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AHR Regulates Metabolic Reprogramming to Promote SIRT1-Dependent Keratinocyte Differentiation.

Sutter CH, Olesen KM, Bhuju J, Guo Z, Sutter TR.

J Invest Dermatol. 2019 Apr;139(4):818-826. doi: 10.1016/j.jid.2018.10.019. Epub 2018 Oct 28.


Breastfeeding duration modifies the effect of smoking during pregnancy on eczema from early childhood to adolescence.

Mukherjee N, Sutter TR, Arshad SH, Holloway JW, Zhang H, Karmaus W.

Clin Exp Allergy. 2018 Dec;48(12):1688-1697. doi: 10.1111/cea.13294.


Differential and Overlapping Effects of 20,23(OH)₂D3 and 1,25(OH)₂D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)₂D3.

Slominski AT, Kim TK, Janjetovic Z, Brożyna AA, Żmijewski MA, Xu H, Sutter TR, Tuckey RC, Jetten AM, Crossman DK.

Int J Mol Sci. 2018 Oct 8;19(10). pii: E3072. doi: 10.3390/ijms19103072.


NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus.

Wible RS, Ramanathan C, Sutter CH, Olesen KM, Kensler TW, Liu AC, Sutter TR.

Elife. 2018 Feb 26;7. pii: e31656. doi: 10.7554/eLife.31656.


Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo.

Wible RS, Tran QT, Fathima S, Sutter CH, Kensler TW, Sutter TR.

Mol Pharmacol. 2018 Apr;93(4):297-308. doi: 10.1124/mol.117.110262. Epub 2018 Jan 24.


Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.

Rybak JM, Dickens CM, Parker JE, Caudle KE, Manigaba K, Whaley SG, Nishimoto AT, Luna-Tapia A, Roy S, Zhang Q, Barker KS, Palmer GE, Sutter TR, Homayouni R, Wiederhold NP, Kelly SL, Rogers PD.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00651-17. doi: 10.1128/AAC.00651-17. Print 2017 Sep.


Soft Cysteine Signaling Network: The Functional Significance of Cysteine in Protein Function and the Soft Acids/Bases Thiol Chemistry That Facilitates Cysteine Modification.

Wible RS, Sutter TR.

Chem Res Toxicol. 2017 Mar 20;30(3):729-762. doi: 10.1021/acs.chemrestox.6b00428. Epub 2017 Feb 13.


Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation.

Campion CM, Leon Carrion S, Mamidanna G, Sutter CH, Sutter TR, Cole JA.

Chem Biol Interact. 2016 Jun 25;253:38-47. doi: 10.1016/j.cbi.2016.04.031. Epub 2016 Apr 23.


Effects of in utero exposure of C57BL/6J mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin on epidermal permeability barrier development and function.

Muenyi CS, Carrion SL, Jones LA, Kennedy LH, Slominski AT, Sutter CH, Sutter TR.

Environ Health Perspect. 2014 Oct;122(10):1052-8. doi: 10.1289/ehp.1308045. Epub 2014 Jun 6.


Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.

Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD.

Cancer Prev Res (Phila). 2014 Jul;7(7):658-65. doi: 10.1158/1940-6207.CAPR-13-0430. Epub 2014 Mar 24.


Epigenetic analysis of neurocognitive development at 1 year of age in a community-based pregnancy cohort.

Krushkal J, Murphy LE, Palmer FB, Graff JC, Sutter TR, Mozhui K, Hovinga CA, Thomas F, Park V, Tylavsky FA, Adkins RM.

Behav Genet. 2014 Mar;44(2):113-25. doi: 10.1007/s10519-014-9641-2. Epub 2014 Jan 23.


Combined treatment with sodium butyrate and PD153035 enhances keratinocyte differentiation.

Leon Carrion S, Sutter CH, Sutter TR.

Exp Dermatol. 2014 Mar;23(3):211-4. doi: 10.1111/exd.12333.


2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation.

Kennedy LH, Sutter CH, Leon Carrion S, Tran QT, Bodreddigari S, Kensicki E, Mohney RP, Sutter TR.

Toxicol Sci. 2013 Mar;132(1):235-49. doi: 10.1093/toxsci/kfs325. Epub 2012 Nov 14.


EGFR regulation of epidermal barrier function.

Tran QT, Kennedy LH, Leon Carrion S, Bodreddigari S, Goodwin SB, Sutter CH, Sutter TR.

Physiol Genomics. 2012 Apr 15;44(8):455-69. doi: 10.1152/physiolgenomics.00176.2011. Epub 2012 Mar 6.


