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Epigenetic Regulation of Dlg1, via Kaiso, Alters Mitotic Spindle Polarity and Promotes Intestinal Tumorigenesis.

Young MA, May S, Damo A, Yoon YS, Hur MW, Swat W, Parry L.

Mol Cancer Res. 2019 Mar;17(3):686-696. doi: 10.1158/1541-7786.MCR-18-0280. Epub 2018 Dec 14.


Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation.

Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ.

Thorax. 2018 May;73(5):489-492. doi: 10.1136/thoraxjnl-2017-211121. Epub 2018 Jan 30.


A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.

Kant S, Standen CL, Morel C, Jung DY, Kim JK, Swat W, Flavell RA, Davis RJ.

Cell Rep. 2017 Sep 19;20(12):2775-2783. doi: 10.1016/j.celrep.2017.08.025.


Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

Graham DB, Osborne DG, Piotrowski JT, Gomez TS, Gmyrek GB, Akilesh HM, Dani A, Billadeau DD, Swat W.

PLoS One. 2014 Jun 2;9(6):e98606. doi: 10.1371/journal.pone.0098606. eCollection 2014.


Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.

Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W.

Cancer Immunol Res. 2013 Dec;1(6):426-37. doi: 10.1158/2326-6066.CIR-13-0065. Epub 2013 Oct 7.


DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis.

Kim ST, Ahn SY, Swat W, Miner JH.

Dev Biol. 2014 Jun 15;390(2):160-9. doi: 10.1016/j.ydbio.2014.03.014. Epub 2014 Mar 31.


Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.

Gmyrek GB, Akilesh HM, Graham DB, Fuchs A, Yang L, Miller MJ, Sandoval GJ, Sheehan KC, Schreiber RD, Diamond MS, Swat W.

PLoS One. 2013 Oct 14;8(10):e76145. doi: 10.1371/journal.pone.0076145. eCollection 2013.


Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.

Ahn SY, Kim Y, Kim ST, Swat W, Miner JH.

J Am Soc Nephrol. 2013 Jun;24(7):1127-38. doi: 10.1681/ASN.2012111074. Epub 2013 May 9.


Polarity gene discs large homolog 1 regulates the generation of memory T cells.

Gmyrek GB, Graham DB, Sandoval GJ, Blaufuss GS, Akilesh HM, Fujikawa K, Xavier RJ, Swat W.

Eur J Immunol. 2013 May;43(5):1185-94. doi: 10.1002/eji.201142362. Epub 2013 Apr 9.


Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.

Sandoval GJ, Graham DB, Bhattacharya D, Sleckman BP, Xavier RJ, Swat W.

J Immunol. 2013 Mar 15;190(6):2485-9. doi: 10.4049/jimmunol.1203208. Epub 2013 Feb 18.


Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.

Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9.


The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors.

Liu W, Chen E, Zhao XW, Wan ZP, Gao YR, Davey A, Huang E, Zhang L, Crocetti J, Sandoval G, Joyce MG, Miceli C, Lukszo J, Aravind L, Swat W, Brzostowski J, Pierce SK.

Sci Signal. 2012 Jul 31;5(235):ra54. doi: 10.1126/scisignal.2002820.


The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.

Dong Z, Davidson D, Pérez-Quintero LA, Kurosaki T, Swat W, Veillette A.

Immunity. 2012 Jun 29;36(6):974-85. doi: 10.1016/j.immuni.2012.03.023. Epub 2012 Jun 7.


TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.

Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ.

Genes Dev. 2011 Oct 1;25(19):2069-78. doi: 10.1101/gad.17224711.


Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation.

Rahaman SO, Swat W, Febbraio M, Silverstein RL.

J Biol Chem. 2011 Mar 4;286(9):7010-7. doi: 10.1074/jbc.M110.192450. Epub 2011 Jan 5.


ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling.

Graham DB, Akilesh HM, Gmyrek GB, Piccio L, Gilfillan S, Sim J, Belizaire R, Carrero JA, Wang Y, Blaufuss GS, Sandoval G, Fujikawa K, Cross AH, Russell JH, Cella M, Swat W.

Blood. 2010 Oct 28;116(17):3208-18. doi: 10.1182/blood-2009-10-250415. Epub 2010 Jul 15.


VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans.

Fujikawa K, Iwata T, Inoue K, Akahori M, Kadotani H, Fukaya M, Watanabe M, Chang Q, Barnett EM, Swat W.

PLoS One. 2010 Feb 4;5(2):e9050. doi: 10.1371/journal.pone.0009050.


The role of SAP97 in synaptic glutamate receptor dynamics.

Howard MA, Elias GM, Elias LA, Swat W, Nicoll RA.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3805-10. doi: 10.1073/pnas.0914422107. Epub 2010 Feb 3.


Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.

Miletic AV, Graham DB, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Cemerski S, Kloeppel T, Billadeau DD, Kanagawa O, Tokunaga M, Swat W.

PLoS One. 2009 Aug 12;4(8):e6599. doi: 10.1371/journal.pone.0006599.


Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.

Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, Swat W.

Autophagy. 2009 Jul;5(5):625-35. Epub 2009 Jul 10.


ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo.

Graham DB, Zinselmeyer BH, Mascarenhas F, Delgado R, Miller MJ, Swat W.

