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Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile.

Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S.

Ann Rheum Dis. 2019 Nov 25. pii: annrheumdis-2019-215894. doi: 10.1136/annrheumdis-2019-215894. [Epub ahead of print]


Pyoderma Gangrenosum-Like Lesion in an Older Adult.

Swindell WR, Gau JT.

J Am Osteopath Assoc. 2019 Sep 16. doi: 10.7556/jaoa.2019.117. [Epub ahead of print]


A Zingerone Analog, Acetyl Zingerone, Bolsters Matrisome Synthesis, Inhibits Matrix Metallopeptidases, and Represses IL-17A Target Gene Expression.

Swindell WR, Bojanowski K, Chaudhuri RK.

J Invest Dermatol. 2019 Aug 27. pii: S0022-202X(19)33150-1. doi: 10.1016/j.jid.2019.07.715. [Epub ahead of print]


ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia.

Swindell WR, Kruse CPS, List EO, Berryman DE, Kopchick JJ.

J Transl Med. 2019 May 22;17(1):170. doi: 10.1186/s12967-019-1909-0.


Correction to: GM6 Attenuates Alzheimer's Disease Pathology in APP Mice.

Yu J, Zhu H, Taheri S, Mondy W, Kirstein C, Swindell WR, Ko D, Kindy MS.

Mol Neurobiol. 2019 Sep;56(9):6397. doi: 10.1007/s12035-019-1558-6.


Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis.

Tsoi LC, Rodriguez E, Degenhardt F, Baurecht H, Wehkamp U, Volks N, Szymczak S, Swindell WR, Sarkar MK, Raja K, Shao S, Patrick M, Gao Y, Uppala R, Perez White BE, Getsios S, Harms PW, Maverakis E, Elder JT, Franke A, Gudjonsson JE, Weidinger S.

J Invest Dermatol. 2019 Jul;139(7):1480-1489. doi: 10.1016/j.jid.2018.12.018. Epub 2019 Jan 11.


GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis.

Swindell WR, Bojanowski K, Kindy MS, Chau RMW, Ko D.

Transl Neurodegener. 2018 Dec 3;7:30. doi: 10.1186/s40035-018-0135-7. eCollection 2018.


Putting a strain on diversity.

Selman C, Swindell WR.

EMBO J. 2018 Nov 15;37(22). pii: e100862. doi: 10.15252/embj.2018100862. Epub 2018 Nov 2. Review. No abstract available.


Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.

Sarkar MK, Hile GA, Tsoi LC, Xing X, Liu J, Liang Y, Berthier CC, Swindell WR, Patrick MT, Shao S, Tsou PS, Uppala R, Beamer MA, Srivastava A, Bielas SL, Harms PW, Getsios S, Elder JT, Voorhees JJ, Gudjonsson JE, Kahlenberg JM.

Ann Rheum Dis. 2018 Nov;77(11):1653-1664. doi: 10.1136/annrheumdis-2018-213197. Epub 2018 Jul 18.


Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue.

Swindell WR, List EO, Berryman DE, Kopchick JJ.

Aging (Albany NY). 2018 Apr 29;10(4):701-746. doi: 10.18632/aging.101424.


RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature.

Swindell WR, Beamer MA, Sarkar MK, Loftus S, Fullmer J, Xing X, Ward NL, Tsoi LC, Kahlenberg MJ, Liang Y, Gudjonsson JE.

Front Immunol. 2018 Jan 29;9:80. doi: 10.3389/fimmu.2018.00080. eCollection 2018.


RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin.

Swindell WR, Sarkar MK, Liang Y, Xing X, Baliwag J, Elder JT, Johnston A, Ward NL, Gudjonsson JE.

Sci Rep. 2017 Dec 22;7(1):18045. doi: 10.1038/s41598-017-18404-9.


IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis.

Mehta NN, Teague HL, Swindell WR, Baumer Y, Ward NL, Xing X, Baugous B, Johnston A, Joshi AA, Silverman J, Barnes DH, Wolterink L, Nair RP, Stuart PE, Playford M, Voorhees JJ, Sarkar MK, Elder JT, Gallagher K, Ganesh SK, Gudjonsson JE.

