Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 325


Force Generation by Myosin Motors: A Structural Perspective.

Robert-Paganin J, Pylypenko O, Kikuti C, Sweeney HL, Houdusse A.

Chem Rev. 2019 Nov 5. doi: 10.1021/acs.chemrev.9b00264. [Epub ahead of print]


Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin.

Barton ER, Pham J, Brisson BK, Park S, Smith LR, Liu M, Tian Z, Hammers DW, Vassilakos G, Sweeney HL.

Muscle Nerve. 2019 Oct;60(4):464-473. doi: 10.1002/mus.26641. Epub 2019 Jul 30.


Evaluating growth failure with diffusion tensor imaging in pediatric survivors of high-risk neuroblastoma treated with high-dose cis-retinoic acid.

Delgado J, Jaramillo D, Chauvin NA, Guo M, Stratton MS, Sweeney HE, Barrera CA, Mostoufi-Moab S.

Pediatr Radiol. 2019 Jul;49(8):1056-1065. doi: 10.1007/s00247-019-04409-1. Epub 2019 May 4.


Smooth muscle atrophy and colon pathology in SMN deficient mice.

Yang Y, Vassilakos G, Hammers DW, Yang Z, Barton ER, Sweeney HL.

Am J Transl Res. 2019 Mar 15;11(3):1789-1799. eCollection 2019.


The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.

Daniel B, Nagy G, Czimmerer Z, Horvath A, Hammers DW, Cuaranta-Monroy I, Poliska S, Tzerpos P, Kolostyak Z, Hays TT, Patsalos A, Houtman R, Sauer S, Francois-Deleuze J, Rastinejad F, Balint BL, Sweeney HL, Nagy L.

Immunity. 2018 Oct 16;49(4):615-626.e6. doi: 10.1016/j.immuni.2018.09.005.


Too much of a good thing.

Sweeney HL.

Elife. 2018 Sep 17;7. pii: e41178. doi: 10.7554/eLife.41178.


Structural and functional cardiac profile after prolonged duration of mechanical unloading: potential implications for myocardial recovery.

Castillero E, Ali ZA, Akashi H, Giangreco N, Wang C, Stöhr EJ, Ji R, Zhang X, Kheysin N, Park JS, Hegde S, Patel S, Stein S, Cuenca C, Leung D, Homma S, Tatonetti NP, Topkara VK, Takeda K, Colombo PC, Naka Y, Sweeney HL, Schulze PC, George I.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1463-H1476. doi: 10.1152/ajpheart.00187.2018. Epub 2018 Aug 24.


Three-dimensional contractile muscle tissue consisting of human skeletal myocyte cell line.

Shima A, Morimoto Y, Sweeney HL, Takeuchi S.

Exp Cell Res. 2018 Sep 1;370(1):168-173. doi: 10.1016/j.yexcr.2018.06.015. Epub 2018 Jun 19.


An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics.

Blanc F, Isabet T, Benisty H, Sweeney HL, Cecchini M, Houdusse A.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6213-6218. doi: 10.1073/pnas.1711512115. Epub 2018 May 29.


Longitudinal timed function tests in Duchenne muscular dystrophy: ImagingDMD cohort natural history.

Arora H, Willcocks RJ, Lott DJ, Harrington AT, Senesac CR, Zilke KL, Daniels MJ, Xu D, Tennekoon GI, Finanger EL, Russman BS, Finkel RS, Triplett WT, Byrne BJ, Walter GA, Sweeney HL, Vandenborne K.

Muscle Nerve. 2018 Nov;58(5):631-638. doi: 10.1002/mus.26161. Epub 2018 Jul 24.


Two-Year Longitudinal Changes in Lower Limb Strength and Its Relation to Loss in Function in a Large Cohort of Patients With Duchenne Muscular Dystrophy.

Batra A, Harrington A, Lott DJ, Willcocks R, Senesac CR, McGehee W, Xu D, Mathur S, Daniels MJ, Rooney WD, Forbes SC, Triplett W, Deol JK, Arpan I, Bendixen R, Finkel R, Finanger E, Tennekoon G, Byrne B, Russman B, Sweeney HL, Walter G, Vandenborne K.

Am J Phys Med Rehabil. 2018 Oct;97(10):734-740. doi: 10.1097/PHM.0000000000000957.


Motor Proteins.

Sweeney HL, Holzbaur ELF.

Cold Spring Harb Perspect Biol. 2018 May 1;10(5). pii: a021931. doi: 10.1101/cshperspect.a021931. Review.


Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy.

