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Items: 1 to 50 of 105

1.

Regulating PMP22 expression as a dosage sensitive neuropathy gene.

Pantera H, Shy ME, Svaren J.

Brain Res. 2019 Oct 3;1726:146491. doi: 10.1016/j.brainres.2019.146491. [Epub ahead of print] Review.

PMID:
31586623
2.

Corrigendum: Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.

Belin S, Ornaghi F, Shackleford G, Wang J, Scapin C, Lopez-Anido C, Silvestri N, Robertson N, Williamson C, Ishii A, Taveggia C, Svaren J, Bansal R, Schwab MH, Nave K, Fratta P, D'Antonio M, Poitelon Y, Feltri ML, Wrabetz L.

Hum Mol Genet. 2019 Jul 1;28(13):2282. doi: 10.1093/hmg/ddz037. No abstract available.

3.

Modifier Gene Candidates in Charcot-Marie-Tooth Disease Type 1A: A Case-Only Genome-Wide Association Study.

Tao F, Beecham GW, Rebelo AP, Blanton SH, Moran JJ, Lopez-Anido C, Svaren J, Abreu L, Rizzo D, Kirk CA, Wu X, Feely S, Verhamme C, Saporta MA, Herrmann DN, Day JW, Sumner CJ, Lloyd TE, Li J, Yum SW, Taroni F, Baas F, Choi BO, Pareyson D, Scherer SS, Reilly MM, Shy ME, Züchner S; Inherited Neuropathy Consortium.

J Neuromuscul Dis. 2019;6(2):201-211. doi: 10.3233/JND-190377.

4.

Schwann cell transcript biomarkers for hereditary neuropathy skin biopsies.

Svaren J, Moran JJ, Wu X, Zuccarino R, Bacon C, Bai Y, Ramesh R, Gutmann L, Anderson DM, Pavelec D, Shy ME.

Ann Neurol. 2019 Jun;85(6):887-898. doi: 10.1002/ana.25480. Epub 2019 Apr 22.

PMID:
30945774
5.

Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A.

Tao F, Beecham GW, Rebelo AP, Svaren J, Blanton SH, Moran JJ, Lopez-Anido C, Morrow JM, Abreu L, Rizzo D, Kirk CA, Wu X, Feely S, Verhamme C, Saporta MA, Herrmann DN, Day JW, Sumner CJ, Lloyd TE, Li J, Yum SW, Taroni F, Baas F, Choi BO, Pareyson D, Scherer SS, Reilly MM, Shy ME, Züchner S; Inherited Neuropathy Consortium.

Ann Neurol. 2019 Mar;85(3):316-330. doi: 10.1002/ana.25426.

PMID:
30706531
6.

Corrigendum: Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.

Belin S, Ornaghi F, Shackleford G, Wang J, Scapin C, Lopez-Anido C, Silvestri N, Robertson N, Williamson C, Ishii A, Taveggia C, Svaren J, Bansal R, Schwab MH, Nave K, Fratta P, D'Antonio M, Poitelon Y, Feltri ML, Wrabetz L.

Hum Mol Genet. 2019 May 15;28(10):1752. doi: 10.1093/hmg/ddz021. No abstract available.

7.

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.

Belin S, Ornaghi F, Shackleford G, Wang J, Scapin C, Lopez-Anido C, Silvestri N, Robertson N, Williamson C, Ishii A, Taveggia C, Svaren J, Bansal R, Schwab MH, Nave K, Fratta P, D'Antonio M, Poitelon Y, Feltri ML, Wrabetz L.

Hum Mol Genet. 2019 Apr 15;28(8):1260-1273. doi: 10.1093/hmg/ddy420. Erratum in: Hum Mol Genet. 2019 May 15;28(10):1752. Hum Mol Genet. 2019 Jul 1;28(13):2282.

PMID:
30535360
8.

Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury.

Ma KH, Duong P, Moran JJ, Junaidi N, Svaren J.

Glia. 2018 Nov;66(11):2487-2502. doi: 10.1002/glia.23500. Epub 2018 Oct 11.

PMID:
30306639
9.

Regulation of the neuropathy-associated Pmp22 gene by a distal super-enhancer.

Pantera H, Moran JJ, Hung HA, Pak E, Dutra A, Svaren J.

Hum Mol Genet. 2018 Aug 15;27(16):2830-2839. doi: 10.1093/hmg/ddy191.

