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Items: 31

1.

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.

Kostich W, Hamman BD, Li YW, Naidu S, Dandapani K, Feng J, Easton A, Bourin C, Baker K, Allen J, Savelieva K, Louis JV, Dokania M, Elavazhagan S, Vattikundala P, Sharma V, Das ML, Shankar G, Kumar A, Holenarsipur VK, Gulianello M, Molski T, Brown JM, Lewis M, Huang Y, Lu Y, Pieschl R, O'Malley K, Lippy J, Nouraldeen A, Lanthorn TH, Ye G, Wilson A, Balakrishnan A, Denton R, Grace JE, Lentz KA, Santone KS, Bi Y, Main A, Swaffield J, Carson K, Mandlekar S, Vikramadithyan RK, Nara SJ, Dzierba C, Bronson J, Macor JE, Zaczek R, Westphal R, Kiss L, Bristow L, Conway CM, Zambrowicz B, Albright CF.

J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. doi: 10.1124/jpet.116.235333. Epub 2016 Jul 13.

2.

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

Salojin KV, Hamman BD, Chang WC, Jhaver KG, Al-Shami A, Crisostomo J, Wilkins C, Digeorge-Foushee AM, Allen J, Patel N, Gopinathan S, Zhou J, Nouraldeen A, Jessop TC, Bagdanoff JT, Augeri DJ, Read R, Vogel P, Swaffield J, Wilson A, Platt KA, Carson KG, Main A, Zambrowicz BP, Oravecz T.

PLoS One. 2014 May 22;9(5):e98151. doi: 10.1371/journal.pone.0098151. eCollection 2014.

3.

Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity.

Appiah KK, Blat Y, Robertson BJ, Pearce BC, Pedicord DL, Gentles RG, Yu XC, Mseeh F, Nguyen N, Swaffield JC, Harden DG, Westphal RS, Banks MN, O'Connell JC.

J Biomol Screen. 2014 Apr;19(4):595-605. doi: 10.1177/1087057113511111. Epub 2013 Nov 15.

PMID:
24241710
4.

Novel potent inhibitors of deoxycytidine kinase identified and compared by multiple assays.

Yu XC, Miranda M, Liu Z, Patel S, Nguyen N, Carson K, Liu Q, Swaffield JC.

J Biomol Screen. 2010 Jan;15(1):72-9. doi: 10.1177/1087057109353604. Epub 2009 Dec 3.

PMID:
19959816
5.

Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.

Jessop TC, Tarver JE, Carlsen M, Xu A, Healy JP, Heim-Riether A, Fu Q, Taylor JA, Augeri DJ, Shen M, Stouch TR, Swanson RV, Tari LW, Hunter M, Hoffman I, Keyes PE, Yu XC, Miranda M, Liu Q, Swaffield JC, David Kimball S, Nouraldeen A, Wilson AG, Foushee AM, Jhaver K, Finch R, Anderson S, Oravecz T, Carson KG.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6784-7. doi: 10.1016/j.bmcl.2009.09.081. Epub 2009 Sep 25.

PMID:
19836232
6.

5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase.

Tarver JE, Jessop TC, Carlsen M, Augeri DJ, Fu Q, Healy JP, Heim-Riether A, Xu A, Taylor JA, Shen M, Keyes PE, David Kimball S, Yu XC, Miranda M, Liu Q, Swaffield JC, Nouraldeen A, Wilson AG, Finch R, Jhaver K, Foushee AM, Anderson S, Oravecz T, Carson KG.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6780-3. doi: 10.1016/j.bmcl.2009.09.082. Epub 2009 Sep 25.

PMID:
19836229
7.

Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.

Bagdanoff JT, Donoviel MS, Nouraldeen A, Tarver J, Fu Q, Carlsen M, Jessop TC, Zhang H, Hazelwood J, Nguyen H, Baugh SD, Gardyan M, Terranova KM, Barbosa J, Yan J, Bednarz M, Layek S, Courtney LF, Taylor J, Digeorge-Foushee AM, Gopinathan S, Bruce D, Smith T, Moran L, O'Neill E, Kramer J, Lai Z, Kimball SD, Liu Q, Sun W, Yu S, Swaffield J, Wilson A, Main A, Carson KG, Oravecz T, Augeri DJ.

J Med Chem. 2009 Jul 9;52(13):3941-53. doi: 10.1021/jm900278w.

PMID:
19489538
8.

Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.

Vogel P, Donoviel MS, Read R, Hansen GM, Hazlewood J, Anderson SJ, Sun W, Swaffield J, Oravecz T.

PLoS One. 2009;4(1):e4112. doi: 10.1371/journal.pone.0004112. Epub 2009 Jan 1.

9.

Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.

