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Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.

Das Gupta K, Shakespear MR, Curson JEB, Murthy AMV, Iyer A, Hodson MP, Ramnath D, Tillu VA, von Pein JB, Reid RC, Tunny K, Hohenhaus DM, Moradi SV, Kelly GM, Kobayashi T, Gunter JH, Stevenson AJ, Xu W, Luo L, Jones A, Johnston WA, Blumenthal A, Alexandrov K, Collins BM, Stow JL, Fairlie DP, Sweet MJ.

Cell Rep. 2020 Feb 25;30(8):2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007.


Complex Multilevel Control of Hemolysin Production by Uropathogenic Escherichia coli.

Nhu NTK, Phan MD, Forde BM, Murthy AMV, Peters KM, Day CJ, Poole J, Kidd TJ, Welch RA, Jennings MP, Ulett GC, Sweet MJ, Beatson SA, Schembri MA.

mBio. 2019 Oct 1;10(5). pii: e02248-19. doi: 10.1128/mBio.02248-19.


SCIMP is a universal Toll-like receptor adaptor in macrophages.

Luo L, Curson JEB, Liu L, Wall AA, Tuladhar N, Lucas RM, Sweet MJ, Stow JL.

J Leukoc Biol. 2020 Feb;107(2):251-262. doi: 10.1002/JLB.2MA0819-138RR. Epub 2019 Aug 29.


Minocycline Prevents the Development of Mechanical Allodynia in Mouse Models of Vincristine-Induced Peripheral Neuropathy.

Starobova H, Mueller A, Allavena R, Lohman RJ, Sweet MJ, Vetter I.

Front Neurosci. 2019 Jun 27;13:653. doi: 10.3389/fnins.2019.00653. eCollection 2019.


Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic type 2 inflammation.

Loh Z, Fitzsimmons RL, Reid RC, Ramnath D, Clouston A, Gupta PK, Irvine KM, Powell EE, Schroder K, Stow JL, Sweet MJ, Fairlie DP, Iyer A.

Br J Pharmacol. 2019 Oct;176(19):3775-3790. doi: 10.1111/bph.14768. Epub 2019 Aug 17.


Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.

Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaat9284. doi: 10.1126/scitranslmed.aat9284.


Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization.

Murthy AMV, Sullivan MJ, Nhu NTK, Lo AW, Phan MD, Peters KM, Boucher D, Schroder K, Beatson SA, Ulett GC, Schembri MA, Sweet MJ.

FASEB J. 2019 Jun;33(6):7437-7450. doi: 10.1096/fj.201802100R. Epub 2019 Mar 14.


Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination.

Stocks CJ, Phan MD, Achard MES, Nhu NTK, Condon ND, Gawthorne JA, Lo AW, Peters KM, McEwan AG, Kapetanovic R, Schembri MA, Sweet MJ.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6341-6350. doi: 10.1073/pnas.1820870116. Epub 2019 Mar 7.


Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.

Chen KW, Monteleone M, Boucher D, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K.

Sci Immunol. 2018 Aug 24;3(26). pii: eaar6676. doi: 10.1126/sciimmunol.aar6676.


Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.

Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K.

Cell Rep. 2018 Aug 7;24(6):1425-1433. doi: 10.1016/j.celrep.2018.07.027.


Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes.

Ramnath D, Irvine KM, Lukowski SW, Horsfall LU, Loh Z, Clouston AD, Patel PJ, Fagan KJ, Iyer A, Lampe G, Stow JL, Schroder K, Fairlie DP, Powell JE, Powell EE, Sweet MJ.

JCI Insight. 2018 Jul 26;3(14). pii: 120274. doi: 10.1172/jci.insight.120274. eCollection 2018 Jul 26.


Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP.

Soderholm AT, Barnett TC, Korn O, Rivera-Hernandez T, Seymour LM, Schulz BL, Nizet V, Wells CA, Sweet MJ, Walker MJ.

Front Cell Infect Microbiol. 2018 May 17;8:160. doi: 10.3389/fcimb.2018.00160. eCollection 2018.


The use of gamification in the teaching of disease epidemics and pandemics.

Robinson LA, Turner IJ, Sweet MJ.

FEMS Microbiol Lett. 2018 Jun 1;365(11). doi: 10.1093/femsle/fny111.


Rediscovery of the critically endangered 'scarce yellow sally stonefly' Isogenus nubecula in United Kingdom after a 22 year period of absence.

Davy-Bowker J, Hammett MJ, Mauvisseau Q, Sweet MJ.

Zootaxa. 2018 Mar 13;4394(2):295-300. doi: 10.11646/zootaxa.4394.2.12.


Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages.

M V Murthy A, Phan MD, Peters KM, Nhu NTK, Welch RA, Ulett GC, Schembri MA, Sweet MJ.

Virulence. 2018 Dec 31;9(1):967-980. doi: 10.1080/21505594.2018.1465786.


pTRAPs: Transmembrane adaptors in innate immune signaling.

Curson JEB, Luo L, Sweet MJ, Stow JL.

