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Items: 1 to 50 of 316

1.

Microbiota-dependent regulation of antimicrobial immunity in the lung.

Maschirow L, Suttorp N, Opitz B.

Am J Respir Cell Mol Biol. 2019 May 6. doi: 10.1165/rcmb.2019-0101TR. [Epub ahead of print]

PMID:
31059654
2.

Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study.

Ahnert P, Creutz P, Horn K, Schwarzenberger F, Kiehntopf M, Hossain H, Bauer M, Brunkhorst FM, Reinhart K, Völker U, Chakraborty T, Witzenrath M, Löffler M, Suttorp N, Scholz M; PROGRESS Study Group.

Crit Care. 2019 Apr 4;23(1):110. doi: 10.1186/s13054-019-2316-x.

3.

Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection.

Dabrowski AN, Conrad C, Behrendt U, Shrivastav A, Baal N, Wienhold SM, Hackstein H, N'Guessan PD, Aly S, Reppe K, Suttorp N, Zahlten J.

Front Microbiol. 2019 Feb 19;10:199. doi: 10.3389/fmicb.2019.00199. eCollection 2019.

4.

Local ablative treatment for synchronous single organ oligometastatic lung cancer-A propensity score analysis of 180 patients.

Frost N, Tessmer A, Schmittel A, van Laak V, Raspe M, Ruwwe-Glösenkamp C, Brunn M, Senger C, Böhmer D, Ochsenreither S, Temmesfeld-Wollbrück B, Furth C, Schmidt B, Neudecker J, Rückert JC, Suttorp N, Witzenrath M, Grohé C.

Lung Cancer. 2018 Nov;125:164-173. doi: 10.1016/j.lungcan.2018.09.021. Epub 2018 Sep 25.

PMID:
30429016
5.

Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.

Berger S, Goekeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M, Nouailles G.

Crit Care. 2018 Nov 1;22(1):287. doi: 10.1186/s13054-018-2224-5.

6.

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.

Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M, Müller-Redetzky HC.

Crit Care. 2018 Oct 29;22(1):282. doi: 10.1186/s13054-018-2213-8.

7.

Bronchial Injury After Atrial Fibrillation Ablation Using the Second-Generation Cryoballoon.

Bellmann B, Hübner RH, Lin T, Paland M, Steiner F, Krause P, Tscholl V, Nagel P, Roser M, Suttorp N, Landmesser U, Rillig A.

Circ Arrhythm Electrophysiol. 2018 Mar;11(3):e005925. doi: 10.1161/CIRCEP.117.005925. No abstract available.

PMID:
29874170
8.

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B.

J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16.

9.

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J.

Sci Rep. 2018 Apr 10;8(1):5723. doi: 10.1038/s41598-018-24152-1.

10.

Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE.

Nat Immunol. 2018 Apr;19(4):386-396. doi: 10.1038/s41590-018-0068-4. Epub 2018 Mar 19.

PMID:
29556002
11.

Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice.

Shrivastav A, Dabrowski AN, Conrad C, Baal N, Hackstein H, Plog S, Dietert K, Gruber AD, N'Guessan PD, Aly S, Suttorp N, Zahlten J.

Front Microbiol. 2018 Feb 1;9:103. doi: 10.3389/fmicb.2018.00103. eCollection 2018.

12.

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS Study Groups ‡ .

Am J Respir Crit Care Med. 2018 Jul 15;198(2):220-231. doi: 10.1164/rccm.201708-1733OC.

PMID:
29447449
13.

Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia.

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):440-448. doi: 10.1165/rcmb.2017-0337MA.

PMID:
29361238
14.

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Imai-Matsushima A, Meyer TF, Paasch L, Mitchell TJ, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC.

Sci Rep. 2018 Jan 9;8(1):182. doi: 10.1038/s41598-017-18468-7.

15.

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B; CAPNETZ Study Group.

PLoS Pathog. 2018 Jan 3;14(1):e1006829. doi: 10.1371/journal.ppat.1006829. eCollection 2018 Jan.