10.

Myelin protein zero mutations and the unfolded protein response in Charcot Marie Tooth disease type 1B.

Bai Y, Wu X, Brennan KM, Wang DS, D'Antonio M, Moran J, Svaren J, Shy ME.

Ann Clin Transl Neurol. 2018 Mar 10;5(4):445-455. doi: 10.1002/acn3.543. eCollection 2018 Apr.

11.

Genome-Edited Cell Lines for High-Throughput Screening.

Dranchak P, Moran JJ, MacArthur R, Lopez-Anido C, Inglese J, Svaren J.

Methods Mol Biol. 2018;1755:1-17. doi: 10.1007/978-1-4939-7724-6_1.

12.

Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination.

Lin HP, Oksuz I, Svaren J, Awatramani R.

Sci Rep. 2018 Feb 28;8(1):3817. doi: 10.1038/s41598-018-22010-8.

13.

Cell transplantation strategies for acquired and inherited disorders of peripheral myelin.

Muhammad AKMG, Kim K, Epifantseva I, Aghamaleky-Sarvestany A, Simpkinson ME, Carmona S, Landeros J, Bell S, Svaren J, Baloh RH.

Ann Clin Transl Neurol. 2018 Jan 22;5(2):186-200. doi: 10.1002/acn3.517. eCollection 2018 Feb.

14.

Epigenetic Control of Schwann Cells.

Ma KH, Svaren J.

Neuroscientist. 2018 Dec;24(6):627-638. doi: 10.1177/1073858417751112. Epub 2018 Jan 7. Review.

PMID:
29307265
15.

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models.

Zhao HT, Damle S, Ikeda-Lee K, Kuntz S, Li J, Mohan A, Kim A, Hung G, Scheideler MA, Scherer SS, Svaren J, Swayze EE, Kordasiewicz HB.

J Clin Invest. 2018 Jan 2;128(1):359-368. doi: 10.1172/JCI96499. Epub 2017 Dec 4.

16.

A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination.

Duncan ID, Bugiani M, Radcliff AB, Moran JJ, Lopez-Anido C, Duong P, August BK, Wolf NI, van der Knaap MS, Svaren J.

Ann Neurol. 2017 May;81(5):690-702. doi: 10.1002/ana.24930. Epub 2017 May 9.

17.

Epigenomic reprogramming in peripheral nerve injury.

Ma KH, Svaren J.

Neural Regen Res. 2016 Dec;11(12):1930-1931. doi: 10.4103/1673-5374.197133. No abstract available.

18.

Dual specificity phosphatase 15 regulates Erk activation in Schwann cells.

Rodríguez-Molina JF, Lopez-Anido C, Ma KH, Zhang C, Olson T, Muth KN, Weider M, Svaren J.

J Neurochem. 2017 Feb;140(3):368-382. doi: 10.1111/jnc.13911. Epub 2017 Jan 9.

19.

Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation.

Gopinath C, Law WD, Rodríguez-Molina JF, Prasad AB, Song L, Crawford GE, Mullikin JC, Svaren J, Antonellis A.

BMC Genomics. 2016 Nov 7;17(1):887.

20.

SOX10 regulates an alternative promoter at the Charcot-Marie-Tooth disease locus MTMR2.

Fogarty EA, Brewer MH, Rodriguez-Molina JF, Law WD, Ma KH, Steinberg NM, Svaren J, Antonellis A.

Hum Mol Genet. 2016 Sep 15;25(18):3925-3936. doi: 10.1093/hmg/ddw233. Epub 2016 Jul 27.

21.

Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury.

Ma KH, Hung HA, Svaren J.

J Neurosci. 2016 Aug 31;36(35):9135-47. doi: 10.1523/JNEUROSCI.1370-16.2016.

22.

Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development.

Lopez-Anido C, Poitelon Y, Gopinath C, Moran JJ, Ma KH, Law WD, Antonellis A, Feltri ML, Svaren J.

Hum Mol Genet. 2016 Jul 15;25(14):3055-3069. Epub 2016 Jun 10.

23.

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.

Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, Wrana JL, Asmani M, Zhao R, Sim FJ, Wrabetz L, Svaren J, Feltri ML.

Nat Neurosci. 2016 Jul;19(7):879-87. doi: 10.1038/nn.4316. Epub 2016 Jun 6.

