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Items: 35

1.

Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies.

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Surry D, Sweeny D, Lau D, Leese P.

Clin Pharmacol Drug Dev. 2016 May;5(3):170-9. doi: 10.1002/cpdd.243. Epub 2016 Mar 23.

PMID:
27163495
2.

Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Grossbard EB, Baluom M, Lau D, Sweeny D, Mant T, Craven K.

Drugs R D. 2016 Mar;16(1):81-92. doi: 10.1007/s40268-015-0118-4.

3.

AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.

Jenkins Y, Sun TQ, Markovtsov V, Foretz M, Li W, Nguyen H, Li Y, Pan A, Uy G, Gross L, Baltgalvis K, Yung SL, Gururaja T, Kinoshita T, Owyang A, Smith IJ, McCaughey K, White K, Godinez G, Alcantara R, Choy C, Ren H, Basile R, Sweeny DJ, Xu X, Issakani SD, Carroll DC, Goff DA, Shaw SJ, Singh R, Boros LG, Laplante MA, Marcotte B, Kohen R, Viollet B, Marette A, Payan DG, Kinsella TM, Hitoshi Y.

PLoS One. 2013 Dec 5;8(12):e81870. doi: 10.1371/journal.pone.0081870. eCollection 2013.

4.

Characterization of the native form of anthrax lethal factor for use in the toxin neutralization assay.

Lu H, Catania J, Baranji K, Feng J, Gu M, Lathey J, Sweeny D, Sanford H, Sapru K, Patamawenu T, Chen JH, Ng A, Fesseha Z, Kluepfel-Stahl S, Minang J, Alleva D.

Clin Vaccine Immunol. 2013 Jul;20(7):986-97. doi: 10.1128/CVI.00046-13. Epub 2013 May 1.

5.

Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey.

Sweeny DJ, Li W, Grossbard E, Lau DT.

Xenobiotica. 2010 Jun;40(6):415-23. doi: 10.3109/00498251003734244.

PMID:
20415544
6.

Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation.

Sweeny DJ, Li W, Clough J, Bhamidipati S, Singh R, Park G, Baluom M, Grossbard E, Lau DT.

Drug Metab Dispos. 2010 Jul;38(7):1166-76. doi: 10.1124/dmd.110.032151. Epub 2010 Apr 6.

PMID:
20371637
7.

Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.

McLaughlin J, Markovtsov V, Li H, Wong S, Gelman M, Zhu Y, Franci C, Lang D, Pali E, Lasaga J, Low C, Zhao F, Chang B, Gururaja TL, Xu W, Baluom M, Sweeny D, Carroll D, Sran A, Thota S, Parmer M, Romane A, Clemens G, Grossbard E, Qu K, Jenkins Y, Kinoshita T, Taylor V, Holland SJ, Argade A, Singh R, Pine P, Payan DG, Hitoshi Y.

J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. doi: 10.1007/s00432-009-0641-1.

PMID:
19609559
8.

Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species.

Haznedar JO, Patyna S, Bello CL, Peng GW, Speed W, Yu X, Zhang Q, Sukbuntherng J, Sweeny DJ, Antonian L, Wu EY.

Cancer Chemother Pharmacol. 2009 Sep;64(4):691-706. doi: 10.1007/s00280-008-0917-1. Epub 2009 Jan 25.

PMID:
19169880
9.

Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416.

Ye C, Sweeny D, Sukbuntherng J, Zhang Q, Tan W, Wong S, Madan A, Ogilvie B, Parkinson A, Antonian L.

Toxicol In Vitro. 2006 Mar;20(2):154-62. Review.

PMID:
16321501
10.

Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat.

Sweeny DJ, Lynch G, Bidgood AM, Lew W, Wang KY, Cundy KC.

Drug Metab Dispos. 2000 Jul;28(7):737-41.

PMID:
10859145
11.

Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity.

Lew W, Escarpe PA, Mendel DB, Sweeny DJ, Kim CU.

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2811-4.

PMID:
10522696
12.

Stereoselective glucuronidation of zileuton isomers by human hepatic microsomes.

Sweeny DJ, Nellans HN.

Drug Metab Dispos. 1995 Jan;23(1):149-53.

PMID:
7720519
13.

Enantiomeric activation of glucuronidation in dog hepatic microsomes.

Sweeny DJ, Nellans HN.

J Biol Chem. 1992 Jul 5;267(19):13171-4.

