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Items: 1 to 50 of 53

1.

Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats.

Ouach A, Vercouillie J, Bertrand E, Rodrigues N, Pin F, Serriere S, Boiaryna L, Chartier A, Percina N, Tangpong P, Gulhan Z, Mothes C, Deloye JB, Guilloteau D, Page G, Suzenet F, Buron F, Chalon S, Routier S.

Eur J Med Chem. 2019 Oct 1;179:449-469. doi: 10.1016/j.ejmech.2019.06.049. Epub 2019 Jun 27.

PMID:
31271958
2.

An original class of small sized molecules as versatile fluorescent probes for cellular imaging.

Sirbu D, Diharce J, Martinić I, Chopin N, Eliseeva SV, Guillaumet G, Petoud S, Bonnet P, Suzenet F.

Chem Commun (Camb). 2019 Jul 2;55(54):7776-7779. doi: 10.1039/c9cc03765a.

PMID:
31210218
3.

Organocatalytic aza-Michael Reaction to 3-Vinyl-1,2,4-triazines as a Valuable Bifunctional Platform.

Buttard F, Berthonneau C, Hiebel MA, Brière JF, Suzenet F.

J Org Chem. 2019 Mar 15;84(6):3702-3714. doi: 10.1021/acs.joc.9b00141. Epub 2019 Mar 1.

PMID:
30791682
4.

Palladium-Catalyzed C3-Arylations of 1 H- and 2 H-Pyrazolo[4,3- b]pyridines on Water.

Faarasse S, El Kazzouli S, Suzenet F, Guillaumet G.

J Org Chem. 2018 Oct 19;83(20):12847-12854. doi: 10.1021/acs.joc.8b01728. Epub 2018 Oct 4.

PMID:
30240222
5.

Access to 1H-indazoles, 1H-benzoindazoles and 1H-azaindazoles from (het)aryl azides: a one-pot Staudinger-aza-Wittig reaction leading to N-N bond formation?

Alaime T, Daniel M, Hiebel MA, Pasquinet E, Suzenet F, Guillaumet G.

Chem Commun (Camb). 2018 Jul 24;54(60):8411-8414. doi: 10.1039/c8cc03612h.

PMID:
29999074
6.

A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism.

Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02510-17. doi: 10.1128/AAC.02510-17. Print 2018 Jun.

7.

Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H2O2-induced oxidative stress.

Loubidi M, Jouha J, Tber Z, Khouili M, Suzenet F, Akssira M, Erdogan MA, Köse FA, Dagcı T, Armagan G, Saso L, Guillaumet G.

Eur J Med Chem. 2018 Feb 10;145:113-123. doi: 10.1016/j.ejmech.2017.12.081. Epub 2017 Dec 27.

PMID:
29324335
8.

"On Water" Direct C-3 Arylation of 2H-Pyrazolo[3,4-b]pyridines.

Faarasse S, El Kazzouli S, Naas M, Jouha J, Suzenet F, Guillaumet G.

J Org Chem. 2017 Dec 1;82(23):12300-12306. doi: 10.1021/acs.joc.7b02136. Epub 2017 Nov 13.

PMID:
29090922
9.

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5.

10.

Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines.

Jouha J, Buttard F, Lorion M, Berthonneau C, Khouili M, Hiebel MA, Guillaumet G, Brière JF, Suzenet F.

Org Lett. 2017 Sep 15;19(18):4770-4773. doi: 10.1021/acs.orglett.7b02132. Epub 2017 Aug 31.

PMID:
28857570
11.

Design and validation of the first cell-impermeant melatonin receptor agonist.

Gbahou F, Cecon E, Viault G, Gerbier R, Jean-Alphonse F, Karamitri A, Guillaumet G, Delagrange P, Friedlander RM, Vilardaga JP, Suzenet F, Jockers R.

Br J Pharmacol. 2017 Jul;174(14):2409-2421. doi: 10.1111/bph.13856. Epub 2017 Jun 11.

12.

Synthesis of new heterocyclic compounds based on pyrazolopyridine scaffold and evaluation of their neuroprotective potential in MPP+-induced neurodegeneration.

Jouha J, Loubidi M, Bouali J, Hamri S, Hafid A, Suzenet F, Guillaumet G, Dagcı T, Khouili M, Aydın F, Saso L, Armagan G.

Eur J Med Chem. 2017 Mar 31;129:41-52. doi: 10.1016/j.ejmech.2017.02.019. Epub 2017 Feb 11.

PMID:
28214632
13.

Nitroimidazole derivatives of polypyridyl ruthenium complexes: Towards understanding their anticancer activity and mode of action.

