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Items: 1 to 50 of 219

1.

Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.

McKinstry KK, Alam F, Flores-Malavet V, Nagy MZ, Sell S, Cooper AM, Swain SL, Strutt TM.

PLoS Pathog. 2019 Aug 14;15(8):e1007989. doi: 10.1371/journal.ppat.1007989. eCollection 2019 Aug.

2.

Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

Devarajan P, Swain SL.

Cell Host Microbe. 2019 Mar 13;25(3):354-355. doi: 10.1016/j.chom.2019.02.009.

PMID:
30870620
3.

Pathogen Recognition by CD4 Effectors Drives Key Effector and Most Memory Cell Generation Against Respiratory Virus.

Devarajan P, Jones MC, Kugler-Umana O, Vong AM, Xia J, Swain SL.

Front Immunol. 2018 Mar 26;9:596. doi: 10.3389/fimmu.2018.00596. eCollection 2018. Review.

4.

IL-15 supports the generation of protective lung-resident memory CD4 T cells.

Strutt TM, Dhume K, Finn CM, Hwang JH, Castonguay C, Swain SL, McKinstry KK.

Mucosal Immunol. 2018 May;11(3):668-680. doi: 10.1038/mi.2017.101. Epub 2017 Nov 29.

5.

The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age.

Swain SL, Kugler-Umana O, Kuang Y, Zhang W.

Cell Immunol. 2017 Nov;321:52-60. doi: 10.1016/j.cellimm.2017.05.009. Epub 2017 Jul 11.

6.

IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo.

Brahmakshatriya V, Kuang Y, Devarajan P, Xia J, Zhang W, Vong AM, Swain SL.

J Immunol. 2017 Apr 1;198(7):2819-2833. doi: 10.4049/jimmunol.1601119. Epub 2017 Mar 1.

7.

NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.

Marshall NB, Vong AM, Devarajan P, Brauner MD, Kuang Y, Nayar R, Schutten EA, Castonguay CH, Berg LJ, Nutt SL, Swain SL.

J Immunol. 2017 Feb 1;198(3):1142-1155. doi: 10.4049/jimmunol.1601297. Epub 2016 Dec 28.

8.

Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory.

Bautista BL, Devarajan P, McKinstry KK, Strutt TM, Vong AM, Jones MC, Kuang Y, Mott D, Swain SL.

J Immunol. 2016 Nov 15;197(10):3936-3949. Epub 2016 Oct 17.

9.

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans.

Zhou X, Hopkins JW, Wang C, Brahmakshatriya V, Swain SL, Kuchel GA, Haynes L, McElhaney JE.

Oncotarget. 2016 Jun 28;7(26):39171-39183. doi: 10.18632/oncotarget.10047.

10.

Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza.

Strutt TM, McKinstry KK, Kuang Y, Finn CM, Hwang JH, Dhume K, Sell S, Swain SL.

J Immunol. 2016 Oct 15;197(8):3260-3270. Epub 2016 Sep 19.

11.

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.

Tinoco R, Carrette F, Barraza ML, Otero DC, Magaña J, Bosenberg MW, Swain SL, Bradley LM.

Immunity. 2016 Jun 21;44(6):1470. doi: 10.1016/j.immuni.2016.05.011. No abstract available.

12.

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.

Tinoco R, Carrette F, Barraza ML, Otero DC, Magaña J, Bosenberg MW, Swain SL, Bradley LM.

Immunity. 2016 May 17;44(5):1190-203. doi: 10.1016/j.immuni.2016.04.015.

13.

New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza.

Devarajan P, Bautista B, Vong AM, McKinstry KK, Strutt TM, Swain SL.

Front Immunol. 2016 Apr 11;7:136. doi: 10.3389/fimmu.2016.00136. eCollection 2016. Review.

14.

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines.

McElhaney JE, Kuchel GA, Zhou X, Swain SL, Haynes L.

Front Immunol. 2016 Feb 25;7:41. doi: 10.3389/fimmu.2016.00041. eCollection 2016. Review.

15.

IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells.

Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A.

J Immunol. 2015 Dec 1;195(11):5251-60. doi: 10.4049/jimmunol.1500777. Epub 2015 Oct 30.

16.

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.

Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM.

J Exp Med. 2015 Aug 24;212(9):1449-63. doi: 10.1084/jem.20141520. Epub 2015 Aug 17.

17.

IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age.

