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Items: 22

1.

AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.

Jenkins Y, Sun TQ, Markovtsov V, Foretz M, Li W, Nguyen H, Li Y, Pan A, Uy G, Gross L, Baltgalvis K, Yung SL, Gururaja T, Kinoshita T, Owyang A, Smith IJ, McCaughey K, White K, Godinez G, Alcantara R, Choy C, Ren H, Basile R, Sweeny DJ, Xu X, Issakani SD, Carroll DC, Goff DA, Shaw SJ, Singh R, Boros LG, Laplante MA, Marcotte B, Kohen R, Viollet B, Marette A, Payan DG, Kinsella TM, Hitoshi Y.

PLoS One. 2013 Dec 5;8(12):e81870. doi: 10.1371/journal.pone.0081870. eCollection 2013.

2.

Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey.

Sweeny DJ, Li W, Grossbard E, Lau DT.

Xenobiotica. 2010 Jun;40(6):415-23. doi: 10.3109/00498251003734244.

PMID:
20415544
3.

Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation.

Sweeny DJ, Li W, Clough J, Bhamidipati S, Singh R, Park G, Baluom M, Grossbard E, Lau DT.

Drug Metab Dispos. 2010 Jul;38(7):1166-76. doi: 10.1124/dmd.110.032151. Epub 2010 Apr 6.

PMID:
20371637
4.

Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species.

Haznedar JO, Patyna S, Bello CL, Peng GW, Speed W, Yu X, Zhang Q, Sukbuntherng J, Sweeny DJ, Antonian L, Wu EY.

Cancer Chemother Pharmacol. 2009 Sep;64(4):691-706. doi: 10.1007/s00280-008-0917-1. Epub 2009 Jan 25.

PMID:
19169880
5.

Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat.

Sweeny DJ, Lynch G, Bidgood AM, Lew W, Wang KY, Cundy KC.

Drug Metab Dispos. 2000 Jul;28(7):737-41.

PMID:
10859145
6.

Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity.

Lew W, Escarpe PA, Mendel DB, Sweeny DJ, Kim CU.

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2811-4.

PMID:
10522696
7.

Stereoselective glucuronidation of zileuton isomers by human hepatic microsomes.

Sweeny DJ, Nellans HN.

Drug Metab Dispos. 1995 Jan;23(1):149-53.

PMID:
7720519
8.

Enantiomeric activation of glucuronidation in dog hepatic microsomes.

Sweeny DJ, Nellans HN.

J Biol Chem. 1992 Jul 5;267(19):13171-4.

9.

Glucuronidation of zileuton (A-64077) by human hepatic microsomes.

Sweeny DJ, Bouska J, Machinist J, Bell R, Carter G, Cepa S, Nellans HN.

Drug Metab Dispos. 1992 Mar-Apr;20(2):328-9. No abstract available.

PMID:
1352229
10.

Bile acid conjugation pattern in the isolated perfused rat liver during infusion of an amino acid formulation.

Sweeny DJ, Barnes S, Diasio RB.

JPEN J Parenter Enteral Nutr. 1991 May-Jun;15(3):303-6.

PMID:
1907679
11.

2-Fluoro-beta-alanine, a previously unrecognized substrate for bile acid coenzyme A:amino acid:N-acyltransferase from human liver.

Johnson MR, Barnes S, Sweeny DJ, Diasio RB.

Biochem Pharmacol. 1990 Sep 15;40(6):1241-6.

PMID:
2119585
12.
13.

N-chenodeoxycholyl-2-fluoro-beta-alanine: a biliary metabolite of 5-fluorouracil in humans.

Sweeny DJ, Martin M, Diasio RB.

Drug Metab Dispos. 1988 Nov-Dec;16(6):892-4. No abstract available.

PMID:
2907471
16.
18.

Diminished pentose cycle flux in perfused livers of ethanol-fed rats.

Reinke LA, Tupper JS, Smith PR, Sweeny DJ.

Mol Pharmacol. 1987 Jun;31(6):631-7.

PMID:
3600608
19.

Effect of ethanol feeding on hepatic microsomal UDP-glucuronyltransferase activity.

Sweeny DJ, Reinke LA.

Biochem Pharmacol. 1987 Apr 15;36(8):1381-3. No abstract available.

PMID:
3109441
21.

Inhibition of glucuronidation and sulfation by dibutyryl cyclic AMP in isolated rat hepatocytes.

Shipley LA, Eacho PI, Sweeny DJ, Weiner M.

Drug Metab Dispos. 1986 Sep-Oct;14(5):526-31.

PMID:
2876857
22.

Metabolism of acetaminophen in hepatocytes isolated from mice and rats of various ages.

Sweeny DJ, Weiner M.

Drug Metab Dispos. 1985 May-Jun;13(3):377-9. No abstract available.

PMID:
2862001

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