Shi ZC, Devasagayaraj A, Gu K, Jin H, Marinelli B, Samala L, Scott S, Stouch T, Tunoori A, Wang Y, Zang Y, Zhang C, Kimball SD, Main AJ, Sun W, Yang Q, Nouraldeen A, Yu XQ, Buxton E, Patel S, Nguyen N, Swaffield J, Powell DR, Wilson A, Liu Q.

J Med Chem. 2008 Jul 10;51(13):3684-7. doi: 10.1021/jm800338j. Epub 2008 Jun 17.

PMID:
18557609
10.

Development of a highthroughput yeast-based assay for detection of metabolically activated genotoxins.

Liu X, Kramer JA, Swaffield JC, Hu Y, Chai G, Wilson AG.

Mutat Res. 2008 May 31;653(1-2):63-9. doi: 10.1016/j.mrgentox.2008.03.006. Epub 2008 Apr 1.

PMID:
18485802
11.

Affinity purification of proteins binding to GST fusion proteins.

Swaffield JC, Johnston SA.

Curr Protoc Mol Biol. 2001 May;Chapter 20:Unit 20.2. doi: 10.1002/0471142727.mb2002s33.

PMID:
18265191
12.

Evolution of proteasomal ATPases.

Wollenberg K, Swaffield JC.

Mol Biol Evol. 2001 Jun;18(6):962-74.

PMID:
11371584
13.

Identification of a phylogenetically conserved Sug1 CAD family member that is differentially expressed in the mouse nervous system.

Sun D, Swaffield JC, Johnston SA, Milligan CE, Zoeller RT, Schwartz LM.

J Neurobiol. 1997 Dec;33(7):877-90.

PMID:
9407011
14.
15.

CADp44: a novel regulatory subunit of the 26S proteasome and the mammalian homolog of yeast Sug2p.

Bauer VW, Swaffield JC, Johnston SA, Andrews MT.

Gene. 1996 Nov 28;181(1-2):63-9.

PMID:
8973309
16.

Quality audit--a review of the literature concerning delivery of continence care.

Swaffield J.

J Clin Nurs. 1995 Sep;4(5):277-82. Review.

PMID:
7551434
17.

A critique of 'at risk' pressure sore assessment tools.

Smith LN, Booth N, Douglas D, Robertson WR, Walker A, Durie M, Fraser A, Hillan EH, Swaffield J.

J Clin Nurs. 1995 May;4(3):153-9. Review.

PMID:
7773524
18.

Interaction of thyroid-hormone receptor with a conserved transcriptional mediator.

Lee JW, Ryan F, Swaffield JC, Johnston SA, Moore DD.

Nature. 1995 Mar 2;374(6517):91-4.

PMID:
7870181
19.

A highly conserved ATPase protein as a mediator between acidic activation domains and the TATA-binding protein.

Swaffield JC, Melcher K, Johnston SA.

Nature. 1995 Mar 2;374(6517):88-91.

PMID:
7870180
20.

PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family.

DeMartino GN, Moomaw CR, Zagnitko OP, Proske RJ, Chu-Ping M, Afendis SJ, Swaffield JC, Slaughter CA.

J Biol Chem. 1994 Aug 19;269(33):20878-84.

22.

Access course to a Master's degree at the University of Glasgow.

Swaffield J.

Br J Nurs. 1993 Jun 10-23;2(11):583-4. No abstract available.

PMID:
8334354
23.

Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4.

Swaffield JC, Bromberg JF, Johnston SA.

Nature. 1992 Dec 24-31;360(6406):768. No abstract available.

PMID:
1465148
24.

Protein folding within the cell is influenced by controlled rates of polypeptide elongation.

Crombie T, Swaffield JC, Brown AJ.

J Mol Biol. 1992 Nov 5;228(1):7-12.

PMID:
1447795
25.
26.

Eukaryotic gene regulation: simple vs complex models.

Swaffield JC, Johnston SA.

SAAS Bull Biochem Biotechnol. 1991 Jan;4:17-9.

PMID:
1367248
27.

Continence. Finding the right medium.

Swaffield J.

Nurs Times. 1987 Apr 15-21;83(15):92. No abstract available.

PMID:
3647399
28.

Avoiding incontinence--health education and preventative care for women.

Swaffield J.

Nursing (Lond). 1986 Oct;3(10 Suppl):6-7. No abstract available.

PMID:
3640282
29.

Continence. Social skills for the mentally handicapped.

Swaffield J.

Nurs Times. 1985 Apr 3-9;81(14):77-9. No abstract available.

PMID:
3846217
30.
31.

The medical officer of health in local government.

Swaffield JC.

Public Health. 1969 Sep;83(6):293-305. No abstract available.

PMID:
5386675

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