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Outcome and characteristics of non-measurable myeloma: A cohort study with population-based data from the Swedish Myeloma Registry.

Wålinder G, Samuelsson J, Näsman P, Hansson M, Juliusson G, Forsberg K, Svensson R, Linder O, Carlson K, Kristinsson SY, Mellqvist UH, Blimark CH, Turesson I, Nahi H.

Eur J Haematol. 2019 Nov 16. doi: 10.1111/ejh.13351. [Epub ahead of print]


The influence of fibrillin-1 and physical activity upon tendon tissue morphology and mechanical properties in mice.

Tran PHT, Skrba T, Wondimu E, Galatioto G, Svensson RB, Olesen AT, Mackey AL, Magnusson SP, Ramirez F, Kjaer M.

Physiol Rep. 2019 Nov;7(21):e14267. doi: 10.14814/phy2.14267.


Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture.

Svensson RJ, Sabiiti W, Kibiki GS, Ntinginya NE, Bhatt N, Davies G, Gillespie SH, Simonsson USH.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00652-19. doi: 10.1128/AAC.00652-19. Print 2019 Oct.


The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer.

Rodón L, Svensson RU, Wiater E, Chun MGH, Tsai WW, Eichner LJ, Shaw RJ, Montminy M.

Sci Adv. 2019 Jul 24;5(7):eaaw6455. doi: 10.1126/sciadv.aaw6455. eCollection 2019 Jul.


The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.

Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ.

Cancer Discov. 2019 Nov;9(11):1606-1627. doi: 10.1158/2159-8290.CD-18-1261. Epub 2019 Jul 26.


Individualised dosing algorithm and personalised treatment of high-dose rifampicin for tuberculosis.

Svensson RJ, Niward K, Davies Forsman L, Bruchfeld J, Paues J, Eliasson E, Schön T, Simonsson USH.

Br J Clin Pharmacol. 2019 Oct;85(10):2341-2350. doi: 10.1111/bcp.14048. Epub 2019 Jul 25.


Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure.

Hjerrild JN, Wobbe A, Stausholm MB, Larsen AE, Josefsen CO, Malmgaard-Clausen NM, Dela F, Kjaer M, Magnusson SP, Hansen M, Svensson RB, Couppé C.

Nutrients. 2019 Jun 22;11(6). pii: E1409. doi: 10.3390/nu11061409.


Muscle-strain injury exudate favors acute tissue healing and prolonged connective tissue formation in humans.

Bayer ML, Bang L, Hoegberget-Kalisz M, Svensson RB, Olesen JL, Karlsson MM, Schjerling P, Hellsten Y, Hoier B, Magnusson SP, Kjaer M.

FASEB J. 2019 Sep;33(9):10369-10382. doi: 10.1096/fj.201900542R. Epub 2019 Jun 18.


Regional differences in turnover, composition, and mechanics of the porcine flexor tendon.

Zhang C, Svensson RB, Couppé C, Schjerling P, Skovgaard D, Kjaer M, Magnusson SP.

Connect Tissue Res. 2019 May 28:1-10. doi: 10.1080/03008207.2019.1620222. [Epub ahead of print]


Age and prior exercise in vivo determine the subsequent in vitro molecular profile of myoblasts and nonmyogenic cells derived from human skeletal muscle.

Bechshøft CJL, Jensen SM, Schjerling P, Andersen JL, Svensson RB, Eriksen CS, Mkumbuzi NS, Kjaer M, Mackey AL.

Am J Physiol Cell Physiol. 2019 Jun 1;316(6):C898-C912. doi: 10.1152/ajpcell.00049.2019. Epub 2019 Mar 27.


Lower HDL-cholesterol, a known marker of cardiovascular risk, was associated with depression in type 1 diabetes: a cross sectional study.

Melin EO, Thulesius HO, Hillman M, Svensson R, Landin-Olsson M, Thunander M.

Lipids Health Dis. 2019 Mar 18;18(1):65. doi: 10.1186/s12944-019-1009-4.


Surgical Technique Influences Rehabilitation Regimen: Response.

