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Evaluation of a biomarker for the diagnosis of pancreas cancer using an animal model.

Fukamachi K, Hagiwara Y, Futakuchi M, Alexander DB, Tsuda H, Suzui M.

J Toxicol Pathol. 2019 Jul;32(3):135-141. doi: 10.1293/tox.2018-0062. Epub 2019 Apr 4.


Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes.

Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H.

Chem Res Toxicol. 2018 Oct 15;31(10):1025-1031. doi: 10.1021/acs.chemrestox.8b00067. Epub 2018 Sep 13.


Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.

Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M.

Int J Mol Sci. 2018 Mar 16;19(3). pii: E888. doi: 10.3390/ijms19030888.


Lethal chronotoxicity induced by seven metal compounds in mice.

Yoshioka H, Nonogaki T, Shinohara Y, Suzui M, Mori Y, Hwang GW, Ohtani K, Miura N.

J Toxicol Sci. 2018;43(2):129-134. doi: 10.2131/jts.43.129.


Bioengineered silkworms with butterfly cytotoxin-modified silk glands produce sericin cocoons with a utility for a new biomaterial.

Otsuki R, Yamamoto M, Matsumoto E, Iwamoto SI, Sezutsu H, Suzui M, Takaki K, Wakabayashi K, Mori H, Kotani E.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6740-6745. doi: 10.1073/pnas.1703449114. Epub 2017 Jun 12.


Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors.

Suzui M, Futakuchi M, Fukamachi K, Numano T, Abdelgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Alexander WT, Jiegou X, Tsuda H.

Cancer Sci. 2016 Jul;107(7):924-35. doi: 10.1111/cas.12954. Epub 2016 Jun 23.


Heterogeneity of tumor cells in the bone microenvironment: Mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer.

Futakuchi M, Fukamachi K, Suzui M.

Adv Drug Deliv Rev. 2016 Apr 1;99(Pt B):206-211. doi: 10.1016/j.addr.2015.11.017. Epub 2015 Dec 4. Review.


C5a inhibitor protects against ischemia/reperfusion injury in rat small intestine.

Tuboly E, Futakuchi M, Varga G, Érces D, Tőkés T, Mészáros A, Kaszaki J, Suzui M, Imai M, Okada A, Okada N, Boros M, Okada H.

Microbiol Immunol. 2016 Jan;60(1):35-46. doi: 10.1111/1348-0421.12338.


In vivo18F-fluorodeoxyglucose-positron emission tomography/computed tomography imaging of pancreatic tumors in a transgenic rat model carrying the human KRASG12V oncogene.

Shibata K, Fukamachi K, Tsuji A, Saga T, Futakuchi M, Nagino M, Tsuda H, Suzui M.

Oncol Lett. 2015 May;9(5):2112-2118. Epub 2015 Mar 18.


Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study.

Xu J, Alexander DB, Iigo M, Hamano H, Takahashi S, Yokoyama T, Kato M, Usami I, Tokuyama T, Tsutsumi M, Tamura M, Oguri T, Niimi A, Hayashi Y, Yokoyama Y, Tonegawa K, Fukamachi K, Futakuchi M, Sakai Y, Suzui M, Kamijima M, Hisanaga N, Omori T, Nakae D, Hirose A, Kanno J, Tsuda H.

Cancer Sci. 2015 Jul;106(7):825-32. doi: 10.1111/cas.12687. Epub 2015 Jun 5.


Rat N-ERC/mesothelin as a marker for in vivo screening of drugs against pancreas cancer.

Fukamachi K, Iigo M, Hagiwara Y, Shibata K, Futakuchi M, Alexander DB, Hino O, Suzui M, Tsuda H.

PLoS One. 2014 Oct 27;9(10):e111481. doi: 10.1371/journal.pone.0111481. eCollection 2014.


A novel transgenic mouse model carrying human Tribbles related protein 3 (TRB3) gene and its site specific phenotype.

Sakai Y, Fukamachi K, Futakuchi M, Miyoshi I, Tsuda H, Suzui M, Hayashi H.

Biol Pharm Bull. 2014;37(6):1068-74.


Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine.

Iigo M, Alexander DB, Xu J, Futakuchi M, Suzui M, Kozu T, Akasu T, Saito D, Kakizoe T, Yamauchi K, Abe F, Takase M, Sekine K, Tsuda H.

Biometals. 2014 Oct;27(5):1017-29. doi: 10.1007/s10534-014-9747-2. Epub 2014 May 28.


Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes.

Xu J, Alexander DB, Futakuchi M, Numano T, Fukamachi K, Suzui M, Omori T, Kanno J, Hirose A, Tsuda H.

Cancer Sci. 2014 Jul;105(7):763-9. doi: 10.1111/cas.12437. Epub 2014 Jul 1.


Comparative study of toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro.

Numano T, Xu J, Futakuchi M, Fukamachi K, Alexander DB, Furukawa F, Kanno J, Hirose A, Tsuda H, Suzui M.

Asian Pac J Cancer Prev. 2014;15(2):929-35.


