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Items: 1 to 50 of 51

1.

A Long-Acting PYY3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates.

Rangwala SM, D'Aquino K, Zhang YM, Bader L, Edwards W, Zheng S, Eckardt A, Lacombe A, Pick R, Moreno V, Kang L, Jian W, Arnoult E, Case M, Jenkinson C, Chi E, Swanson RV, Kievit P, Grove K, Macielag M, Erion MD, SinhaRoy R, Leonard JN.

Cell Metab. 2019 Apr 2;29(4):837-843.e5. doi: 10.1016/j.cmet.2019.01.017. Epub 2019 Feb 14.

PMID:
30773465
2.

Impact of Clofazimine Dosing on Treatment Shortening of the First-Line Regimen in a Mouse Model of Tuberculosis.

Ammerman NC, Swanson RV, Bautista EM, Almeida DV, Saini V, Omansen TF, Guo H, Chang YS, Li SY, Tapley A, Tasneen R, Tyagi S, Betoudji F, Moodley C, Ngcobo B, Pillay L, Bester LA, Singh SD, Chaisson RE, Nuermberger E, Grosset JH.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00636-18. doi: 10.1128/AAC.00636-18. Print 2018 Jul.

3.

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers.

Fung-Leung WP, Edwards W, Liu Y, Ngo K, Angsana J, Castro G, Wu N, Liu X, Swanson RV, Wickenden AD.

PLoS One. 2017 Jan 20;12(1):e0170102. doi: 10.1371/journal.pone.0170102. eCollection 2017.

4.

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.

Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD.

Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662.

5.

Clofazimine has delayed antimicrobial activity against Mycobacterium tuberculosis both in vitro and in vivo.

Ammerman NC, Swanson RV, Tapley A, Moodley C, Ngcobo B, Adamson J, Dorasamy A, Moodley S, Mgaga Z, Bester LA, Singh SD, Almeida DV, Grosset JH.

J Antimicrob Chemother. 2017 Feb;72(2):455-461. doi: 10.1093/jac/dkw417. Epub 2016 Oct 25.

PMID:
27798204
6.

Clofazimine Contributes Sustained Antimicrobial Activity after Treatment Cessation in a Mouse Model of Tuberculosis Chemotherapy.

Swanson RV, Ammerman NC, Ngcobo B, Adamson J, Moodley C, Dorasamy A, Moodley S, Mgaga Z, Bester LA, Singh SD, Almeida DV, Grosset JH.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2864-9. doi: 10.1128/AAC.00177-16. Print 2016 May.

7.

Pharmacokinetics and pharmacodynamics of clofazimine in a mouse model of tuberculosis.

Swanson RV, Adamson J, Moodley C, Ngcobo B, Ammerman NC, Dorasamy A, Moodley S, Mgaga Z, Tapley A, Bester LA, Singh S, Grosset JH, Almeida DV.

Antimicrob Agents Chemother. 2015;59(6):3042-51. doi: 10.1128/AAC.00260-15. Epub 2015 Mar 9.

8.

Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis.

Tyagi S, Ammerman NC, Li SY, Adamson J, Converse PJ, Swanson RV, Almeida DV, Grosset JH.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):869-74. doi: 10.1073/pnas.1416951112. Epub 2015 Jan 5.

9.

Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.

Edwards W, Fung-Leung WP, Huang C, Chi E, Wu N, Liu Y, Maher MP, Bonesteel R, Connor J, Fellows R, Garcia E, Lee J, Lu L, Ngo K, Scott B, Zhou H, Swanson RV, Wickenden AD.

J Biol Chem. 2014 Aug 15;289(33):22704-14. doi: 10.1074/jbc.M114.568642. Epub 2014 Jun 17.

10.

Characterization of a high-affinity human antibody with a disulfide bridge in the third complementarity-determining region of the heavy chain.

Almagro JC, Raghunathan G, Beil E, Janecki DJ, Chen Q, Dinh T, LaCombe A, Connor J, Ware M, Kim PH, Swanson RV, Fransson J.

J Mol Recognit. 2012 Mar;25(3):125-35. doi: 10.1002/jmr.1168.

PMID:
22407976
11.

Genetic construct design and recombinant protein expression for structural biology.

Edavettal SC, Hunter MJ, Swanson RV.

Methods Mol Biol. 2012;841:29-47. doi: 10.1007/978-1-61779-520-6_2.

PMID:
22222447
12.

Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis.

Cianchetta G, Stouch T, Yu W, Shi ZC, Tari LW, Swanson RV, Hunter MJ, Hoffman ID, Liu Q.

Curr Chem Genomics. 2010 Apr 14;4:19-26. doi: 10.2174/1875397301004010019.

13.

Human framework adaptation of a mouse anti-human IL-13 antibody.

