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Items: 39


Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.

Hoang CQ, Hale MA, Azevedo-Pouly AC, Elsässer HP, Deering TG, Willet SG, Pan FC, Magnuson MA, Wright CV, Swift GH, MacDonald RJ.

Mol Cell Biol. 2016 Nov 28;36(24):3033-3047. Print 2016 Dec 15.


MIST1 and PTF1 Collaborate in Feed-Forward Regulatory Loops That Maintain the Pancreatic Acinar Phenotype in Adult Mice.

Jiang M, Azevedo-Pouly AC, Deering TG, Hoang CQ, DiRenzo D, Hess DA, Konieczny SF, Swift GH, MacDonald RJ.

Mol Cell Biol. 2016 Nov 14;36(23):2945-2955. doi: 10.1128/MCB.00370-16. Print 2016 Dec 1.


Isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation.

Houghton JA, Swift GH, Shaw-Smith C, Flanagan SE, de Franco E, Caswell R, Hussain K, Mohamed S, Abdulrasoul M, Hattersley AT, MacDonald RJ, Ellard S.

Diabetes. 2016 Sep;65(9):2810-5. doi: 10.2337/db15-1666. Epub 2016 Jun 9.


A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics.

Ocal O, Pashkov V, Kollipara RK, Zolghadri Y, Cruz VH, Hale MA, Heath BR, Artyukhin AB, Christie AL, Tsoulfas P, Lorens JB, Swift GH, Brekken RA, Wilkie TM.

Dis Model Mech. 2015 Oct 1;8(10):1201-11. doi: 10.1242/dmm.020933.


The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.

Krah NM, De La O JP, Swift GH, Hoang CQ, Willet SG, Chen Pan F, Cash GM, Bronner MP, Wright CV, MacDonald RJ, Murtaugh LC.

Elife. 2015 Jul 7;4. doi: 10.7554/eLife.07125.


The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.

Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ.

Development. 2014 Aug;141(16):3123-33. doi: 10.1242/dev.109405. Epub 2014 Jul 25.


Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility.

Meredith DM, Borromeo MD, Deering TG, Casey BH, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE.

Mol Cell Biol. 2013 Aug;33(16):3166-79. doi: 10.1128/MCB.00364-13. Epub 2013 Jun 10.


LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ.

Genes Dev. 2011 Aug 15;25(16):1674-9. doi: 10.1101/gad.16860911.


Transcriptional control of acinar development and homeostasis.

MacDonald RJ, Swift GH, Real FX.

Prog Mol Biol Transl Sci. 2010;97:1-40. doi: 10.1016/B978-0-12-385233-5.00001-5. Review.


Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.

Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ.

Gastroenterology. 2010 Jul;139(1):270-80. doi: 10.1053/j.gastro.2010.04.003. Epub 2010 Apr 14.


Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex.

Meredith DM, Masui T, Swift GH, MacDonald RJ, Johnson JE.

J Neurosci. 2009 Sep 9;29(36):11139-48. doi: 10.1523/JNEUROSCI.2303-09.2009.


Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.

Masui T, Swift GH, Hale MA, Meredith DM, Johnson JE, Macdonald RJ.

Mol Cell Biol. 2008 Sep;28(17):5458-68. doi: 10.1128/MCB.00549-08. Epub 2008 Jul 7.


A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs.

Kong YM, Macdonald RJ, Wen X, Yang P, Barbera VM, Swift GH.

Gene Expr Patterns. 2006 Oct;6(7):678-86. Epub 2006 Feb 17.


Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development.

Annicotte JS, Fayard E, Swift GH, Selander L, Edlund H, Tanaka T, Kodama T, Schoonjans K, Auwerx J.

Mol Cell Biol. 2003 Oct;23(19):6713-24.


The role of PTF1-P48 in pancreatic acinar gene expression.

Rose SD, Swift GH, Peyton MJ, Hammer RE, MacDonald RJ.

J Biol Chem. 2001 Nov 23;276(47):44018-26. Epub 2001 Sep 18.


A binary mechanism for the selective action of a pancreatic beta -cell transcriptional silencer.

