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Items: 50

1.

Creation of Novel Cores for β-Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy.

Viklund J, Kolmodin K, Nordvall G, Swahn BM, Svensson M, Gravenfors Y, Rahm F.

ACS Med Chem Lett. 2014 Feb 3;5(4):440-5. doi: 10.1021/ml5000433. eCollection 2014 Apr 10.

2.

AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.

Eketjäll S, Janson J, Jeppsson F, Svanhagen A, Kolmodin K, Gustavsson S, Radesäter AC, Eliason K, Briem S, Appelkvist P, Niva C, Berg AL, Karlström S, Swahn BM, Fälting J.

J Neurosci. 2013 Jun 12;33(24):10075-84. doi: 10.1523/JNEUROSCI.1165-13.2013.

3.

Biotransformation of two β-secretase inhibitors including ring opening and contraction of a pyrimidine ring.

Lindgren A, Eklund G, Turek D, Malmquist J, Swahn BM, Holenz J, von Berg S, Karlström S, Bueters T.

Drug Metab Dispos. 2013 May;41(5):1134-47. doi: 10.1124/dmd.112.050351. Epub 2013 Mar 8.

PMID:
23474650
4.

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients.

Forsberg A, Juréus A, Cselényi Z, Eriksdotter M, Freund-Levi Y, Jeppsson F, Swahn BM, Sandell J, Julin P, Schou M, Andersson J, Johnström P, Varnäs K, Halldin C, Farde L, Svensson S.

Eur J Nucl Med Mol Imaging. 2013 Apr;40(4):580-93. doi: 10.1007/s00259-012-2322-6. Epub 2013 Jan 17.

5.

Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.

Jeppsson F, Eketjäll S, Janson J, Karlström S, Gustavsson S, Olsson LL, Radesäter AC, Ploeger B, Cebers G, Kolmodin K, Swahn BM, von Berg S, Bueters T, Fälting J.

J Biol Chem. 2012 Nov 30;287(49):41245-57. doi: 10.1074/jbc.M112.409110. Epub 2012 Oct 9.

6.

New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain.

Gravenfors Y, Viklund J, Blid J, Ginman T, Karlström S, Kihlström J, Kolmodin K, Lindström J, von Berg S, von Kieseritzky F, Bogar K, Slivo C, Swahn BM, Olsson LL, Johansson P, Eketjäll S, Fälting J, Jeppsson F, Strömberg K, Janson J, Rahm F.

J Med Chem. 2012 Nov 8;55(21):9297-311. doi: 10.1021/jm300991n. Epub 2012 Oct 3. Erratum in: J Med Chem. 2012 Nov 26;55(22):10316. Bogar, Krisztian [added].

PMID:
23017051
7.

Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides.

Swahn BM, Kolmodin K, Karlström S, von Berg S, Söderman P, Holenz J, Berg S, Lindström J, Sundström M, Turek D, Kihlström J, Slivo C, Andersson L, Pyring D, Rotticci D, Ohberg L, Kers A, Bogar K, von Kieseritzky F, Bergh M, Olsson LL, Janson J, Eketjäll S, Georgievska B, Jeppsson F, Fälting J.

J Med Chem. 2012 Nov 8;55(21):9346-61. doi: 10.1021/jm3009025. Epub 2012 Sep 17.

PMID:
22924815
8.

Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹⁸F-PET imaging agents for β-amyloid plaques.

Swahn BM, Sandell J, Pyring D, Bergh M, Jeppsson F, Juréus A, Neelissen J, Johnström P, Schou M, Svensson S.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4332-7. doi: 10.1016/j.bmcl.2012.05.011. Epub 2012 May 11.

PMID:
22647721
9.

Aminoimidazoles as BACE-1 inhibitors: the challenge to achieve in vivo brain efficacy.

Swahn BM, Holenz J, Kihlström J, Kolmodin K, Lindström J, Plobeck N, Rotticci D, Sehgelmeble F, Sundström M, Berg Sv, Fälting J, Georgievska B, Gustavsson S, Neelissen J, Ek M, Olsson LL, Berg S.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1854-9. doi: 10.1016/j.bmcl.2012.01.079. Epub 2012 Jan 28.

PMID:
22325942
10.

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules.

Luker T, Alcaraz L, Chohan KK, Blomberg N, Brown DS, Butlin RJ, Elebring T, Griffin AM, Guile S, St-Gallay S, Swahn BM, Swallow S, Waring MJ, Wenlock MC, Leeson PD.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5673-9. doi: 10.1016/j.bmcl.2011.07.074. Epub 2011 Jul 27.

PMID:
21852131
11.

Radiosynthesis of the candidate beta-amyloid radioligand [(11)C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys.