Mazuryk O, Krysiak-Foria O, Żak A, Suzenet F, Ptak-Belowska A, Brzozowski T, Stochel G, Brindell M.

Eur J Pharm Sci. 2017 Apr 1;101:43-55. doi: 10.1016/j.ejps.2017.01.020. Epub 2017 Jan 28.

PMID:
28137470
14.

30ièmes Journées Franco-Belges de Pharmacochimie.

Aci-Sèche S, Buron F, Plé K, Robin L, Suzenet F, Routier S.

Pharmaceuticals (Basel). 2016 Nov 18;9(4). pii: E73.

15.

Synthesis of 2-arylfuro[3,2-b]pyridines: Effect of the C2-aryl group on melatoninergic activity.

Couhert A, Delagrange P, Caignard DH, Chartier A, Suzenet F, Guillaumet G.

Eur J Med Chem. 2016 Feb 15;109:268-75. doi: 10.1016/j.ejmech.2016.01.008. Epub 2016 Jan 12.

PMID:
26785296
16.

Design of α7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies.

Ouach A, Pin F, Bertrand E, Vercouillie J, Gulhan Z, Mothes C, Deloye JB, Guilloteau D, Suzenet F, Chalon S, Routier S.

Eur J Med Chem. 2016 Jan 1;107:153-64. doi: 10.1016/j.ejmech.2015.11.001. Epub 2015 Nov 10.

PMID:
26580980
17.

PET tracers for imaging brain α7 nicotinic receptors: an update.

Chalon S, Vercouillie J, Guilloteau D, Suzenet F, Routier S.

Chem Commun (Camb). 2015 Oct 14;51(80):14826-31. doi: 10.1039/c5cc04536c.

PMID:
26359819
18.

Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [(18)F]-PET Imaging in a Primate Brain.

Deau E, Robin E, Voinea R, Percina N, Satała G, Finaru AL, Chartier A, Tamagnan G, Alagille D, Bojarski AJ, Morisset-Lopez S, Suzenet F, Guillaumet G.

J Med Chem. 2015 Oct 22;58(20):8066-96. doi: 10.1021/acs.jmedchem.5b00874. Epub 2015 Oct 5.

PMID:
26348247
19.

Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels-Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms.

Lorion M, Guillaumet G, Brière JF, Suzenet F.

Org Lett. 2015 Jun 19;17(12):3154-7. doi: 10.1021/acs.orglett.5b01487. Epub 2015 Jun 11.

PMID:
26066589
20.

A Pyridine-Based Ligand with Two Hydrazine Functions for Lanthanide Chelation: Remarkable Kinetic Inertness for a Linear, Bishydrated Complex.

Bonnet CS, Laine S, Buron F, Tircsó G, Pallier A, Helm L, Suzenet F, Tóth É.

Inorg Chem. 2015 Jun 15;54(12):5991-6003. doi: 10.1021/acs.inorgchem.5b00804. Epub 2015 Jun 1.

PMID:
26030671
21.

The biological effect of the nitroimidazole derivative of a polypyridyl ruthenium complex on cancer and endothelial cells.

Mazuryk O, Suzenet F, Kieda C, Brindell M.

Metallomics. 2015 Mar;7(3):553-66. doi: 10.1039/c5mt00037h.

PMID:
25711770
22.

Multifaceted interplay between lipophilicity, protein interaction and luminescence parameters of non-intercalative ruthenium(II) polypyridyl complexes controlling cellular imaging and cytotoxic properties.

Mazuryk O, Magiera K, Rys B, Suzenet F, Kieda C, Brindell M.

J Biol Inorg Chem. 2014 Dec;19(8):1305-16. doi: 10.1007/s00775-014-1187-5. Epub 2014 Aug 26.

23.

Mechanistic studies of Gd3+-based MRI contrast agents for Zn2+ detection: towards rational design.

Bonnet CS, Caillé F, Pallier A, Morfin JF, Petoud S, Suzenet F, Tóth É.

Chemistry. 2014 Aug 25;20(35):10959-69. doi: 10.1002/chem.201403043. Epub 2014 Aug 12.

PMID:
25116889
24.

Design of α7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [(18)F] quinuclidine derivative.

Pin F, Vercouillie J, Ouach A, Mavel S, Gulhan Z, Chicheri G, Jarry C, Massip S, Deloye JB, Guilloteau D, Suzenet F, Chalon S, Routier S.

Eur J Med Chem. 2014 Jul 23;82:214-24. doi: 10.1016/j.ejmech.2014.04.057. Epub 2014 May 9.

PMID:
24904968
25.

Original Design of Fluorescent Ligands by Fusing BODIPY and Melatonin Neurohormone.