16.

Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group.

Crit Care Med. 2018 Mar;46(3):e258-e267. doi: 10.1097/CCM.0000000000002916.

PMID:
29298188
17.

The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans.

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznicka M, Cambier J, Witzenrath M, Schumann RR, Suttorp N, Opitz B.

Infect Immun. 2018 Feb 20;86(3). pii: e00849-17. doi: 10.1128/IAI.00849-17. Print 2018 Mar.

18.

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD.

PLoS One. 2017 Nov 20;12(11):e0188251. doi: 10.1371/journal.pone.0188251. eCollection 2017.

19.

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Hoang VC, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M.

Crit Care. 2017 Nov 13;21(1):274. doi: 10.1186/s13054-017-1851-6.

20.

Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.

Naujoks J, Lippmann J, Suttorp N, Opitz B.

Int J Med Microbiol. 2018 Jan;308(1):161-167. doi: 10.1016/j.ijmm.2017.10.004. Epub 2017 Oct 27. Review.

PMID:
29097162
21.

Human Pulmonary 3D Models For Translational Research.

Zscheppang K, Berg J, Hedtrich S, Verheyen L, Wagner DE, Suttorp N, Hippenstiel S, Hocke AC.

Biotechnol J. 2018 Jan;13(1). doi: 10.1002/biot.201700341. Epub 2017 Sep 20. Review.

PMID:
28865134
22.

Schistosomiasis in European Travelers and Migrants: Analysis of 14 Years TropNet Surveillance Data.

Lingscheid T, Kurth F, Clerinx J, Marocco S, Trevino B, Schunk M, Muñoz J, Gjørup IE, Jelinek T, Develoux M, Fry G, Jänisch T, Schmid ML, Bouchaud O, Puente S, Zammarchi L, Mørch K, Björkman A, Siikamäki H, Neumayr A, Nielsen H, Hellgren U, Paul M, Calleri G, Kosina P, Myrvang B, Ramos JM, Just-Nübling G, Beltrame A, Saraiva da Cunha J, Kern P, Rochat L, Stich A, Pongratz P, Grobusch MP, Suttorp N, Witzenrath M, Hatz C, Zoller T; TropNet Schistosomiasis Investigator Group.

Am J Trop Med Hyg. 2017 Aug;97(2):567-574. doi: 10.4269/ajtmh.17-0034. Epub 2017 Jul 19.

23.

Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.

Berg J, Zscheppang K, Fatykhova D, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Gruber AD, Suttorp N, Hippenstiel S, Hocke AC.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601953. doi: 10.1183/13993003.01953-2016. Print 2017 Jul.

24.

Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling.

Reyes LF, Restrepo MI, Hinojosa CA, Soni NJ, Anzueto A, Babu BL, Gonzalez-Juarbe N, Rodriguez AH, Jimenez A, Chalmers JD, Aliberti S, Sibila O, Winter VT, Coalson JJ, Giavedoni LD, Dela Cruz CS, Waterer GW, Witzenrath M, Suttorp N, Dube PH, Orihuela CJ.

Am J Respir Crit Care Med. 2017 Sep 1;196(5):609-620. doi: 10.1164/rccm.201701-0104OC.

25.

The "Choosing Wisely" initiative in infectious diseases.

Lehmann C, Berner R, Bogner JR, Cornely OA, de With K, Herold S, Kern WV, Lemmen S, Pletz MW, Ruf B, Salzberger B, Stellbrink HJ, Suttorp N, Ullmann AJ, Fätkenheuer G, Jung N.

Infection. 2017 Jun;45(3):263-268. doi: 10.1007/s15010-017-0997-0. Epub 2017 Mar 13. Review.

PMID:
28290130
26.

Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment.

Peter A, Fatykhova D, Kershaw O, Gruber AD, Rueckert J, Neudecker J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Suttorp N, Hocke AC, Hippenstiel S.

