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Items: 1 to 50 of 111


Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.

Zatreanu D, Han Z, Mitter R, Tumini E, Williams H, Gregersen L, Dirac-Svejstrup AB, Roma S, Stewart A, Aguilera A, Svejstrup JQ.

Mol Cell. 2019 Oct 3;76(1):57-69.e9. doi: 10.1016/j.molcel.2019.07.037. Epub 2019 Sep 10.


A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.

Lim M, Newman JA, Williams HL, Masino L, Aitkenhead H, Gravard AE, Gileadi O, Svejstrup JQ.

Structure. 2019 Aug 6;27(8):1316-1325.e6. doi: 10.1016/j.str.2019.05.003. Epub 2019 Jun 13.


SCAF4 and SCAF8, mRNA Anti-Terminator Proteins.

Gregersen LH, Mitter R, Ugalde AP, Nojima T, Proudfoot NJ, Agami R, Stewart A, Svejstrup JQ.

Cell. 2019 Jun 13;177(7):1797-1813.e18. doi: 10.1016/j.cell.2019.04.038. Epub 2019 May 16.


Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes.

Cakiroglu A, Clapier CR, Ehrensberger AH, Darbo E, Cairns BR, Luscombe NM, Svejstrup JQ.

Genome Res. 2019 Jun;29(6):988-998. doi: 10.1101/gr.243139.118. Epub 2019 May 16.


Analysis of RNA polymerase II ubiquitylation and proteasomal degradation.

Tufegdzic Vidakovic A, Harreman M, Dirac-Svejstrup AB, Boeing S, Roy A, Encheva V, Neumann M, Wilson M, Snijders AP, Svejstrup JQ.

Methods. 2019 Apr 15;159-160:146-156. doi: 10.1016/j.ymeth.2019.02.005. Epub 2019 Feb 13.


The Cellular Response to Transcription-Blocking DNA Damage.

Gregersen LH, Svejstrup JQ.

Trends Biochem Sci. 2018 May;43(5):327-341. doi: 10.1016/j.tibs.2018.02.010. Review.


Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.

Weems JC, Slaughter BD, Unruh JR, Boeing S, Hall SM, McLaird MB, Yasukawa T, Aso T, Svejstrup JQ, Conaway JW, Conaway RC.

J Biol Chem. 2017 Apr 21;292(16):6431-6437. doi: 10.1074/jbc.C117.777946. Epub 2017 Mar 14.


UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.

Williamson L, Saponaro M, Boeing S, East P, Mitter R, Kantidakis T, Kelly GP, Lobley A, Walker J, Spencer-Dene B, Howell M, Stewart A, Svejstrup JQ.

Cell. 2017 Feb 23;168(5):843-855.e13. doi: 10.1016/j.cell.2017.01.019. Epub 2017 Feb 16.


Multiomic Analysis of the UV-Induced DNA Damage Response.

Boeing S, Williamson L, Encheva V, Gori I, Saunders RE, Instrell R, Aygün O, Rodriguez-Martinez M, Weems JC, Kelly GP, Conaway JW, Conaway RC, Stewart A, Howell M, Snijders AP, Svejstrup JQ.

Cell Rep. 2016 May 17;15(7):1597-1610. doi: 10.1016/j.celrep.2016.04.047. Epub 2016 May 12.


A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.

Ranes M, Boeing S, Wang Y, Wienholz F, Menoni H, Walker J, Encheva V, Chakravarty P, Mari PO, Stewart A, Giglia-Mari G, Snijders AP, Vermeulen W, Svejstrup JQ.

Nucleic Acids Res. 2016 Jun 20;44(11):5246-55. doi: 10.1093/nar/gkw216. Epub 2016 Apr 7.


Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation.

Wang Y, Jones-Tabah J, Chakravarty P, Stewart A, Muotri A, Laposa RR, Svejstrup JQ.

Cell Rep. 2016 Mar 22;14(11):2554-61. doi: 10.1016/j.celrep.2016.02.051. Epub 2016 Mar 10.


Mutation of cancer driver MLL2 results in transcription stress and genome instability.

Kantidakis T, Saponaro M, Mitter R, Horswell S, Kranz A, Boeing S, Aygün O, Kelly GP, Matthews N, Stewart A, Stewart AF, Svejstrup JQ.

Genes Dev. 2016 Feb 15;30(4):408-20. doi: 10.1101/gad.275453.115.


Correction: Retention of the Native Epigenome in Purified Mammalian Chromatin.

Ehrensberger AH, Franchini DM, East P, George R, Matthews N, Maslen SL, Svejstrup JQ.

PLoS One. 2015 Oct 16;10(10):e0141250. doi: 10.1371/journal.pone.0141250. eCollection 2015. No abstract available.


Retention of the Native Epigenome in Purified Mammalian Chromatin.

Ehrensberger AH, Franchini DM, East P, George R, Matthews N, Maslen SL, Svejstrup JQ.