Thireau J, Marteaux J, Delagrange P, Lefoulon F, Dufourny L, Guillaumet G, Suzenet F.

ACS Med Chem Lett. 2013 Nov 20;5(2):158-61. doi: 10.1021/ml4004155. eCollection 2014 Feb 13.

26.

PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of β-Amyloid Plaques.

Martins AF, Morfin JF, Kubíčková A, Kubíček V, Buron F, Suzenet F, Salerno M, Lazar AN, Duyckaerts C, Arlicot N, Guilloteau D, Geraldes CF, Tóth E.

ACS Med Chem Lett. 2013 Apr 15;4(5):436-40. doi: 10.1021/ml400042w. eCollection 2013 May 9.

27.

3-[(4-Phen-oxy-phen-yl)sulfan-yl]-5-phenyl-1H-1,2,4-triazole.

Ben Othman R, Marchivie M, Suzenet F, Routier S.

Acta Crystallogr Sect E Struct Rep Online. 2014 Apr 30;70(Pt 5):o622-3. doi: 10.1107/S1600536814008204. eCollection 2014 May 1.

28.

A hybrid coumarin-thiazole fluorescent sensor for selective detection of bisulfite anions in vivo and in real samples.

Peng MJ, Yang XF, Yin B, Guo Y, Suzenet F, En D, Li J, Li CW, Duan YW.

Chem Asian J. 2014 Jul;9(7):1817-22. doi: 10.1002/asia.201402113. Epub 2014 May 14.

PMID:
24828246
29.

Synthesis of 3,4-dihydro-1,8-naphthyridin-2(1H)-ones via microwave-activated inverse electron-demand Diels-Alder reactions.

Fadel S, Hajbi Y, Khouili M, Lazar S, Suzenet F, Guillaumet G.

Beilstein J Org Chem. 2014 Jan 28;10:282-6. doi: 10.3762/bjoc.10.24. eCollection 2014.

30.

2-Nitroimidazole-ruthenium polypyridyl complex as a new conjugate for cancer treatment and visualization.

Mazuryk O, Maciuszek M, Stochel G, Suzenet F, Brindell M.

J Inorg Biochem. 2014 May;134:83-91. doi: 10.1016/j.jinorgbio.2014.02.001. Epub 2014 Feb 14.

PMID:
24571925
31.

New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors.

Legros C, Matthey U, Grelak T, Pedragona-Moreau S, Hassler W, Yous S, Thomas E, Suzenet F, Folleas B, Lefoulon F, Berthelot P, Caignard DH, Guillaumet G, Delagrange P, Brayer JL, Nosjean O, Boutin JA.

Int J Mol Sci. 2013 Apr 25;14(5):8948-62. doi: 10.3390/ijms14058948.

32.

Lanthanide-based, near-infrared luminescent and magnetic lipoparticles: monitoring particle integrity.

Lacerda S, Bonnet CS, Pallier A, Villette S, Foucher F, Westall F, Buron F, Suzenet F, Pichon C, Petoud S, Tóth É.

Small. 2013 Aug 26;9(16):2662-6. doi: 10.1002/smll.201201923. Epub 2013 Apr 2. No abstract available.

PMID:
23554181
33.

Isoquinoline-based lanthanide complexes: bright NIR optical probes and efficient MRI agents.

Caillé F, Bonnet CS, Buron F, Villette S, Helm L, Petoud S, Suzenet F, Tóth E.

Inorg Chem. 2012 Feb 20;51(4):2522-32. doi: 10.1021/ic202446e. Epub 2012 Jan 10.

PMID:
22233349
34.

Pyridine-based lanthanide complexes combining MRI and NIR luminescence activities.

Bonnet CS, Buron F, Caillé F, Shade CM, Drahoš B, Pellegatti L, Zhang J, Villette S, Helm L, Pichon C, Suzenet F, Petoud S, Tóth É.

Chemistry. 2012 Jan 27;18(5):1419-31. doi: 10.1002/chem.201102310. Epub 2011 Dec 30.

PMID:
22213187
35.

Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists.

Jeanty M, Suzenet F, Delagrange P, Nosjean O, Boutin JA, Caignard DH, Guillaumet G.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2316-9. doi: 10.1016/j.bmcl.2011.02.097. Epub 2011 Feb 26.

PMID:
21420861
36.

Synthesis and grafting of a BTP derivative onto a quartz crystal microbalance for lanthanide detection.

Mercier D, Leconte N, Méthivier C, Suzenet F, Guillaumet G, Wuillaume A, Pradier CM.

Phys Chem Chem Phys. 2010 Jun 21;12(23):6099-106. doi: 10.1039/b921389a. Epub 2010 Apr 13.