Tsukamoto H, Senju S, Matsumura K, Swain SL, Nishimura Y.

Nat Commun. 2015 Apr 7;6:6702. doi: 10.1038/ncomms7702.

18.

Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza.

Sell S, Guest I, McKinstry KK, Strutt TM, Kohlmeier JE, Brincks E, Tighe M, Blackman MA, Woodland DL, Dutton RW, Swain SL.

Viral Immunol. 2014 Dec;27(10):484-96. doi: 10.1089/vim.2014.0077.

19.

Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2.

McKinstry KK, Strutt TM, Bautista B, Zhang W, Kuang Y, Cooper AM, Swain SL.

Nat Commun. 2014 Nov 5;5:5377. doi: 10.1038/ncomms6377.

20.

Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection.

Nayar R, Schutten E, Bautista B, Daniels K, Prince AL, Enos M, Brehm MA, Swain SL, Welsh RM, Berg LJ.

J Immunol. 2014 Jun 15;192(12):5881-93. doi: 10.4049/jimmunol.1303187. Epub 2014 May 16.

21.

CD4 T cell defects in the aged: causes, consequences and strategies to circumvent.

Zhang W, Brahmakshatriya V, Swain SL.

Exp Gerontol. 2014 Jun;54:67-70. doi: 10.1016/j.exger.2014.01.002. Epub 2014 Jan 15. Review.

22.

CD28 and ITK signals regulate autoreactive T cell trafficking.

Jain N, Miu B, Jiang JK, McKinstry KK, Prince A, Swain SL, Greiner DL, Thomas CJ, Sanderson MJ, Berg LJ, Kang J.

Nat Med. 2013 Dec;19(12):1632-7. doi: 10.1038/nm.3393. Epub 2013 Nov 24.

23.

Location, location, location: the impact of migratory heterogeneity on T cell function.

Baaten BJ, Cooper AM, Swain SL, Bradley LM.

Front Immunol. 2013 Oct 8;4:311. doi: 10.3389/fimmu.2013.00311. Review.

24.

Immune senescence: new insights into defects but continued mystery of root causes.

Swain SL, Blomberg BB.

Curr Opin Immunol. 2013 Aug;25(4):495-7. doi: 10.1016/j.coi.2013.08.001. Epub 2013 Aug 17. No abstract available.

PMID:
23962425
25.

Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus.

Strutt TM, McKinstry KK, Marshall NB, Vong AM, Dutton RW, Swain SL.

Immunol Rev. 2013 Sep;255(1):149-64. doi: 10.1111/imr.12088. Review.

26.

Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful.

McKinstry KK, Dutton RW, Swain SL, Strutt TM.

Arch Immunol Ther Exp (Warsz). 2013 Oct;61(5):341-53. doi: 10.1007/s00005-013-0236-z. Epub 2013 May 25. Review. Erratum in: Arch Immunol Ther Exp (Warsz). 2013 Oct;61(5):355.

27.

Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.

Hamada H, Bassity E, Flies A, Strutt TM, Garcia-Hernandez Mde L, McKinstry KK, Zou T, Swain SL, Dutton RW.

J Immunol. 2013 Jan 1;190(1):296-306. doi: 10.4049/jimmunol.1200571. Epub 2012 Nov 28.

28.

Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors.

Strutt TM, McKinstry KK, Kuang Y, Bradley LM, Swain SL.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2551-60. Epub 2012 Aug 27.

29.

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms.

McKinstry KK, Strutt TM, Kuang Y, Brown DM, Sell S, Dutton RW, Swain SL.

J Clin Invest. 2012 Aug;122(8):2847-56. doi: 10.1172/JCI63689. Epub 2012 Jul 23.

30.

Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects.

Haynes L, Swain SL.

Semin Immunol. 2012 Oct;24(5):350-5. doi: 10.1016/j.smim.2012.04.001. Epub 2012 May 6. Review.

31.

Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection.

Brown DM, Lee S, Garcia-Hernandez Mde L, Swain SL.

J Virol. 2012 Jun;86(12):6792-803. doi: 10.1128/JVI.07172-11. Epub 2012 Apr 4.

32.

Expanding roles for CD4⁺ T cells in immunity to viruses.

Swain SL, McKinstry KK, Strutt TM.

Nat Rev Immunol. 2012 Jan 20;12(2):136-48. doi: 10.1038/nri3152. Review.

33.

Cytotoxic CD4 T cells in antiviral immunity.

