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Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.

Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG.

Cell Rep. 2019 Jul 16;28(3):759-772.e10. doi: 10.1016/j.celrep.2019.06.058.


Palmitate is not an effective fuel for pancreatic islets and amplifies insulin secretion independent of calcium release from endoplasmic reticulum.

Kuok IT, Rountree AM, Jung SR, Sweet IR.

Islets. 2019;11(3):51-64. doi: 10.1080/19382014.2019.1601490. Epub 2019 May 14.


Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.

Kanow MA, Giarmarco MM, Jankowski CS, Tsantilas K, Engel AL, Du J, Linton JD, Farnsworth CC, Sloat SR, Rountree A, Sweet IR, Lindsay KJ, Parker ED, Brockerhoff SE, Sadilek M, Chao JR, Hurley JB.

Elife. 2017 Sep 13;6. pii: e28899. doi: 10.7554/eLife.28899.


NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells.

Santos LRB, Muller C, de Souza AH, Takahashi HK, Spégel P, Sweet IR, Chae H, Mulder H, Jonas JC.

Mol Metab. 2017 Apr 21;6(6):535-547. doi: 10.1016/j.molmet.2017.04.004. eCollection 2017 Jun.


BaroFuse, a novel pressure-driven, adjustable-throughput perfusion system for tissue maintenance and assessment.

Rountree A, Karkamkar A, Khalil G, Folch A, Cook DL, Sweet IR.

Heliyon. 2016 Dec 9;2(12):e00210. eCollection 2016 Dec.


A method for high-throughput functional imaging of single cells within heterogeneous cell preparations.

Neal AS, Rountree AM, Radtke JR, Yin J, Schwartz MW, Hampe CS, Posner JD, Cirulli V, Sweet IR.

Sci Rep. 2016 Dec 16;6:39319. doi: 10.1038/srep39319.


Real-time imaging of intracellular hydrogen peroxide in pancreatic islets.

Neal A, Rountree A, Kernan K, Van Yserloo B, Zhang H, Reed BJ, Osborne W, Wang W, Sweet IR.

Biochem J. 2016 Dec 1;473(23):4443-4456. Epub 2016 Oct 11.


Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina.

Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satrústegui J, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB.

J Biol Chem. 2016 Feb 26;291(9):4698-710. doi: 10.1074/jbc.M115.698985. Epub 2015 Dec 16.


Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate.

Neal A, Rountree AM, Philips CW, Kavanagh TJ, Williams DP, Newham P, Khalil G, Cook DL, Sweet IR.

Toxicol Sci. 2015 Dec;148(2):594-602. doi: 10.1093/toxsci/kfv208. Epub 2015 Sep 22.


Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity.

Stoll EA, Makin R, Sweet IR, Trevelyan AJ, Miwa S, Horner PJ, Turnbull DM.

Stem Cells. 2015 Jul;33(7):2306-19. doi: 10.1002/stem.2042. Epub 2015 Jun 4.


M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling.

Lee WJ, Tateya S, Cheng AM, Rizzo-DeLeon N, Wang NF, Handa P, Wilson CL, Clowes AW, Sweet IR, Bomsztyk K, Schwartz MW, Kim F.

Diabetes. 2015 Aug;64(8):2836-46. doi: 10.2337/db14-1668. Epub 2015 Apr 6.


Control of insulin secretion by cytochrome C and calcium signaling in islets with impaired metabolism.

Rountree AM, Neal AS, Lisowski M, Rizzo N, Radtke J, White S, Luciani DS, Kim F, Hampe CS, Sweet IR.

J Biol Chem. 2014 Jul 4;289(27):19110-9. doi: 10.1074/jbc.M114.556050. Epub 2014 May 19.


Inhibition of HIV by Legalon-SIL is independent of its effect on cellular metabolism.

McClure J, Margineantu DH, Sweet IR, Polyak SJ.

Virology. 2014 Jan 20;449:96-103. doi: 10.1016/j.virol.2013.11.003. Epub 2013 Nov 27.


Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina.

Du J, Cleghorn WM, Contreras L, Lindsay K, Rountree AM, Chertov AO, Turner SJ, Sahaboglu A, Linton J, Sadilek M, Satrústegui J, Sweet IR, Paquet-Durand F, Hurley JB.

J Biol Chem. 2013 Dec 13;288(50):36129-40. doi: 10.1074/jbc.M113.507285. Epub 2013 Nov 1.


The fractalkine/CX3CR1 system regulates β cell function and insulin secretion.

Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J.

Cell. 2013 Apr 11;153(2):413-25. doi: 10.1016/j.cell.2013.03.001.


High titers of autoantibodies to glutamate decarboxylase in type 1 diabetes patients: epitope analysis and inhibition of enzyme activity.