PLoS One. 2009;4(2):e4652. doi: 10.1371/journal.pone.0004652. Epub 2009 Feb 27.


Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes.

Liu JY, Seno H, Miletic AV, Mills JC, Swat W, Stappenbeck TS.

J Cell Sci. 2009 Feb 1;122(Pt 3):324-34. doi: 10.1242/jcs.033720. Epub 2009 Jan 12.


Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis.

Cremasco V, Graham DB, Novack DV, Swat W, Faccio R.

Arthritis Rheum. 2008 Sep;58(9):2712-22. doi: 10.1002/art.23757.


The autophagy gene ATG5 plays an essential role in B lymphocyte development.

Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW 4th.

Autophagy. 2008 Apr;4(3):309-14. Epub 2007 Dec 24.


An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.

Graham DB, Stephenson LM, Lam SK, Brim K, Lee HM, Bautista J, Gilfillan S, Akilesh S, Fujikawa K, Swat W.

J Exp Med. 2007 Nov 26;204(12):2889-97. Epub 2007 Nov 5.


Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.

Graham DB, Robertson CM, Bautista J, Mascarenhas F, Diacovo MJ, Montgrain V, Lam SK, Cremasco V, Dunne WM, Faccio R, Coopersmith CM, Swat W.

J Clin Invest. 2007 Nov;117(11):3445-52.


DLGH1 is a negative regulator of T-lymphocyte proliferation.

Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W.

Mol Cell Biol. 2007 Nov;27(21):7574-81. Epub 2007 Aug 27.


Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.

Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W.

Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19872-7. Epub 2006 Dec 15.


Vav proteins control MyD88-dependent oxidative burst.

Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W.

Blood. 2007 Apr 15;109(8):3360-8. Epub 2006 Dec 7.


Vav proteins regulate the plasma cell program and secretory Ig production.

Stephenson LM, Miletic AV, Kloeppel T, Kusin S, Swat W.

J Immunol. 2006 Dec 15;177(12):8620-5.


Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation.

Miletic AV, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Gomez TS, Ota N, Kloeppel T, Kanagawa O, Tokunaga M, Billadeau DD, Swat W.

J Biol Chem. 2006 Dec 15;281(50):38257-65. Epub 2006 Oct 18.


Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression.

Charvet C, Canonigo AJ, Bécart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A.

J Immunol. 2006 Oct 15;177(8):5024-31.


Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.

Graham DB, Cella M, Giurisato E, Fujikawa K, Miletic AV, Kloeppel T, Brim K, Takai T, Shaw AS, Colonna M, Swat W.

J Immunol. 2006 Aug 15;177(4):2349-55.


Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis.

Hunter SG, Zhuang G, Brantley-Sieders D, Swat W, Cowan CW, Chen J.

Mol Cell Biol. 2006 Jul;26(13):4830-42.


Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.

Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS.

Immunity. 2006 Mar;24(3):305-16.


Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival.

Swat W, Montgrain V, Doggett TA, Douangpanya J, Puri K, Vermi W, Diacovo TG.

Blood. 2006 Mar 15;107(6):2415-22. Epub 2005 Nov 22.


The Vav family: at the crossroads of signaling pathways.

Swat W, Fujikawa K.

Immunol Res. 2005;32(1-3):259-65. Review.


Vav3 regulates osteoclast function and bone mass.

Faccio R, Teitelbaum SL, Fujikawa K, Chappel J, Zallone A, Tybulewicz VL, Ross FP, Swat W.

Nat Med. 2005 Mar;11(3):284-90. Epub 2005 Feb 13.


Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.

Cella M, Fujikawa K, Tassi I, Kim S, Latinis K, Nishi S, Yokoyama W, Colonna M, Swat W.

J Exp Med. 2004 Sep 20;200(6):817-23. Epub 2004 Sep 13.


Discs large (Dlg1) complexes in lymphocyte activation.

Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B.

J Cell Biol. 2004 Jul 19;166(2):173-8.


Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.

Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS.

J Cell Biol. 2004 Jul 19;166(2):273-82. Epub 2004 Jul 12.


Requirement for cyclin D3 in lymphocyte development and T cell leukemias.

Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P.

Cancer Cell. 2003 Dec;4(6):451-61.


Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.

Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W.

J Exp Med. 2003 Nov 17;198(10):1595-608.


Transferrin receptor 1 is differentially required in lymphocyte development.

Ned RM, Swat W, Andrews NC.

Blood. 2003 Nov 15;102(10):3711-8. Epub 2003 Jul 24.


Cytoskeletal remodeling in lymphocyte activation.

Miletic AV, Swat M, Fujikawa K, Swat W.

Curr Opin Immunol. 2003 Jun;15(3):261-8. Review.


Essential role for Vav1 in activation, but not development, of gammadelta T cells.

Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW.

Int Immunol. 2003 Feb;15(2):215-21.


Knock-ins and conditional knockouts: in vivo analysis of glucocorticoid receptor regulation and function.

Brewer JA, Vogt SK, Sleckman BP, Swat W, Kanagawa O, Muglia LJ.

Endocr Res. 2002 Nov;28(4):545-50.


The mechanism and regulation of chromosomal V(D)J recombination.

Bassing CH, Swat W, Alt FW.

Cell. 2002 Apr;109 Suppl:S45-55. Review.

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