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Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β.

Smith MR, Alnajjar KS, Hoitsma NM, Sweasy JB, Freudenthal BD.

J Biol Chem. 2019 Dec 31. pii: jbc.RA119.011569. doi: 10.1074/jbc.RA119.011569. [Epub ahead of print]


The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer.

Alvarado-Cruz I, Meas R, Paluri SLA, Carufe KEW, Khan M, Sweasy JB.

Mutagenesis. 2019 Dec 27. pii: gez049. doi: 10.1093/mutage/gez049. [Epub ahead of print]


A pre-catalytic non-covalent step governs DNA polymerase β fidelity.

Alnajjar KS, Krylov IS, Negahbani A, Haratipour P, Kashemirov BA, Huang J, Mahmoud M, McKenna CE, Goodman MF, Sweasy JB.

Nucleic Acids Res. 2019 Dec 16;47(22):11839-11849. doi: 10.1093/nar/gkz1076.


Synthesis of ortho-Formylphenylphosphonic Acids as Covalent Probes of Active Site Lysines.

Duro MVV, Alnajjar KS, Sweasy JB, Kashemirov BA, McKenna CE.

Phosphorus Sulfur Silicon Relat Elem. 2019;194(4-6):313-314. doi: 10.1080/10426507.2018.1539996. Epub 2019 Feb 13.


A new perspective on oxidation of DNA repair proteins and cancer.

Alnajjar KS, Sweasy JB.

DNA Repair (Amst). 2019 Apr;76:60-69. doi: 10.1016/j.dnarep.2019.02.006. Epub 2019 Feb 18. Review.


I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity.

Liptak C, Mahmoud MM, Eckenroth BE, Moreno MV, East K, Alnajjar KS, Huang J, Towle-Weicksel JB, Doublié S, Loria JP, Sweasy JB.

Nucleic Acids Res. 2018 Nov 16;46(20):10740-10756. doi: 10.1093/nar/gky825.


The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase β.

Huang J, Alnajjar KS, Mahmoud MM, Eckenroth B, Doublié S, Sweasy JB.

J Biol Chem. 2018 Sep 28;293(39):15084-15094. doi: 10.1074/jbc.RA118.004564. Epub 2018 Aug 1.


Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.

Oertell K, Kashemirov BA, Negahbani A, Minard C, Haratipour P, Alnajjar KS, Sweasy JB, Batra VK, Beard WA, Wilson SH, McKenna CE, Goodman MF.

Biochemistry. 2018 Jul 3;57(26):3925-3933. doi: 10.1021/acs.biochem.8b00417. Epub 2018 Jun 19.


DNA polymerase beta participates in DNA End-joining.

Ray S, Breuer G, DeVeaux M, Zelterman D, Bindra R, Sweasy JB.

Nucleic Acids Res. 2018 Jan 9;46(1):242-255. doi: 10.1093/nar/gkx1147.


The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation.

Galick HA, Marsden CG, Kathe S, Dragon JA, Volk L, Nemec AA, Wallace SS, Prakash A, Doublié S, Sweasy JB.

Oncotarget. 2017 Sep 8;8(49):85883-85895. doi: 10.18632/oncotarget.20716. eCollection 2017 Oct 17.


Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.

Mahmoud MM, Schechter A, Alnajjar KS, Huang J, Towle-Weicksel J, Eckenroth BE, Doublié S, Sweasy JB.

Biochemistry. 2017 Oct 17;56(41):5550-5559. doi: 10.1021/acs.biochem.7b00869. Epub 2017 Oct 2.


DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.

Alnajjar KS, Negahbani A, Nakhjiri M, Krylov IS, Kashemirov BA, McKenna CE, Goodman MF, Sweasy JB.

Biochemistry. 2017 Oct 10;56(40):5449-5456. doi: 10.1021/acs.biochem.7b00713. Epub 2017 Sep 20.


Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes.

Maher RL, Marsden CG, Averill AM, Wallace SS, Sweasy JB, Pederson DS.

DNA Repair (Amst). 2017 Sep;57:91-97. doi: 10.1016/j.dnarep.2017.06.029. Epub 2017 Jul 5.


Base Excision Repair Variants in Cancer.

Marsden CG, Dragon JA, Wallace SS, Sweasy JB.

Methods Enzymol. 2017;591:119-157. doi: 10.1016/bs.mie.2017.03.003. Epub 2017 May 5.