Andersson JD, Varnäs K, Cselényi Z, Gulyás B, Wensbo D, Finnema SJ, Swahn BM, Svensson S, Nyberg S, Farde L, Halldin C.

Synapse. 2010 Oct;64(10):733-41. doi: 10.1002/syn.20782.

PMID:
20698029
12.

Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand.

Juréus A, Swahn BM, Sandell J, Jeppsson F, Johnson AE, Johnström P, Neelissen JA, Sunnemark D, Farde L, Svensson SP.

J Neurochem. 2010 Aug;114(3):784-94. doi: 10.1111/j.1471-4159.2010.06812.x. Epub 2010 May 13.

13.

Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for beta-amyloid plaques.

Swahn BM, Wensbo D, Sandell J, Sohn D, Slivo C, Pyring D, Malmström J, Arzel E, Vallin M, Bergh M, Jeppsson F, Johnson AE, Juréus A, Neelissen J, Svensson S.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1976-80. doi: 10.1016/j.bmcl.2010.01.105. Epub 2010 Jan 25.

PMID:
20153963
14.

Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.

Swahn BM, Macsari I, Viklund J, Ohberg L, Sjödin J, Neelissen J, Lindquist J.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):2009-12. doi: 10.1016/j.bmcl.2009.02.039. Epub 2009 Feb 13.

PMID:
19264481
15.

Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.

Swahn BM, Xue Y, Arzel E, Kallin E, Magnus A, Plobeck N, Viklund J.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1397-401. Epub 2005 Dec 5.

PMID:
16337120
16.

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3.

Swahn BM, Huerta F, Kallin E, Malmström J, Weigelt T, Viklund J, Womack P, Xue Y, Ohberg L.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9.

PMID:
16140012
17.

Two non-racemic preparations of a piperidine-based NMDA antagonist with analgesic activity.

Swahn BM, Edvinsson KM, Kallin E, Larsson U, Berge OG, Molin H, Pelcman B, Claesson A.

Bioorg Med Chem. 1997 Jul;5(7):1293-9.

PMID:
9377089
18.

The properties of the polyethylene catheter.

Swahn B, Gunne I.

Ann Radiol (Paris). 1979 May;22(4):356-7. No abstract available.

PMID:
496283
19.

[Regional tumor registers--unnecessary officialism?].

Berge T, Dahlgren S, Rundcrantz H, Rybo G, Swahn B.

Lakartidningen. 1974 May 29;71(22):2263-4. Swedish. No abstract available.

PMID:
4840631
20.

[Planning of acute consultation in the hospital of Lund].

Dahn I, Markroth I, Hornýanszky S, Swahn B.

Lakartidningen. 1970 May 27;67(22):2543-8. Swedish. No abstract available.

PMID:
5485953
21.

[Therapy of herpes zoster].

Swahn B.

Bibl Psychiatr Neurol. 1969;139:370-4. German. No abstract available.

PMID:
4109459
22.

Coronary heart disease in a population in the south of Sweden.

Biörck G, Blomqvist G, Hall P, Johansson BW, Larsson E, Malmros H, Sievers J, Swahn B.

Acta Med Scand. 1966 Jun;179(6):663-71. No abstract available.

PMID:
5941322
23.

Effect of normally occurring rabbit antibodies on fluorescent-antibody reactions.

Bergman S, Forsgren A, Swahn B.

J Bacteriol. 1966 Apr;91(4):1664-5. No abstract available.

24.

PROTEIN PATTERN OF CEREBROSPINAL FLUID DURING THE COURSE OF ACUTE POLYRADICULONEUROPATHY.

DENCKER SJ, SWAHN B, URSING B.

Acta Med Scand. 1964 Apr;175:499-506. No abstract available.

PMID:
14149655
25.

Protein pattern of cerebrospinal fluid in meningitis and meningo-encephalitis.

URSING B, DENCKER SJ, SWAHN B.

Acta Med Scand. 1962 Jun;171:715-22. No abstract available.

PMID:
13923939
26.

Proteins of central nervous origin present in cerebrospinal fluid.

DENCKER SJ, SWAHN B.

Nature. 1962 Apr 21;194:288-9. No abstract available.

PMID:
13885395
27.

Immunoelectrophoretic studies of cerebrospinal fluid. Investigations in patients with tumor in the central nervous system.

SVENNILSON E, DENCKER SJ, SWAHN B.

Neurology. 1961 Nov;11:989-95. No abstract available.

PMID:
13918691
28.
29.

Demonstration of large blood proteins in cerebrospinal fluid.

DENCKER SJ, BRONNESTAM R, SWAHN B.

Neurology. 1961 May;11:441-4. No abstract available.

PMID:
13721829
30.

The diagnostic value of lipoprotein determinations in cerebrospinal fluid.

Dencker SJ, Swahn B.