2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation.

Sutter CH, Bodreddigari S, Campion C, Wible RS, Sutter TR.

Toxicol Sci. 2011 Nov;124(1):128-37. doi: 10.1093/toxsci/kfr205. Epub 2011 Aug 11.


Collection and storage of human blood and adipose for genomic analysis of clinical samples.

Cashion AK, Umberger RA, Goodwin SB, Sutter TR.

Res Nurs Health. 2011 Oct;34(5):408-18. doi: 10.1002/nur.20448. Epub 2011 Aug 2.


Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity.

Ahmed MM, Wang T, Luo Y, Ye S, Wu Q, Guo Z, Roebuck BD, Sutter TR, Yang JY.

Hepatology. 2011 Oct;54(4):1322-32. doi: 10.1002/hep.24493. Epub 2011 Sep 6.


Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses.

Ouyang X, Tran QT, Goodwin S, Wible RS, Sutter CH, Sutter TR.

Free Radic Biol Med. 2011 Jan 1;50(1):1-13. doi: 10.1016/j.freeradbiomed.2010.10.697. Epub 2010 Nov 6.


Analysis of the CYP1A1 mRNA dose-response in human keratinocytes indicates that relative potencies of dioxins, furans, and PCBs are species and congener specific.

Sutter CH, Bodreddigari S, Sutter TR, Carlson EA, Silkworth JB.

Toxicol Sci. 2010 Dec;118(2):704-15. doi: 10.1093/toxsci/kfq262. Epub 2010 Sep 6.


Divergent transcriptomic responses to aryl hydrocarbon receptor agonists between rat and human primary hepatocytes.

Carlson EA, McCulloch C, Koganti A, Goodwin SB, Sutter TR, Silkworth JB.

Toxicol Sci. 2009 Nov;112(1):257-72. doi: 10.1093/toxsci/kfp200. Epub 2009 Aug 19.


Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW.

Carcinogenesis. 2009 Jun;30(6):1024-31. doi: 10.1093/carcin/bgp100. Epub 2009 Apr 21.


EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes.

Sutter CH, Yin H, Li Y, Mammen JS, Bodreddigari S, Stevens G, Cole JA, Sutter TR.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4266-71. doi: 10.1073/pnas.0900874106. Epub 2009 Mar 2. Erratum in: Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9121.


Analyzing microarray data with transitive directed acyclic graphs.

Phan V, Olusegun George E, Tran QT, Goodwin S, Bodreddigari S, Sutter TR.

J Bioinform Comput Biol. 2009 Feb;7(1):135-56.


Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.

Roebuck BD, Johnson DN, Sutter CH, Egner PA, Scholl PF, Friesen MD, Baumgartner KJ, Ware NM, Bodreddigari S, Groopman JD, Kensler TW, Sutter TR.

Toxicol Sci. 2009 May;109(1):41-9. doi: 10.1093/toxsci/kfp003. Epub 2009 Jan 23.


Chemical genomics of cancer chemopreventive dithiolethiones.

Tran QT, Xu L, Phan V, Goodwin SB, Rahman M, Jin VX, Sutter CH, Roebuck BD, Kensler TW, George EO, Sutter TR.

Carcinogenesis. 2009 Mar;30(3):480-6. doi: 10.1093/carcin/bgn292. Epub 2009 Jan 6.


Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource.

Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW.

Front Neurosci. 2009 Nov 10;3:55. doi: 10.3389/neuro.15.003.2009. eCollection 2009.


Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.

Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR.

Chem Res Toxicol. 2008 May;21(5):1134-42. doi: 10.1021/tx7004458. Epub 2008 Apr 15.


Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry.

Johnson DN, Egner PA, Obrian G, Glassbrook N, Roebuck BD, Sutter TR, Payne GA, Kensler TW, Groopman JD.

Chem Res Toxicol. 2008 Mar;21(3):752-60. doi: 10.1021/tx700397n. Epub 2008 Feb 12.


CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.

Rahman M, Lax SF, Sutter CH, Tran QT, Stevens GL, Emmert GL, Russo J, Santen RJ, Sutter TR.

Drug Metab Dispos. 2008 May;36(5):963-70. doi: 10.1124/dmd.107.018960. Epub 2008 Feb 6.


Toxicogenomic analysis of gender, chemical, and dose effects in livers of TCDD- or aroclor 1254-exposed rats using a multifactor linear model.

Silkworth JB, Carlson EA, McCulloch C, Illouz K, Goodwin S, Sutter TR.