Marshall NB, Swain SL.

J Biomed Biotechnol. 2011;2011:954602. doi: 10.1155/2011/954602. Epub 2011 Nov 22. Review.

34.

Control of innate immunity by memory CD4 T cells.

Strutt TM, McKinstry KK, Swain SL.

Adv Exp Med Biol. 2011;780:57-68. doi: 10.1007/978-1-4419-5632-3_6. Review.

35.

Krüppel-like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL-17 expression during Th17 differentiation.

An J, Golech S, Klaewsongkram J, Zhang Y, Subedi K, Huston GE, Wood WH 3rd, Wersto RP, Becker KG, Swain SL, Weng N.

FASEB J. 2011 Oct;25(10):3634-45. doi: 10.1096/fj.11-186924. Epub 2011 Jun 17.

36.

Hallmarks of CD4 T cell immunity against influenza.

McKinstry KK, Strutt TM, Swain SL.

J Intern Med. 2011 May;269(5):507-18. doi: 10.1111/j.1365-2796.2011.02367.x. Epub 2011 Mar 25. Review.

37.

TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism.

Jones SC, Brahmakshatriya V, Huston G, Dibble J, Swain SL.

J Immunol. 2010 Dec 1;185(11):6783-94. doi: 10.4049/jimmunol.0901296. Epub 2010 Oct 27.

38.

Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects.

Tsukamoto H, Huston GE, Dibble J, Duso DK, Swain SL.

J Immunol. 2010 Oct 15;185(8):4535-44. doi: 10.4049/jimmunol.1001668. Epub 2010 Sep 15.

39.

Regulation of CD4+ T-cell contraction during pathogen challenge.

McKinstry KK, Strutt TM, Swain SL.

Immunol Rev. 2010 Jul;236:110-24. doi: 10.1111/j.1600-065X.2010.00921.x. Review.

40.

Memory CD4+ T cells induce innate responses independently of pathogen.

Strutt TM, McKinstry KK, Dibble JP, Winchell C, Kuang Y, Curtis JD, Huston G, Dutton RW, Swain SL.

Nat Med. 2010 May;16(5):558-64, 1p following 564. doi: 10.1038/nm.2142. Epub 2010 May 2.

41.

The potential of CD4 T-cell memory.

McKinstry KK, Strutt TM, Swain SL.

Immunology. 2010 May;130(1):1-9. doi: 10.1111/j.1365-2567.2010.03259.x. Epub 2010 Mar 16. Review.

42.

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects.

Tsukamoto H, Clise-Dwyer K, Huston GE, Duso DK, Buck AL, Johnson LL, Haynes L, Swain SL.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18333-8. doi: 10.1073/pnas.0910139106. Epub 2009 Oct 8.

43.

T-cell immunosenescence: lessons learned from mouse models of aging.

Maue AC, Yager EJ, Swain SL, Woodland DL, Blackman MA, Haynes L.

Trends Immunol. 2009 Jul;30(7):301-5. doi: 10.1016/j.it.2009.04.007. Epub 2009 Jun 21. Review.

44.

IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge.

McKinstry KK, Strutt TM, Buck A, Curtis JD, Dibble JP, Huston G, Tighe M, Hamada H, Sell S, Dutton RW, Swain SL.

J Immunol. 2009 Jun 15;182(12):7353-63. doi: 10.4049/jimmunol.0900657.

45.

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells.

Brown DM, Kamperschroer C, Dilzer AM, Roberts DM, Swain SL.

Cell Immunol. 2009;257(1-2):69-79. doi: 10.1016/j.cellimm.2009.03.002. Epub 2009 Mar 31.

46.

Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.

Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW.

J Immunol. 2009 Mar 15;182(6):3469-81. doi: 10.4049/jimmunol.0801814.

47.

Key research opportunities in immune system aging.

Swain SL, Nikolich-Zugich J.

J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):183-6. doi: 10.1093/gerona/gln068. Epub 2009 Feb 27. Review.

48.

Functionally diverse subsets in CD4 T cell responses against influenza.

Strutt TM, McKinstry KK, Swain SL.

J Clin Immunol. 2009 Mar;29(2):145-50. doi: 10.1007/s10875-008-9266-4. Epub 2008 Dec 3.

49.
50.

SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation.

Kamperschroer C, Roberts DM, Zhang Y, Weng NP, Swain SL.

J Immunol. 2008 Sep 15;181(6):3994-4003.

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