14.

Glucuronidation of zileuton (A-64077) by human hepatic microsomes.

Sweeny DJ, Bouska J, Machinist J, Bell R, Carter G, Cepa S, Nellans HN.

Drug Metab Dispos. 1992 Mar-Apr;20(2):328-9. No abstract available.

PMID:
1352229
15.

Bile acid conjugation pattern in the isolated perfused rat liver during infusion of an amino acid formulation.

Sweeny DJ, Barnes S, Diasio RB.

JPEN J Parenter Enteral Nutr. 1991 May-Jun;15(3):303-6.

PMID:
1907679
16.

2-Fluoro-beta-alanine, a previously unrecognized substrate for bile acid coenzyme A:amino acid:N-acyltransferase from human liver.

Johnson MR, Barnes S, Sweeny DJ, Diasio RB.

Biochem Pharmacol. 1990 Sep 15;40(6):1241-6.

PMID:
2119585
17.
18.

N-chenodeoxycholyl-2-fluoro-beta-alanine: a biliary metabolite of 5-fluorouracil in humans.

Sweeny DJ, Martin M, Diasio RB.

Drug Metab Dispos. 1988 Nov-Dec;16(6):892-4. No abstract available.

PMID:
2907471
21.
23.

Diminished pentose cycle flux in perfused livers of ethanol-fed rats.

Reinke LA, Tupper JS, Smith PR, Sweeny DJ.

Mol Pharmacol. 1987 Jun;31(6):631-7.

PMID:
3600608
24.

Effect of ethanol feeding on hepatic microsomal UDP-glucuronyltransferase activity.

Sweeny DJ, Reinke LA.

Biochem Pharmacol. 1987 Apr 15;36(8):1381-3. No abstract available.

PMID:
3109441
26.

Inhibition of glucuronidation and sulfation by dibutyryl cyclic AMP in isolated rat hepatocytes.

Shipley LA, Eacho PI, Sweeny DJ, Weiner M.

Drug Metab Dispos. 1986 Sep-Oct;14(5):526-31.

PMID:
2876857
27.

Metabolism of acetaminophen in hepatocytes isolated from mice and rats of various ages.

Sweeny DJ, Weiner M.

Drug Metab Dispos. 1985 May-Jun;13(3):377-9. No abstract available.

PMID:
2862001
28.

Effects of glucose and fructose on conjugation of p-nitrophenol in hepatocytes of normal and streptozotocin-diabetic rats.

Eacho PI, Sweeny D, Weiner M.

Biochem Pharmacol. 1981 Sep 15;30(18):2616-9. No abstract available.

PMID:
7030348
29.

Conjugation of p-nitroanisole and p-nitrophenol in hepatocytes isolated from streptozotocin diabetic rats.

Eacho PI, Sweeny D, Weiner M.

J Pharmacol Exp Ther. 1981 Jul;218(1):34-40.

PMID:
6787190
30.

Physicians must have national leadership; only the AMA qualifies.

Sweeny DN Jr.

Mich Med. 1971 Mar;70(6):213-4. No abstract available.

PMID:
5547083
31.

Decreased blood urea levels after resection of adrenocortical tumor for Cushing's syndrome.

WOLFSON WQ, DE FILIPPIS V, TAYLOR NM, SWEENY DN Jr.

J Clin Endocrinol Metab. 1955 Jan;15(1):156-60. No abstract available.

PMID:
13221639
32.

Thrombo-angiitis obliterans in women; report of a case.

FISHER RL, ZUKERMAN M, SWEENY DN Jr.

Angiology. 1951 Apr;2(2):132-7. No abstract available.

PMID:
14819710
33.

The swollen leg.

SWEENY DN Jr.

J Mich State Med Soc. 1949 Jun;48(6):732. No abstract available.

PMID:
18145358
34.

Tetraethylammonium chloride in treatment of herpes zoster and intercostal neuralgia.

FISHER RL, ZUKERMAN M, SWEENY DN Jr.

Arch Neurol Psychiatry. 1949 Feb;61(2):194-8. No abstract available.

PMID:
18152784
35.

The Use of Thiouracil in the Preparation of Patients With Hyperthyroidism for Thyroidectomy.

Moore FD, Sweeny DN, Cope O, Rawson RW, Means JH.

Ann Surg. 1944 Aug;120(2):152-69. No abstract available.

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