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Items: 1 to 50 of 355

1.

Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop.

Andersen ME, Gentry PR, Swenberg JA, Mundt KA, White KW, Thompson C, Bus J, Sherman JH, Greim H, Bolt H, Marsh GM, Checkoway H, Coggon D, Clewell HJ 3rd.

Regul Toxicol Pharmacol. 2019 Aug;106:210-223. doi: 10.1016/j.yrtph.2019.04.015. Epub 2019 May 3.

2.

Evaluation of inhaled low-dose formaldehyde-induced DNA adducts and DNA-protein cross-links by liquid chromatography-tandem mass spectrometry.

Leng J, Liu CW, Hartwell HJ, Yu R, Lai Y, Bodnar WM, Lu K, Swenberg JA.

Arch Toxicol. 2019 Mar;93(3):763-773. doi: 10.1007/s00204-019-02393-x. Epub 2019 Jan 30.

PMID:
30701286
3.

Understanding the importance of low-molecular weight (ethylene oxide- and propylene oxide-induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions.

Pottenger LH, Boysen G, Brown K, Cadet J, Fuchs RP, Johnson GE, Swenberg JA.

Environ Mol Mutagen. 2019 Mar;60(2):100-121. doi: 10.1002/em.22248. Epub 2018 Dec 10. Review.

4.

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin.

Quist EM, Boorman GA, Cullen JM, Maronpot RR, Remick AK, Swenberg JA, Freshwater L, Hardisty JF.

Toxicol Pathol. 2019 Jan;47(1):11-17. doi: 10.1177/0192623318809304. Epub 2018 Nov 1.

PMID:
30384807
5.

Accurate Measurement of Formaldehyde-Induced DNA-Protein Cross-Links by High-Resolution Orbitrap Mass Spectrometry.

Liu CW, Tian X, Hartwell HJ, Leng J, Chi L, Lu K, Swenberg JA.

Chem Res Toxicol. 2018 May 21;31(5):350-357. doi: 10.1021/acs.chemrestox.8b00040. Epub 2018 Apr 20.

PMID:
29651845
6.

Editor's Highlight: High-Throughput Functional Genomics Identifies Modulators of TCE Metabolite Genotoxicity and Candidate Susceptibility Genes.

De La Rosa VY, Asfaha J, Fasullo M, Loguinov A, Li P, Moore LE, Rothman N, Nakamura J, Swenberg JA, Scelo G, Zhang L, Smith MT, Vulpe CD.

Toxicol Sci. 2017 Nov 1;160(1):111-120. doi: 10.1093/toxsci/kfx159.

7.

N6-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N6-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats.

Edrissi B, Taghizadeh K, Moeller BC, Yu R, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC.

Chem Res Toxicol. 2017 Aug 21;30(8):1572-1576. doi: 10.1021/acs.chemrestox.7b00075. Epub 2017 Jul 27.

8.

Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.

Klaus V, Bastek H, Damme K, Collins LB, Frötschl R, Benda N, Lutter D, Ellinger-Ziegelbauer H, Swenberg JA, Dietrich DR, Stemmer K.

Arch Toxicol. 2017 Oct;91(10):3427-3438. doi: 10.1007/s00204-017-1953-6. Epub 2017 Mar 27.

9.

DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure.

Gao L, Mutlu E, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA.

Chem Res Toxicol. 2017 Mar 20;30(3):794-803. doi: 10.1021/acs.chemrestox.6b00368. Epub 2017 Feb 16.

10.

Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium.

Tian X, Patel K, Ridpath JR, Chen Y, Zhou YH, Neo D, Clement J, Takata M, Takeda S, Sale J, Wright FA, Swenberg JA, Nakamura J.

PLoS One. 2016 Dec 1;11(12):e0167503. doi: 10.1371/journal.pone.0167503. eCollection 2016.

11.

Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.

Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J.

Oncotarget. 2016 Sep 13;7(37):59795-59808. doi: 10.18632/oncotarget.10928.

12.

Polychlorinated Biphenyls Induce Oxidative DNA Adducts in Female Sprague-Dawley Rats.

Mutlu E, Gao L, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA.

