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Items: 13


Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.

Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5462-5467. doi: 10.1073/pnas.1718338115. Epub 2018 May 7.


The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation.

Davis RJ, Swanger J, Hughes BT, Clurman BE.

Mol Cell Biol. 2017 Mar 31;37(8). pii: e00657-16. doi: 10.1128/MCB.00657-16. Print 2017 Apr 15.


Fbw7 dimerization determines the specificity and robustness of substrate degradation.

Welcker M, Larimore EA, Swanger J, Bengoechea-Alonso MT, Grim JE, Ericsson J, Zheng N, Clurman BE.

Genes Dev. 2013 Dec 1;27(23):2531-6. doi: 10.1101/gad.229195.113.


Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.

Hughes BT, Sidorova J, Swanger J, Monnat RJ Jr, Clurman BE.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8954-9. doi: 10.1073/pnas.1302927110. Epub 2013 May 13.


The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE.

Genes Dev. 2013 Jan 15;27(2):151-6. doi: 10.1101/gad.207720.112. Epub 2013 Jan 15.


Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.

Hizli AA, Chi Y, Swanger J, Carter JH, Liao Y, Welcker M, Ryazanov AG, Clurman BE.

Mol Cell Biol. 2013 Feb;33(3):596-604. doi: 10.1128/MCB.01270-12. Epub 2012 Nov 26.


Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.

Grim JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI, Clurman BE.

Mol Cell Biol. 2012 Jun;32(11):2160-7. doi: 10.1128/MCB.00305-12. Epub 2012 Apr 2.


Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase.

Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE.

J Cell Biol. 2008 Jun 16;181(6):913-20. doi: 10.1083/jcb.200802076.


Kinase-independent function of cyclin E.

Geng Y, Lee YM, Welcker M, Swanger J, Zagozdzon A, Winer JD, Roberts JM, Kaldis P, Clurman BE, Sicinski P.

Mol Cell. 2007 Jan 12;25(1):127-39.


p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation.

Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE.

Curr Biol. 2002 Oct 29;12(21):1817-27.


Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex.

Smitherman M, Lee K, Swanger J, Kapur R, Clurman BE.

Mol Cell Biol. 2000 Aug;20(15):5631-42.


Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination.

Sheaff RJ, Singer JD, Swanger J, Smitherman M, Roberts JM, Clurman BE.

Mol Cell. 2000 Feb;5(2):403-10.


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