PMID:
20390153
37.

Desulfitative cross-coupling of protecting group-free 2-thiouracil derivatives with organostannanes.

Sun Q, Suzenet F, Guillaumet G.

J Org Chem. 2010 May 21;75(10):3473-6. doi: 10.1021/jo1003482.

PMID:
20359202
38.

SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling.

Badarau E, Bugno R, Suzenet F, Bojarski AJ, Finaru AL, Guillaumet G.

Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. doi: 10.1016/j.bmc.2010.01.035. Epub 2010 Jan 18.

PMID:
20138771
39.

Hydrophobic chromophore cargo in micellar structures: a different strategy to sensitize lanthanide cations.

Bonnet CS, Pellegatti L, Buron F, Shade CM, Villette S, Kubícek V, Guillaumet G, Suzenet F, Petoud S, Tóth E.

Chem Commun (Camb). 2010 Jan 7;46(1):124-6. doi: 10.1039/b918881a. Epub 2009 Nov 20.

PMID:
20024314
40.

New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation.

Badarau E, Putey A, Suzenet F, Joseph B, Bojarski A, Finaru A, Guillaumet G.

J Enzyme Inhib Med Chem. 2010 Jun;25(3):301-5. doi: 10.3109/14756360903179393.

PMID:
19874209
41.

Synthesis of 4- and 6-azaindoles via the Fischer reaction.

Jeanty M, Blu J, Suzenet F, Guillaumet G.

Org Lett. 2009 Nov 19;11(22):5142-5. doi: 10.1021/ol902139r.

PMID:
19839585
42.

Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.

Badarau E, Suzenet F, Bojarski AJ, Fînaru AL, Guillaumet G.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1600-3. doi: 10.1016/j.bmcl.2009.02.008. Epub 2009 Feb 8.

PMID:
19237285
43.

Pyridine-based lanthanide complexes: towards bimodal agents operating as near infrared luminescent and MRI reporters.

Pellegatti L, Zhang J, Drahos B, Villette S, Suzenet F, Guillaumet G, Petoud S, Tóth E.

Chem Commun (Camb). 2008 Dec 28;(48):6591-3. doi: 10.1039/b817343e. Epub 2008 Nov 12.

PMID:
19057789
44.

Synthesis of C3-substituted 4-azaindoles: an easy access to 4-azamelatonin and protected 4-azatryptophan.

Jeanty M, Suzenet F, Guillaumet G.

J Org Chem. 2008 Sep 19;73(18):7390-3. doi: 10.1021/jo8011623. Epub 2008 Aug 26.

PMID:
18729406
45.

Oxazolinethiones and oxazolidinethiones for the first copper-catalyzed desulfurative cross-coupling reaction and first sonogashira applications.

Silva S, Sylla B, Suzenet F, Tatibouët A, Rauter AP, Rollin P.

Org Lett. 2008 Mar 6;10(5):853-6. doi: 10.1021/ol703003e. Epub 2008 Feb 5.

PMID:
18247631
46.

Studies towards the conception of new selective PPARbeta/delta ligands.

Basséne CE, Suzenet F, Hennuyer N, Staels B, Caignard DH, Dacquet C, Renard P, Guillaumet G.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4528-32. Epub 2006 Jun 23.

PMID:
16797985
47.

Easy access to 3- or 5-heteroarylamino-1,2,4-triazines by S(N)Ar, S(N)H, and palladium-catalyzed N-heteroarylations.

Garnier E, Audoux J, Pasquinet E, Suzenet F, Poullain D, Lebret B, Guillaumet G.

J Org Chem. 2004 Nov 12;69(23):7809-15.

PMID:
15527255
48.

Highly diastereoselective synthesis of C6-functionalized dihydroimidazotriazines.

Garnier E, Guillard J, Pasquinet E, Suzenet F, Poullain D, Jarry C, Léger JM, Lebret B, Guillaumet G.

Org Lett. 2003 Nov 27;5(24):4595-8.

PMID:
14627392
49.

Synthesis of 5-substituted-2,3-dihydro-1,4-benzoxathiins: biological evaluation as melatonin receptors ligands.

Charton I, Suzenet F, Boutin JA, Audinot V, Delagrange P, Bennejean C, Renard P, Guillaumet G.

J Enzyme Inhib Med Chem. 2003 Apr;18(2):187-93.

PMID:
12943203
50.

Copper(I)-promoted palladium-catalyzed cross-coupling of unsaturated tri-n-butylstannane with heteroaromatic thioether.

Alphonse FA, Suzenet F, Keromnes A, Lebret B, Guillaumet G.

Org Lett. 2003 Mar 20;5(6):803-5.

PMID:
12633076

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