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Items: 25

1.

High-throughput elucidation of thrombus formation reveals sources of platelet function variability.

Geffen JPV, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten CCFMJ, Bourry N, Frontini M, Jurk K, Krause M, Pillitteri D, Swieringa F, Verdoold R, Cavill R, Kuijpers MJE, Ouwehand WH, Downes K, Heemskerk JWM.

Haematologica. 2018 Dec 13. pii: haematol.2018.198853. doi: 10.3324/haematol.2018.198853. [Epub ahead of print]

2.

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding.

Baaten CCFMJ, Meacham S, de Witt SM, Feijge MAH, Adams DJ, Akkerman JN, Cosemans JMEM, Grassi L, Jupe S, Kostadima M, Mattheij NJA, Prins MH, Ramirez-Solis R, Soehnlein O, Swieringa F, Weber C, White JK, Ouwehand WH, Heemskerk JWM.

Blood. 2018 Dec 13;132(24):e35-e46. doi: 10.1182/blood-2018-02-831982. Epub 2018 Oct 1.

PMID:
30275110
3.

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects.

Baaten CCFMJ, Swieringa F, Misztal T, Mastenbroek TG, Feijge MAH, Bock PE, Donners MMPC, Collins PW, Li R, van der Meijden PEJ, Heemskerk JWM.

Blood Adv. 2018 Sep 25;2(18):2320-2331. doi: 10.1182/bloodadvances.2017011544.

4.

Integrating platelet and coagulation activation in fibrin clot formation.

Swieringa F, Spronk HMH, Heemskerk JWM, van der Meijden PEJ.

Res Pract Thromb Haemost. 2018 May 20;2(3):450-460. doi: 10.1002/rth2.12107. eCollection 2018 Jul. Review.

5.

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.

Lepropre S, Kautbally S, Octave M, Ginion A, Onselaer MB, Steinberg GR, Kemp BE, Hego A, Wéra O, Brouns S, Swieringa F, Giera M, Darley-Usmar VM, Ambroise J, Guigas B, Heemskerk J, Bertrand L, Oury C, Beauloye C, Horman S.

Blood. 2018 Sep 13;132(11):1180-1192. doi: 10.1182/blood-2018-02-831503. Epub 2018 Jul 17.

6.

Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy.

Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ.

Haematologica. 2018 Sep;103(9):1557-1567. doi: 10.3324/haematol.2017.185165. Epub 2018 Jun 7.

7.

Platelet proteomics: from discovery to diagnosis.

Looße C, Swieringa F, Heemskerk JWM, Sickmann A, Lorenz C.

Expert Rev Proteomics. 2018 Jun;15(6):467-476. doi: 10.1080/14789450.2018.1480111. Epub 2018 Jun 8.

PMID:
29787335
8.

Suppressive Role of Tissue Factor Pathway Inhibitor-α in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength.

Thomassen S, Mastenbroek TG, Swieringa F, Winckers K, Feijge MAH, Schrijver R, Cosemans JMEM, Maroney SA, Mast AE, Hackeng TM, Heemskerk JWM.

Thromb Haemost. 2018 Mar;118(3):502-513. doi: 10.1055/s-0038-1627453. Epub 2018 Feb 16.

PMID:
29452445
9.

Use of microfluidics to assess the platelet-based control of coagulation.

Nagy M, Heemskerk JWM, Swieringa F.

Platelets. 2017 Jul;28(5):441-448. doi: 10.1080/09537104.2017.1293809. Epub 2017 Mar 30. Review.

PMID:
28358995
10.

TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report.

Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2152-2157. Epub 2016 Sep 15.

PMID:
27634832
11.

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome.

Solari FA, Mattheij NJ, Burkhart JM, Swieringa F, Collins PW, Cosemans JM, Sickmann A, Heemskerk JW, Zahedi RP.

Mol Cell Proteomics. 2016 Oct;15(10):3154-3169. Epub 2016 Aug 17.

12.

Platelets and coagulation in thrombus formation: aberrations in the Scott syndrome.

van Geffen JP, Swieringa F, Heemskerk JW.

Thromb Res. 2016 May;141 Suppl 2:S12-6. doi: 10.1016/S0049-3848(16)30355-3. Review.

PMID:
27207414
13.

PO-19 - Platelet (PLT) adhesion under flow condition in essential thrombocythemia (ET) and polycythemia vera (PV) is variably influenced according to patient mutational status.

Vignoli A, Tessarolo S, Marchetti M, Gamba S, Piras F, Finazzi G, van der Meijden PE, Swieringa F, Ten Cate H, Heemskerk JW, Rambaldi A, Falanga A.

