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Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription.

Al-Mehdi AB, Pastukh VM, Swiger BM, Reed DJ, Patel MR, Bardwell GC, Pastukh VV, Alexeyev MF, Gillespie MN.

Sci Signal. 2012 Jul 3;5(231):ra47. doi: 10.1126/scisignal.2002712.


Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes.

Ruchko MV, Gorodnya OM, Pastukh VM, Swiger BM, Middleton NS, Wilson GL, Gillespie MN.

Free Radic Biol Med. 2009 Feb 1;46(3):352-9. doi: 10.1016/j.freeradbiomed.2008.09.038. Epub 2008 Oct 18.

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