Sci Rep. 2017 Oct 23;7(1):13831. doi: 10.1038/s41598-017-14365-1.


Rapamycin in mice.

Swindell WR.

Aging (Albany NY). 2017 Sep 1;9(9):1941-1942. doi: 10.18632/aging.101289. No abstract available.


Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.

Swindell WR, Michaels KA, Sutter AJ, Diaconu D, Fritz Y, Xing X, Sarkar MK, Liang Y, Tsoi A, Gudjonsson JE, Ward NL.

Genome Med. 2017 Mar 9;9(1):24. doi: 10.1186/s13073-017-0415-3.


Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses.

Lambert S, Swindell WR, Tsoi LC, Stoll SW, Elder JT.

J Invest Dermatol. 2017 Jul;137(7):1501-1511. doi: 10.1016/j.jid.2016.12.032. Epub 2017 Mar 6.


Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation.

Sarkar MK, Kaplan N, Tsoi LC, Xing X, Liang Y, Swindell WR, Hoover P, Aravind M, Baida G, Clark M, Voorhees JJ, Nair RP, Elder JT, Budunova I, Getsios S, Gudjonsson JE.

J Invest Dermatol. 2017 Jul;137(7):1474-1483. doi: 10.1016/j.jid.2017.02.972. Epub 2017 Mar 1. Erratum in: J Invest Dermatol. 2017 Dec;137(12):2665.


Synthesis and activity of the salicylic acid ester of bakuchiol in psoriasis-surrogate keratinocytes and skin substitutes.

Ma S, Gobis K, Swindell WR, Chaudhuri R, Bojanowski R, Bojanowski K.

Clin Exp Dermatol. 2017 Apr;42(3):251-260. doi: 10.1111/ced.13024. Epub 2017 Jan 4.


A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases.

Liang Y, Tsoi LC, Xing X, Beamer MA, Swindell WR, Sarkar MK, Berthier CC, Stuart PE, Harms PW, Nair RP, Elder JT, Voorhees JJ, Kahlenberg JM, Gudjonsson JE.

Nat Immunol. 2017 Feb;18(2):152-160. doi: 10.1038/ni.3643. Epub 2016 Dec 19.


Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice.

Fritz Y, Klenotic PA, Swindell WR, Yin ZQ, Groft SG, Zhang L, Baliwag J, Camhi MI, Diaconu D, Young AB, Foster AM, Johnston A, Gudjonsson JE, McCormick TS, Ward NL.

J Invest Dermatol. 2017 Mar;137(3):696-705. doi: 10.1016/j.jid.2016.10.021. Epub 2016 Oct 27.


Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders.

Liang Y, Xing X, Beamer MA, Swindell WR, Sarkar MK, Roberts LW, Voorhees JJ, Kahlenberg JM, Harms PW, Johnston A, Gudjonsson JE.

J Allergy Clin Immunol. 2017 Apr;139(4):1217-1227. doi: 10.1016/j.jaci.2016.10.021. Epub 2016 Nov 21.


Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL.

JCI Insight. 2016 Sep 22;1(15):e88843. doi: 10.1172/jci.insight.88843.


Meta-Analysis of 29 Experiments Evaluating the Effects of Rapamycin on Life Span in the Laboratory Mouse.

Swindell WR.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1024-1032. doi: 10.1093/gerona/glw153.


IL-17 Responses Are the Dominant Inflammatory Signal Linking Inverse, Erythrodermic, and Chronic Plaque Psoriasis.

Xing X, Liang Y, Sarkar MK, Wolterink L, Swindell WR, Voorhees JJ, Harms PW, Kahlenberg JM, Johnston A, Gudjonsson JE.

J Invest Dermatol. 2016 Dec;136(12):2498-2501. doi: 10.1016/j.jid.2016.07.008. Epub 2016 Jul 21. No abstract available.


Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?