Chem Res Toxicol. 2016 Aug 15;29(8):1335-1344. doi: 10.1021/acs.chemrestox.6b00146. Epub 2016 Jul 20.

13.

DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg JA, Xiao AZ.

Nature. 2016 Apr 21;532(7599):329-33. doi: 10.1038/nature17640. Epub 2016 Mar 30.

14.

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations.

Sharma V, Collins LB, Chen TH, Herr N, Takeda S, Sun W, Swenberg JA, Nakamura J.

Oncotarget. 2016 May 3;7(18):25377-90. doi: 10.18632/oncotarget.8298.

15.

Measurement of Endogenous versus Exogenous Formaldehyde-Induced DNA-Protein Crosslinks in Animal Tissues by Stable Isotope Labeling and Ultrasensitive Mass Spectrometry.

Lai Y, Yu R, Hartwell HJ, Moeller BC, Bodnar WM, Swenberg JA.

Cancer Res. 2016 May 1;76(9):2652-61. doi: 10.1158/0008-5472.CAN-15-2527. Epub 2016 Mar 16.

16.

The bottom-up approach to bounding potential low-dose cancer risks from formaldehyde: An update.

Starr TB, Swenberg JA.

Regul Toxicol Pharmacol. 2016 Jun;77:167-74. doi: 10.1016/j.yrtph.2016.01.021. Epub 2016 Feb 4.

17.

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R, Arends MJ, Chandrasekaran G, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ.

Mol Cell. 2015 Oct 1;60(1):177-88. doi: 10.1016/j.molcel.2015.08.020. Epub 2015 Sep 24.

18.

Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.

Leng S, Wu G, Collins LB, Thomas CL, Tellez CS, Jauregui AR, Picchi MA, Zhang X, Juri DE, Desai D, Amin SG, Crowell RE, Stidley CA, Liu Y, Swenberg JA, Lin Y, Wathelet MG, Gilliland FD, Belinsky SA.

Cancer Res. 2015 Aug 1;75(15):3108-17. doi: 10.1158/0008-5472.CAN-15-0243. Epub 2015 Jul 16.

19.

Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells.

Hashimoto K, Takeda S, Swenberg JA, Nakamura J.

Mutagenesis. 2015 Nov;30(6):821-8. doi: 10.1093/mutage/gev042. Epub 2015 Jun 17.

20.

Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage.

Yu R, Lai Y, Hartwell HJ, Moeller BC, Doyle-Eisele M, Kracko D, Bodnar WM, Starr TB, Swenberg JA.

Toxicol Sci. 2015 Jul;146(1):170-82. doi: 10.1093/toxsci/kfv079. Epub 2015 Apr 21.

21.

Response to Crump et al.

Starr TB, Swenberg JA.

Regul Toxicol Pharmacol. 2014 Dec;70(3):737-8. doi: 10.1016/j.yrtph.2014.10.007. Epub 2014 Oct 22. No abstract available.

PMID:
25455228
22.

A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner.

Donohoe DR, Holley D, Collins LB, Montgomery SA, Whitmore AC, Hillhouse A, Curry KP, Renner SW, Greenwalt A, Ryan EP, Godfrey V, Heise MT, Threadgill DS, Han A, Swenberg JA, Threadgill DW, Bultman SJ.

Cancer Discov. 2014 Dec;4(12):1387-97. doi: 10.1158/2159-8290.CD-14-0501. Epub 2014 Sep 29.

23.

Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication.

Shibutani T, Ito S, Toda M, Kanao R, Collins LB, Shibata M, Urabe M, Koseki H, Masuda Y, Swenberg JA, Masutani C, Hanaoka F, Iwai S, Kuraoka I.

Sci Rep. 2014 Jun 9;4:5220. doi: 10.1038/srep05220.

24.

Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells.

Sharma V, Collins LB, Clement JM, Zhang Z, Nakamura J, Swenberg JA.

Chem Res Toxicol. 2014 Apr 21;27(4):480-2. doi: 10.1021/tx5000602. Epub 2014 Mar 26.

25.

Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species.

Kotapati S, Sangaraju D, Esades A, Hallberg L, Walker VE, Swenberg JA, Tretyakova NY.