Colon preneoplastic lesions in animal models.

Suzui M, Morioka T, Yoshimi N.

J Toxicol Pathol. 2013 Dec;26(4):335-41. doi: 10.1293/tox.2013-0028. Epub 2013 Dec 26. Review.


Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles.

Xu J, Futakuchi M, Alexander DB, Fukamachi K, Numano T, Suzui M, Shimizu H, Omori T, Kanno J, Hirose A, Tsuda H.

Arch Toxicol. 2014 Jan;88(1):65-75. doi: 10.1007/s00204-013-1086-5. Epub 2013 Jul 6.


Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer.

Yabushita S, Fukamachi K, Kikuchi F, Ozaki M, Miyata K, Sukata T, Deguchi Y, Tanaka H, Kakehashi A, Kawamura S, Uwagawa S, Wanibuchi H, Suzui M, Alexander DB, Tsuda H.

Pancreas. 2013 Aug;42(6):1034-9. doi: 10.1097/MPA.0b013e3182883624.


Promotive effects of cell proliferation and chromosomal instability induced by tribbles-related protein 3 in mouse mammary tumor cells.

Sakai Y, Fukamachi K, Futakuchi M, Hayashi H, Suzui M.

Oncol Rep. 2013 Jul;30(1):64-70. doi: 10.3892/or.2013.2441. Epub 2013 Apr 30.


Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.

Yabushita S, Fukamachi K, Tanaka H, Fukuda T, Sumida K, Deguchi Y, Mikata K, Nishioka K, Kawamura S, Uwagawa S, Suzui M, Alexander DB, Tsuda H.

Carcinogenesis. 2013 Jun;34(6):1251-9. doi: 10.1093/carcin/bgt053. Epub 2013 Feb 7.


A novel reporter rat strain that expresses LacZ upon Cre-mediated recombination.

Fukamachi K, Tanaka H, Sakai Y, Alexander DB, Futakuchi M, Tsuda H, Suzui M.

Genesis. 2013 Apr;51(4):268-74. doi: 10.1002/dvg.22371. Epub 2013 Feb 25.


Somatic evolution of head and neck cancer - biological robustness and latent vulnerability.

Masuda M, Toh S, Wakasaki T, Suzui M, Joe AK.

Mol Oncol. 2013 Feb;7(1):14-28. doi: 10.1016/j.molonc.2012.10.009. Epub 2012 Nov 2. Review.


Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats.

Xu J, Futakuchi M, Shimizu H, Alexander DB, Yanagihara K, Fukamachi K, Suzui M, Kanno J, Hirose A, Ogata A, Sakamoto Y, Nakae D, Omori T, Tsuda H.

Cancer Sci. 2012 Dec;103(12):2045-50. doi: 10.1111/cas.12005. Epub 2012 Oct 10.


Lactoferrin: an alternative view of its role in human biological fluids.

Alexander DB, Iigo M, Yamauchi K, Suzui M, Tsuda H.

Biochem Cell Biol. 2012 Jun;90(3):279-306. doi: 10.1139/o2012-013. Epub 2012 May 3. Review.


Circulating microRNAs in serum of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.

Yabushita S, Fukamachi K, Tanaka H, Sumida K, Deguchi Y, Sukata T, Kawamura S, Uwagawa S, Suzui M, Tsuda H.

Pancreas. 2012 Oct;41(7):1013-8. doi: 10.1097/MPA.0b013e31824ac3a5.


Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice.

Sagawa Y, Futakuchi M, Xu J, Fukamachi K, Sakai Y, Ikarashi Y, Nishimura T, Suzui M, Tsuda H, Morita A.

J Toxicol Sci. 2012;37(2):317-27.


Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats.

Xu J, Sagawa Y, Futakuchi M, Fukamachi K, Alexander DB, Furukawa F, Ikarashi Y, Uchino T, Nishimura T, Morita A, Suzui M, Tsuda H.

Food Chem Toxicol. 2011 Jun;49(6):1298-302. doi: 10.1016/j.fct.2011.03.011. Epub 2011 Mar 23.


Stat3 orchestrates tumor development and progression: the Achilles' heel of head and neck cancers?

Masuda M, Wakasaki T, Suzui M, Toh S, Joe AK, Weinstein IB.

Curr Cancer Drug Targets. 2010 Feb;10(1):117-26. Review.


Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide.

Naoi K, Sunagawa N, Yoshida I, Morioka T, Nakashima M, Ishihara M, Fukamachi K, Itoh Y, Tsuda H, Yoshimi N, Suzui M.

Oncol Rep. 2010 Feb;23(2):337-44.


Pharmaceutical interventions facilitate premedication and prevent opioid-induced constipation and emesis in cancer patients.

Ishihara M, Iihara H, Okayasu S, Yasuda K, Matsuura K, Suzui M, Itoh Y.

Support Care Cancer. 2010 Dec;18(12):1531-8. doi: 10.1007/s00520-009-0775-3. Epub 2009 Nov 18.


Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells.

Tatsuda Y, Iguchi K, Usui S, Suzui M, Hirano K.