Thromb Res. 2016 Apr;140 Suppl 1:S183. doi: 10.1016/S0049-3848(16)30152-9. Epub 2016 Apr 8.

PMID:
27161708
14.

OC-08 - Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy.

Baaten CC, Moenen FC, Henskens YM, Swieringa F, Wetzels R, van Oerle R, Ten Cate H, Beckers EA, Heemskerk JW, van der Meijden PE.

Thromb Res. 2016 Apr;140 Suppl 1:S171. doi: 10.1016/S0049-3848(16)30125-6. Epub 2016 Apr 8.

PMID:
27161680
15.

Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow.

Swieringa F, Baaten CC, Verdoold R, Mastenbroek TG, Rijnveld N, van der Laan KO, Breel EJ, Collins PW, Lancé MD, Henskens YM, Cosemans JM, Heemskerk JW, van der Meijden PE.

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):692-9. doi: 10.1161/ATVBAHA.115.306537. Epub 2016 Feb 4.

PMID:
26848157
16.

Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII.

Mattheij NJ, Swieringa F, Mastenbroek TG, Berny-Lang MA, May F, Baaten CC, van der Meijden PE, Henskens YM, Beckers EA, Suylen DP, Nolte MW, Hackeng TM, McCarty OJ, Heemskerk JW, Cosemans JM.

Haematologica. 2016 Apr;101(4):427-36. doi: 10.3324/haematol.2015.131441. Epub 2015 Dec 31.

17.

Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity.

Mastenbroek TG, Feijge MA, Kremers RM, van den Bosch MT, Swieringa F, De Groef L, Moons L, Bennett C, Ghevaert C, Johnson JL, van der Meijden PE, Cosemans JM.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2554-61. doi: 10.1161/ATVBAHA.115.306153. Epub 2015 Oct 15.

PMID:
26471268
18.

Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication.

Baaten CC, Veenstra LF, Wetzels R, van Geffen JP, Swieringa F, de Witt SM, Henskens YM, Crijns H, Nylander S, van Giezen JJ, Heemskerk JW, van der Meijden PE.

Haematologica. 2015 Sep;100(9):1131-8. doi: 10.3324/haematol.2014.122457. Epub 2015 Jun 25.

19.

Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding.

Swieringa F, Lancé MD, Fuchs B, Feijge MA, Solecka BA, Verheijen LP, Hughes KR, van Oerle R, Deckmyn H, Kannicht C, Heemskerk JW, van der Meijden PE.

J Thromb Haemost. 2015 Aug;13(8):1503-13. doi: 10.1111/jth.13007. Epub 2015 Jun 11.

20.

Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow.

Swieringa F, Kuijpers MJ, Lamers MM, van der Meijden PE, Heemskerk JW.

Haematologica. 2015 Jun;100(6):748-56. doi: 10.3324/haematol.2014.116863. Epub 2015 Mar 13.

21.

Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow.

Whyte CS, Swieringa F, Mastenbroek TG, Lionikiene AS, Lancé MD, van der Meijden PE, Heemskerk JW, Mutch NJ.

Blood. 2015 Apr 16;125(16):2568-78. doi: 10.1182/blood-2014-09-599480. Epub 2015 Feb 23.

22.

Identification of platelet function defects by multi-parameter assessment of thrombus formation.

de Witt SM, Swieringa F, Cavill R, Lamers MM, van Kruchten R, Mastenbroek T, Baaten C, Coort S, Pugh N, Schulz A, Scharrer I, Jurk K, Zieger B, Clemetson KJ, Farndale RW, Heemskerk JW, Cosemans JM.

Nat Commun. 2014 Jul 16;5:4257. doi: 10.1038/ncomms5257.

23.

Targeting platelet receptor function in thrombus formation: the risk of bleeding.

Swieringa F, Kuijpers MJ, Heemskerk JW, van der Meijden PE.

Blood Rev. 2014 Jan;28(1):9-21. doi: 10.1016/j.blre.2013.12.001. Epub 2013 Dec 26. Review.

PMID:
24411640
24.

Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation.

van Kruchten R, Mattheij NJ, Saunders C, Feijge MA, Swieringa F, Wolfs JL, Collins PW, Heemskerk JW, Bevers EM.

Blood. 2013 Mar 7;121(10):1850-7. doi: 10.1182/blood-2012-09-454314. Epub 2013 Jan 9.

25.

Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation.

van der Meijden PE, Feijge MA, Swieringa F, Gilio K, Nergiz-Unal R, Hamulyák K, Heemskerk JW.

Cell Mol Life Sci. 2012 Oct;69(20):3481-92. doi: 10.1007/s00018-012-1033-2. Epub 2012 Jun 6.

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