Barnard AM, Willcocks RJ, Finanger EL, Daniels MJ, Triplett WT, Rooney WD, Lott DJ, Forbes SC, Wang DJ, Senesac CR, Harrington AT, Finkel RS, Russman BS, Byrne BJ, Tennekoon GI, Walter GA, Sweeney HL, Vandenborne K.

PLoS One. 2018 Mar 19;13(3):e0194283. doi: 10.1371/journal.pone.0194283. eCollection 2018.


Muscle Contraction.

Sweeney HL, Hammers DW.

Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2). pii: a023200. doi: 10.1101/cshperspect.a023200. Review.


Leg muscle MRI in identical twin boys with duchenne muscular dystrophy.

Willcocks RJ, Triplett WT, Lott DJ, Forbes SC, Batra A, Sweeney HL, Mendell JR, Vandenborne K, Walter GA.

Muscle Nerve. 2018 Jan 24. doi: 10.1002/mus.26081. [Epub ahead of print] No abstract available.


226th ENMC International Workshop:: Towards validated and qualified biomarkers for therapy development for Duchenne muscular dystrophy 20-22 January 2017, Heemskerk, The Netherlands.

Aartsma-Rus A, Ferlini A, McNally EM, Spitali P, Sweeney HL; workshop participants.

Neuromuscul Disord. 2018 Jan;28(1):77-86. doi: 10.1016/j.nmd.2017.10.002. Epub 2017 Oct 26. No abstract available.


Mapping suicide mortality in Ohio: A spatial epidemiological analysis of suicide clusters and area level correlates.

Fontanella CA, Saman DM, Campo JV, Hiance-Steelesmith DL, Bridge JA, Sweeney HA, Root ED.

Prev Med. 2018 Jan;106:177-184. doi: 10.1016/j.ypmed.2017.10.033. Epub 2017 Nov 10.


A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy.

Victor RG, Sweeney HL, Finkel R, McDonald CM, Byrne B, Eagle M, Goemans N, Vandenborne K, Dubrovsky AL, Topaloglu H, Miceli MC, Furlong P, Landry J, Elashoff R, Cox D; Tadalafil DMD Study Group.

Neurology. 2017 Oct 24;89(17):1811-1820. doi: 10.1212/WNL.0000000000004570. Epub 2017 Sep 29.


Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

McDonald CM, Campbell C, Torricelli RE, Finkel RS, Flanigan KM, Goemans N, Heydemann P, Kaminska A, Kirschner J, Muntoni F, Osorio AN, Schara U, Sejersen T, Shieh PB, Sweeney HL, Topaloglu H, Tulinius M, Vilchez JJ, Voit T, Wong B, Elfring G, Kroger H, Luo X, McIntosh J, Ong T, Riebling P, Souza M, Spiegel RJ, Peltz SW, Mercuri E; Clinical Evaluator Training Group; ACT DMD Study Group.

Lancet. 2017 Sep 23;390(10101):1489-1498. doi: 10.1016/S0140-6736(17)31611-2. Epub 2017 Jul 17.


Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis.

Collum SD, Chen NY, Hernandez AM, Hanmandlu A, Sweeney H, Mertens TCJ, Weng T, Luo F, Molina JG, Davies J, Horan IP, Morrell NW, Amione-Guerra J, Al-Jabbari O, Youker K, Sun W, Rajadas J, Bollyky PL, Akkanti BH, Jyothula S, Sinha N, Guha A, Karmouty-Quintana H.

Br J Pharmacol. 2017 Oct;174(19):3284-3301. doi: 10.1111/bph.13947. Epub 2017 Aug 17.


Supraphysiological levels of GDF11 induce striated muscle atrophy.

Hammers DW, Merscham-Banda M, Hsiao JY, Engst S, Hartman JJ, Sweeney HL.

EMBO Mol Med. 2017 Apr;9(4):531-544. doi: 10.15252/emmm.201607231.


Service Use in the Month and Year Prior to Suicide Among Adults Enrolled in Ohio Medicaid.

Fontanella CA, Warner LA, Hiance-Steelesmith DL, Sweeney HA, Bridge JA, McKeon R, Campo JV.

Psychiatr Serv. 2017 Jul 1;68(7):674-680. doi: 10.1176/ Epub 2017 Feb 15.


Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.

Hammers DW, Sleeper MM, Forbes SC, Coker CC, Jirousek MR, Zimmer M, Walter GA, Sweeney HL.

JCI Insight. 2016 Dec 22;1(21):e90341. doi: 10.1172/jci.insight.90341.


Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.

