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Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies.

Bucaite G, Kang-Pettinger T, Moreira J, Gould HJ, James LK, Sutton BJ, McDonnell JM.

J Immunol. 2019 Aug 28. pii: ji1900509. doi: 10.4049/jimmunol.1900509. [Epub ahead of print]


Mapping of the binding site for FcμR in human IgM-Fc.

Nyamboya RA, Sutton BJ, Calvert RA.

Biochim Biophys Acta Proteins Proteom. 2019 Aug 23:140266. doi: 10.1016/j.bbapap.2019.140266. [Epub ahead of print]


A Mass-Spectrometry-Based Modelling Workflow for Accurate Prediction of IgG Antibody Conformations in the Gas Phase.

Hansen K, Lau AM, Giles K, McDonnell JM, Struwe WB, Sutton BJ, Politis A.

Angew Chem Int Ed Engl. 2018 Dec 21;57(52):17194-17199. doi: 10.1002/anie.201812018. Epub 2018 Nov 27.


The structure of PghL hydrolase bound to its substrate poly-γ-glutamate.

Ramaswamy S, Rasheed M, Morelli CF, Calvio C, Sutton BJ, Pastore A.

FEBS J. 2018 Dec;285(24):4575-4589. doi: 10.1111/febs.14688. Epub 2018 Nov 19.


Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.

Mitropoulou AN, Bowen H, Dodev TS, Davies AM, Bax HJ, Beavil RL, Beavil AJ, Gould HJ, James LK, Sutton BJ.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8707-E8716. doi: 10.1073/pnas.1806840115. Epub 2018 Aug 27.


Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.

Chen JB, Ramadani F, Pang MOY, Beavil RL, Holdom MD, Mitropoulou AN, Beavil AJ, Gould HJ, Chang TW, Sutton BJ, McDonnell JM, Davies AM.

Sci Rep. 2018 Aug 1;8(1):11548. doi: 10.1038/s41598-018-29664-4.


Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.

Doré KA, Kashiwakura JI, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM.

Mol Immunol. 2018 Jan;93:216-222. doi: 10.1016/j.molimm.2017.11.022. Epub 2017 Dec 5.


Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.

Doré KA, Davies AM, Drinkwater N, Beavil AJ, McDonnell JM, Sutton BJ.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt A):1336-1347. doi: 10.1016/j.bbapap.2017.08.005. Epub 2017 Aug 24.


IgE Trimers Drive SPE-7 Cytokinergic Activity.

Bax HJ, Bowen H, Beavil RL, Chung R, Ward M, Davies AM, Dodev TS, McDonnell JM, Beavil AJ, Sutton BJ, Gould HJ.

Sci Rep. 2017 Aug 15;7(1):8164. doi: 10.1038/s41598-017-08212-6.


Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.

Davies AM, Allan EG, Keeble AH, Delgado J, Cossins BP, Mitropoulou AN, Pang MOY, Ceska T, Beavil AJ, Craggs G, Westwood M, Henry AJ, McDonnell JM, Sutton BJ.

J Biol Chem. 2017 Jun 16;292(24):9975-9987. doi: 10.1074/jbc.M117.776476. Epub 2017 Apr 24.


IgE binds asymmetrically to its B cell receptor CD23.

Dhaliwal B, Pang MO, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ.

Sci Rep. 2017 Mar 31;7:45533. doi: 10.1038/srep45533.


IgY: a key isotype in antibody evolution.

Zhang X, Calvert RA, Sutton BJ, Doré KA.

Biol Rev Camb Philos Soc. 2017 Nov;92(4):2144-2156. doi: 10.1111/brv.12325. Epub 2017 Mar 16. Review.


Room temperature structure of human IgG4-Fc from crystals analysed in situ.

Davies AM, Rispens T, Ooijevaar-de Heer P, Aalberse RC, Sutton BJ.

Mol Immunol. 2017 Jan;81:85-91. doi: 10.1016/j.molimm.2016.11.021. Epub 2016 Dec 1.


Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps.

Chen JB, James LK, Davies AM, Wu YB, Rimmer J, Lund VJ, Chen JH, McDonnell JM, Chan YC, Hutchins GH, Chang TW, Sutton BJ, Kariyawasam HH, Gould HJ.

J Allergy Clin Immunol. 2017 Apr;139(4):1195-1204.e11. doi: 10.1016/j.jaci.2016.06.066. Epub 2016 Sep 19.


Ontogeny of human IgE-expressing B cells and plasma cells.

Ramadani F, Bowen H, Upton N, Hobson PS, Chan YC, Chen JB, Chang TW, McDonnell JM, Sutton BJ, Fear DJ, Gould HJ.

Allergy. 2017 Jan;72(1):66-76. doi: 10.1111/all.12911. Epub 2016 Jun 8.


IgG4 Characteristics and Functions in Cancer Immunity.

Crescioli S, Correa I, Karagiannis P, Davies AM, Sutton BJ, Nestle FO, Karagiannis SN.

Curr Allergy Asthma Rep. 2016 Jan;16(1):7. doi: 10.1007/s11882-015-0580-7. Review.


Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII.

Sutton BJ, Davies AM.

Immunol Rev. 2015 Nov;268(1):222-35. doi: 10.1111/imr.12340. Review.


Human IgG4: a structural perspective.

Davies AM, Sutton BJ.

Immunol Rev. 2015 Nov;268(1):139-59. doi: 10.1111/imr.12349. Review.


Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE.

Ramadani F, Upton N, Hobson P, Chan YC, Mzinza D, Bowen H, Kerridge C, Sutton BJ, Fear DJ, Gould HJ.

Allergy. 2015 Oct;70(10):1269-77. doi: 10.1111/all.12679. Epub 2015 Jul 24.


Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.

Hussein D, Starr A, Heikal L, McNeill E, Channon KM, Brown PR, Sutton BJ, McDonnell JM, Nandi M.

Br J Pharmacol. 2015 Aug;172(16):4146-57. doi: 10.1111/bph.13202. Epub 2015 Jul 14.


Mechanism of the antigen-independent cytokinergic SPE-7 IgE activation of human mast cells in vitro.

Bax HJ, Bowen H, Dodev TS, Sutton BJ, Gould HJ.

Sci Rep. 2015 Apr 20;5:9538. doi: 10.1038/srep09538.


Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class.

Dodev TS, Bowen H, Shamji MH, Bax HJ, Beavil AJ, McDonnell JM, Durham SR, Sutton BJ, Gould HJ, James LK.

Allergy. 2015 Jun;70(6):720-4. doi: 10.1111/all.12607. Epub 2015 Mar 28.


Antibody mimetics: promising complementary agents to animal-sourced antibodies.

Baloch AR, Baloch AW, Sutton BJ, Zhang X.

Crit Rev Biotechnol. 2016;36(2):268-75. doi: 10.3109/07388551.2014.958431. Epub 2014 Sep 29. Review.


Crystal structure of deglycosylated human IgG4-Fc.

Davies AM, Jefferis R, Sutton BJ.

Mol Immunol. 2014 Nov;62(1):46-53. doi: 10.1016/j.molimm.2014.05.015. Epub 2014 Jun 24.


Human immunoglobulin E flexes between acutely bent and extended conformations.

Drinkwater N, Cossins B, Keeble AH, Wright M, Cain K, Hailu H, Oxbrow A, Delgado J, Shuttleworth LK, Kao MW, McDonnell JM, Beavil AJ, Henry AJ, Sutton BJ.

Nat Struct Mol Biol. 2014 Apr;21(4):397-404. doi: 10.1038/nsmb.2795. Epub 2014 Mar 16.


A range of Cℇ3-Cℇ4 interdomain angles in IgE Fc accommodate binding to its receptor CD23.

Dhaliwal B, Pang MO, Yuan D, Beavil AJ, Sutton BJ.

Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):305-9. doi: 10.1107/S2053230X14003355. Epub 2014 Feb 20.


Generation and characterization of chicken-sourced single-chain variable fragments (scFvs) against porcine interferon-gamma (pIFN-γ).

Chen HX, He F, Sun Y, Luo Y, Qiu HJ, Zhang XY, Sutton BJ.

J Immunoassay Immunochem. 2015;36(1):27-44. doi: 10.1080/15321819.2014.892511.


Human IgE against the major allergen Bet v 1--defining an epitope with limited cross-reactivity between different PR-10 family proteins.

Levin M, Davies AM, Liljekvist M, Carlsson F, Gould HJ, Sutton BJ, Ohlin M.

Clin Exp Allergy. 2014 Feb;44(2):288-99. doi: 10.1111/cea.12230.


Non-mass-associated intraductal papillomas: is excision necessary?

Weisman PS, Sutton BJ, Siziopikou KP, Hansen N, Khan SA, Neuschler EI, Rohan SM, Franz JM, Sullivan ME.

Hum Pathol. 2014 Mar;45(3):583-8. doi: 10.1016/j.humpath.2013.10.027. Epub 2013 Nov 6.


Dynamics of inter-heavy chain interactions in human immunoglobulin G (IgG) subclasses studied by kinetic Fab arm exchange.

Rispens T, Davies AM, Ooijevaar-de Heer P, Absalah S, Bende O, Sutton BJ, Vidarsson G, Aalberse RC.

J Biol Chem. 2014 Feb 28;289(9):6098-109. doi: 10.1074/jbc.M113.541813. Epub 2014 Jan 14.


Distribution of rat neonatal Fc receptor in the principal organs of neonatal and pubertal rats.

Tian Z, Sutton BJ, Zhang X.

J Recept Signal Transduct Res. 2014 Apr;34(2):137-42. doi: 10.3109/10799893.2013.865745. Epub 2013 Dec 4.


Immunology: Allergy's Achilles' heel?

Sutton BJ.

Nat Chem Biol. 2013 Dec;9(12):757-9. doi: 10.1038/nchembio.1390. No abstract available.


Structural determinants of unique properties of human IgG4-Fc.

Davies AM, Rispens T, Ooijevaar-de Heer P, Gould HJ, Jefferis R, Aalberse RC, Sutton BJ.

J Mol Biol. 2014 Feb 6;426(3):630-44. doi: 10.1016/j.jmb.2013.10.039. Epub 2013 Nov 6.


Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.

Dhaliwal B, Pang MO, Yuan D, Yahya N, Fabiane SM, McDonnell JM, Gould HJ, Beavil AJ, Sutton BJ.

Mol Immunol. 2013 Dec;56(4):693-7. doi: 10.1016/j.molimm.2013.07.005. Epub 2013 Aug 7.


Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.

Yuan D, Keeble AH, Hibbert RG, Fabiane S, Gould HJ, McDonnell JM, Beavil AJ, Sutton BJ, Dhaliwal B.

J Biol Chem. 2013 Jul 26;288(30):21667-77. doi: 10.1074/jbc.M113.480657. Epub 2013 Jun 17.


A redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activity.

Godlewska M, Góra M, Buckle AM, Porebski BT, Kemp EH, Sutton BJ, Czarnocka B, Banga JP.

Thyroid. 2014 Feb;24(2):371-82. doi: 10.1089/thy.2013.0127. Epub 2013 Sep 26.


Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange.

Davies AM, Rispens T, den Bleker TH, McDonnell JM, Gould HJ, Aalberse RC, Sutton BJ.

Mol Immunol. 2013 May;54(1):1-7. doi: 10.1016/j.molimm.2012.10.029. Epub 2012 Nov 17.


Mapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction.

Borthakur S, Hibbert RG, Pang MO, Yahya N, Bax HJ, Kao MW, Cooper AM, Beavil AJ, Sutton BJ, Gould HJ, McDonnell JM.