Acta Psychiatr Scand. 1961;36(2):325-36. No abstract available.

PMID:
13721832
31.

Identification of separate proteins in cerebrospinal fluid with the aid of micro-immuno-electrophoresis.

DENCKER SJ, SWAHN B.

Acta Psychiatr Scand Suppl. 1961;36(150):319-23. No abstract available.

PMID:
13721831
32.

[Micro-immuno-electrophoresis, a contribution to cerebrospinal fluid diagnosis].

DENCKER SJ, BRONNESTAM R, SWAHN B.

Nord Med. 1960 Nov 24;64:1477-80. Swedish. No abstract available.

PMID:
13721830
33.

[Anaphylactic shock with fatal outcome after heparin injection].

BRANDT L, NORDEN A, SWAHN B.

Sven Lakartidn. 1960 Jun 17;57:1924-8. Swedish. No abstract available.

PMID:
13803904
34.

Subacute bacterial endocarditis due to coagulase-negative Staphylococcus albus.

BRANDT L, SWAHN B.

Acta Med Scand. 1960 Feb 17;166:125-32. No abstract available.

PMID:
13803905
35.

Paper electrophoretic investigation of protein bound lipids in cerebrospinal fluid. A preliminary report.

DENCKER SJ, GOTTFRIES I, SWAHN B.

Acta Med Scand. 1959 Oct 16;165:157-9. No abstract available.

PMID:
13815888
36.

Destruction of some agglutinins but not of others by two sulfhydryl compounds.

GRUBB R, SWAHN B.

Acta Pathol Microbiol Scand. 1958;43(3):305-9. No abstract available.

PMID:
13594446
37.

Purification of hemagglutinating factors in rheumatoid arthritic sera by Cohn's method 10 and ultracentrifugation.

SWAHN B, GRUBB R.

Acta Pathol Microbiol Scand. 1958;42(2):173-80. No abstract available.

PMID:
13508260
38.

Physical activity and the diet in populations differing in serum cholesterol.

ANDERSON JT, ARESU M, BIORCK G, BROCK JF, BRONTE-STEWART B, DEL VECCHIO A, FIDANZA F, KEYS A, KEYS MH, MALMROS H, POPPI A, POSTELI T, SWAHN B.

J Clin Invest. 1956 Oct;35(10):1173-81. No abstract available.

39.

Hypertension, atherosclerosis and the diet.

MALMROS H, BIORCK G, SWAHN B.

Acta Med Scand Suppl. 1956;312:71-8. No abstract available.

PMID:
13339147
40.

Effects of diet on blood lipids in man, particularly cholesterol and lipoproteins.

KEYS A, ANDERSON JT, FIDANZA F, KEYS MH, SWAHN B.

Clin Chem. 1955 Feb;1(1):34-52. No abstract available.

41.

Studies on lipids, proteins and lipoproteins in serum from newborn infants.

RAFSTEDT S, SWAHN B.

Acta Paediatr. 1954 May;43(3):221-34. No abstract available.

PMID:
13180326
42.

Essential hyperlipaemia.

MALMROS H, SWAHN B, TRUEDSSON E.

Acta Med Scand. 1954;149(2):91-108. No abstract available.

PMID:
13180219
43.

Electrophoretical mobility of chylomicrons.

SWAHN B.

Scand J Clin Lab Invest. 1953;5 Suppl. 9:80-110. No abstract available.

PMID:
13156506
44.

A micromethod for the determination of serum lipids after electrophoretical separation of filter paper.

SWAHN B.

Scand J Clin Lab Invest. 1953;5 Suppl. 9:44-79. No abstract available.

PMID:
13156505
45.

A micromethod for the determination of total lipids in serum.

SWAHN B.

Scand J Clin Lab Invest. 1953;5 Suppl. 9:7-43. No abstract available.

PMID:
13156504
46.

Hyperlipemia.

MALMROS H, SWAHN B, TRUEDSSON E.

Acta Med Scand Suppl. 1953;287:86-90. No abstract available.

PMID:
13137979
47.

Lipid metabolism in myxedema.

MALMROS H, SWAHN B.

Acta Med Scand. 1953;145(5):361-9. No abstract available.

PMID:
13079648
48.

[Lipoprotein studies].

MALMROS H, SWAHN B.

Nord Med. 1952 Jul 25;47(30):1028-31. Undetermined Language. No abstract available.

PMID:
14948104
49.

A method for localization and determination of serum lipids after electrophoretical separation on filter paper.

SWAHN B.

Scand J Clin Lab Invest. 1952;4(2):98-103. No abstract available.

PMID:
14950096
50.

A new micromethod for the determination of total lipids in serum.

SWAHN B.

Scand J Clin Lab Invest. 1952;4(3):247-8. No abstract available.

PMID:
13014999

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