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Items: 16


The NLRP3 inflammasome: molecular activation and regulation to therapeutics.

Swanson KV, Deng M, Ting JP.

Nat Rev Immunol. 2019 Aug;19(8):477-489. doi: 10.1038/s41577-019-0165-0. Review.


A noncanonical function of cGAMP in inflammasome priming and activation.

Swanson KV, Junkins RD, Kurkjian CJ, Holley-Guthrie E, Pendse AA, El Morabiti R, Petrucelli A, Barber GN, Benedict CA, Ting JP.

J Exp Med. 2017 Dec 4;214(12):3611-3626. doi: 10.1084/jem.20171749. Epub 2017 Oct 13.


Reining in uncontrolled inflammasome with PKA.

Swanson KV, Ting JP.

Nat Immunol. 2016 Sep 20;17(10):1137-8. doi: 10.1038/ni.3556. No abstract available.


NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting JP.

Immunity. 2014 Mar 20;40(3):329-41. doi: 10.1016/j.immuni.2014.01.010. Epub 2014 Feb 20. Review.


Construction and characterization of a derivative of Neisseria gonorrhoeae strain MS11 devoid of all opa genes.

LeVan A, Zimmerman LI, Mahle AC, Swanson KV, DeShong P, Park J, Edwards VL, Song W, Stein DC.

J Bacteriol. 2012 Dec;194(23):6468-78. doi: 10.1128/JB.00969-12. Epub 2012 Sep 21.


The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.

Schneider M, Zimmermann AG, Roberts RA, Zhang L, Swanson KV, Wen H, Davis BK, Allen IC, Holl EK, Ye Z, Rahman AH, Conti BJ, Eitas TK, Koller BH, Ting JP.

Nat Immunol. 2012 Sep;13(9):823-31. doi: 10.1038/ni.2378. Epub 2012 Aug 5.


Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis.

Taxman DJ, Swanson KV, Broglie PM, Wen H, Holley-Guthrie E, Huang MT, Callaway JB, Eitas TK, Duncan JA, Ting JP.

J Biol Chem. 2012 Sep 21;287(39):32791-9. Epub 2012 Jul 26.


The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP.

Immunity. 2012 Jun 29;36(6):933-46. doi: 10.1016/j.immuni.2012.03.025.


Neisseria gonorrhoeae-induced transactivation of EGFR enhances gonococcal invasion.

Swanson KV, Griffiss JM, Edwards VL, Stein DC, Song W.

Cell Microbiol. 2011 Jul;13(7):1078-90. doi: 10.1111/j.1462-5822.2011.01603.x. Epub 2011 May 30.


Structural characterization of an oligosaccharide made by Neisseria sicca.

O'Connor ET, Zhou H, Bullock K, Swanson KV, Griffiss JM, Reinhold VN, Miller CJ, Stein DC.

J Bacteriol. 2009 May;191(10):3311-20. doi: 10.1128/JB.01433-08. Epub 2009 Mar 6.


Structural requirements for monoclonal antibody 2-1-L8 recognition of neisserial lipooligosaccharides.

O'Connor ET, Swanson KV, Cheng H, Fluss K, Griffiss JM, Stein DC.

Hybridoma (Larchmt). 2008 Apr;27(2):71-9.


Biochemical analysis of Lpt3, a protein responsible for phosphoethanolamine addition to lipooligosaccharide of pathogenic Neisseria.

O'Connor ET, Piekarowicz A, Swanson KV, Griffiss JM, Stein DC.

J Bacteriol. 2006 Feb;188(3):1039-48.


Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected.

John CM, Jarvis GA, Swanson KV, Leffler H, Cooper MD, Huflejt ME, Griffiss JM.

Cell Microbiol. 2002 Oct;4(10):649-62.


CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells.

Swanson KV, Jarvis GA, Brooks GF, Barham BJ, Cooper MD, Griffiss JM.

Cell Microbiol. 2001 Oct;3(10):681-91.


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