Histochem Cell Biol. 2017 Jun;147(6):707-719. doi: 10.1007/s00418-017-1551-y. Epub 2017 Mar 1.

PMID:
28247028
27.

Severe malaria in Europe: an 8-year multi-centre observational study.

Kurth F, Develoux M, Mechain M, Malvy D, Clerinx J, Antinori S, Gjørup IE, Gascon J, Mørch K, Nicastri E, Ramharter M, Bartoloni A, Visser L, Rolling T, Zanger P, Calleri G, Salas-Coronas J, Nielsen H, Just-Nübling G, Neumayr A, Hachfeld A, Schmid ML, Antonini P, Lingscheid T, Kern P, Kapaun A, da Cunha JS, Pongratz P, Soriano-Arandes A, Schunk M, Suttorp N, Hatz C, Zoller T.

Malar J. 2017 Jan 31;16(1):57. doi: 10.1186/s12936-016-1673-z.

28.

[Infectious Causes of Granulomatous Lung Diseases].

Grund D, Isner C, Temmesfeld-Wollbrück B, Suttorp N, Witzenrath M.

Dtsch Med Wochenschr. 2017 Jan;142(1):32-40. doi: 10.1055/s-0042-109659. Epub 2017 Jan 5. Review. German.

PMID:
28056475
29.

Human lung ex vivo infection models.

Hocke AC, Suttorp N, Hippenstiel S.

Cell Tissue Res. 2017 Mar;367(3):511-524. doi: 10.1007/s00441-016-2546-z. Epub 2016 Dec 20. Review.

PMID:
27999962
30.

Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.

Tabeling C, Herbert J, Hocke AC, Lamb DJ, Wollin SL, Erb KJ, Boiarina E, Movassagh H, Scheffel J, Doehn JM, Hippenstiel S, Maurer M, Gounni AS, Kuebler WM, Suttorp N, Witzenrath M.

Allergy. 2017 Jul;72(7):1061-1072. doi: 10.1111/all.13101. Epub 2017 Jan 12.

PMID:
27906453
31.

A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.

Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow ADJ, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH.

Cell Chem Biol. 2016 Nov 17;23(11):1407-1416. doi: 10.1016/j.chembiol.2016.09.016. Epub 2016 Nov 3.

32.

Neue Antiinfektiva und Impfstoffe.

Suttorp N.

Drug Res (Stuttg). 2016 Nov;66(S 01):S11-S12. Epub 2016 Nov 2. German. No abstract available.

PMID:
27806392
Free Article
33.

Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.

Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AVS, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM.

EBioMedicine. 2016 Oct;12:239-246. doi: 10.1016/j.ebiom.2016.08.043. Epub 2016 Sep 15.

34.

PROGRESS - prospective observational study on hospitalized community acquired pneumonia.

Ahnert P, Creutz P, Scholz M, Schütte H, Engel C, Hossain H, Chakraborty T, Bauer M, Kiehntopf M, Völker U, Hammerschmidt S, Loeffler M, Suttorp N; PROGRESS study group.

BMC Pulm Med. 2016 Jul 28;16(1):108. doi: 10.1186/s12890-016-0255-8.

35.

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence.

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B.

Sci Rep. 2016 Aug 1;6:30943. doi: 10.1038/srep30943.

36.

Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

Rabes A, Suttorp N, Opitz B.

Curr Top Microbiol Immunol. 2016;397:215-27. doi: 10.1007/978-3-319-41171-2_11. Review.

PMID:
27460812
37.

Hemolysis after Oral Artemisinin Combination Therapy for Uncomplicated Plasmodium falciparum Malaria.

Kurth F, Lingscheid T, Steiner F, Stegemann MS, Bélard S, Menner N, Pongratz P, Kim J, von Bernuth H, Mayer B, Damm G, Seehofer D, Salama A, Suttorp N, Zoller T.

Emerg Infect Dis. 2016 Aug;22(8):1381-6. doi: 10.3201/eid2208.151905.

38.

Lung perfusion and emphysema distribution affect the outcome of endobronchial valve therapy.