Milewicz DM, Trybus KM, Guo DC, Sweeney HL, Regalado E, Kamm K, Stull JT.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):26-34. doi: 10.1161/ATVBAHA.116.303229. Epub 2016 Nov 22. Review. Erratum in: Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):e12.


Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy.

Liu M, Hammers DW, Barton ER, Sweeney HL.

PLoS One. 2016 Nov 21;11(11):e0166803. doi: 10.1371/journal.pone.0166803. eCollection 2016.


How Myosin Generates Force on Actin Filaments.

Houdusse A, Sweeney HL.

Trends Biochem Sci. 2016 Dec;41(12):989-997. doi: 10.1016/j.tibs.2016.09.006. Epub 2016 Oct 4. Review.


The myosin X motor is optimized for movement on actin bundles.

Ropars V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar CV, Sweeney HL, Houdusse A.

Nat Commun. 2016 Sep 1;7:12456. doi: 10.1038/ncomms12456.


Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.

Hammers DW, Sleeper MM, Forbes SC, Shima A, Walter GA, Sweeney HL.

J Am Heart Assoc. 2016 Aug 9;5(8). pii: e003911. doi: 10.1161/JAHA.116.003911.


Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities.

Chang AN, Mahajan P, Knapp S, Barton H, Sweeney HL, Kamm KE, Stull JT.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3824-33. doi: 10.1073/pnas.1600633113. Epub 2016 Jun 20.


Benzodiazepine use and risk of mortality among patients with schizophrenia: a retrospective longitudinal study.

Fontanella CA, Campo JV, Phillips GS, Hiance-Steelesmith DL, Sweeney HA, Tam K, Lehrer D, Klein R, Hurst M.

J Clin Psychiatry. 2016 May;77(5):661-7. doi: 10.4088/JCP.15m10271.


Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype.

Capote J, Kramerova I, Martinez L, Vetrone S, Barton ER, Sweeney HL, Miceli MC, Spencer MJ.

J Cell Biol. 2016 Apr 25;213(2):275-88. doi: 10.1083/jcb.201510086. Epub 2016 Apr 18.


Force-producing ADP state of myosin bound to actin.

Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse AM, Schröder RR.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1844-52. doi: 10.1073/pnas.1516598113. Epub 2016 Mar 14.


Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish.

Abrams J, Einhorn Z, Seiler C, Zong AB, Sweeney HL, Pack M.

Dis Model Mech. 2016 May 1;9(5):529-40. doi: 10.1242/dmm.023309. Epub 2016 Feb 18.


Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort.

Willcocks RJ, Rooney WD, Triplett WT, Forbes SC, Lott DJ, Senesac CR, Daniels MJ, Wang DJ, Harrington AT, Tennekoon GI, Russman BS, Finanger EL, Byrne BJ, Finkel RS, Walter GA, Sweeney HL, Vandenborne K.

Ann Neurol. 2016 Apr;79(4):535-47. doi: 10.1002/ana.24599. Epub 2016 Feb 19.


Factors Associated With Timely Follow-Up Care After Psychiatric Hospitalization for Youths With Mood Disorders.

Fontanella CA, Hiance-Steelesmith DL, Bridge JA, Lester N, Sweeney HA, Hurst M, Campo JV.

Psychiatr Serv. 2016 Mar;67(3):324-31. doi: 10.1176/ Epub 2015 Dec 1.


Increased collagen cross-linking is a signature of dystrophin-deficient muscle.

Smith LR, Hammers DW, Sweeney HL, Barton ER.

Muscle Nerve. 2016 Jun;54(1):71-8. doi: 10.1002/mus.24998. Epub 2016 Feb 22.


How a patient advocacy group developed the first proposed draft guidance document for industry for submission to the U.S. Food and Drug Administration.

Furlong P, Bridges JF, Charnas L, Fallon JR, Fischer R, Flanigan KM, Franson TR, Gulati N, McDonald C, Peay H, Sweeney HL.

Orphanet J Rare Dis. 2015 Jun 24;10:82. doi: 10.1186/s13023-015-0281-2.


Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements.

Vohra RS, Lott D, Mathur S, Senesac C, Deol J, Germain S, Bendixen R, Forbes SC, Sweeney HL, Walter GA, Vandenborne K.

PLoS One. 2015 Jun 23;10(6):e0128915. doi: 10.1371/journal.pone.0128915. eCollection 2015.


Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy.

Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, Naka Y, Mancini D, Sweeney HL, D Armiento J, Ali ZA, Schulze PC, George I.