J Leukoc Biol. 2018 Mar 30. doi: 10.1002/JLB.2RI1117-474R. [Epub ahead of print]


Lysine Deacetylases and Regulated Glycolysis in Macrophages.

Shakespear MR, Iyer A, Cheng CY, Das Gupta K, Singhal A, Fairlie DP, Sweet MJ.

Trends Immunol. 2018 Jun;39(6):473-488. doi: 10.1016/ Epub 2018 Mar 19. Review.


For when bacterial infections persist: Toll-like receptor-inducible direct antimicrobial pathways in macrophages.

Stocks CJ, Schembri MA, Sweet MJ, Kapetanovic R.

J Leukoc Biol. 2018 Jan;103(1):35-51. doi: 10.1002/JLB.4RI0917-358R. Epub 2018 Jan 3. Review.


Genome-Wide Discovery of Genes Required for Capsule Production by Uropathogenic Escherichia coli.

Goh KGK, Phan MD, Forde BM, Chong TM, Yin WF, Chan KG, Ulett GC, Sweet MJ, Beatson SA, Schembri MA.

mBio. 2017 Oct 24;8(5). pii: e01558-17. doi: 10.1128/mBio.01558-17.


Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies.

Soderholm AT, Barnett TC, Sweet MJ, Walker MJ.

J Leukoc Biol. 2018 Feb;103(2):193-213. doi: 10.1189/jlb.4MR0617-227RR. Epub 2017 Dec 29. Review.


In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis.

Duszyc K, Gomez GA, Schroder K, Sweet MJ, Yap AS.

Tissue Barriers. 2017 Oct 2;5(4):e1345353. doi: 10.1080/21688370.2017.1345353. Epub 2017 Jul 7. Review.


Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP.

Luo L, Tong SJ, Wall AA, Khromykh T, Sweet MJ, Stow JL.

Immunol Cell Biol. 2017 Jul;95(6):564-570. doi: 10.1038/icb.2017.10. Epub 2017 Mar 14.


Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.

Wall AA, Luo L, Hung Y, Tong SJ, Condon ND, Blumenthal A, Sweet MJ, Stow JL.

J Biol Chem. 2017 Mar 17;292(11):4411-4422. doi: 10.1074/jbc.M116.766337. Epub 2017 Jan 27.


SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.

Luo L, Bokil NJ, Wall AA, Kapetanovic R, Lansdaal NM, Marceline F, Burgess BJ, Tong SJ, Guo Z, Alexandrov K, Ross IL, Hibbs ML, Stow JL, Sweet MJ.

Nat Commun. 2017 Jan 18;8:14133. doi: 10.1038/ncomms14133.


An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.

Do A, Reid RC, Lohman RJ, Sweet MJ, Fairlie DP, Iyer A.

J Pharmacol Exp Ther. 2017 Jan;360(1):140-151. Epub 2016 Nov 8.


Baseline reef health surveys at Bangka Island (North Sulawesi, Indonesia) reveal new threats.

Ponti M, Fratangeli F, Dondi N, Segre Reinach M, Serra C, Sweet MJ.

PeerJ. 2016 Oct 25;4:e2614. eCollection 2016.


The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection.

Shepherd M, Achard ME, Idris A, Totsika M, Phan MD, Peters KM, Sarkar S, Ribeiro CA, Holyoake LV, Ladakis D, Ulett GC, Sweet MJ, Poole RK, McEwan AG, Schembri MA.

Sci Rep. 2016 Oct 21;6:35285. doi: 10.1038/srep35285.


CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites.

Irvine KM, Banh X, Gadd VL, Wojcik KK, Ariffin JK, Jose S, Lukowski S, Baillie GJ, Sweet MJ, Powell EE.

JCI Insight. 2016 Jun 2;1(8):e86914. doi: 10.1172/jci.insight.86914.


The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair.

Ramnath D, Powell EE, Scholz GM, Sweet MJ.

Semin Cell Dev Biol. 2017 Jan;61:22-30. doi: 10.1016/j.semcdb.2016.08.014. Epub 2016 Aug 20. Review.


Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus.

Lerebours A, Chapman EC, Sweet MJ, Heupel MR, Rotchell JM.

Mar Environ Res. 2016 Sep;120:130-5. doi: 10.1016/j.marenvres.2016.07.009. Epub 2016 Jul 28.


TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target.

Ullah MO, Sweet MJ, Mansell A, Kellie S, Kobe B.

J Leukoc Biol. 2016 Jul;100(1):27-45. doi: 10.1189/jlb.2RI1115-531R. Epub 2016 May 9. Review.


Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, Suen JY, Fairlie DP.

Sci Rep. 2016 Apr 20;6:24575. doi: 10.1038/srep24575.


The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists.

Chen KW, Bezbradica JS, Groß CJ, Wall AA, Sweet MJ, Stow JL, Schroder K.

Eur J Immunol. 2016 Apr;46(4):1004-10. doi: 10.1002/eji.201545943. Epub 2016 Feb 1.


Influence of Resource Availability on the Foraging Strategies of the Triangle Butterflyfish Chaetodon triangulum in the Maldives.

Chandler JF, Burn D, Berggren P, Sweet MJ.