Toxicol Sci. 2008 Apr;102(2):291-309. doi: 10.1093/toxsci/kfm313. Epub 2008 Jan 3.


Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol.

Huang Y, Fernandez SV, Goodwin S, Russo PA, Russo IH, Sutter TR, Russo J.

Cancer Res. 2007 Dec 1;67(23):11147-57.


Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study.

Yang XR, Pfeiffer RM, Garcia-Closas M, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Cartun RW, Mandich D, Sasano H, Evans DB, Sutter TR, Sherman ME.

Cancer Res. 2007 Nov 1;67(21):10608-17. Epub 2007 Oct 29.


Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum.

Olsen CM, Huang Y, Goodwin S, Ciobanu DC, Lu L, Sutter TR, Winder DG.

Physiol Genomics. 2008 Feb 19;32(3):283-98. Epub 2007 Oct 2.


Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1.

Rahman M, Hayes Sutter C, Emmert GL, Sutter TR.

Toxicol Appl Pharmacol. 2006 Nov 1;216(3):469-78. Epub 2006 Jun 15.


Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women.

Gaudet MM, Chanock S, Lissowska J, Berndt SI, Yang XR, Peplonska B, Brinton LA, Welch R, Yeager M, Bardin-Mikolajczak A, Sherman ME, Sutter TR, Garcia-Closas M.

Pharmacogenet Genomics. 2006 Aug;16(8):547-53.


How replicable are mRNA expression QTL?

Peirce JL, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Goodwin S, Sutter TR, Williams RW, Lu L.

Mamm Genome. 2006 Jun;17(6):643-56. Epub 2006 Jun 12.


Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW.

Cancer Res. 2006 Feb 15;66(4):2488-94.


Uncertainties related to the assignment of a toxic equivalency factor for 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin.

Sutter CH, Rahman M, Sutter TR.

Regul Toxicol Pharmacol. 2006 Apr;44(3):219-25. Epub 2006 Feb 3. Review.


3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats.

Karuri AR, Huang Y, Bodreddigari S, Sutter CH, Roebuck BD, Kensler TW, Sutter TR.

J Pharmacol Exp Ther. 2006 Apr;317(1):61-7. Epub 2005 Dec 21.


Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione.

Huang Y, Yan J, Lubet R, Kensler TW, Sutter TR.

Physiol Genomics. 2006 Jan 12;24(2):144-53. Epub 2005 Nov 29.


Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene.

Harrigan JA, McGarrigle BP, Sutter TR, Olson JR.

Toxicol In Vitro. 2006 Jun;20(4):426-38. Epub 2005 Sep 28.


Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.

Mammen JS, Kleiner HE, DiGiovanni J, Sutter TR, Strickland PT.

Pharmacogenet Genomics. 2005 Mar;15(3):183-8.


Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers.

Kim JH, Sherman ME, Curriero FC, Guengerich FP, Strickland PT, Sutter TR.

Toxicol Appl Pharmacol. 2004 Sep 15;199(3):210-9.


Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats.

Fu X, Blaydes BS, Weis CC, Latendresse JR, Muskhelishvili L, Sutter TR, Delclos KB.

Chem Biol Interact. 2003 Dec 15;146(3):273-84.


Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz.

Roebuck BD, Curphey TJ, Li Y, Baumgartner KJ, Bodreddigari S, Yan J, Gange SJ, Kensler TW, Sutter TR.

Carcinogenesis. 2003 Dec;24(12):1919-28. Epub 2003 Oct 10.


Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol.

Mammen JS, Pittman GS, Li Y, Abou-Zahr F, Bejjani BA, Bell DA, Strickland PT, Sutter TR.

Carcinogenesis. 2003 Jul;24(7):1247-55. Epub 2003 Jun 5.


Multiple comparisons model-based clustering and ternary pattern tree numerical display of gene response to treatment: procedure and application to the preclinical evaluation of chemopreventive agents.

Sutter TR, He XR, Dimitrov P, Xu L, Narasimhan G, George EO, Sutter CH, Grubbs C, Savory R, Stephan-Gueldner M, Kreder D, Taylor MJ, Lubet R, Patterson TA, Kensler TW.

Mol Cancer Ther. 2002 Dec;1(14):1283-92.


Genotyping human cytochrome: P450 1B1 variants.

Sutter CH, Qian Z, Hong YP, Mammen JS, Strickland PT, Sutter TR.

Methods Enzymol. 2002;357:53-8. No abstract available.


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