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Early Termination of Cardiac Rehabilitation Is More Common With Heart Failure With Reduced Ejection Fraction Than With Ischemic Heart Disease.

Bostrom J, Searcy R, Walia A, Rzucidlo J, Banco D, Quien M, Sweeney G, Pierre A, Tang Y, Mola A, Xia Y, Whiteson J, Dodson JA.

J Cardiopulm Rehabil Prev. 2020 Feb 19. doi: 10.1097/HCR.0000000000000495. [Epub ahead of print]


Author Correction: Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress.

Sung HK, Song E, Jahng JWS, Pantopoulos K, Sweeney G.

Sci Rep. 2020 Jan 30;10(1):1836. doi: 10.1038/s41598-020-58752-7.


Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure.

Byrne NJ, Matsumura N, Maayah ZH, Ferdaoussi M, Takahara S, Darwesh AM, Levasseur JL, Jahng JWS, Vos D, Parajuli N, El-Kadi AOS, Braam B, Young ME, Verma S, Light PE, Sweeney G, Seubert JM, Dyck JRB.

Circ Heart Fail. 2020 Jan;13(1):e006277. doi: 10.1161/CIRCHEARTFAILURE.119.006277. Epub 2020 Jan 20.


Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases.

Liu Y, Vu V, Sweeney G.

Front Endocrinol (Lausanne). 2019 Dec 11;10:842. doi: 10.3389/fendo.2019.00842. eCollection 2019. Review.


What Does Multiple Production of Artworks Teach Us About Authenticity and Germline Editing?

Sweeney G.

AMA J Ethics. 2019 Dec 1;21(12):E1098-1102. doi: 10.1001/amajethics.2019.1098.


Mobile health and cardiac rehabilitation in older adults.

Bostrom J, Sweeney G, Whiteson J, Dodson JA.

Clin Cardiol. 2020 Feb;43(2):118-126. doi: 10.1002/clc.23306. Epub 2019 Dec 11. Review.


A Unique Conformational Distortion Mechanism Drives Lipocalin 2 Binding to Bacterial Siderophores.

Huang X, Slavkovic S, Song E, Botta A, Mehrazma B, Lento C, Johnson PE, Sweeney G, Wilson DJ.

ACS Chem Biol. 2020 Jan 17;15(1):234-242. doi: 10.1021/acschembio.9b00820. Epub 2019 Oct 28.


Iron overload inhibits late stage autophagic flux leading to insulin resistance.

Jahng JWS, Alsaadi RM, Palanivel R, Song E, Hipolito VEB, Sung HK, Botelho RJ, Russell RC, Sweeney G.

EMBO Rep. 2019 Oct 4;20(10):e47911. doi: 10.15252/embr.201947911. Epub 2019 Aug 23.


Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes.

Yoon N, Dadson K, Dang T, Chu T, Noskovicova N, Hinz B, Raignault A, Thorin E, Kim S, Jeon JS, Jonkman J, McKee TD, Grant J, Peterson JD, Kelly SP, Sweeney G.

Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E760-E772. doi: 10.1152/ajpendo.00564.2018. Epub 2019 Jul 16.


Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress.

Sung HK, Song E, Jahng JWS, Pantopoulos K, Sweeney G.

Sci Rep. 2019 Mar 15;9(1):4668. doi: 10.1038/s41598-019-41111-6. Erratum in: Sci Rep. 2020 Jan 30;10(1):1836.


An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of oxidative stress.

Botta A, Liu Y, Wannaiampikul S, Tungtrongchitr R, Dadson K, Park TS, Sweeney G.

Nutr Metab (Lond). 2019 Feb 21;16:14. doi: 10.1186/s12986-019-0342-y. eCollection 2019.


Healthy and sustainable diets for future generations.

Green H, Broun P, Cook D, Cooper K, Drewnowski A, Pollard D, Sweeney G, Roulin A.

J Sci Food Agric. 2018 Jul;98(9):3219-3224. doi: 10.1002/jsfa.8953. Epub 2018 Mar 25.


Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes.

Song E, Ramos SV, Huang X, Liu Y, Botta A, Sung HK, Turnbull PC, Wheeler MB, Berger T, Wilson DJ, Perry CGR, Mak TW, Sweeney G.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1576-1581. doi: 10.1073/pnas.1720570115. Epub 2018 Jan 29.


Adiponectin improves insulin sensitivity via activation of autophagic flux.

Ahlstrom P, Rai E, Chakma S, Cho HH, Rengasamy P, Sweeney G.

J Mol Endocrinol. 2017 Nov;59(4):339-350. doi: 10.1530/JME-17-0096.


Transendothelial movement of adiponectin is restricted by glucocorticoids.

Dang TQ, Yoon N, Chasiotis H, Dunford EC, Feng Q, He P, Riddell MC, Kelly SP, Sweeney G.

J Endocrinol. 2017 Aug;234(2):101-114. doi: 10.1530/JOE-16-0363.


Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge.

Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AA, Berger T, Mak TW, George I, Schulze PC, Wang Y, Xu A, Sweeney G.

Am J Transl Res. 2017 Jun 15;9(6):2723-2735. eCollection 2017.


Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers.

Tobin SW, Hashemi S, Dadson K, Turdi S, Ebrahimian K, Zhao J, Sweeney G, Grigull J, McDermott JC.

Sci Rep. 2017 Jun 30;7(1):4476. doi: 10.1038/s41598-017-04762-x.


Logging into therapy: Adolescent perceptions of online therapies for mental health problems.

Sweeney GM, Donovan CL, March S, Forbes Y.

Internet Interv. 2016 Dec 24;15:93-99. doi: 10.1016/j.invent.2016.12.001. eCollection 2019 Mar.


Lipocalin-2 (NGAL) Attenuates Autophagy to Exacerbate Cardiac Apoptosis Induced by Myocardial Ischemia.

Sung HK, Chan YK, Han M, Jahng JWS, Song E, Danielson E, Berger T, Mak TW, Sweeney G.

J Cell Physiol. 2017 Aug;232(8):2125-2134. doi: 10.1002/jcp.25672. Epub 2017 Mar 24.


Erratum. APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice. Diabetes 2011;60:3044-3054.

Wang Y, Cheng KK, Lam KS, Wu D, Wang Y, Huang Y, Vanhoutte PM, Sweeney G, Li Y, Xu A.

Diabetes. 2016 Oct;65(10):3219. doi: 10.2337/db16-er10c. No abstract available.


The kinetics and mechanism of the organo-iridium catalysed racemisation of amines.

Stirling MJ, Mwansa JM, Sweeney G, Blacker AJ, Page MI.

Org Biomol Chem. 2016 Aug 7;14(29):7092-8. doi: 10.1039/c6ob00884d. Epub 2016 Jul 5.


Cellular, structural and functional cardiac remodelling following pressure overload and unloading.

Dadson K, Kovacevic V, Rengasamy P, Kim GH, Boo S, Li RK, George I, Schulze PC, Hinz B, Sweeney G.

Int J Cardiol. 2016 Aug 1;216:32-42. doi: 10.1016/j.ijcard.2016.03.240. Epub 2016 Apr 23.


Lipocalin-2 inhibits autophagy and induces insulin resistance in H9c2 cells.

Chan YK, Sung HK, Jahng JW, Kim GH, Han M, Sweeney G.

Mol Cell Endocrinol. 2016 Jul 15;430:68-76. doi: 10.1016/j.mce.2016.04.006. Epub 2016 Apr 16.


The association between PGC-1α and Alzheimer's disease.

Sweeney G, Song J.

Anat Cell Biol. 2016 Mar;49(1):1-6. doi: 10.5115/acb.2016.49.1.1. Epub 2016 Mar 28. Review. Erratum in: Anat Cell Biol. 2016 Jun;49(2):163.


The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines.

Stirling MJ, Sweeney G, MacRory K, Blacker AJ, Page MI.

Org Biomol Chem. 2016 Apr 14;14(14):3614-22. doi: 10.1039/c6ob00245e. Epub 2016 Mar 17.


Crosstalk between the heart and peripheral organs in heart failure.

Jahng JW, Song E, Sweeney G.

Exp Mol Med. 2016 Mar 11;48:e217. doi: 10.1038/emm.2016.20. Review.


Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy.

Chan YK, Sung HK, Sweeney G.

Clin Sci (Lond). 2015 Nov;129(10):851-62. doi: 10.1042/CS20150075. Review.


Adiponectin is required for cardiac MEF2 activation during pressure overload induced hypertrophy.

Dadson K, Turdi S, Hashemi S, Zhao J, Polidovitch N, Beca S, Backx PH, McDermott JC, Sweeney G.

J Mol Cell Cardiol. 2015 Sep;86:102-9. doi: 10.1016/j.yjmcc.2015.06.020. Epub 2015 Jul 19.


Biomarkers of insulin sensitivity and insulin resistance: Past, present and future.

Park SE, Park CY, Sweeney G.

Crit Rev Clin Lab Sci. 2015;52(4):180-90. doi: 10.3109/10408363.2015.1023429. Epub 2015 Jun 4. Review.


Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency.

Jahng JW, Turdi S, Kovacevic V, Dadson K, Li RK, Sweeney G.

Endocrinology. 2015 Jul;156(7):2667-77. doi: 10.1210/en.2015-1162. Epub 2015 May 11.


Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action.

Liu Y, Sen S, Wannaiampikul S, Palanivel R, Hoo RL, Isserlin R, Bader GD, Tungtrongchitr R, Deshaies Y, Xu A, Sweeney G.

Biochem J. 2015 Jul 1;469(1):71-82. doi: 10.1042/BJ20141455. Epub 2015 Apr 27.


Temporal and Molecular Analyses of Cardiac Extracellular Matrix Remodeling following Pressure Overload in Adiponectin Deficient Mice.

Dadson K, Turdi S, Boo S, Hinz B, Sweeney G.