DNA repair and systemic lupus erythematosus.

Meas R, Burak MJ, Sweasy JB.

DNA Repair (Amst). 2017 Aug;56:174-182. doi: 10.1016/j.dnarep.2017.06.020. Epub 2017 Jun 9. Review.


Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.

Eckenroth BE, Towle-Weicksel JB, Nemec AA, Murphy DL, Sweasy JB, Doublié S.

Biochemistry. 2017 May 9;56(18):2363-2371. doi: 10.1021/acs.biochem.6b01287. Epub 2017 Apr 21.


A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant.

Alnajjar KS, Garcia-Barboza B, Negahbani A, Nakhjiri M, Kashemirov B, McKenna C, Goodman MF, Sweasy JB.

Biochemistry. 2017 Apr 18;56(15):2096-2105. doi: 10.1021/acs.biochem.6b01230. Epub 2017 Apr 6.


DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.

Nemec AA, Abriola L, Merkel JS, de Stanchina E, DeVeaux M, Zelterman D, Glazer PM, Sweasy JB.

Mol Cancer Res. 2017 Mar;15(3):269-280. doi: 10.1158/1541-7786.MCR-16-0227-T. Epub 2017 Jan 10.


Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.

Nemec AA, Bush KB, Towle-Weicksel JB, Taylor BF, Schulz V, Weidhaas JB, Tuck DP, Sweasy JB.

Mol Cancer Res. 2016 Nov;14(11):1068-1077. Epub 2016 Sep 12.


The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.

Marsden CG, Jensen RB, Zagelbaum J, Rothenberg E, Morrical SW, Wallace SS, Sweasy JB.

PLoS Genet. 2016 Aug 11;12(8):e1006208. doi: 10.1371/journal.pgen.1006208. eCollection 2016 Aug.


Evelyn Witkin and the coordinated response to DNA damage.

Sweasy JB, Lieberman HB, Volkert M, George D.

DNA Repair (Amst). 2015 Nov;35:154-5. doi: 10.1016/j.dnarep.2015.10.005. Epub 2015 Oct 21. No abstract available.


The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformation.

Sizova DV, Keh A, Taylor BF, Sweasy JB.

DNA Repair (Amst). 2015 Jul;31:73-9. doi: 10.1016/j.dnarep.2015.05.005. Epub 2015 May 14.


Pools and Pols: Mechanism of a mutator phenotype.

Sohl CD, Ray S, Sweasy JB.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):5864-5. doi: 10.1073/pnas.1505169112. Epub 2015 Apr 30. No abstract available.


Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders.

Lokanga RA, Senejani AG, Sweasy JB, Usdin K.

PLoS Genet. 2015 Apr 17;11(4):e1005181. doi: 10.1371/journal.pgen.1005181. eCollection 2015 Apr.


Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.

Chen J, Morrical MD, Donigan KA, Weidhaas JB, Sweasy JB, Averill AM, Tomczak JA, Morrical SW.

Nucleic Acids Res. 2015 Jan;43(2):1098-111. doi: 10.1093/nar/gku1337. Epub 2014 Dec 24.


A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation.

Sjolund A, Nemec AA, Paquet N, Prakash A, Sung P, Doublié S, Sweasy JB.

PLoS Genet. 2014 Nov 6;10(11):e1004753. doi: 10.1371/journal.pgen.1004753. eCollection 2014 Nov.


Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.

Towle-Weicksel JB, Dalal S, Sohl CD, Doublié S, Anderson KS, Sweasy JB.

J Biol Chem. 2014 Jun 6;289(23):16541-50. doi: 10.1074/jbc.M114.561878. Epub 2014 Apr 24.


The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.

Nemec AA, Murphy DL, Donigan KA, Sweasy JB.

J Biol Chem. 2014 May 16;289(20):13708-16. doi: 10.1074/jbc.M114.550400. Epub 2014 Mar 25.


Crystal structure of DNA polymerase β with DNA containing the base lesion spiroiminodihydantoin in a templating position.

Eckenroth BE, Fleming AM, Sweasy JB, Burrows CJ, Doublié S.

Biochemistry. 2014 Apr 8;53(13):2075-7. doi: 10.1021/bi500270e. Epub 2014 Mar 26.



Sweasy JB, Glazer PM.

Yale J Biol Med. 2013 Dec;86(4):441-2. No abstract available.


Interplay between DNA repair and inflammation, and the link to cancer.

Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB.

Crit Rev Biochem Mol Biol. 2014 Mar-Apr;49(2):116-39. doi: 10.3109/10409238.2013.875514. Epub 2014 Jan 13. Review.


Mutation of POLB causes lupus in mice.

Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB.

Cell Rep. 2014 Jan 16;6(1):1-8. doi: 10.1016/j.celrep.2013.12.017. Epub 2014 Jan 2.


Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing.

Prakash A, Carroll BL, Sweasy JB, Wallace SS, Doublié S.

DNA Repair (Amst). 2014 Feb;14:17-26. doi: 10.1016/j.dnarep.2013.12.003. Epub 2013 Dec 29.


Cellular roles of DNA polymerase beta.

Ray S, Menezes MR, Senejani A, Sweasy JB.

Yale J Biol Med. 2013 Dec 13;86(4):463-9. Review.


The E295K cancer variant of human polymerase β favors the mismatch conformational pathway during nucleotide selection.

Eckenroth BE, Towle-Weicksel JB, Sweasy JB, Doublié S.

J Biol Chem. 2013 Nov 29;288(48):34850-60. doi: 10.1074/jbc.M113.510891. Epub 2013 Oct 16.


Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation.

Galick HA, Kathe S, Liu M, Robey-Bond S, Kidane D, Wallace SS, Sweasy JB.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14314-9. doi: 10.1073/pnas.1306752110. Epub 2013 Aug 12.


Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β.

Gridley CL, Rangarajan S, Firbank S, Dalal S, Sweasy JB, Jaeger J.

Biochemistry. 2013 Jun 25;52(25):4422-32. doi: 10.1021/bi301368f. Epub 2013 Jun 12.


Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells.

Kidane D, Sakkas D, Nottoli T, McGrath J, Sweasy JB.

PLoS One. 2013;8(4):e58585. doi: 10.1371/journal.pone.0058585. Epub 2013 Apr 1.


MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.

Sjolund AB, Senejani AG, Sweasy JB.

Mutat Res. 2013 Mar-Apr;743-744:12-25. doi: 10.1016/j.mrfmmm.2012.11.001. Epub 2012 Nov 26. Review.


A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.

Yamtich J, Nemec AA, Keh A, Sweasy JB.

PLoS Genet. 2012;8(11):e1003052. doi: 10.1371/journal.pgen.1003052. Epub 2012 Nov 8.


Targeting cancer with a lupus autoantibody.

Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM.

Sci Transl Med. 2012 Oct 24;4(157):157ra142. doi: 10.1126/scitranslmed.3004385.


Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.

Lamb KL, Liu Y, Ishiguro K, Kwon Y, Paquet N, Sartorelli AC, Sung P, Rockwell S, Sweasy JB.

Mol Carcinog. 2014 Mar;53(3):201-10. doi: 10.1002/mc.21964. Epub 2012 Oct 12.


DNA polymerases and their role in genomic stability.

Eckert KA, Sweasy JB.

Environ Mol Mutagen. 2012 Dec;53(9):643-4. doi: 10.1002/em.21746. Epub 2012 Oct 11. No abstract available.


The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery.

Kidane D, Ayora S, Sweasy JB, Graumann PL, Alonso JC.

Crit Rev Biochem Mol Biol. 2012 Nov-Dec;47(6):531-55. doi: 10.3109/10409238.2012.729562. Epub 2012 Oct 9. Review.


Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.

Klvaňa M, Murphy DL, Jeřábek P, Goodman MF, Warshel A, Sweasy JB, Florián J.

Biochemistry. 2012 Nov 6;51(44):8829-43. doi: 10.1021/bi300783t. Epub 2012 Oct 29.


Mouse models of DNA polymerases.

Menezes MR, Sweasy JB.

Environ Mol Mutagen. 2012 Dec;53(9):645-65. doi: 10.1002/em.21731. Epub 2012 Sep 22. Review.


DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.

Donigan KA, Tuck D, Schulz V, Sweasy JB.

Mutagenesis. 2012 Nov;27(6):683-91. doi: 10.1093/mutage/ges034. Epub 2012 Aug 21.


Tipping the balance in the powerhouse of the cell to "protect" colorectal cancer.

Kidane D, Sweasy JB.

PLoS Genet. 2012;8(6):e1002758. doi: 10.1371/journal.pgen.1002758. Epub 2012 Jun 7. No abstract available.

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