, Swinkels DW, Ikizler TA, Gupta A.

J Clin Pharmacol. 2017 Mar;57(3):312-320. doi: 10.1002/jcph.819. Epub 2016 Oct 3.


Seven days of high carbohydrate ingestion does not attenuate post-exercise IL-6 and hepcidin levels.

Badenhorst CE, Dawson B, Cox GR, Sim M, Laarakkers CM, Swinkels DW, Peeling P.

Eur J Appl Physiol. 2016 Sep;116(9):1715-24. doi: 10.1007/s00421-016-3426-7. Epub 2016 Jul 5.


Hyperferritinemia and iron metabolism in Gaucher disease: Potential pathophysiological implications.

Regenboog M, van Kuilenburg AB, Verheij J, Swinkels DW, Hollak CE.

Blood Rev. 2016 Nov;30(6):431-437. doi: 10.1016/j.blre.2016.05.003. Epub 2016 May 27. Review.


Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.

Nioi P, Sigurdsson A, Thorleifsson G, Helgason H, Agustsdottir AB, Norddahl GL, Helgadottir A, Magnusdottir A, Jonasdottir A, Gretarsdottir S, Jonsdottir I, Steinthorsdottir V, Rafnar T, Swinkels DW, Galesloot TE, Grarup N, Jørgensen T, Vestergaard H, Hansen T, Lauritzen T, Linneberg A, Friedrich N, Krarup NT, Fenger M, Abildgaard U, Hansen PR, Galløe AM, Braund PS, Nelson CP, Hall AS, Williams MJ, van Rij AM, Jones GT, Patel RS, Levey AI, Hayek S, Shah SH, Reilly M, Eyjolfsson GI, Sigurdardottir O, Olafsson I, Kiemeney LA, Quyyumi AA, Rader DJ, Kraus WE, Samani NJ, Pedersen O, Thorgeirsson G, Masson G, Holm H, Gudbjartsson D, Sulem P, Thorsteinsdottir U, Stefansson K.

N Engl J Med. 2016 Jun 2;374(22):2131-41. doi: 10.1056/NEJMoa1508419. Epub 2016 May 18.


Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material.

van der Vorm LN, Hendriks JC, Laarakkers CM, Klaver S, Armitage AE, Bamberg A, Geurts-Moespot AJ, Girelli D, Herkert M, Itkonen O, Konrad RJ, Tomosugi N, Westerman M, Bansal SS, Campostrini N, Drakesmith H, Fillet M, Olbina G, Pasricha SR, Pitts KR, Sloan JH, Tagliaro F, Weykamp CW, Swinkels DW.

Clin Chem. 2016 Jul;62(7):993-1001. doi: 10.1373/clinchem.2016.256768. Epub 2016 May 12.


Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease.

Helgadottir A, Gretarsdottir S, Thorleifsson G, Hjartarson E, Sigurdsson A, Magnusdottir A, Jonasdottir A, Kristjansson H, Sulem P, Oddsson A, Sveinbjornsson G, Steinthorsdottir V, Rafnar T, Masson G, Jonsdottir I, Olafsson I, Eyjolfsson GI, Sigurdardottir O, Daneshpour MS, Khalili D, Azizi F, Swinkels DW, Kiemeney L, Quyyumi AA, Levey AI, Patel RS, Hayek SS, Gudmundsdottir IJ, Thorgeirsson G, Thorsteinsdottir U, Gudbjartsson DF, Holm H, Stefansson K.

Nat Genet. 2016 Jun;48(6):634-9. doi: 10.1038/ng.3561. Epub 2016 May 2.


Hepcidin in the diagnosis of iron disorders.

Girelli D, Nemeth E, Swinkels DW.

Blood. 2016 Jun 9;127(23):2809-13. doi: 10.1182/blood-2015-12-639112. Epub 2016 Apr 4. Review.

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