Magnusson SP, Eliasson P, Agergaard AS, Couppe C, Svensson R, Krogsgaard M, Kjaer M.

Am J Sports Med. 2019 Jan;47(1):NP7. doi: 10.1177/0363546518810704. No abstract available.


Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults.

Eriksen CS, Svensson RB, Gylling AT, Couppé C, Magnusson SP, Kjaer M.

BMC Geriatr. 2019 Jan 31;19(1):30. doi: 10.1186/s12877-019-1043-0.


Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models.

Eichner LJ, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU.

Cell Metab. 2019 Feb 5;29(2):285-302.e7. doi: 10.1016/j.cmet.2018.10.005. Epub 2018 Nov 8.


Cellular homeostatic tension and force transmission measured in human engineered tendon.

Giannopoulos A, Svensson RB, Heinemeier KM, Schjerling P, Kadler KE, Holmes DF, Kjaer M, Magnusson SP.

J Biomech. 2018 Sep 10;78:161-165. doi: 10.1016/j.jbiomech.2018.07.032. Epub 2018 Jul 30.


Role of tissue perfusion, muscle strength recovery, and pain in rehabilitation after acute muscle strain injury: A randomized controlled trial comparing early and delayed rehabilitation.

Bayer ML, Hoegberget-Kalisz M, Jensen MH, Olesen JL, Svensson RB, Couppé C, Boesen M, Nybing JD, Kurt EY, Magnusson SP, Kjaer M.

Scand J Med Sci Sports. 2018 Dec;28(12):2579-2591. doi: 10.1111/sms.13269. Epub 2018 Aug 16.


The Ruptured Achilles Tendon Elongates for 6 Months After Surgical Repair Regardless of Early or Late Weightbearing in Combination With Ankle Mobilization: A Randomized Clinical Trial.

Eliasson P, Agergaard AS, Couppé C, Svensson R, Hoeffner R, Warming S, Warming N, Holm C, Jensen MH, Krogsgaard M, Kjaer M, Magnusson SP.

Am J Sports Med. 2018 Aug;46(10):2492-2502. doi: 10.1177/0363546518781826. Epub 2018 Jul 2.


An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice.

Skogh A, Lesniak A, Sköld C, Karlgren M, Gaugaz FZ, Svensson R, Diwakarla S, Jonsson A, Fransson R, Nyberg F, Hallberg M, Sandström A.

Bioorg Med Chem Lett. 2018 Aug 1;28(14):2446-2450. doi: 10.1016/j.bmcl.2018.06.009. Epub 2018 Jun 15.


The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis.

Svensson EM, Svensson RJ, Te Brake LHM, Boeree MJ, Heinrich N, Konsten S, Churchyard G, Dawson R, Diacon AH, Kibiki GS, Minja LT, Ntingiya NE, Sanne I, Gillespie SH, Hoelscher M, Phillips PPJ, Simonsson USH, Aarnoutse R.

Clin Infect Dis. 2018 Jun 18;67(1):34-41. doi: 10.1093/cid/ciy026.


Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S.

Nat Commun. 2018 May 22;9(1):2071. doi: 10.1038/s41467-018-04198-5.


Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations.

Svensson RJ, Svensson EM, Aarnoutse RE, Diacon AH, Dawson R, Gillespie SH, Moodley M, Boeree MJ, Simonsson USH.

J Infect Dis. 2018 Aug 14;218(6):991-999. doi: 10.1093/infdis/jiy242.


Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin.

Wicha SG, Clewe O, Svensson RJ, Gillespie SH, Hu Y, Coates ARM, Simonsson USH.

Clin Pharmacol Ther. 2018 Dec;104(6):1208-1218. doi: 10.1002/cpt.1102. Epub 2018 Jun 19.


Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave.

Melin EO, Svensson R, Thulesius HO.

Scand J Prim Health Care. 2018 Jun;36(2):123-133. doi: 10.1080/02813432.2018.1459225. Epub 2018 Apr 25.


Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.

Ladds MJGW, Pastor-Fernández A, Popova G, van Leeuwen IMM, Eng KE, Drummond CJ, Johansson L, Svensson R, Westwood NJ, McCarthy AR, Tholander F, Popa M, Lane DP, McCormack E, McInerney GM, Bhatia R, Laín S.