Rittié L, Tejasvi T, Harms PW, Xing X, Nair RP, Gudjonsson JE, Swindell WR, Elder JT.

J Invest Dermatol. 2016 Sep;136(9):1792-1800. doi: 10.1016/j.jid.2016.05.113. Epub 2016 Jun 14.


Deficiency of myeloid-related proteins 8 and 14 (Mrp8/Mrp14) does not block inflammaging but prevents steatosis.

Swindell WR, Xing X, Fritz Y, Diaconu D, Simon DI, Ward NL, Gudjonsson JE.

Oncotarget. 2016 Jun 14;7(24):35535-35551. doi: 10.18632/oncotarget.9550.


Cross-Disease Transcriptomics: Unique IL-17A Signaling in Psoriasis Lesions and an Autoimmune PBMC Signature.

Swindell WR, Sarkar MK, Liang Y, Xing X, Gudjonsson JE.

J Invest Dermatol. 2016 Sep;136(9):1820-1830. doi: 10.1016/j.jid.2016.04.035. Epub 2016 May 17. Review.


Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.

Stout MB, Swindell WR, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM.

Oncotarget. 2015 Sep 29;6(29):26702-15. doi: 10.18632/oncotarget.5760.


Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance.

Swindell WR, Remmer HA, Sarkar MK, Xing X, Barnes DH, Wolterink L, Voorhees JJ, Nair RP, Johnston A, Elder JT, Gudjonsson JE.

Genome Med. 2015 Aug 4;7(1):86. doi: 10.1186/s13073-015-0208-5. eCollection 2015.


Dissecting the heterogeneity of skin gene expression patterns in systemic sclerosis.

Assassi S, Swindell WR, Wu M, Tan FD, Khanna D, Furst DE, Tashkin DP, Jahan-Tigh RR, Mayes MD, Gudjonsson JE, Chang JT.

Arthritis Rheumatol. 2015 Nov;67(11):3016-26. doi: 10.1002/art.39289.


The EGF receptor ligand amphiregulin controls cell division via FoxM1.

Stoll SW, Stuart PE, Swindell WR, Tsoi LC, Li B, Gandarillas A, Lambert S, Johnston A, Nair RP, Elder JT.

Oncogene. 2016 Apr 21;35(16):2075-86. doi: 10.1038/onc.2015.269. Epub 2015 Aug 3.


Nuclear respiratory factor 2 induces SIRT3 expression.

Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MC.

Aging Cell. 2015 Oct;14(5):818-25. doi: 10.1111/acel.12360. Epub 2015 Jun 24.


Age-Associated Increase in Skin Fibroblast-Derived Prostaglandin E2 Contributes to Reduced Collagen Levels in Elderly Human Skin.

Li Y, Lei D, Swindell WR, Xia W, Weng S, Fu J, Worthen CA, Okubo T, Johnston A, Gudjonsson JE, Voorhees JJ, Fisher GJ.

J Invest Dermatol. 2015 Sep;135(9):2181-2188. doi: 10.1038/jid.2015.157. Epub 2015 Apr 23.


Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites.

Swindell WR, Sarkar MK, Stuart PE, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE.

Clin Transl Med. 2015 Mar 19;4:13. doi: 10.1186/s40169-015-0054-5. eCollection 2015.


Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin.

Tsoi LC, Iyer MK, Stuart PE, Swindell WR, Gudjonsson JE, Tejasvi T, Sarkar MK, Li B, Ding J, Voorhees JJ, Kang HM, Nair RP, Chinnaiyan AM, Abecasis GR, Elder JT.

Genome Biol. 2015 Jan 30;16:24. doi: 10.1186/s13059-014-0570-4.


A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia.

Gordon WM, Zeller MD, Klein RH, Swindell WR, Ho H, Espetia F, Gudjonsson JE, Baldi PF, Andersen B.

J Clin Invest. 2014 Dec;124(12):5205-18. doi: 10.1172/JCI77138. Epub 2014 Oct 27.


IL-32 is a molecular marker of a host defense network in human tuberculosis.

Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL.