PLoS One. 2015 Apr 24;10(4):e0121049. doi: 10.1371/journal.pone.0121049. eCollection 2015.


Emerging role of autophagy in mediating widespread actions of ADIPOQ/adiponectin.

Xu A, Sweeney G.

Autophagy. 2015 Apr 3;11(4):723-4. doi: 10.1080/15548627.2015.1034418.


The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes.

Eid HM, Nachar A, Thong F, Sweeney G, Haddad PS.

Pharmacogn Mag. 2015 Jan-Mar;11(41):74-81. doi: 10.4103/0973-1296.149708.


Skeletal muscle glucose metabolism and inflammation in the development of the metabolic syndrome.

Marette A, Liu Y, Sweeney G.

Rev Endocr Metab Disord. 2014 Dec;15(4):299-305. doi: 10.1007/s11154-014-9296-6. Review.


Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus.

Le Quang K, Bouchareb R, Lachance D, Laplante MA, El Husseini D, Boulanger MC, Fournier D, Fang XP, Avramoglu RK, Pibarot P, Deshaies Y, Sweeney G, Mathieu P, Marette A.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2283-91. doi: 10.1161/ATVBAHA.114.304205. Epub 2014 Aug 14.


Palmitate induces ER stress and autophagy in H9c2 cells: implications for apoptosis and adiponectin resistance.

Park M, Sabetski A, Kwan Chan Y, Turdi S, Sweeney G.

J Cell Physiol. 2015 Mar;230(3):630-9. doi: 10.1002/jcp.24781.


Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes.

Palanivel R, Ganguly R, Turdi S, Xu A, Sweeney G.

Metabolism. 2014 Oct;63(10):1363-73. doi: 10.1016/j.metabol.2014.07.005. Epub 2014 Jul 11.


Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice.

Liu Y, Palanivel R, Rai E, Park M, Gabor TV, Scheid MP, Xu A, Sweeney G.

Diabetes. 2015 Jan;64(1):36-48. doi: 10.2337/db14-0267. Epub 2014 Jul 28.


The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.

Cheng KK, Zhu W, Chen B, Wang Y, Wu D, Sweeney G, Wang B, Lam KS, Xu A.

Diabetes. 2014 Nov;63(11):3748-58. doi: 10.2337/db14-0337. Epub 2014 May 30.


Understand me; believe in me; accept me as I am: perceptions of psychiatry of later life service.

Grady TO, Gilrane-McGarry U, Sweeney G, Cryan M, McCarthy G.

Ir J Psychol Med. 2014 Jun;31(2):97-106. doi: 10.1017/ipm.2014.14.


Altered transendothelial transport of hormones as a contributor to diabetes.

Yoon N, Dang TQ, Chasiotis H, Kelly SP, Sweeney G.

Diabetes Metab J. 2014 Apr;38(2):92-9. doi: 10.4093/dmj.2014.38.2.92. Review.


The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction.

Prentice KJ, Luu L, Allister EM, Liu Y, Jun LS, Sloop KW, Hardy AB, Wei L, Jia W, Fantus IG, Sweet DH, Sweeney G, Retnakaran R, Dai FF, Wheeler MB.

Cell Metab. 2014 Apr 1;19(4):653-66. doi: 10.1016/j.cmet.2014.03.008.


The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations.

Kohen Avramoglu R, Laplante MA, Le Quang K, Deshaies Y, Després JP, Larose E, Mathieu P, Poirier P, Pérusse L, Vohl MC, Sweeney G, Ylä-Herttuala S, Laakso M, Uusitupa M, Marette A.

Can J Diabetes. 2013 Oct;37(5):351-8. doi: 10.1016/j.jcjd.2013.08.262. Review.


Adiponectin action in skeletal muscle.

Liu Y, Sweeney G.

Best Pract Res Clin Endocrinol Metab. 2014 Jan;28(1):33-41. doi: 10.1016/j.beem.2013.08.003. Epub 2013 Sep 14. Review.


Adiponectin mediated APPL1-AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts.

Dadson K, Chasiotis H, Wannaiampikul S, Tungtrongchitr R, Xu A, Sweeney G.

J Cell Biochem. 2014 Apr;115(4):785-93. doi: 10.1002/jcb.24722.


The role of adiponectin signaling in metabolic syndrome and cancer.

Scheid MP, Sweeney G.

Rev Endocr Metab Disord. 2014 Jun;15(2):157-67. doi: 10.1007/s11154-013-9265-5. Review.


APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction.

Park M, Wu D, Park T, Choi CS, Li RK, Cheng KK, Xu A, Sweeney G.

Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E795-804. doi: 10.1152/ajpendo.00257.2013. Epub 2013 Aug 6.


TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt.

Cheng KK, Lam KS, Wang Y, Wu D, Zhang M, Wang B, Li X, Hoo RL, Huang Z, Sweeney G, Xu A.

Biochem J. 2013 Oct 15;455(2):207-16. doi: 10.1042/BJ20130760.


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