PLoS One. 2018 Apr 23;13(4):e0195956. doi: 10.1371/journal.pone.0195956. eCollection 2018.


Improving treatment outcome assessment in a mouse tuberculosis model.

Mourik BC, Svensson RJ, de Knegt GJ, Bax HI, Verbon A, Simonsson USH, de Steenwinkel JEM.

Sci Rep. 2018 Apr 9;8(1):5714. doi: 10.1038/s41598-018-24067-x.


Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders.

Jensen JK, Nygaard RH, Svensson RB, Hove HD, Magnusson SP, Kjær M, Couppé C.

Eur J Appl Physiol. 2018 Jul;118(7):1301-1307. doi: 10.1007/s00421-018-3862-7. Epub 2018 Apr 5.


Lower tendon stiffness in very old compared with old individuals is unaffected by short-term resistance training of skeletal muscle.

Eriksen CS, Henkel C, Svensson RB, Agergaard AS, Couppé C, Kjaer M, Magnusson SP.

J Appl Physiol (1985). 2018 Jul 1;125(1):205-214. doi: 10.1152/japplphysiol.00028.2018. Epub 2018 Mar 29.


A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S.

Nat Commun. 2018 Mar 16;9(1):1107. doi: 10.1038/s41467-018-03441-3. Erratum in: Nat Commun. 2018 May 22;9(1):2071.


Effects of maturation and advanced glycation on tensile mechanics of collagen fibrils from rat tail and Achilles tendons.

Svensson RB, Smith ST, Moyer PJ, Magnusson SP.

Acta Biomater. 2018 Apr 1;70:270-280. doi: 10.1016/j.actbio.2018.02.005. Epub 2018 Feb 13.


Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound.

Islam MK, Strand M, Saleeb M, Svensson R, Baranczewski P, Artursson P, Wadell G, Ahlm C, Elofsson M, Evander M.

Sci Rep. 2018 Jan 31;8(1):1925. doi: 10.1038/s41598-018-20362-9.


An examination of the interaction between morality and self-control in offending: A study of differences between girls and boys.

Ivert AK, Andersson F, Svensson R, Pauwels LJR, Torstensson Levander M.

Crim Behav Ment Health. 2018 Jun;28(3):282-294. doi: 10.1002/cbm.2065. Epub 2018 Jan 16.


Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.

Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF.

Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28.


Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration.

Skogh A, Lesniak A, Gaugaz FZ, Svensson R, Lindeberg G, Fransson R, Nyberg F, Hallberg M, Sandström A.

Eur J Pharm Sci. 2017 Nov 15;109:533-540. doi: 10.1016/j.ejps.2017.09.007. Epub 2017 Sep 5.


Effects of anti-inflammatory (NSAID) treatment on human tendinopathic tissue.

Heinemeier KM, Øhlenschlæger TF, Mikkelsen UR, Sønder F, Schjerling P, Svensson RB, Kjaer M.

J Appl Physiol (1985). 2017 Nov 1;123(5):1397-1405. doi: 10.1152/japplphysiol.00281.2017. Epub 2017 Aug 31.


Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure.

Maccarana M, Svensson RB, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, Eyre D, Warman M, Kalamajski S.

PLoS One. 2017 Aug 31;12(8):e0184028. doi: 10.1371/journal.pone.0184028. eCollection 2017.


Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation.

Kuang Q, Purhonen P, Ålander J, Svensson R, Hoogland V, Winerdal J, Spahiu L, Ottosson-Wadlund A, Jegerschöld C, Morgenstern R, Hebert H.

Sci Rep. 2017 Aug 11;7(1):7897. doi: 10.1038/s41598-017-07912-3.


Retraction Notice to: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule.

Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Nilsson KF, Hammarström LGJ, Ernfors P.

Cell. 2017 Jul 13;170(2):407. doi: 10.1016/j.cell.2017.06.044. No abstract available.


A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses.

Svensson RJ, Aarnoutse RE, Diacon AH, Dawson R, Gillespie SH, Boeree MJ, Simonsson USH.