PLoS One. 2016 Mar 21;11(3):e0151923. doi: 10.1371/journal.pone.0151923. eCollection 2016.


Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases.

Das Gupta K, Shakespear MR, Iyer A, Fairlie DP, Sweet MJ.

Clin Transl Immunology. 2016 Jan 29;5(1):e62. doi: 10.1038/cti.2015.46. eCollection 2016 Jan. Review.


Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages.

Kapetanovic R, Bokil NJ, Achard ME, Ong CL, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walker MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ.

FASEB J. 2016 May;30(5):1901-12. doi: 10.1096/fj.201500061. Epub 2016 Feb 2.


The E3 ubiquitin ligase RNF144B is LPS-inducible in human, but not mouse, macrophages and promotes inducible IL-1β expression.

Ariffin JK, Kapetanovic R, Schaale K, Gatica-Andrades M, Blumenthal A, Schroder K, Sweet MJ.

J Leukoc Biol. 2016 Jul;100(1):155-61. doi: 10.1189/jlb.2AB0815-339R. Epub 2016 Jan 27.


Co-transcriptomic Analysis by RNA Sequencing to Simultaneously Measure Regulated Gene Expression in Host and Bacterial Pathogen.

Ravasi T, Mavromatis CH, Bokil NJ, Schembri MA, Sweet MJ.

Methods Mol Biol. 2016;1390:145-58. doi: 10.1007/978-1-4939-3335-8_10.


Baseline coral disease surveys within three marine parks in Sabah, Borneo.

Miller J, Sweet MJ, Wood E, Bythell J.

PeerJ. 2015 Nov 3;3:e1391. doi: 10.7717/peerj.1391. eCollection 2015.


Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages.

Ariffin JK, das Gupta K, Kapetanovic R, Iyer A, Reid RC, Fairlie DP, Sweet MJ.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1521-9. doi: 10.1128/AAC.01876-15.


Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death.

Arnež KH, Kindlova M, Bokil NJ, Murphy JM, Sweet MJ, Gunčar G.

Biosci Rep. 2015 Dec 24;36(1):e00291. doi: 10.1042/BSR20150246.


Age-Related Shifts in Bacterial Diversity in a Reef Coral.

Williams AD, Brown BE, Putchim L, Sweet MJ.

PLoS One. 2015 Dec 23;10(12):e0144902. doi: 10.1371/journal.pone.0144902. eCollection 2015.


Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer.

D'Souza C, Henriques ST, Wang CK, Cheneval O, Chan LY, Bokil NJ, Sweet MJ, Craik DJ.

Biochemistry. 2016 Jan 19;55(2):396-405. doi: 10.1021/acs.biochem.5b00529. Epub 2016 Jan 6.


Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis.

Lohman RJ, Iyer A, Fairlie TJ, Cotterell A, Gupta P, Reid RC, Vesey DA, Sweet MJ, Fairlie DP.

J Pharmacol Exp Ther. 2016 Feb;356(2):387-96. doi: 10.1124/jpet.115.229328. Epub 2015 Dec 10.


The role of H4 flagella in Escherichia coli ST131 virulence.

Kakkanat A, Totsika M, Schaale K, Duell BL, Lo AW, Phan MD, Moriel DG, Beatson SA, Sweet MJ, Ulett GC, Schembri MA.

Sci Rep. 2015 Nov 9;5:16149. doi: 10.1038/srep16149.


Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.

Stammler D, Eigenbrod T, Menz S, Frick JS, Sweet MJ, Shakespear MR, Jantsch J, Siegert I, Wölfle S, Langer JD, Oehme I, Schaefer L, Fischer A, Knievel J, Heeg K, Dalpke AH, Bode KA.

J Immunol. 2015 Dec 1;195(11):5421-31. doi: 10.4049/jimmunol.1501195. Epub 2015 Oct 30.


Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury.

Irvine KM, Clouston AD, Gadd VL, Miller GC, Wong WY, Melino M, Maradana MR, MacDonald K, Lang RA, Sweet MJ, Blumenthal A, Powell EE.

Fibrogenesis Tissue Repair. 2015 Oct 15;8:19. doi: 10.1186/s13069-015-0036-7. eCollection 2015.


Uropathogenic Escherichia coli Engages CD14-Dependent Signaling to Enable Bladder-Macrophage-Dependent Control of Acute Urinary Tract Infection.

Carey AJ, Sullivan MJ, Duell BL, Crossman DK, Chattopadhyay D, Brooks AJ, Tan CK, Crowley M, Sweet MJ, Schembri MA, Ulett GC.

J Infect Dis. 2016 Feb 15;213(4):659-68. doi: 10.1093/infdis/jiv424. Epub 2015 Aug 30.


TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes.

Ramnath D, Tunny K, Hohenhaus DM, Pitts CM, Bergot AS, Hogarth PM, Hamilton JA, Kapetanovic R, Sturm RA, Scholz GM, Sweet MJ.

Immunol Cell Biol. 2015 Oct;93(9):771-9. doi: 10.1038/icb.2015.77. Epub 2015 Aug 25.


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