Carcinogenesis. 2014 Jun;35(6):1371-8. doi: 10.1093/carcin/bgu047. Epub 2014 Feb 14.

26.

An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.

Pottenger LH, Andrews LS, Bachman AN, Boogaard PJ, Cadet J, Embry MR, Farmer PB, Himmelstein MW, Jarabek AM, Martin EA, Mauthe RJ, Persaud R, Preston RJ, Schoeny R, Skare J, Swenberg JA, Williams GM, Zeiger E, Zhang F, Kim JH.

Crit Rev Toxicol. 2014 Apr;44(4):348-91. doi: 10.3109/10408444.2013.873768. Epub 2014 Feb 4. Review.

PMID:
24494825
27.

Gut microbiome phenotypes driven by host genetics affect arsenic metabolism.

Lu K, Mahbub R, Cable PH, Ru H, Parry NM, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR.

Chem Res Toxicol. 2014 Feb 17;27(2):172-4. doi: 10.1021/tx400454z. Epub 2014 Feb 3.

28.

Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis.

Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, Swenberg JA, Tannenbaum SR, Fox JG.

Environ Health Perspect. 2014 Mar;122(3):284-91. doi: 10.1289/ehp.1307429. Epub 2014 Jan 10.

29.

Formaldehyde-associated changes in microRNAs: tissue and temporal specificity in the rat nose, white blood cells, and bone marrow.

Rager JE, Moeller BC, Miller SK, Kracko D, Doyle-Eisele M, Swenberg JA, Fry RC.

Toxicol Sci. 2014 Mar;138(1):36-46. doi: 10.1093/toxsci/kft267. Epub 2013 Dec 4.

30.

Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation.

Lu K, Cable PH, Abo RP, Ru H, Graffam ME, Schlieper KA, Parry NM, Levine S, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR.

Chem Res Toxicol. 2013 Dec 16;26(12):1893-903. doi: 10.1021/tx4002868. Epub 2013 Nov 18.

31.

Dosimetry of N⁶-formyllysine adducts following [¹³C²H₂]-formaldehyde exposures in rats.

Edrissi B, Taghizadeh K, Moeller BC, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC.

Chem Res Toxicol. 2013 Oct 21;26(10):1421-3. doi: 10.1021/tx400320u. Epub 2013 Oct 10.

32.

Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure.

Moeller BC, Recio L, Green A, Sun W, Wright FA, Bodnar WM, Swenberg JA.

Toxicol Sci. 2013 May;133(1):1-12. doi: 10.1093/toxsci/kft029. Epub 2013 Feb 19.

33.

A novel bottom-up approach to bounding low-dose human cancer risks from chemical exposures.

Starr TB, Swenberg JA.

Regul Toxicol Pharmacol. 2013 Apr;65(3):311-5. doi: 10.1016/j.yrtph.2013.01.004. Epub 2013 Jan 23.

34.

Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates.

Rager JE, Moeller BC, Doyle-Eisele M, Kracko D, Swenberg JA, Fry RC.

Environ Health Perspect. 2013 Mar;121(3):339-44. doi: 10.1289/ehp.1205582. Epub 2013 Jan 15.

35.

Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment.

Swenberg JA, Moeller BC, Lu K, Rager JE, Fry RC, Starr TB.

Toxicol Pathol. 2013 Feb;41(2):181-9. doi: 10.1177/0192623312466459. Epub 2012 Nov 16. Review.

36.

Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell system.

Nakamura J, Gul H, Tian X, Bultman SJ, Swenberg JA.

PLoS One. 2012;7(3):e33563. doi: 10.1371/journal.pone.0033563. Epub 2012 Mar 12.

37.

A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-Oxoethyl)guanine in sprague-dawley rats.

Mutlu E, Jeong YC, Collins LB, Ham AJ, Upton PB, Hatch G, Winsett D, Evansky P, Swenberg JA.

Chem Res Toxicol. 2012 Feb 20;25(2):391-9. doi: 10.1021/tx200447w. Epub 2012 Jan 24.

38.

Formation of hydroxymethyl DNA adducts in rats orally exposed to stable isotope labeled methanol.