Eur J Pharmacol. 2010 Feb 10;627(1-3):348-53. doi: 10.1016/j.ejphar.2009.10.067. Epub 2009 Nov 10.


Long term effects of high fat and sucrose diets on obesity and lymphocyte proliferation in mice.

Sato Mito N, Suzui M, Yoshino H, Kaburagi T, Sato K.

J Nutr Health Aging. 2009 Aug;13(7):602-6.


Growth inhibitory activity of ethanol extracts of Chinese and Brazilian propolis in four human colon carcinoma cell lines.

Ishihara M, Naoi K, Hashita M, Itoh Y, Suzui M.

Oncol Rep. 2009 Aug;22(2):349-54.


[Effort to improve advanced problem-based learning tutorial].

Adachi T, Suzui M, Naoi K, Kamiya T, Hara H.

Yakugaku Zasshi. 2009 Jan;129(1):177-82. Japanese.


Inhibitory effect of rice bran-derived crude glycosphingolipid on colon preneoplastic biomarker lesions induced by azoxymethane in male F344 rats.

Sunagawa N, Inamine M, Morioka T, Chiba I, Morita N, Aoki Y, Suzui M, Yoshimi N.

Mol Med Rep. 2009 Jan-Feb;2(1):45-9. doi: 10.3892/mmr_00000060.


Antioxidative and modifying effects of a tropical plant Azadirachta indica (Neem) on azoxymethane-induced preneoplastic lesions in the rat colon.

Arakaki J, Suzui M, Morioka T, Kinjo T, Kaneshiro T, Inamine M, Sunagawa N, Nishimaki T, Yoshimi N.

Asian Pac J Cancer Prev. 2006 Jul-Sep;7(3):467-71.


Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation.

Kaneshiro T, Morioka T, Inamine M, Kinjo T, Arakaki J, Chiba I, Sunagawa N, Suzui M, Yoshimi N.

Eur J Pharmacol. 2006 Dec 28;553(1-3):46-53. Epub 2006 Sep 23.


Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors.

Kinjo T, Suzui M, Morioka T, Inamine M, Kaneshiro T, Arakaki J, Chiba I, Sunagawa N, Nishimaki T, Yoshimi N.

Anticancer Res. 2006 Jul-Aug;26(4B):2829-32.


Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.

Kinjo T, Suzui M, Morioka T, Nabandith V, Inamine M, Kaneshiro T, Arakaki J, Nishimaki T, Yoshimi N.

J Exp Clin Cancer Res. 2006 Mar;25(1):89-95.


Sulindac sulfide and exisulind inhibit expression of the estrogen and progesterone receptors in human breast cancer cells.

Lim JT, Joe AK, Suzui M, Shimizu M, Masuda M, Weinstein IB.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3478-84.


Growth inhibitory activities of crude extracts obtained from herbal plants in the Ryukyu Islands on several human colon carcinoma cell lines.

Kaneshiro T, Suzui M, Takamatsu R, Murakami A, Ohigashi H, Fujino T, Yoshimi N.

Asian Pac J Cancer Prev. 2005 Jul-Sep;6(3):353-8.


An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies.

Suzuki R, Kohno H, Suzui M, Yoshimi N, Tsuda H, Wakabayashi K, Tanaka T.

Carcinogenesis. 2006 Mar;27(3):619-30. Epub 2005 Oct 11.


Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis.

Suzui M, Inamine M, Kaneshiro T, Morioka T, Yoshimi N, Suzuki R, Kohno H, Tanaka T.

Int J Oncol. 2005 Nov;27(5):1391-9.


Modifying effects of Terminalia catappa on azoxymethane-induced colon carcinogenesis in male F344 rats.

Morioka T, Suzui M, Nabandith V, Inamine M, Aniya Y, Nakayama T, Ichiba T, Yoshimi N.

Eur J Cancer Prev. 2005 Apr;14(2):101-5.


Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat.

Nabandith V, Suzui M, Morioka T, Kaneshiro T, Kinjo T, Matsumoto K, Akao Y, Iinuma M, Yoshimi N.

Asian Pac J Cancer Prev. 2004 Oct-Dec;5(4):433-8.


Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride.

Yoshimi N, Morioka T, Kinjo T, Inamine M, Kaneshiro T, Shimizu T, Suzui M, Yamada Y, Mori H.

Cancer Sci. 2004 Oct;95(10):792-7.


Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells.

Shimizu M, Suzui M, Deguchi A, Lim JT, Xiao D, Hayes JH, Papadopoulos KP, Weinstein IB.

Clin Cancer Res. 2004 Oct 1;10(19):6710-21.


The modifying effect of Peucedanum japonicum, a herb in the Ryukyu Islands, on azoxymethane-induced colon preneoplastic lesions in male F344 rats.

Morioka T, Suzui M, Nabandith V, Inamine M, Aniya Y, Nakayama T, Ichiba T, Mori H, Yoshimi N.

Cancer Lett. 2004 Mar 18;205(2):133-41.


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