Sci Transl Med. 2014 Aug 20;6(250):250ra114. doi: 10.1126/scitranslmed.3009546.


Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis.

Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M.

J Invest Dermatol. 2015 Jan;135(1):151-159. doi: 10.1038/jid.2014.352. Epub 2014 Aug 11.


Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era.

Swindell WR, Stuart PE, Sarkar MK, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE.

BMC Med Genomics. 2014 May 22;7:27. doi: 10.1186/1755-8794-7-27.


Intertissue control of the nucleolus via a myokine-dependent longevity pathway.

Demontis F, Patel VK, Swindell WR, Perrimon N.

Cell Rep. 2014 Jun 12;7(5):1481-1494. doi: 10.1016/j.celrep.2014.05.001. Epub 2014 May 29.


Integrative RNA-seq and microarray data analysis reveals GC content and gene length biases in the psoriasis transcriptome.

Swindell WR, Xing X, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE.

Physiol Genomics. 2014 Aug 1;46(15):533-46. doi: 10.1152/physiolgenomics.00022.2014. Epub 2014 May 20.


Early tissue responses in psoriasis to the antitumour necrosis factor-α biologic etanercept suggest reduced interleukin-17 receptor expression and signalling.

Johnston A, Guzman AM, Swindell WR, Wang F, Kang S, Gudjonsson JE.

Br J Dermatol. 2014 Jul;171(1):97-107. doi: 10.1111/bjd.12937. Epub 2014 Jun 24.


Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.

Li B, Tsoi LC, Swindell WR, Gudjonsson JE, Tejasvi T, Johnston A, Ding J, Stuart PE, Xing X, Kochkodan JJ, Voorhees JJ, Kang HM, Nair RP, Abecasis GR, Elder JT.

J Invest Dermatol. 2014 Jul;134(7):1828-1838. doi: 10.1038/jid.2014.28. Epub 2014 Jan 17.


Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation.

Swindell WR, Johnston A, Xing X, Voorhees JJ, Elder JT, Gudjonsson JE.

PLoS One. 2013 Nov 15;8(11):e79253. doi: 10.1371/journal.pone.0079253. eCollection 2013.


Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice.

Sun LY, Spong A, Swindell WR, Fang Y, Hill C, Huber JA, Boehm JD, Westbrook R, Salvatori R, Bartke A.

Elife. 2013 Oct 29;2:e01098. doi: 10.7554/eLife.01098.


Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients.

Swindell WR, Johnston A, Voorhees JJ, Elder JT, Gudjonsson JE.

BMC Genomics. 2013 Aug 1;14:527. doi: 10.1186/1471-2164-14-527.


Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation.

Swindell WR, Johnston A, Xing X, Little A, Robichaud P, Voorhees JJ, Fisher G, Gudjonsson JE.

Sci Rep. 2013;3:1215. doi: 10.1038/srep01215. Epub 2013 Feb 5.


Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.

Johnston A, Xing X, Swindell WR, Kochkodan J, Riblett M, Nair RP, Stuart PE, Ding J, Voorhees JJ, Elder JT, Gudjonsson JE.

Hum Mol Genet. 2013 May 1;22(9):1807-15. doi: 10.1093/hmg/ddt034. Epub 2013 Jan 31.


Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis.

Gordon K, Kochkodan JJ, Blatt H, Lin SY, Kaplan N, Johnston A, Swindell WR, Hoover P, Schlosser BJ, Elder JT, Gudjonsson JE, Getsios S.

J Invest Dermatol. 2013 Mar;133(3):712-722. doi: 10.1038/jid.2012.391. Epub 2012 Nov 29.


Data mining identifies Digit Symbol Substitution Test score and serum cystatin C as dominant predictors of mortality in older men and women.

Swindell WR, Cummings SR, Sanders JL, Caserotti P, Rosano C, Satterfield S, Strotmeyer ES, Harris TB, Simonsick EM, Cawthon PM.

Rejuvenation Res. 2012 Aug;15(4):405-13. doi: 10.1089/rej.2011.1297. Epub 2012 May 18.

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