Fransson J, Teplyakov A, Raghunathan G, Chi E, Cordier W, Dinh T, Feng Y, Giles-Komar J, Gilliland G, Lollo B, Malia TJ, Nishioka W, Obmolova G, Zhao S, Zhao Y, Swanson RV, Almagro JC.

J Mol Biol. 2010 Apr 30;398(2):214-31. doi: 10.1016/j.jmb.2010.03.004. Epub 2010 Mar 10.

PMID:
20226193
14.

Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.

Jessop TC, Tarver JE, Carlsen M, Xu A, Healy JP, Heim-Riether A, Fu Q, Taylor JA, Augeri DJ, Shen M, Stouch TR, Swanson RV, Tari LW, Hunter M, Hoffman I, Keyes PE, Yu XC, Miranda M, Liu Q, Swaffield JC, David Kimball S, Nouraldeen A, Wilson AG, Foushee AM, Jhaver K, Finch R, Anderson S, Oravecz T, Carson KG.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6784-7. doi: 10.1016/j.bmcl.2009.09.081. Epub 2009 Sep 25.

PMID:
19836232
15.

Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.

Tari LW, Hoffman ID, Bensen DC, Hunter MJ, Nix J, Nelson KJ, McRee DE, Swanson RV.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91. Epub 2006 Nov 2.

PMID:
17157005
16.

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.

Somoza JR, Skene RJ, Katz BA, Mol C, Ho JD, Jennings AJ, Luong C, Arvai A, Buggy JJ, Chi E, Tang J, Sang BC, Verner E, Wynands R, Leahy EM, Dougan DR, Snell G, Navre M, Knuth MW, Swanson RV, McRee DE, Tari LW.

Structure. 2004 Jul;12(7):1325-34.

17.

N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding.

Aertgeerts K, Ye S, Shi L, Prasad SG, Witmer D, Chi E, Sang BC, Wijnands RA, Webb DR, Swanson RV.

Protein Sci. 2004 Jan;13(1):145-54.

18.

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis.

Hosfield DJ, Zhang Y, Dougan DR, Broun A, Tari LW, Swanson RV, Finn J.

J Biol Chem. 2004 Mar 5;279(10):8526-9. Epub 2003 Dec 12.

19.

Crystal structures of active fully assembled substrate- and product-bound complexes of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) from Haemophilus influenzae.

Mol CD, Brooun A, Dougan DR, Hilgers MT, Tari LW, Wijnands RA, Knuth MW, McRee DE, Swanson RV.

J Bacteriol. 2003 Jul;185(14):4152-62.

20.

The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode.

Ye S, Von Delft F, Brooun A, Knuth MW, Swanson RV, McRee DE.

J Bacteriol. 2003 Jul;185(14):4144-51.

21.

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.

Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, Rogers J, Sang BC, Scheibe DN, Swanson RV, Thompson DA.

Structure. 2002 Dec;10(12):1659-67.

22.

The genome of M. acetivorans reveals extensive metabolic and physiological diversity.

Galagan JE, Nusbaum C, Roy A, Endrizzi MG, Macdonald P, FitzHugh W, Calvo S, Engels R, Smirnov S, Atnoor D, Brown A, Allen N, Naylor J, Stange-Thomann N, DeArellano K, Johnson R, Linton L, McEwan P, McKernan K, Talamas J, Tirrell A, Ye W, Zimmer A, Barber RD, Cann I, Graham DE, Grahame DA, Guss AM, Hedderich R, Ingram-Smith C, Kuettner HC, Krzycki JA, Leigh JA, Li W, Liu J, Mukhopadhyay B, Reeve JN, Smith K, Springer TA, Umayam LA, White O, White RH, Conway de Macario E, Ferry JG, Jarrell KF, Jing H, Macario AJ, Paulsen I, Pritchett M, Sowers KR, Swanson RV, Zinder SH, Lander E, Metcalf WW, Birren B.

Genome Res. 2002 Apr;12(4):532-42.

23.

The solution structure and interactions of CheW from Thermotoga maritima.

Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW.

Nat Struct Biol. 2002 Feb;9(2):121-5.

PMID:
11799399
24.

Comparative genomic analysis of archaeal genotypic variants in a single population and in two different oceanic provinces.

Béjà O, Koonin EV, Aravind L, Taylor LT, Seitz H, Stein JL, Bensen DC, Feldman RA, Swanson RV, DeLong EF.

Appl Environ Microbiol. 2002 Jan;68(1):335-45.

25.

Application of genomics for understanding the evolution of hyperthermophilic and nonthermophilic Crenarchaeota.

Delong EF, Schleper C, Feldman R, Swanson RV.

Biol Bull. 1999 Jun;196(3):363-5; discussion 365-6. No abstract available.

PMID:
11536912
26.

Genome of Aquifex aeolicus.

Swanson RV.

