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Items: 18

1.

Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.

Griffith DA, Kung DW, Esler WP, Amor PA, Bagley SW, Beysen C, Carvajal-Gonzalez S, Doran SD, Limberakis C, Mathiowetz AM, McPherson K, Price DA, Ravussin E, Sonnenberg GE, Southers JA, Sweet LJ, Turner SM, Vajdos FF.

J Med Chem. 2014 Dec 26;57(24):10512-26. doi: 10.1021/jm5016022. Epub 2014 Dec 11.

2.

Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.

Rudolph J, Esler WP, O'connor S, Coish PD, Wickens PL, Brands M, Bierer DE, Bloomquist BT, Bondar G, Chen L, Chuang CY, Claus TH, Fathi Z, Fu W, Khire UR, Kristie JA, Liu XG, Lowe DB, McClure AC, Michels M, Ortiz AA, Ramsden PD, Schoenleber RW, Shelekhin TE, Vakalopoulos A, Tang W, Wang L, Yi L, Gardell SJ, Livingston JN, Sweet LJ, Bullock WH.

J Med Chem. 2007 Oct 18;50(21):5202-16. Epub 2007 Sep 21.

PMID:
17887659
3.

Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss.

Esler WP, Rudolph J, Claus TH, Tang W, Barucci N, Brown SE, Bullock W, Daly M, Decarr L, Li Y, Milardo L, Molstad D, Zhu J, Gardell SJ, Livingston JN, Sweet LJ.

Endocrinology. 2007 Nov;148(11):5175-85. Epub 2007 Jul 26.

PMID:
17656463
4.

PDE-10A inhibitors as insulin secretagogues.

Cantin LD, Magnuson S, Gunn D, Barucci N, Breuhaus M, Bullock WH, Burke J, Claus TH, Daly M, Decarr L, Gore-Willse A, Hoover-Litty H, Kumarasinghe ES, Li Y, Liang SX, Livingston JN, Lowinger T, Macdougall M, Ogutu HO, Olague A, Ott-Morgan R, Schoenleber RW, Tersteegen A, Wickens P, Zhang Z, Zhu J, Zhu L, Sweet LJ.

Bioorg Med Chem Lett. 2007 May 15;17(10):2869-73. Epub 2007 Feb 25.

PMID:
17400452
5.

Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis.

Ren JM, Li PM, Zhang WR, Sweet LJ, Cline G, Shulman GI, Livingston JN, Goldstein BJ.

Diabetes. 1998 Mar;47(3):493-7.

PMID:
9519761
6.
7.
9.

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.

Alcorta DA, Crews CM, Sweet LJ, Bankston L, Jones SW, Erikson RL.

Mol Cell Biol. 1989 Sep;9(9):3850-9.

11.

Transfer of functional insulin receptors to receptor-deficient target cells.

Hofmann C, Thys R, Sweet LJ, Spector AA, Pessin JE.

Endocrinology. 1988 Jun;122(6):2865-72.

PMID:
3286228
12.
13.

Phospholipid activation of the insulin receptor kinase: regulation by phosphatidylinositol.

Sweet LJ, Dudley DT, Pessin JE, Spector AA.

FASEB J. 1987 Jul;1(1):55-9.

PMID:
3038645
17.

Incorporation of the purified human placental insulin receptor into phospholipid vesicles.

Sweet LJ, Wilden PA, Spector AA, Pessin JE.

Biochemistry. 1985 Nov 5;24(23):6571-80.

PMID:
4084539

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