Clin Pharmacol Ther. 2018 Apr;103(4):674-683. doi: 10.1002/cpt.778. Epub 2017 Aug 7.


Gender, alexithymia and physical inactivity associated with abdominal obesity in type 1 diabetes mellitus: a cross sectional study at a secondary care hospital diabetes clinic.

Melin EO, Svensson R, Thunander M, Hillman M, Thulesius HO, Landin-Olsson M.

BMC Obes. 2017 Jun 2;4:21. doi: 10.1186/s40608-017-0157-1. eCollection 2017.


Importance of N- and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration.

Skogh A, Lesniak A, Gaugaz FZ, Svensson R, Lindeberg G, Fransson R, Nyberg F, Hallberg M, Sandström A.

Eur J Pharm Sci. 2017 Aug 30;106:345-351. doi: 10.1016/j.ejps.2017.06.004. Epub 2017 Jun 3.


Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation.

Spahiu L, Ålander J, Ottosson-Wadlund A, Svensson R, Lehmer C, Armstrong RN, Morgenstern R.

Biochemistry. 2017 Jun 20;56(24):3089-3098. doi: 10.1021/acs.biochem.7b00285. Epub 2017 Jun 9.


Incidence, characteristics, and outcome of solitary plasmacytoma and plasma cell leukemia. Population-based data from the Swedish Myeloma Register.

Nahi H, Genell A, Wålinder G, Uttervall K, Juliusson G, Karin F, Hansson M, Svensson R, Linder O, Carlson K, Björkstrand B, Kristinsson SY, Mellqvist UH, Blimark C, Turesson I.

Eur J Haematol. 2017 Sep;99(3):216-222. doi: 10.1111/ejh.12907. Epub 2017 Jun 28.


Improved power for TB Phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods.

Svensson RJ, Gillespie SH, Simonsson USH.

J Antimicrob Chemother. 2017 Aug 1;72(8):2311-2319. doi: 10.1093/jac/dkx129.


Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KSA, Wallner OA, Hammarström LGJ, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Carreras Puigvert J, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jenmalm Jensen A, Artursson P, Nilsson JA, Stenmark P, Scobie M; Ulrika Warpman Berglund &Thomas Helleday.

Nature. 2017 Apr 26;544(7651):508. doi: 10.1038/nature22083. No abstract available.


An advanced glycation endproduct (AGE)-rich diet promotes accumulation of AGEs in Achilles tendon.

Skovgaard D, Svensson RB, Scheijen J, Eliasson P, Mogensen P, Hag AM, Kjær M, Schalkwijk CG, Schjerling P, Magnusson SP, Couppé C.

Physiol Rep. 2017 Mar;5(6). pii: e13215. doi: 10.14814/phy2.13215.


Simvastatin and atorvastatin reduce the mechanical properties of tendon constructs in vitro and introduce catabolic changes in the gene expression pattern.

Eliasson P, Svensson RB, Giannopoulos A, Eismark C, Kjær M, Schjerling P, Heinemeier KM.

PLoS One. 2017 Mar 6;12(3):e0172797. doi: 10.1371/journal.pone.0172797. eCollection 2017.


Skin autofluorescence is associated with arterial stiffness and insulin level in endurance runners and healthy controls - Effects of aging and endurance exercise.

Couppé C, Dall CH, Svensson RB, Olsen RH, Karlsen A, Praet S, Prescott E, Magnusson SP.

Exp Gerontol. 2017 May;91:9-14. doi: 10.1016/j.exger.2017.02.002. Epub 2017 Feb 9.


N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors.

Sunduru N, Svensson M, Cipriano M, Marwaha S, Andersson CD, Svensson R, Fowler CJ, Elofsson M.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):513-521. doi: 10.1080/14756366.2016.1265520.


Evidence of structurally continuous collagen fibrils in tendons.

Svensson RB, Herchenhan A, Starborg T, Larsen M, Kadler KE, Qvortrup K, Magnusson SP.

Acta Biomater. 2017 Mar 1;50:293-301. doi: 10.1016/j.actbio.2017.01.006. Epub 2017 Jan 5.

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