24.

Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2.

Ma KH, Hung HA, Srinivasan R, Xie H, Orkin SH, Svaren J.

J Neurosci. 2015 Jun 3;35(22):8640-52. doi: 10.1523/JNEUROSCI.2257-14.2015.

25.

Differential Sox10 genomic occupancy in myelinating glia.

Lopez-Anido C, Sun G, Koenning M, Srinivasan R, Hung HA, Emery B, Keles S, Svaren J.

Glia. 2015 Nov;63(11):1897-1914. doi: 10.1002/glia.22855. Epub 2015 May 14.

26.

Dynamic regulation of Schwann cell enhancers after peripheral nerve injury.

Hung HA, Sun G, Keles S, Svaren J.

J Biol Chem. 2015 Mar 13;290(11):6937-50. doi: 10.1074/jbc.M114.622878. Epub 2015 Jan 22.

27.

In silico pooling of ChIP-seq control experiments.

Sun G, Srinivasan R, Lopez-Anido C, Hung HA, Svaren J, Keleş S.

PLoS One. 2014 Nov 7;9(11):e109691. doi: 10.1371/journal.pone.0109691. eCollection 2014.

28.

Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease.

Inglese J, Dranchak P, Moran JJ, Jang SW, Srinivasan R, Santiago Y, Zhang L, Guha R, Martinez N, MacArthur R, Cost GJ, Svaren J.

ACS Chem Biol. 2014 Nov 21;9(11):2594-602. doi: 10.1021/cb5005492. Epub 2014 Sep 16.

29.

Associations between early life stress and gene methylation in children.

Romens SE, McDonald J, Svaren J, Pollak SD.

Child Dev. 2015 Jan-Feb;86(1):303-9. doi: 10.1111/cdev.12270. Epub 2014 Jul 24.

30.

MicroRNA and transcriptional crosstalk in myelinating glia.

Svaren J.

Neurochem Int. 2014 Nov;77:50-7. doi: 10.1016/j.neuint.2014.06.010. Epub 2014 Jun 27. Review.

31.

Haplotype-specific modulation of a SOX10/CREB response element at the Charcot-Marie-Tooth disease type 4C locus SH3TC2.

Brewer MH, Ma KH, Beecham GW, Gopinath C, Baas F, Choi BO, Reilly MM, Shy ME, Züchner S, Svaren J, Antonellis A.

Hum Mol Genet. 2014 Oct 1;23(19):5171-87. doi: 10.1093/hmg/ddu240. Epub 2014 May 15.

32.

A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation.

Yang B, Wagner J, Damaschke N, Yao T, Wuerzberger-Davis SM, Lee MH, Svaren J, Miyamoto S, Jarrard DF.

PLoS One. 2014 Feb 18;9(2):e88052. doi: 10.1371/journal.pone.0088052. eCollection 2014.

33.

Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice.

Kim EH, Gasper DJ, Lee SH, Plisch EH, Svaren J, Suresh M.

J Immunol. 2014 Feb 1;192(3):985-95. doi: 10.4049/jimmunol.1302378. Epub 2013 Dec 23.

34.

A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination.

Pemberton TJ, Choi S, Mayer JA, Li FY, Gokey N, Svaren J, Safra N, Bannasch DL, Sullivan K, Breuhaus B, Patel PI, Duncan ID.

Glia. 2014 Jan;62(1):39-51. doi: 10.1002/glia.22582.

35.

Epigenetic susceptibility factors for prostate cancer with aging.

Damaschke NA, Yang B, Bhusari S, Svaren JP, Jarrard DF.

Prostate. 2013 Dec;73(16):1721-30. doi: 10.1002/pros.22716. Epub 2013 Sep 2. Review.

36.

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes.

Bujalka H, Koenning M, Jackson S, Perreau VM, Pope B, Hay CM, Mitew S, Hill AF, Lu QR, Wegner M, Srinivasan R, Svaren J, Willingham M, Barres BA, Emery B.

PLoS Biol. 2013;11(8):e1001625. doi: 10.1371/journal.pbio.1001625. Epub 2013 Aug 13.

37.

Multivalent recognition of histone tails by the PHD fingers of CHD5.

Oliver SS, Musselman CA, Srinivasan R, Svaren JP, Kutateladze TG, Denu JM.