Lu K, Gul H, Upton PB, Moeller BC, Swenberg JA.

Toxicol Sci. 2012 Mar;126(1):28-38. doi: 10.1093/toxsci/kfr328. Epub 2011 Dec 8.

39.

Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine.

Lu K, Craft S, Nakamura J, Moeller BC, Swenberg JA.

Chem Res Toxicol. 2012 Mar 19;25(3):664-75. doi: 10.1021/tx200426b. Epub 2012 Jan 9.

40.

Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers.

Boysen G, Georgieva NI, Bordeerat NK, Sram RJ, Vacek P, Albertini RJ, Swenberg JA.

Toxicol Sci. 2012 Jan;125(1):30-40. doi: 10.1093/toxsci/kfr272. Epub 2011 Oct 14.

41.

Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells.

King CL, Ramachandran S, Chaney SG, Collins L, Swenberg JA, DeKrafft KE, Lin W, Cicurel L, Barbier M.

Cancer Chemother Pharmacol. 2012 Mar;69(3):665-77. doi: 10.1007/s00280-011-1744-3. Epub 2011 Oct 4.

42.

Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links.

Bhattacharyya D, Ramachandran S, Sharma S, Pathmasiri W, King CL, Baskerville-Abraham I, Boysen G, Swenberg JA, Campbell SL, Dokholyan NV, Chaney SG.

PLoS One. 2011;6(8):e23582. doi: 10.1371/journal.pone.0023582. Epub 2011 Aug 10.

43.

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y.

Science. 2011 Sep 2;333(6047):1300-3. doi: 10.1126/science.1210597. Epub 2011 Jul 21.

44.

Atrazine and breast cancer: a framework assessment of the toxicological and epidemiological evidence.

Simpkins JW, Swenberg JA, Weiss N, Brusick D, Eldridge JC, Stevens JT, Handa RJ, Hovey RC, Plant TM, Pastoor TP, Breckenridge CB.

Toxicol Sci. 2011 Oct;123(2):441-59. doi: 10.1093/toxsci/kfr176. Epub 2011 Jul 18. Erratum in: Toxicol Sci. 2017 Oct 1;159(2):480.

45.

Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia.

Jung D, Matson CW, Collins LB, Laban G, Stapleton HM, Bickham JW, Swenberg JA, Di Giulio RT.

Ecotoxicology. 2011 Nov;20(8):1890-9. doi: 10.1007/s10646-011-0727-9. Epub 2011 Jun 26.

46.

Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.

Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Swenberg JA, Beland FA, Pardo-Manuel Devillena F, Rusyn I, Pogribny IP.

Toxicol Sci. 2011 Aug;122(2):448-56. doi: 10.1093/toxsci/kfr133. Epub 2011 May 20.

47.

Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference.

Adami HO, Berry SC, Breckenridge CB, Smith LL, Swenberg JA, Trichopoulos D, Weiss NS, Pastoor TP.

Toxicol Sci. 2011 Aug;122(2):223-34. doi: 10.1093/toxsci/kfr113. Epub 2011 May 10.

48.

Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.

Begemann P, Boysen G, Georgieva NI, Sangaiah R, Koshlap KM, Koc H, Zhang D, Golding BT, Gold A, Swenberg JA.

Chem Res Toxicol. 2011 Jul 18;24(7):1048-61. doi: 10.1021/tx200055c. Epub 2011 Jun 9.

49.

Persistence and repair of bifunctional DNA adducts in tissues of laboratory animals exposed to 1,3-butadiene by inhalation.

Goggin M, Sangaraju D, Walker VE, Wickliffe J, Swenberg JA, Tretyakova N.

Chem Res Toxicol. 2011 Jun 20;24(6):809-17. doi: 10.1021/tx200009b. Epub 2011 Apr 13.

50.

The application of mass spectrometry in molecular dosimetry: ethylene oxide as an example.

Wu KY, Chiang SY, Shih WC, Huang CC, Chen MF, Swenberg JA.

Mass Spectrom Rev. 2011 Sep-Oct;30(5):733-56. doi: 10.1002/mas.20299. Epub 2011 Feb 16. Review.

PMID:
21328599

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