Am J Physiol Heart Circ Physiol. 2015 Aug 1;309(3):H459-70. doi: 10.1152/ajpheart.00056.2015. Epub 2015 Jun 8.


Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy.

Hathout Y, Brody E, Clemens PR, Cripe L, DeLisle RK, Furlong P, Gordish-Dressman H, Hache L, Henricson E, Hoffman EP, Kobayashi YM, Lorts A, Mah JK, McDonald C, Mehler B, Nelson S, Nikrad M, Singer B, Steele F, Sterling D, Sweeney HL, Williams S, Gold L.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7153-8. doi: 10.1073/pnas.1507719112. Epub 2015 May 26.


A Comparison of Benefit Limits in Mental Health.

Olesiuk WJ, Sweeney HA, Seiber EE, Zhu H, Schweikhart SB, Shoben AB, Tam KK.

Adm Policy Ment Health. 2016 Jul;43(4):524-34. doi: 10.1007/s10488-015-0656-7.


How actin initiates the motor activity of Myosin.

Llinas P, Isabet T, Song L, Ropars V, Zong B, Benisty H, Sirigu S, Morris C, Kikuti C, Safer D, Sweeney HL, Houdusse A.

Dev Cell. 2015 May 26;33(4):401-12. doi: 10.1016/j.devcel.2015.03.025. Epub 2015 Apr 30.


Myosin VI deafness mutation prevents the initiation of processive runs on actin.

Pylypenko O, Song L, Shima A, Yang Z, Houdusse AM, Sweeney HL.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1201-9. doi: 10.1073/pnas.1420989112. Epub 2015 Mar 6.


Widening rural-urban disparities in youth suicides, United States, 1996-2010.

Fontanella CA, Hiance-Steelesmith DL, Phillips GS, Bridge JA, Lester N, Sweeney HA, Campo JV.

JAMA Pediatr. 2015 May;169(5):466-73. doi: 10.1001/jamapediatrics.2014.3561.


Early loss of ambulation is not a representative clinical feature in Duchenne muscular dystrophy dogs: remarks on the article of Barthélémy et al.

Duan D, Hakim CH, Ambrosio CE, Smith BF, Sweeney HL.

Dis Model Mech. 2015 Mar;8(3):193-4. doi: 10.1242/dmm.019216. No abstract available.


Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy.

Castillero E, Akashi H, Wang C, Najjar M, Ji R, Kennel PJ, Sweeney HL, Schulze PC, George I.

Biochem Biophys Res Commun. 2015 Jan 30;457(1):106-11. doi: 10.1016/j.bbrc.2014.12.057. Epub 2014 Dec 18.


Urinary creatinine excretion, bioelectrical impedance analysis, and clinical outcomes in patients with CKD: the CRIC study.

Wilson FP, Xie D, Anderson AH, Leonard MB, Reese PP, Delafontaine P, Horwitz E, Kallem R, Navaneethan S, Ojo A, Porter AC, Sondheimer JH, Sweeney HL, Townsend RR, Feldman HI; CRIC Study Investigators.

Clin J Am Soc Nephrol. 2014 Dec 5;9(12):2095-103. doi: 10.2215/CJN.03790414. Epub 2014 Nov 7.


Improving residency training in arthroscopic knee surgery with use of a virtual-reality simulator. A randomized blinded study.

Cannon WD, Garrett WE Jr, Hunter RE, Sweeney HJ, Eckhoff DG, Nicandri GT, Hutchinson MR, Johnson DD, Bisson LJ, Bedi A, Hill JA, Koh JL, Reinig KD.

J Bone Joint Surg Am. 2014 Nov 5;96(21):1798-806. doi: 10.2106/JBJS.N.00058.


Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study.

Forbes SC, Willcocks RJ, Triplett WT, Rooney WD, Lott DJ, Wang DJ, Pollaro J, Senesac CR, Daniels MJ, Finkel RS, Russman BS, Byrne BJ, Finanger EL, Tennekoon GI, Walter GA, Sweeney HL, Vandenborne K.

PLoS One. 2014 Sep 9;9(9):e106435. doi: 10.1371/journal.pone.0106435. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e111822.


Myosin VI must dimerize and deploy its unusual lever arm in order to perform its cellular roles.

Mukherjea M, Ali MY, Kikuti C, Safer D, Yang Z, Sirkia H, Ropars V, Houdusse A, Warshaw DM, Sweeney HL.

Cell Rep. 2014 Sep 11;8(5):1522-32. doi: 10.1016/j.celrep.2014.07.041. Epub 2014 Aug 21.

Supplemental Content

Loading ...
Support Center