PLoS One. 2015 Aug 6;10(8):e0133246. doi: 10.1371/journal.pone.0133246. eCollection 2015. Erratum in: PLoS One. 2015;10(10):e0141250.


Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.

Wang Y, Chakravarty P, Ranes M, Kelly G, Brooks PJ, Neilan E, Stewart A, Schiavo G, Svejstrup JQ.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14454-9. doi: 10.1073/pnas.1412569111. Epub 2014 Sep 23.


RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress.

Saponaro M, Kantidakis T, Mitter R, Kelly GP, Heron M, Williams H, Söding J, Stewart A, Svejstrup JQ.

Cell. 2014 May 22;157(5):1037-49. doi: 10.1016/j.cell.2014.03.048. Epub 2014 May 15.


Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress.

Wilson MD, Harreman M, Taschner M, Reid J, Walker J, Erdjument-Bromage H, Tempst P, Svejstrup JQ.

Cell. 2013 Aug 29;154(5):983-995. doi: 10.1016/j.cell.2013.07.028.


Mechanistic interpretation of promoter-proximal peaks and RNAPII density maps.

Ehrensberger AH, Kelly GP, Svejstrup JQ.

Cell. 2013 Aug 15;154(4):713-5. doi: 10.1016/j.cell.2013.07.032. No abstract available.


Synovial sarcoma mechanisms: a series of unfortunate events.

Svejstrup JQ.

Cell. 2013 Mar 28;153(1):11-2. doi: 10.1016/j.cell.2013.03.015.


RNA polymerase II transcript elongation.

Svejstrup JQ.

Biochim Biophys Acta. 2013 Jan;1829(1):1. doi: 10.1016/j.bbagrm.2012.12.008. No abstract available.


MultiDsk: a ubiquitin-specific affinity resin.

Wilson MD, Saponaro M, Leidl MA, Svejstrup JQ.

PLoS One. 2012;7(10):e46398. doi: 10.1371/journal.pone.0046398. Epub 2012 Oct 3.


RNA polymerase II collision interrupts convergent transcription.

Hobson DJ, Wei W, Steinmetz LM, Svejstrup JQ.

Mol Cell. 2012 Nov 9;48(3):365-74. doi: 10.1016/j.molcel.2012.08.027. Epub 2012 Oct 4.


Ubiquitylation and degradation of elongating RNA polymerase II: the last resort.

Wilson MD, Harreman M, Svejstrup JQ.

Biochim Biophys Acta. 2013 Jan;1829(1):151-7. doi: 10.1016/j.bbagrm.2012.08.002. Epub 2012 Aug 31. Review.


Reprogramming chromatin.

Ehrensberger AH, Svejstrup JQ.

Crit Rev Biochem Mol Biol. 2012 Sep;47(5):464-82. doi: 10.3109/10409238.2012.697125. Epub 2012 Jul 3. Review.


Transcription: another mark in the tail.

Svejstrup JQ.

EMBO J. 2012 Jun 13;31(12):2753-4. doi: 10.1038/emboj.2012.154. Epub 2012 May 22.


DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.

Close P, East P, Dirac-Svejstrup AB, Hartmann H, Heron M, Maslen S, Chariot A, Söding J, Skehel M, Svejstrup JQ.

Nature. 2012 Mar 25;484(7394):386-9. doi: 10.1038/nature10925.


Studying RNA-protein interactions in vivo by RNA immunoprecipitation.

Selth LA, Close P, Svejstrup JQ.

Methods Mol Biol. 2011;791:253-64. doi: 10.1007/978-1-61779-316-5_19.


GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein.

Staresincic L, Walker J, Dirac-Svejstrup AB, Mitter R, Svejstrup JQ.

J Biol Chem. 2011 Oct 14;286(41):35553-61. doi: 10.1074/jbc.M111.286161. Epub 2011 Aug 15.


Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity.

Walker J, Kwon SY, Badenhorst P, East P, McNeill H, Svejstrup JQ.

Genetics. 2011 Apr;187(4):1067-75. doi: 10.1534/genetics.110.123893. Epub 2011 Feb 1.


In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo.

Ertel F, Dirac-Svejstrup AB, Hertel CB, Blaschke D, Svejstrup JQ, Korber P.

Mol Cell Biol. 2010 Aug;30(16):4060-76. doi: 10.1128/MCB.01399-09. Epub 2010 Jun 21.


A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.

Anindya R, Mari PO, Kristensen U, Kool H, Giglia-Mari G, Mullenders LH, Fousteri M, Vermeulen W, Egly JM, Svejstrup JQ.

Mol Cell. 2010 Jun 11;38(5):637-48. doi: 10.1016/j.molcel.2010.04.017.


Evidence that transcript cleavage is essential for RNA polymerase II transcription and cell viability.

Sigurdsson S, Dirac-Svejstrup AB, Svejstrup JQ.