Thomsen C, Theilig D, Herzog D, Poellinger A, Doellinger F, Schreiter N, Schreiter V, Schürmann D, Temmesfeld-Wollbrueck B, Hippenstiel S, Suttorp N, Hubner RH.

Int J Chron Obstruct Pulmon Dis. 2016 Jun 9;11:1245-59. doi: 10.2147/COPD.S101003. eCollection 2016.

39.

Impact of pneumococcal vaccination in children on serotype distribution in adult community-acquired pneumonia using the serotype-specific multiplex urinary antigen detection assay.

Pletz MW, Ewig S, Rohde G, Schuette H, Rupp J, Welte T, Suttorp N, Forstner C; CAPNETZ Study Group.

Vaccine. 2016 Apr 29;34(20):2342-8. doi: 10.1016/j.vaccine.2016.03.052. Epub 2016 Mar 24.

PMID:
27016653
40.

[CAPNETZ. The competence network for community-acquired pneumonia (CAP)].

Suttorp N, Welte T, Marre R, Stenger S, Pletz M, Rupp J, Schütte H, Rohde G; CAPNETZ-Studiengruppe.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Apr;59(4):475-81. doi: 10.1007/s00103-016-2318-7. German.

PMID:
26984399
41.

MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation.

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B.

J Infect Dis. 2016 Jul 15;214(2):288-99. doi: 10.1093/infdis/jiw109. Epub 2016 Mar 16.

PMID:
26984146
42.

Community-acquired Haemophilus influenzae pneumonia--New insights from the CAPNETZ study.

Forstner C, Rohde G, Rupp J, Schuette H, Ott SR, Hagel S, Harrison N, Thalhammer F, von Baum H, Suttorp N, Welte T, Pletz MW; CAPNETZ Study Group.

J Infect. 2016 May;72(5):554-63. doi: 10.1016/j.jinf.2016.02.010. Epub 2016 Mar 3.

PMID:
26940505
43.

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.

Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M.

J Vasc Res. 2015;52(4):279-88. doi: 10.1159/000443402. Epub 2016 Feb 19.

PMID:
26890419
44.

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B.

PLoS Pathog. 2016 Feb 1;12(2):e1005408. doi: 10.1371/journal.ppat.1005408. eCollection 2016 Feb.

45.

Outcomes of Endobronchial Valve Treatment Based on the Precise Criteria of an Endobronchial Catheter for Detection of Collateral Ventilation under Spontaneous Breathing.

Herzog D, Thomsen C, Poellinger A, Doellinger F, Schreiter N, Froeling V, Schuermann D, Temmesfeld-Wollbruck B, Hippenstiel S, Suttorp N, Huebner RH.

Respiration. 2016;91(1):69-78. doi: 10.1159/000442886. Epub 2015 Dec 24.

46.

[New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia].

Lienau J, Müller-Redetzky H, Suttorp N, Witzenrath M.

Pneumologie. 2016 Jun;70(6):372-8. doi: 10.1055/s-0035-1563788. Epub 2015 Dec 4. Review. German.

PMID:
26637049
47.

[Smoking: Cardiovascular effects and abstinence strategies].

Suttorp N, Nitschmann S.

Internist (Berl). 2015 Nov;56(11):1325-8. doi: 10.1007/s00108-015-3829-2. German. No abstract available.

PMID:
26446677
48.

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M.

Infect Immun. 2015 Dec;83(12):4617-29. doi: 10.1128/IAI.00948-15. Epub 2015 Sep 14.

49.

Therapeutic strategies in pneumonia: going beyond antibiotics.

Müller-Redetzky H, Lienau J, Suttorp N, Witzenrath M.

Eur Respir Rev. 2015 Sep;24(137):516-24. doi: 10.1183/16000617.0034-2015. Review.

50.

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B.

PLoS One. 2015 Aug 28;10(8):e0137108. doi: 10.1371/journal.pone.0137108. eCollection 2015.

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