Methods Enzymol. 2001;330:158-69. No abstract available.

PMID:
11210496
27.

Crystal structure of the beta-glycosidase from the hyperthermophile Thermosphaera aggregans: insights into its activity and thermostability.

Chi YI, Martinez-Cruz LA, Jancarik J, Swanson RV, Robertson DE, Kim SH.

FEBS Lett. 1999 Feb 26;445(2-3):375-83.

28.

Genomic analysis reveals chromosomal variation in natural populations of the uncultured psychrophilic archaeon Cenarchaeum symbiosum.

Schleper C, DeLong EF, Preston CM, Feldman RA, Wu KY, Swanson RV.

J Bacteriol. 1998 Oct;180(19):5003-9.

29.
30.

The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.

Deckert G, Warren PV, Gaasterland T, Young WG, Lenox AL, Graham DE, Overbeek R, Snead MA, Keller M, Aujay M, Huber R, Feldman RA, Short JM, Olsen GJ, Swanson RV.

Nature. 1998 Mar 26;392(6674):353-8.

PMID:
9537320
31.

Crystal structures of CheY from Thermotoga maritima do not support conventional explanations for the structural basis of enhanced thermostability.

Usher KC, de la Cruz AF, Dahlquist FW, Swanson RV, Simon MI, Remington SJ.

Protein Sci. 1998 Feb;7(2):403-12.

32.

Characterization of a DNA polymerase from the uncultivated psychrophilic archaeon Cenarchaeum symbiosum.

Schleper C, Swanson RV, Mathur EJ, DeLong EF.

J Bacteriol. 1997 Dec;179(24):7803-11.

34.

Phosphotransfer and CheY-binding domains of the histidine autokinase CheA are joined by a flexible linker.

Zhou H, McEvoy MM, Lowry DF, Swanson RV, Simon MI, Dahlquist FW.

Biochemistry. 1996 Jan 16;35(2):433-43.

PMID:
8555213
35.
36.

The response regulators CheB and CheY exhibit competitive binding to the kinase CheA.

Li J, Swanson RV, Simon MI, Weis RM.

Biochemistry. 1995 Nov 14;34(45):14626-36.

PMID:
7578071
37.
38.

Localized perturbations in CheY structure monitored by NMR identify a CheA binding interface.

Swanson RV, Lowry DF, Matsumura P, McEvoy MM, Simon MI, Dahlquist FW.

Nat Struct Biol. 1995 Oct;2(10):906-10.

PMID:
7552716
39.

Mutations in the chemotactic response regulator, CheY, that confer resistance to the phosphatase activity of CheZ.

Sanna MG, Swanson RV, Bourret RB, Simon MI.

Mol Microbiol. 1995 Mar;15(6):1069-79.

PMID:
7623663
40.

Histidine and aspartate phosphorylation: two-component systems and the limits of homology.

Swanson RV, Alex LA, Simon MI.

Trends Biochem Sci. 1994 Nov;19(11):485-90. Review.

PMID:
7855892
41.

Signal transduction. Bringing the eukaryotes up to speed.

Swanson RV, Simon MI.

Curr Biol. 1994 Mar 1;4(3):234-7. Review.

PMID:
7922328
42.

Assembly and function of a quaternary signal transduction complex monitored by surface plasmon resonance.

Schuster SC, Swanson RV, Alex LA, Bourret RB, Simon MI.

Nature. 1993 Sep 23;365(6444):343-7.

PMID:
8377825
43.

Expression of CheA fragments which define domains encoding kinase, phosphotransfer, and CheY binding activities.

Swanson RV, Schuster SC, Simon MI.

Biochemistry. 1993 Aug 3;32(30):7623-9.

PMID:
8347572
44.

Intermolecular complementation of the kinase activity of CheA.

Swanson RV, Bourret RB, Simon MI.

Mol Microbiol. 1993 May;8(3):435-41.

PMID:
8326858
45.

Characterization of phycocyanin produced by cpcE and cpcF mutants and identification of an intergenic suppressor of the defect in bilin attachment.

Swanson RV, Zhou J, Leary JA, Williams T, de Lorimier R, Bryant DA, Glazer AN.

J Biol Chem. 1992 Aug 15;267(23):16146-54.

46.

Genes encoding the phycobilisome rod substructure are clustered on the Anabaena chromosome: characterization of the phycoerythrocyanin operon.

Swanson RV, de Lorimier R, Glazer AN.

J Bacteriol. 1992 Apr;174(8):2640-7. Erratum in: J Bacteriol 1992 Aug;174(16):5488.

47.
50.

Separation of phycobiliprotein subunits by reverse-phase high-pressure liquid chromatography.

Swanson RV, Glazer AN.

Anal Biochem. 1990 Aug 1;188(2):295-9.

PMID:
2221378

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