Viswanath RL, Rose SD, Swift GH, MacDonald RJ.

J Biol Chem. 2000 Dec 22;275(51):40273-81.


Assessment of RNA quality by semi-quantitative RT-PCR of multiple regions of a long ubiquitous mRNA.

Swift GH, Peyton MJ, MacDonald RJ.

Biotechniques. 2000 Mar;28(3):524, 526, 528, 530-1.


Analysis of transcriptional regulatory regions in vivo.

MacDonald RJ, Swift GH.

Int J Dev Biol. 1998;42(7):983-94. Review.


An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).

Swift GH, Liu Y, Rose SD, Bischof LJ, Steelman S, Buchberg AM, Wright CV, MacDonald RJ.

Mol Cell Biol. 1998 Sep;18(9):5109-20.


Cooperation between elements of an organ-specific transcriptional enhancer in animals.

Kruse F, Rose SD, Swift GH, Hammer RE, MacDonald RJ.

Mol Cell Biol. 1995 Aug;15(8):4385-94.


A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut.

Rose SD, Kruse F, Swift GH, MacDonald RJ, Hammer RE.

Mol Cell Biol. 1994 Mar;14(3):2048-57.


An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer.

Kruse F, Rose SD, Swift GH, Hammer RE, MacDonald RJ.

Genes Dev. 1993 May;7(5):774-86.


The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.

Hammer RE, Swift GH, Ornitz DM, Quaife CJ, Palmiter RD, Brinster RL, MacDonald RJ.

Mol Cell Biol. 1987 Aug;7(8):2956-67.


Targeted expression of cloned genes in transgenic mice.

MacDonald RJ, Swift GH, Hammer RE, Ornitz DM, Davis BP, Brinster RL, Palmiter RD.

Prog Brain Res. 1987;71:3-12. No abstract available.


Isolation of RNA using guanidinium salts.

MacDonald RJ, Swift GH, Przybyla AE, Chirgwin JM.

Methods Enzymol. 1987;152:219-27. No abstract available.


Transgenic progeny inherit tissue-specific expression of rat elastase I genes.

MacDonald RJ, Hammer RE, Swift GH, Davis BP, Brinster RL.

DNA. 1986 Oct;5(5):393-401.


Tissue-specific expression of pancreatic genes in transgenic mice.

MacDonald RJ, Hammer RE, Swift GH, Ornitz DM, Davis BP, Palmiter RD, Brinster RL.

Ann N Y Acad Sci. 1986;478:131-46. Review. No abstract available.


Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice.

Ornitz DM, Palmiter RD, Hammer RE, Brinster RL, Swift GH, MacDonald RJ.

Nature. 1985 Feb 14-20;313(6003):600-2.


Structure of the two related elastase genes expressed in the rat pancreas.

Swift GH, Craik CS, Stary SJ, Quinto C, Lahaie RG, Rutter WJ, MacDonald RJ.

J Biol Chem. 1984 Nov 25;259(22):14271-8.


Structure of two related rat pancreatic trypsin genes.

Craik CS, Choo QL, Swift GH, Quinto C, MacDonald RJ, Rutter WJ.

J Biol Chem. 1984 Nov 25;259(22):14255-64.


Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice.

Swift GH, Hammer RE, MacDonald RJ, Brinster RL.

Cell. 1984 Oct;38(3):639-46.


Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme.

Swift GH, Dagorn JC, Ashley PL, Cummings SW, MacDonald RJ.

Proc Natl Acad Sci U S A. 1982 Dec;79(23):7263-7.


Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide sequences of the cloned cDNAs.

MacDonald RJ, Stary SJ, Swift GH.

J Biol Chem. 1982 Aug 25;257(16):9724-32.


Primary structure of two distinct rat pancreatic preproelastases determined by sequence analysis of the complete cloned messenger ribonucleic acid sequences.

MacDonald RJ, Swift GH, Quinto C, Swain W, Pictet RL, Nikovits W, Rutter WJ.

Biochemistry. 1982 Mar 16;21(6):1453-63.


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