Mol Cell. 2010 Apr 23;38(2):202-10. doi: 10.1016/j.molcel.2010.02.026.


Transcript Elongation by RNA Polymerase II.

Selth LA, Sigurdsson S, Svejstrup JQ.

Annu Rev Biochem. 2010;79:271-93. doi: 10.1146/annurev.biochem.78.062807.091425. Review.


The interface between transcription and mechanisms maintaining genome integrity.

Svejstrup JQ.

Trends Biochem Sci. 2010 Jun;35(6):333-8. doi: 10.1016/j.tibs.2010.02.001. Epub 2010 Mar 1. Review.


RNA immunoprecipitation to determine RNA-protein associations in vivo.

Selth LA, Gilbert C, Svejstrup JQ.

Cold Spring Harb Protoc. 2009 Jun;2009(6):pdb.prot5234. doi: 10.1101/pdb.prot5234. No abstract available.


RECQL5 helicase: connections to DNA recombination and RNA polymerase II transcription.

Aygün O, Svejstrup JQ.

DNA Repair (Amst). 2010 Mar 2;9(3):345-53. doi: 10.1016/j.dnarep.2009.12.008. Epub 2010 Jan 18. Review.


Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.

Harreman M, Taschner M, Sigurdsson S, Anindya R, Reid J, Somesh B, Kong SE, Banks CA, Conaway RC, Conaway JW, Svejstrup JQ.

Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20705-10. doi: 10.1073/pnas.0907052106. Epub 2009 Nov 17.


A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae.

Taschner M, Harreman M, Teng Y, Gill H, Anindya R, Maslen SL, Skehel JM, Waters R, Svejstrup JQ.

Mol Cell Biol. 2010 Jan;30(2):436-46. doi: 10.1128/MCB.00822-09. Epub 2009 Nov 9.


Interacting partners of the Tfb2 subunit from yeast TFIIH.

Kainov DE, Selth LA, Svejstrup JQ, Egly JM, Poterzsman A.

DNA Repair (Amst). 2010 Jan 2;9(1):33-9. doi: 10.1016/j.dnarep.2009.10.002. Epub 2009 Nov 7.


Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.

Vispé S, DeVries L, Créancier L, Besse J, Bréand S, Hobson DJ, Svejstrup JQ, Annereau JP, Cussac D, Dumontet C, Guilbaud N, Barret JM, Bailly C.

Mol Cancer Ther. 2009 Oct;8(10):2780-90. doi: 10.1158/1535-7163.MCT-09-0549. Epub 2009 Oct 6.


Stability, flexibility, and dynamic interactions of colliding RNA polymerase II elongation complexes.

Saeki H, Svejstrup JQ.

Mol Cell. 2009 Jul 31;35(2):191-205. doi: 10.1016/j.molcel.2009.06.009.


Direct inhibition of RNA polymerase II transcription by RECQL5.

Aygün O, Xu X, Liu Y, Takahashi H, Kong SE, Conaway RC, Conaway JW, Svejstrup JQ.

J Biol Chem. 2009 Aug 28;284(35):23197-203. doi: 10.1074/jbc.M109.015750. Epub 2009 Jul 1.


An rtt109-independent role for vps75 in transcription-associated nucleosome dynamics.

Selth LA, Lorch Y, Ocampo-Hafalla MT, Mitter R, Shales M, Krogan NJ, Kornberg RD, Svejstrup JQ.

Mol Cell Biol. 2009 Aug;29(15):4220-34. doi: 10.1128/MCB.01882-08. Epub 2009 May 26.


An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.

Greenwood C, Selth LA, Dirac-Svejstrup AB, Svejstrup JQ.

J Biol Chem. 2009 Jan 2;284(1):141-9. doi: 10.1074/jbc.M805312200. Epub 2008 Nov 5.


Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3.

Kvint K, Uhler JP, Taschner MJ, Sigurdsson S, Erdjument-Bromage H, Tempst P, Svejstrup JQ.

Mol Cell. 2008 May 23;30(4):498-506. doi: 10.1016/j.molcel.2008.04.018.


RNA immunoprecipitation for determining RNA-protein associations in vivo.

Gilbert C, Svejstrup JQ.

Curr Protoc Mol Biol. 2006 Aug;Chapter 27:Unit 27.4. doi: 10.1002/0471142727.mb2704s75. Review.


A role for noncoding transcription in activation of the yeast PHO5 gene.

Uhler JP, Hertel C, Svejstrup JQ.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8011-6. Epub 2007 Apr 30.


Elongator complex: how many roles does it play?

Svejstrup JQ.

Curr Opin Cell Biol. 2007 Jun;19(3):331-6. Epub 2007 Apr 26. Review.


Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD.

Somesh BP, Sigurdsson S, Saeki H, Erdjument-Bromage H, Tempst P, Svejstrup JQ.

Cell. 2007 Apr 6;129(1):57-68.

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