J Biol Chem. 2012 Sep 7;287(37):31457-61. doi: 10.1074/jbc.C112.397059. Epub 2012 Jul 19.


Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI.

Dhaliwal B, Yuan D, Pang MO, Henry AJ, Cain K, Oxbrow A, Fabiane SM, Beavil AJ, McDonnell JM, Gould HJ, Sutton BJ.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12686-91. doi: 10.1073/pnas.1207278109. Epub 2012 Jul 16.


A fluorescent biosensor reveals conformational changes in human immunoglobulin E Fc: implications for mechanisms of receptor binding, inhibition, and allergen recognition.

Hunt J, Keeble AH, Dale RE, Corbett MK, Beavil RL, Levitt J, Swann MJ, Suhling K, Ameer-Beg S, Sutton BJ, Beavil AJ.

J Biol Chem. 2012 May 18;287(21):17459-70. doi: 10.1074/jbc.M111.331967. Epub 2012 Mar 22.


Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE.

Offermann DA, McKendrick JE, Sejberg JJ, Mo B, Holdom MD, Helm BA, Leatherbarrow RJ, Beavil AJ, Sutton BJ, Spivey AC.

J Org Chem. 2012 Apr 6;77(7):3197-214. doi: 10.1021/jo202604q. Epub 2012 Mar 7.


Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

Cooper AM, Hobson PS, Jutton MR, Kao MW, Drung B, Schmidt B, Fear DJ, Beavil AJ, McDonnell JM, Sutton BJ, Gould HJ.

J Immunol. 2012 Apr 1;188(7):3199-207. doi: 10.4049/jimmunol.1102689. Epub 2012 Mar 5.


Aggressive angiomyxoma.

Sutton BJ, Laudadio J.

Arch Pathol Lab Med. 2012 Feb;136(2):217-21. doi: 10.5858/arpa.2011-0056-RS. Review.


Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution.

Carr JL, Sejberg JJ, Saab F, Holdom MD, Davies AM, White AJ, Leatherbarrow RJ, Beavil AJ, Sutton BJ, Lindell SD, Spivey AC.

Org Biomol Chem. 2011 Oct 7;9(19):6814-24. doi: 10.1039/c1ob05862b. Epub 2011 Aug 15.


Incessant ventricular tachycardia and cardiogenic shock: a common presentation of an uncommon diagnosis.

Drafts BC, Sutton BJ, Dubose TD Jr, Thohan V.

Am J Med Sci. 2011 Dec;342(6):527-9. doi: 10.1097/MAJ.0b013e31822a6bdd.


Leptomeningeal melanocytosis in an adult male without large congenital nevi: a rare and atypical case of neurocutaneous melanosis.

Sutton BJ, Tatter SB, Stanton CA, Mott RT.

Clin Neuropathol. 2011 Jul-Aug;30(4):178-82. Review.


Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ.

Nat Struct Mol Biol. 2011 May;18(5):571-6. doi: 10.1038/nsmb.2044. Epub 2011 Apr 24.


Filamentous bacteria masquerading as fungi: a diagnostic pitfall in direct smear interpretation with report of two cases.

Sutton BJ, Parsons AC, Palavecino EL.

J Clin Pathol. 2011 Oct;64(10):927-9. doi: 10.1136/jcp.2011.089284. Epub 2011 Mar 17.


Cushing's syndrome and nocardiosis associated with a pulmonary carcinoid tumor: report of a case and review of the literature.

Sutton BJ, Parks GE, Manavi CK, Palavecino EL, Geisinger KR.

Diagn Cytopathol. 2011 May;39(5):359-62. doi: 10.1002/dc.21428. Epub 2010 Sep 20. Review.


Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether.

Carr JL, Offermann DA, Holdom MD, Dusart P, White AJ, Beavil AJ, Leatherbarrow RJ, Lindell SD, Sutton BJ, Spivey AC.

Chem Commun (Camb). 2010 Mar 21;46(11):1824-6. doi: 10.1039/b923528k. Epub 2009 Dec 23.

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