Hampe CS, Maitland ME, Gilliam LK, Phan TH, Sweet IR, Radtke JR, Bota V, Ransom BR, Hirsch IB.

Endocr Pract. 2013 Jul-Aug;19(4):663-8. doi: 10.4158/EP12318.OR.


Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes.

Rountree AM, Reed BJ, Cummings BP, Jung SR, Stanhope KL, Graham JL, Griffen SC, Hull RL, Havel PJ, Sweet IR.

Diabetologia. 2013 Apr;56(4):803-13. doi: 10.1007/s00125-012-2808-6. Epub 2013 Feb 13.


Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic β cell function.

Suckow AT, Zhang C, Egodage S, Comoletti D, Taylor P, Miller MT, Sweet IR, Chessler SD.

J Biol Chem. 2012 Jun 8;287(24):19816-26. doi: 10.1074/jbc.M111.280537. Epub 2012 Apr 23.


Microencapsulated 3-dimensional sensor for the measurement of oxygen in single isolated pancreatic islets.

Chen W, Lisowski M, Khalil G, Sweet IR, Shen AQ.

PLoS One. 2012;7(3):e33070. doi: 10.1371/journal.pone.0033070. Epub 2012 Mar 29.


NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes.

Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller CL, Sweet IR, Pennathur S, Abel ED, Chait A.

J Biol Chem. 2012 Mar 23;287(13):10379-93. doi: 10.1074/jbc.M111.304998. Epub 2012 Jan 27.


Differential expression of the glutamate transporter GLT-1 in pancreas.

Meabon JS, Lee A, Meeker KD, Bekris LM, Fujimura RK, Yu CE, Watson GS, Pow DV, Sweet IR, Cook DG.

J Histochem Cytochem. 2012 Feb;60(2):139-51. doi: 10.1369/0022155411430095. Epub 2011 Nov 22.


Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism.

Stoll EA, Cheung W, Mikheev AM, Sweet IR, Bielas JH, Zhang J, Rostomily RC, Horner PJ.

J Biol Chem. 2011 Nov 4;286(44):38592-601. doi: 10.1074/jbc.M111.252171. Epub 2011 Sep 7.


Roles of glucose in photoreceptor survival.

Chertov AO, Holzhausen L, Kuok IT, Couron D, Parker E, Linton JD, Sadilek M, Sweet IR, Hurley JB.

J Biol Chem. 2011 Oct 7;286(40):34700-11. doi: 10.1074/jbc.M111.279752. Epub 2011 Aug 12.


Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic islets.

Jung SR, Kuok IT, Couron D, Rizzo N, Margineantu DH, Hockenbery DM, Kim F, Sweet IR.

J Biol Chem. 2011 May 20;286(20):17422-34. doi: 10.1074/jbc.M110.202820. Epub 2011 Mar 10.


TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes.

Sahni J, Tamura R, Sweet IR, Scharenberg AM.

Cell Cycle. 2010 Sep 1;9(17):3565-74. doi: 10.4161/cc.9.17.12798. Epub 2010 Sep 25.


BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells.

Houamed KM, Sweet IR, Satin LS.

J Physiol. 2010 Sep 15;588(Pt 18):3511-23. doi: 10.1113/jphysiol.2009.184341. Epub 2010 Jul 19.


Flow of energy in the outer retina in darkness and in light.

Linton JD, Holzhausen LC, Babai N, Song H, Miyagishima KJ, Stearns GW, Lindsay K, Wei J, Chertov AO, Peters TA, Caffe R, Pluk H, Seeliger MW, Tanimoto N, Fong K, Bolton L, Kuok DL, Sweet IR, Bartoletti TM, Radu RA, Travis GH, Zagotta WN, Townes-Anderson E, Parker E, Van der Zee CE, Sampath AP, Sokolov M, Thoreson WB, Hurley JB.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8599-604. doi: 10.1073/pnas.1002471107. Epub 2010 May 5.


A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.

Jung SR, Reed BJ, Sweet IR.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E717-27. doi: 10.1152/ajpendo.00282.2009. Epub 2009 Jul 7.


Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation.

Maloney E, Sweet IR, Hockenbery DM, Pham M, Rizzo NO, Tateya S, Handa P, Schwartz MW, Kim F.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1370-5. doi: 10.1161/ATVBAHA.109.188813. Epub 2009 Jun 18.


The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.

Bollyky PL, Bice JB, Sweet IR, Falk BA, Gebe JA, Clark AE, Gersuk VH, Aderem A, Hawn TR, Nepom GT.

PLoS One. 2009;4(4):e5063. doi: 10.1371/journal.pone.0005063. Epub 2009 Apr 1.


Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration.

Sweet IR, Gilbert M, Maloney E, Hockenbery DM, Schwartz MW, Kim F.

Diabetologia. 2009 May;52(5):921-31. doi: 10.1007/s00125-009-1272-4. Epub 2009 Feb 14.


Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat.

Cummings BP, Digitale EK, Stanhope KL, Graham JL, Baskin DG, Reed BJ, Sweet IR, Griffen SC, Havel PJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1782-93. doi: 10.1152/ajpregu.90635.2008. Epub 2008 Oct 1.


Islet oxygen consumption and insulin secretion tightly coupled to calcium derived from L-type calcium channels but not from the endoplasmic reticulum.

Gilbert M, Jung SR, Reed BJ, Sweet IR.

J Biol Chem. 2008 Sep 5;283(36):24334-42. doi: 10.1074/jbc.M802097200. Epub 2008 Jul 1.


Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.

Raffo A, Hancock K, Polito T, Xie Y, Andan G, Witkowski P, Hardy M, Barba P, Ferrara C, Maffei A, Freeby M, Goland R, Leibel RL, Sweet IR, Harris PE.

J Endocrinol. 2008 Jul;198(1):41-9. doi: 10.1677/JOE-07-0632.


Treatment of diabetic rats with encapsulated islets.

Sweet IR, Yanay O, Waldron L, Gilbert M, Fuller JM, Tupling T, Lernmark A, Osborne WR.

J Cell Mol Med. 2008 Dec;12(6B):2644-50. doi: 10.1111/j.1582-4934.2008.00322.x. Epub 2008 Mar 28.


Glucose-stimulated increment in oxygen consumption rate as a standardized test of human islet quality.

Sweet IR, Gilbert M, Scott S, Todorov I, Jensen R, Nair I, Al-Abdullah I, Rawson J, Kandeel F, Ferreri K.

Am J Transplant. 2008 Jan;8(1):183-92. Epub 2007 Nov 12.


2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition.

Schwartz PS, Manion MK, Emerson CB, Fry JS, Schulz CM, Sweet IR, Hockenbery DM.

Mol Cancer Ther. 2007 Jul;6(7):2073-80.


Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.

Weydt P, Pineda VV, Torrence AE, Libby RT, Satterfield TF, Lazarowski ER, Gilbert ML, Morton GJ, Bammler TK, Strand AD, Cui L, Beyer RP, Easley CN, Smith AC, Krainc D, Luquet S, Sweet IR, Schwartz MW, La Spada AR.

Cell Metab. 2006 Nov;4(5):349-62. Epub 2006 Oct 19.


Identification and characterization of a novel isoform of the vesicular gamma-aminobutyric acid transporter with glucose-regulated expression in rat islets.

Suckow AT, Sweet IR, Van Yserloo B, Rutledge EA, Hall TR, Waldrop M, Chessler SD.

J Mol Endocrinol. 2006 Feb;36(1):187-99.


Glucose stimulation of cytochrome C reduction and oxygen consumption as assessment of human islet quality.

Sweet IR, Gilbert M, Jensen R, Sabek O, Fraga DW, Gaber AO, Reems J.

Transplantation. 2005 Oct 27;80(8):1003-11.


Insulin secretion in the conscious mouse is biphasic and pulsatile.

Nunemaker CS, Wasserman DH, McGuinness OP, Sweet IR, Teague JC, Satin LS.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E523-9. Epub 2005 Oct 25.


Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.

Niswender CM, Willis BS, Wallen A, Sweet IR, Jetton TL, Thompson BR, Wu C, Lange AJ, McKnight GS.

Genesis. 2005 Nov;43(3):109-19.


Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass.

Hampe CS, Wallen AR, Schlosser M, Ziegler M, Sweet IR.

Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):381-7.


Non-invasive imaging of beta cell mass: a quantitative analysis.

Sweet IR, Cook DL, Lernmark A, Greenbaum CJ, Krohn KA.

Diabetes Technol Ther. 2004 Oct;6(5):652-9.


Systematic screening of potential beta-cell imaging agents.

Sweet IR, Cook DL, Lernmark A, Greenbaum CJ, Wallen AR, Marcum ES, Stekhova SA, Krohn KA.

Biochem Biophys Res Commun. 2004 Feb 20;314(4):976-83.


Regulation of ATP/ADP in pancreatic islets.

Sweet IR, Cook DL, DeJulio E, Wallen AR, Khalil G, Callis J, Reems J.

Diabetes. 2004 Feb;53(2):401-9.


Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol.

Matsumoto S, Qualley SA, Goel S, Hagman DK, Sweet IR, Poitout V, Strong DM, Robertson RP, Reems JA.

Transplantation. 2002 Nov 27;74(10):1414-9.


Continuous measurement of oxygen consumption by pancreatic islets.

Sweet IR, Khalil G, Wallen AR, Steedman M, Schenkman KA, Reems JA, Kahn SE, Callis JB.

Diabetes Technol Ther. 2002;4(5):661-72.


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