Biochemistry. 2012 Aug 21;51(33):6534-44. doi: 10.1021/bi3006972. Epub 2012 Aug 8.

38.

Identification of drug modulators targeting gene-dosage disease CMT1A.

Jang SW, Lopez-Anido C, MacArthur R, Svaren J, Inglese J.

ACS Chem Biol. 2012 Jul 20;7(7):1205-13. doi: 10.1021/cb300048d. Epub 2012 May 2.

39.

Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve.

Srinivasan R, Sun G, Keles S, Jones EA, Jang SW, Krueger C, Moran JJ, Svaren J.

Nucleic Acids Res. 2012 Aug;40(14):6449-60. doi: 10.1093/nar/gks313. Epub 2012 Apr 9.

40.

The nucleosome remodeling and deacetylase chromatin remodeling (NuRD) complex is required for peripheral nerve myelination.

Hung H, Kohnken R, Svaren J.

J Neurosci. 2012 Feb 1;32(5):1517-27. doi: 10.1523/JNEUROSCI.2895-11.2012.

41.

Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22.

Jones EA, Brewer MH, Srinivasan R, Krueger C, Sun G, Charney KN, Keles S, Antonellis A, Svaren J.

Hum Mol Genet. 2012 Apr 1;21(7):1581-91. doi: 10.1093/hmg/ddr595. Epub 2011 Dec 15.

42.

Developmental regulation of microRNA expression in Schwann cells.

Gokey NG, Srinivasan R, Lopez-Anido C, Krueger C, Svaren J.

Mol Cell Biol. 2012 Jan;32(2):558-68. doi: 10.1128/MCB.06270-11. Epub 2011 Nov 7.

43.

SOX10 regulates expression of the SH3-domain kinase binding protein 1 (Sh3kbp1) locus in Schwann cells via an alternative promoter.

Hodonsky CJ, Kleinbrink EL, Charney KN, Prasad M, Bessling SL, Jones EA, Srinivasan R, Svaren J, McCallion AS, Antonellis A.

Mol Cell Neurosci. 2012 Feb;49(2):85-96. doi: 10.1016/j.mcn.2011.10.004. Epub 2011 Oct 19.

44.

Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression.

Gokey NG, Lopez-Anido C, Gillian-Daniel AL, Svaren J.

J Biol Chem. 2011 Aug 26;286(34):29501-10. doi: 10.1074/jbc.M111.263509. Epub 2011 Jun 28.

45.

SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer.

Prasad MK, Reed X, Gorkin DU, Cronin JC, McAdow AR, Chain K, Hodonsky CJ, Jones EA, Svaren J, Antonellis A, Johnson SL, Loftus SK, Pavan WJ, McCallion AS.

BMC Dev Biol. 2011 Jun 14;11:40. doi: 10.1186/1471-213X-11-40.

46.

Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding.

Jagalur NB, Ghazvini M, Mandemakers W, Driegen S, Maas A, Jones EA, Jaegle M, Grosveld F, Svaren J, Meijer D.

J Neurosci. 2011 Jun 8;31(23):8585-94. doi: 10.1523/JNEUROSCI.0659-11.2011.

47.

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination.

Chen Y, Wang H, Yoon SO, Xu X, Hottiger MO, Svaren J, Nave KA, Kim HA, Olson EN, Lu QR.

Nat Neurosci. 2011 Apr;14(4):437-41. doi: 10.1038/nn.2780. Epub 2011 Mar 20.

48.

Regulation of the PMP22 gene through an intronic enhancer.

Jones EA, Lopez-Anido C, Srinivasan R, Krueger C, Chang LW, Nagarajan R, Svaren J.

J Neurosci. 2011 Mar 16;31(11):4242-50. doi: 10.1523/JNEUROSCI.5893-10.2011.

49.

Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination.

He Y, Kim JY, Dupree J, Tewari A, Melendez-Vasquez C, Svaren J, Casaccia P.

Nat Neurosci. 2010 Dec;13(12):1472-80. doi: 10.1038/nn.2686. Epub 2010 Nov 7.

50.

Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes.

Jang SW, Srinivasan R, Jones EA, Sun G, Keles S, Krueger C, Chang LW, Nagarajan R, Svaren J.

J Neurochem. 2010 Dec;115(6):1409-20. doi: 10.1111/j.1471-4159.2010.07045.x. Epub 2010 Nov 4.

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